kynurenine has been researched along with Cataract in 37 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Proteins isolated from the nuclei of normal lenses and lenses with and types I to IV nuclear cataract were hydrolyzed in 6 M HCl, and the levels of kynurenine-lysine and kynurenine-histidine were determined by HPLC." | 7.72 | Protein-bound kynurenine decreases with the progression of age-related nuclear cataract. ( Parker, NR; Sheil, M; Truscott, RJ; Vazquez, S, 2004) |
| "We compared the concentrations of protein-unbound non-tryptophan fluorescent substances in the water-soluble fraction between non-brunescent (NBr) and brunescent (Br) human cataractous lens nuclei." | 7.69 | [Comparison of free non-tryptophan fluorescent substances in water-soluble fraction of brunescent and non-brunescent human cataract]. ( Fukuda, R; Iwase, T; Matsukawa, S; Shirao, E; Shirao, Y, 1996) |
| "In 43 patients with presenile cataracts an oral tryptophan loading test with 5 g L-tryptophan was performed and the 24-hour urinary excretion of kynurenine and xanthurenic acid was determined." | 7.68 | Tryptophan metabolic studies in patients with presenile cataracts. ( Franke, G; Grimm, U; Knapp, A; Mellenthin, R; Seidlitz, G, 1990) |
| "In order to clarify the role of tryptophan in the patogenesis of senile cataract, we have studied the serum total and free levels of tryptophan in cataract patients as compared with age and sex-matched controls, and the urinary excretion of 10 metabolites after oral load of the amino acid." | 7.66 | Metabolism and serum levels of tryptophan in senile cataract patients. ( Allegri, G; Angi, MR; Costa, C; De Carli, M; Vanzan, S, 1982) |
| "The kynurenine content was threefold higher in homTg than in hemTg but was not detected in wild-type (Wt) lenses." | 5.35 | Indoleamine 2,3-dioxygenase overexpression causes kynurenine-modification of proteins, fiber cell apoptosis and cataract formation in the mouse lens. ( Butler, H; Caprara, MH; Doller, C; Howell, S; Mailankot, M; Nagaraj, RH; Reneker, LW; Staniszewska, MM; Wang, B, 2009) |
| "Age-related nuclear cataract is associated with coloration and insolubilization of lens proteins and extensive oxidation of cysteine and methionine residues." | 5.33 | 3-Hydroxykynurenine oxidizes alpha-crystallin: potential role in cataractogenesis. ( Aquilina, JA; Hains, PG; Korlimbinis, A; Truscott, RJ, 2006) |
| "ARN cataract is also characterized by extensive oxidation, insolubilization, and cross-linking of polypeptides, particularly in the nucleus of the lens." | 5.33 | Identification of 3-hydroxykynurenine bound to proteins in the human lens. A possible role in age-related nuclear cataract. ( Korlimbinis, A; Truscott, RJ, 2006) |
| "3-Hydroxykynurenine was detected at concentrations of 0." | 5.29 | Deamination of 3-hydroxykynurenine in bovine lenses: a possible mechanism of cataract formation in general. ( Malina, HZ; Martin, XD, 1995) |
| "1." | 5.29 | Relationship between serum tryptophan and tryptophan metabolite levels after tryptophan ingestion in normal subjects and age-related cataract patients. ( Elderfield, AJ; Truscott, RJ, 1995) |
| "In human cataract lenses the UV filters, 3-hydroxykynurenine glucoside (3OHKG) and kynurenine (Kyn) were found to be covalently bound to proteins and the levels in the nucleus were much higher than in the cortex." | 3.74 | Protein-bound and free UV filters in cataract lenses. The concentration of UV filters is much lower than in normal lenses. ( Aquilina, JA; Korlimbinis, A; Truscott, RJ, 2007) |
| "Proteins isolated from the nuclei of normal lenses and lenses with and types I to IV nuclear cataract were hydrolyzed in 6 M HCl, and the levels of kynurenine-lysine and kynurenine-histidine were determined by HPLC." | 3.72 | Protein-bound kynurenine decreases with the progression of age-related nuclear cataract. ( Parker, NR; Sheil, M; Truscott, RJ; Vazquez, S, 2004) |
| "The levels of the two major primate UV filters, 3-hydroxykynurenine glucoside (3OHKG) and 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid glucoside (AHBG), in cataract lenses were markedly decreased compared with levels in normal lenses." | 3.72 | Lenticular levels of amino acids and free UV filters differ significantly between normals and cataract patients. ( Jamie, JF; Streete, IM; Truscott, RJ, 2004) |
| "3-Hydroxykynurenine (3OHKyn), the precursor of UV filters in human lens, is highly autooxidizable, generates H2O2, and binds to lens proteins, yielding a tanned/yellow product resembling senile nuclear cataractous materials." | 3.70 | Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens. Relevance for senile nuclear cataract. ( Jamie, JF; Littlejohn, T; Takikawa, O; Truscott, RJ; Walker, MJ, 1999) |
| "The kynurenine pathway catabolite 3-hydroxykynurenine (3HK) and redox-active metals such as copper and iron are implicated in cataractogenesis." | 3.70 | 3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction. ( Atwood, CS; Bowden, EF; Bush, AI; Chylack, LT; Faget, KY; Goldstein, LE; Hartshorn, M; Huang, X; Leopold, MC; Lim, JT; Muffat, JA; Saunders, AJ; Scarpa, RC; Tanzi, RE, 2000) |
| "We compared the concentrations of protein-unbound non-tryptophan fluorescent substances in the water-soluble fraction between non-brunescent (NBr) and brunescent (Br) human cataractous lens nuclei." | 3.69 | [Comparison of free non-tryptophan fluorescent substances in water-soluble fraction of brunescent and non-brunescent human cataract]. ( Fukuda, R; Iwase, T; Matsukawa, S; Shirao, E; Shirao, Y, 1996) |
| "In 43 patients with presenile cataracts an oral tryptophan loading test with 5 g L-tryptophan was performed and the 24-hour urinary excretion of kynurenine and xanthurenic acid was determined." | 3.68 | Tryptophan metabolic studies in patients with presenile cataracts. ( Franke, G; Grimm, U; Knapp, A; Mellenthin, R; Seidlitz, G, 1990) |
| "In order to clarify the role of tryptophan in the patogenesis of senile cataract, we have studied the serum total and free levels of tryptophan in cataract patients as compared with age and sex-matched controls, and the urinary excretion of 10 metabolites after oral load of the amino acid." | 3.66 | Metabolism and serum levels of tryptophan in senile cataract patients. ( Allegri, G; Angi, MR; Costa, C; De Carli, M; Vanzan, S, 1982) |
| "Age-onset cataracts are believed to be expedited by the accumulation of UV-damaged human γD-crystallins in the eye lens." | 1.39 | UV-radiation induced disruption of dry-cavities in human γD-crystallin results in decreased stability and faster unfolding. ( Huynh, T; King, JA; Xia, Z; Yang, Z; Zhou, R, 2013) |
| "The kynurenine content was threefold higher in homTg than in hemTg but was not detected in wild-type (Wt) lenses." | 1.35 | Indoleamine 2,3-dioxygenase overexpression causes kynurenine-modification of proteins, fiber cell apoptosis and cataract formation in the mouse lens. ( Butler, H; Caprara, MH; Doller, C; Howell, S; Mailankot, M; Nagaraj, RH; Reneker, LW; Staniszewska, MM; Wang, B, 2009) |
| "Age-related nuclear cataract is associated with coloration and insolubilization of lens proteins and extensive oxidation of cysteine and methionine residues." | 1.33 | 3-Hydroxykynurenine oxidizes alpha-crystallin: potential role in cataractogenesis. ( Aquilina, JA; Hains, PG; Korlimbinis, A; Truscott, RJ, 2006) |
| "ARN cataract is also characterized by extensive oxidation, insolubilization, and cross-linking of polypeptides, particularly in the nucleus of the lens." | 1.33 | Identification of 3-hydroxykynurenine bound to proteins in the human lens. A possible role in age-related nuclear cataract. ( Korlimbinis, A; Truscott, RJ, 2006) |
| "L-kynurenine was also formed from the reaction of nitrite with free tryptophan." | 1.31 | The Nitrite/alpha crystallin reaction: a possible mechanism in lens matrix damage. ( Dillon, J; Paik, DC, 2000) |
| "3-Hydroxykynurenine was detected at concentrations of 0." | 1.29 | Deamination of 3-hydroxykynurenine in bovine lenses: a possible mechanism of cataract formation in general. ( Malina, HZ; Martin, XD, 1995) |
| "1." | 1.29 | Relationship between serum tryptophan and tryptophan metabolite levels after tryptophan ingestion in normal subjects and age-related cataract patients. ( Elderfield, AJ; Truscott, RJ, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (24.32) | 18.7374 |
| 1990's | 11 (29.73) | 18.2507 |
| 2000's | 12 (32.43) | 29.6817 |
| 2010's | 5 (13.51) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ehrenshaft, M | 1 |
| Roberts, JE | 1 |
| Mason, RP | 1 |
| Xia, Z | 2 |
| Yang, Z | 2 |
| Huynh, T | 2 |
| King, JA | 2 |
| Zhou, R | 2 |
| Linetsky, M | 1 |
| Raghavan, CT | 1 |
| Johar, K | 1 |
| Fan, X | 1 |
| Monnier, VM | 1 |
| Vasavada, AR | 1 |
| Nagaraj, RH | 2 |
| Mailankot, M | 1 |
| Staniszewska, MM | 1 |
| Butler, H | 1 |
| Caprara, MH | 1 |
| Howell, S | 1 |
| Wang, B | 1 |
| Doller, C | 1 |
| Reneker, LW | 1 |
| Varma, SD | 1 |
| Hegde, KR | 1 |
| Vazquez, S | 1 |
| Parker, NR | 1 |
| Sheil, M | 1 |
| Truscott, RJ | 9 |
| Laganovska, G | 1 |
| Martinsons, A | 1 |
| Pitrans, B | 1 |
| Widner, B | 1 |
| Fuchs, D | 1 |
| Streete, IM | 1 |
| Jamie, JF | 2 |
| Korlimbinis, A | 3 |
| Hains, PG | 1 |
| Aquilina, JA | 2 |
| Raju, TN | 1 |
| Kanth, VR | 1 |
| Reddy, PU | 1 |
| Snytnikova, OA | 1 |
| Fursova, AZh | 1 |
| Chernyak, EI | 1 |
| Vasiliev, VG | 1 |
| Morozov, SV | 1 |
| Kolosova, NG | 1 |
| Tsentalovich, YP | 1 |
| Dillon, J | 3 |
| Garcia Castineiras, S | 1 |
| Santiago, MA | 1 |
| Spector, A | 1 |
| Costa, C | 2 |
| Angi, MR | 2 |
| De Carli, M | 1 |
| Vanzan, S | 2 |
| Allegri, G | 2 |
| Yamamoto, K | 1 |
| Nishikiori, T | 1 |
| Kurimoto, Y | 1 |
| Malina, HZ | 2 |
| Martin, XD | 2 |
| Elderfield, AJ | 2 |
| Iwase, T | 1 |
| Shirao, E | 2 |
| Shirao, Y | 1 |
| Matsukawa, S | 1 |
| Fukuda, R | 1 |
| Dhir, P | 1 |
| Akhtar, NJ | 1 |
| Sun, TX | 1 |
| Liang, JJ | 1 |
| Chiarugi, A | 1 |
| Rapizzi, E | 1 |
| Moroni, F | 2 |
| Paik, DC | 1 |
| Garner, B | 1 |
| Shaw, DC | 1 |
| Lindner, RA | 1 |
| Carver, JA | 1 |
| Takikawa, O | 1 |
| Littlejohn, T | 1 |
| Walker, MJ | 1 |
| Goldstein, LE | 1 |
| Leopold, MC | 1 |
| Huang, X | 1 |
| Atwood, CS | 1 |
| Saunders, AJ | 1 |
| Hartshorn, M | 1 |
| Lim, JT | 1 |
| Faget, KY | 1 |
| Muffat, JA | 1 |
| Scarpa, RC | 1 |
| Chylack, LT | 1 |
| Bowden, EF | 1 |
| Tanzi, RE | 1 |
| Bush, AI | 1 |
| Elderfield, A | 1 |
| Truscott, R | 1 |
| Grimm, U | 1 |
| Knapp, A | 1 |
| Seidlitz, G | 1 |
| Franke, G | 1 |
| Mellenthin, R | 1 |
| Tomoda, A | 1 |
| Yoneyama, Y | 1 |
| Yamaguchi, T | 1 |
| Kawasaki, K | 1 |
| Van Heyningen, R | 1 |
| Kurzel, RB | 1 |
| Wolbarsht, ML | 1 |
| Yamanashi, BS | 1 |
| Binazzi, M | 1 |
| Calandra, P | 1 |
| Pirie, A | 1 |
37 other studies available for kynurenine and Cataract
| Article | Year |
|---|---|
Hypericin-mediated photooxidative damage of α-crystallin in human lens epithelial cells.
Topics: alpha-Crystallins; Animals; Anthracenes; Cataract; Cattle; Cell Line; Epithelial Cells; Humans; Kynu | 2013 |
UV-radiation induced disruption of dry-cavities in human γD-crystallin results in decreased stability and faster unfolding.
Topics: Cataract; gamma-Crystallins; Humans; Hydrophobic and Hydrophilic Interactions; Kynurenine; Molecular | 2013 |
Dissecting the contributions of β-hairpin tyrosine pairs to the folding and stability of long-lived human γD-crystallins.
Topics: Alanine; Cataract; Cations; gamma-Crystallins; Humans; Hydrophobic and Hydrophilic Interactions; Kyn | 2014 |
UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: implications for human lens aging and cataract formation.
Topics: Animals; Ascorbic Acid; Cataract; Crystallins; Glycation End Products, Advanced; Humans; Indoleamine | 2014 |
Indoleamine 2,3-dioxygenase overexpression causes kynurenine-modification of proteins, fiber cell apoptosis and cataract formation in the mouse lens.
Topics: Animals; Apoptosis; Cataract; Glutathione; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lens, C | 2009 |
Kynurenine-induced photo oxidative damage to lens in vitro: protective effect of caffeine.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Biological Transport; Caffeine; Cataract; Electron Sp | 2010 |
Protein-bound kynurenine decreases with the progression of age-related nuclear cataract.
Topics: Aged; Aged, 80 and over; Aging; Cataract; Chromatography, High Pressure Liquid; Crystallins; Disease | 2004 |
Kynurenine and neopterin in the aqueous humor of the anterior chamber of the eye and in serum of cataract patients.
Topics: Aged; Aged, 80 and over; Aqueous Humor; Cataract; Exfoliation Syndrome; Humans; Kynurenine; Neopteri | 2003 |
Lenticular levels of amino acids and free UV filters differ significantly between normals and cataract patients.
Topics: Adult; Aged; Aged, 80 and over; Cataract; Chromatography, High Pressure Liquid; Glucosides; Humans; | 2004 |
3-Hydroxykynurenine oxidizes alpha-crystallin: potential role in cataractogenesis.
Topics: alpha-Crystallins; Animals; Catalysis; Cataract; Cattle; Chromatography, High Pressure Liquid; Cyste | 2006 |
Identification of 3-hydroxykynurenine bound to proteins in the human lens. A possible role in age-related nuclear cataract.
Topics: Aging; Animals; Butterflies; Cataract; Humans; Kynurenine; Lens, Crystalline; Moths; Oxidation-Reduc | 2006 |
Protein-bound and free UV filters in cataract lenses. The concentration of UV filters is much lower than in normal lenses.
Topics: Aged; Aged, 80 and over; Cataract; Chromatography, High Pressure Liquid; Eye Proteins; Glucosides; H | 2007 |
Influence of kynurenines in pathogenesis of cataract formation in tryptophan-deficient regimen in Wistar rats.
Topics: Animals; Antioxidants; Cataract; Diet; Kynurenine; Lens, Crystalline; Microscopy, Fluorescence; Oxid | 2007 |
Deaminated UV filter 3-hydroxykynurenine O-beta-D-glucoside is found in cataractous human lenses.
Topics: Aged; Aged, 80 and over; Cataract; Chromatography, High Pressure Liquid; Deamination; Glucosides; Gl | 2008 |
The endopeptidase-resistant protein fraction from human cataractous lenses.
Topics: Amino Acids; Cataract; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, High Pres | 1984 |
Photolytic changes in lens proteins.
Topics: Adolescent; Aged; Aging; Animals; Cataract; Cattle; Crystallins; Glucosides; Humans; In Vitro Techni | 1984 |
Metabolism and serum levels of tryptophan in senile cataract patients.
Topics: Age Factors; Aged; Cataract; Female; Humans; Kynurenine; Male; Middle Aged; Sex Factors; Tryptophan | 1982 |
Tryptophan lens levels in senile cataract.
Topics: Aged; Cataract; Female; Humans; Kynurenine; Lens, Crystalline; Male; Middle Aged; Oxidation-Reductio | 1982 |
[Brown cataract and kynurenine (author's transl)].
Topics: Aged; Cataract; Crystallins; Humans; Kynurenine | 1981 |
Deamination of 3-hydroxykynurenine in bovine lenses: a possible mechanism of cataract formation in general.
Topics: Animals; Cataract; Cattle; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Ciliary | 1995 |
Relationship between serum tryptophan and tryptophan metabolite levels after tryptophan ingestion in normal subjects and age-related cataract patients.
Topics: Age Factors; Aged; Aged, 80 and over; Case-Control Studies; Cataract; Fasting; Female; Humans; Kynur | 1995 |
[Comparison of free non-tryptophan fluorescent substances in water-soluble fraction of brunescent and non-brunescent human cataract].
Topics: Cataract; Chromatography, High Pressure Liquid; Fluorescence; Glucosides; Humans; Kynurenine; Lens, | 1996 |
Is an altered tryptophan metabolism responsible for age-related cataract?
Topics: 3-Hydroxyanthranilic Acid; Aged; Cataract; Chromatography, High Pressure Liquid; Female; Humans; Kyn | 1996 |
Xanthurenic acid derivative formation in the lens is responsible for senile cataract in humans.
Topics: Adult; Aging; Cataract; Chromatography, Thin Layer; Crystallins; Deamination; Electrophoresis, Polya | 1996 |
Photooxidized products of recombinant alpha A-crystallin and W9F mutant.
Topics: Cataract; Crystallins; Humans; In Vitro Techniques; Kynurenine; Mutation; Oxidation-Reduction; Photo | 1999 |
The kynurenine metabolic pathway in the eye: studies on 3-hydroxykynurenine, a putative cataractogenic compound.
Topics: Alanine; Animals; Cataract; Ciliary Body; Eye; Hydrolases; Iris; Kynurenine; Kynurenine 3-Monooxygen | 1999 |
The Nitrite/alpha crystallin reaction: a possible mechanism in lens matrix damage.
Topics: Aging; Animals; Cataract; Cattle; Chromatography, High Pressure Liquid; Crystallins; Electrophoresis | 2000 |
Non-oxidative modification of lens crystallins by kynurenine: a novel post-translational protein modification with possible relevance to ageing and cataract.
Topics: Aging; Animals; Cataract; Cattle; Crystallins; Kynurenine; Lens, Crystalline; Oxidation-Reduction; P | 2000 |
Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens. Relevance for senile nuclear cataract.
Topics: Aged; Cataract; Cell Line; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenin | 1999 |
3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction.
Topics: 3-Hydroxyanthranilic Acid; Animals; Ascorbic Acid; Cataract; Cattle; Copper; Crystallins; Electroche | 2000 |
Tryptophan metabolism in senile cataract patients assessed by high-performance liquid chromatography.
Topics: Aging; Cataract; Chromatography, High Pressure Liquid; Humans; Kynurenic Acid; Kynurenine; Tryptopha | 1991 |
Tryptophan metabolic studies in patients with presenile cataracts.
Topics: Adolescent; Adult; Cataract; Female; Humans; Kynurenine; Male; Pyridoxine; Tryptophan; Xanthurenates | 1990 |
Mechanism of coloration of human lenses induced by near-ultraviolet-photo-oxidized 3-hydroxykynurenine.
Topics: Amino Acids; Cataract; Color; Crystallins; Humans; Kynurenine; Lens Nucleus, Crystalline; Lens, Crys | 1990 |
Assay of fluorescent glucosides in the human lens.
Topics: Adolescent; Adult; Age Factors; Aged; Cataract; Child; Child, Preschool; Chromatography, Gel; Electr | 1973 |
Spectral studies on normal and cataractous intact human lenses.
Topics: Cataract; Crystallins; Humans; Kynurenine; Lens, Crystalline; Pigmentation; Spectrum Analysis; Trypt | 1973 |
Identification of an error in the tryptophan--niacin pathway in carriers of some dermatoses conditioned or aggravated by sunlight.
Topics: Adult; Aged; Animals; Atrophy; Cataract; Female; Gastric Juice; Humans; Hydrolases; Kynurenine; Ligh | 1971 |
Formation of N'-formylkynurenine in proteins from lens and other sources by exposure to sunlight.
Topics: Animals; Cataract; Cattle; Chromatography; Crystallins; Electrophoresis; Fluorescence; Humans; In Vi | 1971 |