kynurenine has been researched along with Chronic Kidney Diseases in 17 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In symptomatic patients with severe aortic stenosis undergoing transcatheter aortic valve replacement, circulating levels of long-chain acylcarnitines were independently associated with measures of maladaptive LV remodeling, and metabolic perturbations lessened after procedure completion." | 7.88 | Association of Acylcarnitines With Left Ventricular Remodeling in Patients With Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement. ( Elmariah, S; Farrell, LA; Furman, D; Gerszten, RE; Lindman, BR; Morningstar, JE; Rhee, EP; Shi, X, 2018) |
| "Amelioration of both oxidative and inflammation status after cholesterol lowering treatment in CKD might be mediated by restoration of antioxidant taurine concentrations during therapy (from 51." | 5.20 | Impact of cholesterol lowering treatment on plasma kynurenine and tryptophan concentrations in chronic kidney disease: relationship with oxidative stress improvement. ( Carru, C; Mangoni, AA; Sanna, M; Satta, AE; Sotgia, S; Zinellu, A, 2015) |
| "In symptomatic patients with severe aortic stenosis undergoing transcatheter aortic valve replacement, circulating levels of long-chain acylcarnitines were independently associated with measures of maladaptive LV remodeling, and metabolic perturbations lessened after procedure completion." | 3.88 | Association of Acylcarnitines With Left Ventricular Remodeling in Patients With Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement. ( Elmariah, S; Farrell, LA; Furman, D; Gerszten, RE; Lindman, BR; Morningstar, JE; Rhee, EP; Shi, X, 2018) |
| " Plasma MED concentrations, inflammation and oxidative stress indices [Kynurenine/Tryptophan (Kyn/Trp) ratio, malondialdehyde (MDA) and allantoin/uric acid (All/UA) ratio] were measured in 30 CKD patients randomized to three cholesterol lowering regimens for 12 months (simvastatin 40mg/day, ezetimibe/simvastatin 10/20mg/day, or ezetimibe/simvastatin 10/40mg/day)." | 3.83 | Effect of cholesterol lowering treatment on plasma markers of endothelial dysfunction in chronic kidney disease. ( Carru, C; Ena, S; Mangoni, AA; Satta, AE; Sotgia, S; Sotgiu, E; Zinellu, A, 2016) |
| "CC-chemokines and kynurenine pathway (KP) metabolites are associated with accelerated atherosclerosis in chronic kidney disease (CKD) patients." | 3.76 | 3-hydroxyanthranilic acid is independently associated with monocyte chemoattractant protein-1 (CCL2) and macrophage inflammatory protein-1beta (CCL4) in patients with chronic kidney disease. ( Kowalewska, A; Mysliwiec, M; Pawlak, D; Pawlak, K, 2010) |
| "Serum samples of 32 patients with ESRD (n = 13) and CKD (n = 19) were analyzed using chemical isotope labeling liquid chromatography-mass spectrometry metabolomics approach." | 1.91 | Metabolomics profiling distinctively identified end-stage renal disease patients from chronic kidney disease patients. ( Abdel Rahman, A; Alabdaljabar, MS; Dahabiyeh, LA; Hussein, MH; Jacob, M; Nimer, RM; Sabi, EM; Sumaily, KM, 2023) |
| "Kynurenine levels were significantly lower in the group under RASis compared to the untreated group (1." | 1.56 | RAS inhibition modulates kynurenine levels in a CKD population with and without type 2 diabetes mellitus. ( Benvenga, S; Bolignano, D; Buemi, M; Cernaro, V; Cigala, RM; Crea, F; De Stefano, C; Ferlazzo, VT; Gembillo, G; Genovese, ARR; Loddo, S; Macaione, V; Santoro, D; Vita, R, 2020) |
| "LP533401 is an inhibitor of peripheral serotonin synthesis." | 1.56 | Modulation of the Paracrine Kynurenic System in Bone as a New Regulator of Osteoblastogenesis and Bone Mineral Status in an Animal Model of Chronic Kidney Disease Treated with LP533401. ( Cylwik, B; Domaniewski, T; Kalaska, B; Mor, A; Pawlak, D; Pawlak, K; Sieklucka, B; Zieminska, M, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 8 (47.06) | 24.3611 |
| 2020's | 8 (47.06) | 2.80 |
| Authors | Studies |
|---|---|
| Walker, JA | 2 |
| Richards, S | 2 |
| Whelan, SA | 2 |
| Yoo, SB | 1 |
| Russell, TL | 1 |
| Arinze, N | 1 |
| Lotfollahzadeh, S | 2 |
| Napoleon, MA | 2 |
| Belghasem, M | 2 |
| Lee, N | 2 |
| Dember, LM | 2 |
| Ravid, K | 2 |
| Chitalia, VC | 3 |
| Arinze, NV | 1 |
| Yin, W | 1 |
| Ravid, JD | 1 |
| Hassan Kamel, M | 1 |
| Siracuse, JJ | 1 |
| Anderson, S | 1 |
| Farber, A | 1 |
| Sherr, D | 1 |
| Francis, J | 1 |
| Hamburg, NM | 1 |
| Rahimi, N | 1 |
| Wee, HN | 1 |
| Liu, JJ | 1 |
| Ching, J | 1 |
| Kovalik, JP | 1 |
| Lim, SC | 1 |
| Dahabiyeh, LA | 1 |
| Nimer, RM | 1 |
| Sumaily, KM | 1 |
| Alabdaljabar, MS | 1 |
| Jacob, M | 1 |
| Sabi, EM | 1 |
| Hussein, MH | 1 |
| Abdel Rahman, A | 1 |
| Hui, Y | 1 |
| Zhao, J | 3 |
| Yu, Z | 1 |
| Wang, Y | 1 |
| Qin, Y | 1 |
| Zhang, Y | 1 |
| Xing, Y | 1 |
| Han, M | 1 |
| Wang, A | 1 |
| Guo, S | 1 |
| Yuan, J | 1 |
| Zhao, Y | 1 |
| Ning, X | 1 |
| Sun, S | 1 |
| Cernaro, V | 1 |
| Loddo, S | 1 |
| Macaione, V | 1 |
| Ferlazzo, VT | 1 |
| Cigala, RM | 1 |
| Crea, F | 1 |
| De Stefano, C | 1 |
| Genovese, ARR | 1 |
| Gembillo, G | 1 |
| Bolignano, D | 1 |
| Santoro, D | 1 |
| Vita, R | 1 |
| Buemi, M | 1 |
| Benvenga, S | 1 |
| Cheng, Y | 1 |
| Li, Y | 1 |
| Benkowitz, P | 1 |
| Lamina, C | 1 |
| Köttgen, A | 1 |
| Sekula, P | 1 |
| Mor, A | 1 |
| Pawlak, K | 2 |
| Kalaska, B | 1 |
| Domaniewski, T | 1 |
| Sieklucka, B | 1 |
| Zieminska, M | 1 |
| Cylwik, B | 1 |
| Pawlak, D | 2 |
| Elmariah, S | 1 |
| Farrell, LA | 1 |
| Furman, D | 1 |
| Lindman, BR | 1 |
| Shi, X | 1 |
| Morningstar, JE | 1 |
| Rhee, EP | 1 |
| Gerszten, RE | 1 |
| Kolachalama, VB | 1 |
| Shashar, M | 1 |
| Alousi, F | 1 |
| Shivanna, S | 1 |
| Rijal, K | 1 |
| Belghasem, ME | 1 |
| Walker, J | 1 |
| Matsuura, S | 1 |
| Chang, GH | 1 |
| Gibson, CM | 1 |
| Francis, JM | 1 |
| Bao, YS | 1 |
| Ji, Y | 1 |
| Zhao, SL | 1 |
| Ma, LL | 1 |
| Xie, RJ | 1 |
| Na, SP | 1 |
| Zinellu, A | 2 |
| Sotgia, S | 2 |
| Mangoni, AA | 2 |
| Sanna, M | 1 |
| Satta, AE | 2 |
| Carru, C | 2 |
| Sotgiu, E | 1 |
| Ena, S | 1 |
| Schefold, JC | 1 |
| Zeden, JP | 1 |
| Fotopoulou, C | 1 |
| von Haehling, S | 1 |
| Pschowski, R | 1 |
| Hasper, D | 1 |
| Volk, HD | 1 |
| Schuett, C | 1 |
| Reinke, P | 1 |
| Kowalewska, A | 1 |
| Mysliwiec, M | 1 |
2 reviews available for kynurenine and Chronic Kidney Diseases
| Article | Year |
|---|---|
The Kynurenine Pathway in Acute Kidney Injury and Chronic Kidney Disease.
Topics: Acute Kidney Injury; Animals; Humans; Kynurenine; Renal Insufficiency, Chronic | 2021 |
The Role of Tryptophan Metabolism in the Occurrence and Progression of Acute and Chronic Kidney Diseases.
Topics: Acute Kidney Injury; Humans; Kynurenine; Renal Insufficiency, Chronic; Signal Transduction; Tryptoph | 2023 |
2 trials available for kynurenine and Chronic Kidney Diseases
| Article | Year |
|---|---|
Plasma kynurenic acid/tryptophan ratio: a sensitive and reliable biomarker for the assessment of renal function.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Female; Humans; Hypertension; Kidney Function Tes | 2013 |
Impact of cholesterol lowering treatment on plasma kynurenine and tryptophan concentrations in chronic kidney disease: relationship with oxidative stress improvement.
Topics: Aged; Allantoin; Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Dose-Res | 2015 |
13 other studies available for kynurenine and Chronic Kidney Diseases
| Article | Year |
|---|---|
Indoleamine 2,3-dioxygenase-1, a Novel Therapeutic Target for Post-Vascular Injury Thrombosis in CKD.
Topics: Animals; Aorta; Carotid Artery Injuries; Carotid Artery Thrombosis; Culture Media; Enzyme Induction; | 2021 |
Tryptophan metabolites suppress the Wnt pathway and promote adverse limb events in chronic kidney disease.
Topics: Aged; Aged, 80 and over; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Line; Disease M | 2022 |
Metabolomics profiling distinctively identified end-stage renal disease patients from chronic kidney disease patients.
Topics: Biomarkers; Disease Progression; Glomerular Filtration Rate; Humans; Kidney Failure, Chronic; Kynure | 2023 |
RAS inhibition modulates kynurenine levels in a CKD population with and without type 2 diabetes mellitus.
Topics: Aged; Aged, 80 and over; Angiotensins; Correlation of Data; Cross-Sectional Studies; Diabetes Mellit | 2020 |
The relationship between blood metabolites of the tryptophan pathway and kidney function: a bidirectional Mendelian randomization analysis.
Topics: Biomarkers; Disease Progression; Glomerular Filtration Rate; Humans; Indican; Indoles; Kynurenine; M | 2020 |
Modulation of the Paracrine Kynurenic System in Bone as a New Regulator of Osteoblastogenesis and Bone Mineral Status in an Animal Model of Chronic Kidney Disease Treated with LP533401.
Topics: Animals; Bone Diseases, Metabolic; Calcification, Physiologic; Kynurenine; Male; Mice; Osteoblasts; | 2020 |
Association of Acylcarnitines With Left Ventricular Remodeling in Patients With Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement.
Topics: Aged, 80 and over; Aortic Valve Stenosis; Biomarkers; Carnitine; Choline; Diabetes Complications; Fe | 2018 |
Uremic Solute-Aryl Hydrocarbon Receptor-Tissue Factor Axis Associates with Thrombosis after Vascular Injury in Humans.
Topics: Adult; Aged; Clinical Trials as Topic; Female; Humans; Indican; Kynurenine; Male; Metabolomics; Midd | 2018 |
Serum levels and activity of indoleamine2,3-dioxygenase and tryptophanyl-tRNA synthetase and their association with disease severity in patients with chronic kidney disease.
Topics: Adult; Biomarkers; Case-Control Studies; Female; Glomerular Filtration Rate; Humans; Indoleamine-Pyr | 2013 |
Simultaneous determination of plasma creatinine, uric acid, kynurenine and tryptophan by high-performance liquid chromatography: method validation and in application to the assessment of renal function.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Creatinine; Female; Humans; Hypertension; Kidney | 2015 |
Effect of cholesterol lowering treatment on plasma markers of endothelial dysfunction in chronic kidney disease.
Topics: Allantoin; Anticholesteremic Agents; Arginine; Biomarkers; Cholesterol; Endothelium; Ezetimibe; Fema | 2016 |
Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms.
Topics: 5-Hydroxytryptophan; Adult; Aged; C-Reactive Protein; Case-Control Studies; Creatinine; Female; Huma | 2009 |
3-hydroxyanthranilic acid is independently associated with monocyte chemoattractant protein-1 (CCL2) and macrophage inflammatory protein-1beta (CCL4) in patients with chronic kidney disease.
Topics: 3-Hydroxyanthranilic Acid; Adult; Aged; Atherosclerosis; Chemokine CCL2; Chemokine CCL4; Chemokines, | 2010 |