kynurenine has been researched along with Central Nervous System Disease in 15 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quinolinic acid is an agonist at the population of glutamate receptors which are sensitive to N-methyl-D-aspartate (NMDA), and kynurenic acid is an antagonist at several glutamate receptors." | 6.42 | Tryptophan metabolites and brain disorders. ( Clark, CJ; Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW, 2003) |
| "Quinolinic acid (QUIN) is a neurotoxic metabolite of the kynurenine pathway that accumulates within the central nervous system following immune activation." | 5.29 | Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children. ( Heyes, MP; Milstien, S; Saito, K; Schiff, SJ, 1995) |
| "Quinolinic acid is an agonist at the population of glutamate receptors which are sensitive to N-methyl-D-aspartate (NMDA), and kynurenic acid is an antagonist at several glutamate receptors." | 2.42 | Tryptophan metabolites and brain disorders. ( Clark, CJ; Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW, 2003) |
| "In patients with no apparent CNS disease, CSF PIC levels were 10-fold higher in samples taken between 20:00 and 16:00 h compared with those collected between 04:00 and 12:00 h." | 1.35 | Age and circadian influences on picolinic acid concentrations in human cerebrospinal fluid. ( Bilgin, A; Coggan, SE; Grant, RS; Smythe, GA, 2009) |
| "Quinolinic acid (QUIN) is a neurotoxic metabolite of the kynurenine pathway that accumulates within the central nervous system following immune activation." | 1.29 | Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children. ( Heyes, MP; Milstien, S; Saito, K; Schiff, SJ, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (13.33) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 7 (46.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fazio, F | 1 |
| Ulivieri, M | 1 |
| Volpi, C | 1 |
| Gargaro, M | 1 |
| Fallarino, F | 1 |
| Vécsei, L | 4 |
| Dounay, AB | 1 |
| Tuttle, JB | 1 |
| Verhoest, PR | 1 |
| Török, N | 1 |
| Majláth, Z | 1 |
| Fülöp, F | 2 |
| Toldi, J | 3 |
| Anderson, G | 1 |
| Coggan, SE | 1 |
| Smythe, GA | 1 |
| Bilgin, A | 1 |
| Grant, RS | 1 |
| Kandanearatchi, A | 1 |
| Brew, BJ | 1 |
| Szalárdy, L | 1 |
| Stone, TW | 2 |
| Mackay, GM | 1 |
| Forrest, CM | 1 |
| Clark, CJ | 1 |
| Darlington, LG | 1 |
| Klivényi, P | 1 |
| Topczewska-Bruns, J | 1 |
| Pawlak, D | 1 |
| Tankiewicz, A | 1 |
| Chabielska, E | 1 |
| Buczko, W | 1 |
| Linkswiler, H | 1 |
| Heyes, MP | 1 |
| Saito, K | 1 |
| Milstien, S | 1 |
| Schiff, SJ | 1 |
| Raine, DN | 1 |
8 reviews available for kynurenine and Central Nervous System Disease
| Article | Year |
|---|---|
Targeting metabotropic glutamate receptors for the treatment of neuroinflammation.
Topics: Animals; Central Nervous System Diseases; Humans; Inflammation; Kynurenine; Mental Disorders; Microg | 2018 |
Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway.
Topics: Animals; Antineoplastic Agents; Central Nervous System Diseases; Enzyme Inhibitors; Humans; Indoleam | 2015 |
Brain Aging and Disorders of the Central Nervous System: Kynurenines and Drug Metabolism.
Topics: Aging; Animals; Brain; Central Nervous System Diseases; Humans; Kynurenine; Pharmaceutical Preparati | 2016 |
The kynurenine pathway and quinolinic acid: pivotal roles in HIV associated neurocognitive disorders.
Topics: Central Nervous System Diseases; Cognition Disorders; HIV; HIV Infections; Humans; Kynurenine; Quino | 2012 |
Kynurenines in the CNS: recent advances and new questions.
Topics: Animals; Autoimmune Diseases; Central Nervous System Diseases; Drug Design; Drug Evaluation, Preclin | 2013 |
Tryptophan metabolites and brain disorders.
Topics: AIDS Dementia Complex; Brain Diseases; Central Nervous System Diseases; Humans; Huntington Disease; | 2003 |
Kynurenines in neurodegenerative disorders: therapeutic consideration.
Topics: AIDS Dementia Complex; Animals; Central Nervous System Diseases; Down Syndrome; Enzyme Inhibitors; H | 2004 |
Kynurenines in the CNS: from endogenous obscurity to therapeutic importance.
Topics: Animals; Central Nervous System; Central Nervous System Diseases; Humans; Kynurenine; Neurotoxins; Q | 2001 |
7 other studies available for kynurenine and Central Nervous System Disease
| Article | Year |
|---|---|
[Nature Reviews Drug Discovery: editorial article of neuroscientists from Szeged about kynurenine (IF: 33.078)].
Topics: Animals; Central Nervous System Diseases; Humans; Kynurenine; Tryptophan | 2014 |
Editorial: The Kynurenine and Melatonergic Pathways in Psychiatric and CNS Disorders.
Topics: Central Nervous System Diseases; Humans; Kynurenine; Melatonin; Mental Disorders; Signal Transductio | 2016 |
Age and circadian influences on picolinic acid concentrations in human cerebrospinal fluid.
Topics: Aging; Analysis of Variance; C-Reactive Protein; Case-Control Studies; Central Nervous System Diseas | 2009 |
Kynurenine metabolism in central nervous system in experimental chronic renal failure.
Topics: Animals; Central Nervous System; Central Nervous System Diseases; Kidney Failure, Chronic; Kynurenin | 2003 |
Biochemical and physiological changes in vitamin B6 deficiency.
Topics: Alanine Transaminase; Anemia, Hypochromic; Central Nervous System Diseases; Cysteine; Erythrocytes; | 1967 |
Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children.
Topics: Adolescent; Adult; Bacterial Infections; Biomarkers; Biopterins; Central Nervous System Diseases; Ce | 1995 |
Effect of treatment on tryptophan metabolism in childhood epilepsy.
Topics: Adrenocorticotropic Hormone; Adult; Anticonvulsants; Central Nervous System Diseases; Child; Child, | 1969 |