kynurenine has been researched along with Cerebral Ischemia in 20 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Post-stroke inflammation may induce upregulation of the kynurenine (KYN) pathway for tryptophan (TRP) oxidation, resulting in neuroprotective (kynurenic acid, KA) and neurotoxic metabolites (3-hydroxyanthranillic acid, 3-HAA)." | 7.76 | The role of tryptophan catabolism along the kynurenine pathway in acute ischemic stroke. ( Aerts, T; Brouns, R; De Deyn, PP; De Surgeloose, D; Scharpé, S; Verkerk, R; Wauters, A, 2010) |
| "Kynurenines are a wide range of catabolites which derive from tryptophan through the "Kynurenine Pathway" (KP)." | 6.53 | The Kynurenine Pathway in the Acute and Chronic Phases of Cerebral Ischemia. ( Ballesteros, I; Cuartero, MI; de la Parra, J; García-Culebras, A; Lizasoain, I; Moro, MÁ, 2016) |
| " These findings indicate that stroke patients with PSF have a lower bioavailability of TRP for 5-HT synthesis in the brain in the acute stroke phase." | 5.40 | Activation of the kynurenine pathway in the acute phase of stroke and its role in fatigue and depression following stroke. ( Amthor, KF; Ormstad, H; Sandvik, L; Verkerk, R, 2014) |
| "L-kynurenine sulfate was administered 15 min before permanent focal cerebral ischemia produced by electrocoagulation of the distal middle cerebral artery in mice." | 5.34 | Neuroprotective effect of L-kynurenine sulfate administered before focal cerebral ischemia in mice and global cerebral ischemia in gerbils. ( Gigler, G; Hársing, LG; Lévay, G; Sas, K; Simó, A; Szénási, G; Toldi, J; Vécsei, L, 2007) |
| "Indoleamine 2,3-dioxygenase (IDO) and the tryptophan-kynurenine pathway (TRP-KP) are upregulated in ageing and could be implicated in the pathogenesis of delirium." | 4.31 | Lipopolysaccharide-Induced Delirium-like Behaviour in a Rat Model of Chronic Cerebral Hypoperfusion Is Associated with Increased Indoleamine 2,3-Dioxygenase Expression and Endotoxin Tolerance. ( Ahmad, NS; Ang, HP; Embong, H; Makpol, S; Nasaruddin, ML; Tan, JK; Wan Zaidi, WA, 2023) |
| "Post-stroke inflammation may induce upregulation of the kynurenine (KYN) pathway for tryptophan (TRP) oxidation, resulting in neuroprotective (kynurenic acid, KA) and neurotoxic metabolites (3-hydroxyanthranillic acid, 3-HAA)." | 3.76 | The role of tryptophan catabolism along the kynurenine pathway in acute ischemic stroke. ( Aerts, T; Brouns, R; De Deyn, PP; De Surgeloose, D; Scharpé, S; Verkerk, R; Wauters, A, 2010) |
| "Kynurenines are a wide range of catabolites which derive from tryptophan through the "Kynurenine Pathway" (KP)." | 2.53 | The Kynurenine Pathway in the Acute and Chronic Phases of Cerebral Ischemia. ( Ballesteros, I; Cuartero, MI; de la Parra, J; García-Culebras, A; Lizasoain, I; Moro, MÁ, 2016) |
| " The toxic effects of 3-hydroxy-L-kynurenine are mediated by free radicals." | 2.48 | Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: novel therapeutic strategies for neurodegenerative disorders. ( Fülöp, F; Klivényi, P; Szalárdy, L; Toldi, J; Vécsei, L; Zádori, D, 2012) |
| " These findings indicate that stroke patients with PSF have a lower bioavailability of TRP for 5-HT synthesis in the brain in the acute stroke phase." | 1.40 | Activation of the kynurenine pathway in the acute phase of stroke and its role in fatigue and depression following stroke. ( Amthor, KF; Ormstad, H; Sandvik, L; Verkerk, R, 2014) |
| "L-kynurenine is a metabolic precursor of kynurenic acid, which is one of the few known endogenous N-methyl-D-aspartate receptor inhibitors." | 1.35 | Neuroprotection achieved in the ischaemic rat cortex with L-kynurenine sulphate. ( Agoston, M; Gigler, G; Robotka, H; Rózsa, E; Sas, K; Szénási, G; Toldi, J; Vécsei, L, 2008) |
| "L-kynurenine sulfate was administered 15 min before permanent focal cerebral ischemia produced by electrocoagulation of the distal middle cerebral artery in mice." | 1.34 | Neuroprotective effect of L-kynurenine sulfate administered before focal cerebral ischemia in mice and global cerebral ischemia in gerbils. ( Gigler, G; Hársing, LG; Lévay, G; Sas, K; Simó, A; Szénási, G; Toldi, J; Vécsei, L, 2007) |
| "Quinolinic acid is an excitotoxic kynurenine pathway metabolite, the concentration of which increases in human brain during immune activation." | 1.30 | Species heterogeneity between gerbils and rats: quinolinate production by microglia and astrocytes and accumulations in response to ischemic brain injury and systemic immune activation. ( Beagles, KE; Chen, CY; Heyes, MP; Kawai, K; Li, J; Markey, SP; Nowak, TS; Proescholdt, MA; Proescholdt, MG; Saito, K; Zito, MA, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 7 (35.00) | 29.6817 |
| 2010's | 9 (45.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ang, HP | 1 |
| Makpol, S | 1 |
| Nasaruddin, ML | 1 |
| Ahmad, NS | 1 |
| Tan, JK | 1 |
| Wan Zaidi, WA | 1 |
| Embong, H | 1 |
| Koo, YS | 1 |
| Kim, H | 1 |
| Park, JH | 1 |
| Kim, MJ | 1 |
| Shin, YI | 1 |
| Choi, BT | 1 |
| Lee, SY | 1 |
| Shin, HK | 1 |
| Ormstad, H | 2 |
| Verkerk, R | 2 |
| Amthor, KF | 1 |
| Sandvik, L | 1 |
| Cuartero, MI | 2 |
| de la Parra, J | 2 |
| García-Culebras, A | 1 |
| Ballesteros, I | 2 |
| Lizasoain, I | 2 |
| Moro, MÁ | 2 |
| Harkin, AL | 1 |
| Abautret-Daly, A | 1 |
| Sherwin, E | 1 |
| Fernández-Salguero, P | 1 |
| Corbí, AL | 1 |
| Padmanabhan, A | 1 |
| Haldar, SM | 1 |
| Eilertsen, G | 1 |
| Vamos, E | 1 |
| Pardutz, A | 1 |
| Klivenyi, P | 2 |
| Toldi, J | 4 |
| Vecsei, L | 5 |
| Sas, K | 4 |
| Brouns, R | 1 |
| Aerts, T | 1 |
| De Surgeloose, D | 1 |
| Wauters, A | 1 |
| Scharpé, S | 1 |
| De Deyn, PP | 1 |
| Zádori, D | 1 |
| Szalárdy, L | 1 |
| Fülöp, F | 1 |
| Carpenedo, R | 2 |
| Meli, E | 2 |
| Peruginelli, F | 1 |
| Pellegrini-Giampietro, DE | 2 |
| Moroni, F | 3 |
| Csete, K | 1 |
| Papp, JG | 1 |
| Cozzi, A | 1 |
| Chiarugi, A | 1 |
| Gigler, G | 2 |
| Szénási, G | 2 |
| Simó, A | 1 |
| Lévay, G | 1 |
| Hársing, LG | 1 |
| Robotka, H | 1 |
| Agoston, M | 1 |
| Rózsa, E | 1 |
| Heyes, MP | 1 |
| Saito, K | 1 |
| Chen, CY | 1 |
| Proescholdt, MG | 1 |
| Nowak, TS | 1 |
| Li, J | 1 |
| Beagles, KE | 1 |
| Proescholdt, MA | 1 |
| Zito, MA | 1 |
| Kawai, K | 1 |
| Markey, SP | 1 |
| Stone, TW | 1 |
| Nozaki, K | 1 |
| Beal, MF | 1 |
5 reviews available for kynurenine and Cerebral Ischemia
| Article | Year |
|---|---|
The Kynurenine Pathway in the Acute and Chronic Phases of Cerebral Ischemia.
Topics: Acute Disease; Brain Ischemia; Chronic Disease; Humans; Kynurenine; Metabolic Networks and Pathways; | 2016 |
The role of kynurenines in disorders of the central nervous system: possibilities for neuroprotection.
Topics: Alzheimer Disease; Animals; Brain; Brain Diseases; Brain Ischemia; Epilepsy; Humans; Huntington Dise | 2009 |
Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: novel therapeutic strategies for neurodegenerative disorders.
Topics: Animals; Brain Ischemia; Encephalitis; Humans; Huntington Disease; Kynurenine; Mitochondria | 2012 |
Tryptophan metabolism and brain function: focus on kynurenine and other indole metabolites.
Topics: Animals; Brain; Brain Ischemia; Enzyme Inhibitors; Hydrolases; Indoles; Kynurenine; Receptors, N-Met | 1999 |
Kynurenic acid antagonists and kynurenine pathway inhibitors.
Topics: Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Neu | 2001 |
15 other studies available for kynurenine and Cerebral Ischemia
| Article | Year |
|---|---|
Lipopolysaccharide-Induced Delirium-like Behaviour in a Rat Model of Chronic Cerebral Hypoperfusion Is Associated with Increased Indoleamine 2,3-Dioxygenase Expression and Endotoxin Tolerance.
Topics: Animals; Brain Ischemia; Delirium; Endotoxin Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynure | 2023 |
Indoleamine 2,3-Dioxygenase-Dependent Neurotoxic Kynurenine Metabolism Contributes to Poststroke Depression Induced in Mice by Ischemic Stroke along with Spatial Restraint Stress.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Brain Ischemia; Depressive Disorder; Indoleamine-Pyr | 2018 |
Activation of the kynurenine pathway in the acute phase of stroke and its role in fatigue and depression following stroke.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Brain Ischemia; Case-Control Studies; Depression; Fatigu | 2014 |
L-kynurenine/aryl hydrocarbon receptor pathway mediates brain damage after experimental stroke.
Topics: Animals; Azo Compounds; Basic Helix-Loop-Helix Transcription Factors; Brain; Brain Ischemia; Disease | 2014 |
Neuroprotection in ischemic stroke: AhR we making progress?
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Brain Ischemia; Humans; Infarction, Middle Ce | 2014 |
A biopsychosocial model of fatigue and depression following stroke.
Topics: Acute Disease; Brain Ischemia; Cytokines; Depression; Fatigue; Humans; Immune System; Kynurenine; Mo | 2015 |
Potential role of glutamate neurotransmission in the pathogenesis of ischemic brain damage and of depression. Effects of L-kynurenine on the survival of the hippocampal neurons and on the corticocerebral blood flow in ischemic animal models.
Topics: Animals; Brain Ischemia; Cell Survival; Cerebrovascular Circulation; Chromatography, High Pressure L | 2010 |
The role of tryptophan catabolism along the kynurenine pathway in acute ischemic stroke.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aged, 80 and over; Brain Ischemia; Free Radical Scavengers; Humans; | 2010 |
Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures.
Topics: Alanine; Animals; Brain Ischemia; Cell Death; Cell Hypoxia; Culture Media, Conditioned; Enzyme Inhib | 2002 |
Effect of systemic administration of L-kynurenine on corticocerebral blood flow under normal and ischemic conditions of the brain in conscious rabbits.
Topics: Animals; Atropine; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Heart Rate; Kynureni | 2003 |
Studies on the neuroprotective action of kynurenine mono-oxygenase inhibitors in post-ischemic brain damage.
Topics: Animals; Brain Ischemia; Cell Death; Enzyme Inhibitors; Glutamic Acid; Hippocampus; In Vitro Techniq | 2003 |
Neuroprotective effect of L-kynurenine sulfate administered before focal cerebral ischemia in mice and global cerebral ischemia in gerbils.
Topics: Amino Acids; Animals; Behavior, Animal; Blood-Brain Barrier; Body Temperature; Brain; Brain Ischemia | 2007 |
Neuroprotection achieved in the ischaemic rat cortex with L-kynurenine sulphate.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Fluoresceins; Kynurenine; Neu | 2008 |
Species heterogeneity between gerbils and rats: quinolinate production by microglia and astrocytes and accumulations in response to ischemic brain injury and systemic immune activation.
Topics: Animals; Astrocytes; Brain Ischemia; Encephalitis; Gerbillinae; Immune System; Injections, Intraperi | 1997 |
Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Dose-Response Re | 1992 |