kynurenine has been researched along with Cardiomegaly in 4 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Protocatechuic acid (3,4-dihydroxybenzoic acid) prevents oxidative stress, inflammation and cardiac hypertrophy." | 8.31 | Protocatechuic acid prevents isoproterenol-induced heart failure in mice by downregulating kynurenine-3-monooxygenase. ( Bai, L; Han, X; He, X; Jeon, MJ; Jeong, MH; Jeong, SM; Kee, HJ; Kee, SJ; Kim, SH; Zhou, H, 2023) |
| "Aberrant amino acid metabolism is implicated in cardiac hypertrophy, while the involvement of tryptophan metabolism in pathological cardiac hypertrophy remains elusive." | 8.31 | Indoleamine 2,3-Dioxygenase 1 Deletion-Mediated Kynurenine Insufficiency Inhibits Pathological Cardiac Hypertrophy. ( Cheng, J; Jiao, L; Nie, D; Song, J; Wang, CY; Wang, DW; Wang, F; Wang, Y; Wang, Z; Wen, Z; Wu, J; Yu, K; Yu, Q; Zhang, S; Zhao, C; Zhou, L, 2023) |
| " It was found that in a part of patients the long-term administration of antihypertensive drugs led to an increased accumulation of kynurenine as a manifestation of pyridoxal-5-phosphate deficiency." | 5.28 | Increased blood kynurenine level as a factor inhibiting the therapeutic effect of antihypertensive agents in combined long-term treatment of essential hypertension. ( Liepinja, DJ; Rudzite, VK; Silava, AK; Vitols, AV, 1990) |
| "Protocatechuic acid (3,4-dihydroxybenzoic acid) prevents oxidative stress, inflammation and cardiac hypertrophy." | 4.31 | Protocatechuic acid prevents isoproterenol-induced heart failure in mice by downregulating kynurenine-3-monooxygenase. ( Bai, L; Han, X; He, X; Jeon, MJ; Jeong, MH; Jeong, SM; Kee, HJ; Kee, SJ; Kim, SH; Zhou, H, 2023) |
| "Aberrant amino acid metabolism is implicated in cardiac hypertrophy, while the involvement of tryptophan metabolism in pathological cardiac hypertrophy remains elusive." | 4.31 | Indoleamine 2,3-Dioxygenase 1 Deletion-Mediated Kynurenine Insufficiency Inhibits Pathological Cardiac Hypertrophy. ( Cheng, J; Jiao, L; Nie, D; Song, J; Wang, CY; Wang, DW; Wang, F; Wang, Y; Wang, Z; Wen, Z; Wu, J; Yu, K; Yu, Q; Zhang, S; Zhao, C; Zhou, L, 2023) |
| " It was found that in a part of patients the long-term administration of antihypertensive drugs led to an increased accumulation of kynurenine as a manifestation of pyridoxal-5-phosphate deficiency." | 1.28 | Increased blood kynurenine level as a factor inhibiting the therapeutic effect of antihypertensive agents in combined long-term treatment of essential hypertension. ( Liepinja, DJ; Rudzite, VK; Silava, AK; Vitols, AV, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (75.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bai, L | 1 |
| Han, X | 1 |
| Kee, HJ | 1 |
| He, X | 1 |
| Kim, SH | 1 |
| Jeon, MJ | 1 |
| Zhou, H | 1 |
| Jeong, SM | 1 |
| Kee, SJ | 1 |
| Jeong, MH | 1 |
| Wang, Y | 1 |
| Song, J | 1 |
| Yu, K | 1 |
| Nie, D | 1 |
| Zhao, C | 2 |
| Jiao, L | 1 |
| Wang, Z | 1 |
| Zhou, L | 1 |
| Wang, F | 1 |
| Yu, Q | 1 |
| Zhang, S | 1 |
| Wen, Z | 1 |
| Wu, J | 1 |
| Wang, CY | 1 |
| Wang, DW | 1 |
| Cheng, J | 1 |
| Liu, Y | 1 |
| Li, S | 2 |
| Gao, Z | 1 |
| Tan, Q | 1 |
| Li, Y | 1 |
| Wang, D | 1 |
| Wang, Q | 1 |
| Rudzite, VK | 1 |
| Vitols, AV | 1 |
| Liepinja, DJ | 1 |
| Silava, AK | 1 |
4 other studies available for kynurenine and Cardiomegaly
| Article | Year |
|---|---|
Protocatechuic acid prevents isoproterenol-induced heart failure in mice by downregulating kynurenine-3-monooxygenase.
Topics: Animals; Cardiomegaly; Heart Failure; Isoproterenol; Kynurenine; Kynurenine 3-Monooxygenase; Mice; M | 2023 |
Indoleamine 2,3-Dioxygenase 1 Deletion-Mediated Kynurenine Insufficiency Inhibits Pathological Cardiac Hypertrophy.
Topics: Animals; Cardiomegaly; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mass Spectrometry; | 2023 |
Indoleamine 2,3-Dioxygenase 1 (IDO1) Promotes Cardiac Hypertrophy via a PI3K-AKT-mTOR-Dependent Mechanism.
Topics: Adult; Aged; Animals; Cardiomegaly; Case-Control Studies; Cells, Cultured; Disease Models, Animal; F | 2021 |
Increased blood kynurenine level as a factor inhibiting the therapeutic effect of antihypertensive agents in combined long-term treatment of essential hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Cardiac Volume; Cardiomegaly; Clonidine; Drug Therap | 1990 |