kynurenine has been researched along with Carcinogenesis in 8 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Carcinogenesis: The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We identified tryptophan, methionine, kynurenine, and 5-methylthioadenosine as differentially regulated metabolites (DRM) in glioblastoma cells compared with normal human astrocytes (NHAs)." | 7.83 | Methionine and Kynurenine Activate Oncogenic Kinases in Glioblastoma, and Methionine Deprivation Compromises Proliferation. ( Bassett, E; Chakravarti, A; Fischer, SM; Gordon, N; Jacob, JR; Kanji, S; Lautenschlaeger, T; Litzenberg, KT; Palanichamy, K; Patel, D; Ramasubramanian, B; Ray-Chaudhury, A; Sebastian, N; Singh, R; Thirumoorthy, K, 2016) |
| "Tryptophan metabolism, via the kynurenine (Kyn) pathway, and microbial transformation of tryptophan to indolic compounds are fundamental for host health; both of which are altered in colon carcinogenesis." | 5.12 | Targeting Dietary and Microbial Tryptophan-Indole Metabolism as Therapeutic Approaches to Colon Cancer. ( Greathouse, KL; Wyatt, M, 2021) |
| "We identified tryptophan, methionine, kynurenine, and 5-methylthioadenosine as differentially regulated metabolites (DRM) in glioblastoma cells compared with normal human astrocytes (NHAs)." | 3.83 | Methionine and Kynurenine Activate Oncogenic Kinases in Glioblastoma, and Methionine Deprivation Compromises Proliferation. ( Bassett, E; Chakravarti, A; Fischer, SM; Gordon, N; Jacob, JR; Kanji, S; Lautenschlaeger, T; Litzenberg, KT; Palanichamy, K; Patel, D; Ramasubramanian, B; Ray-Chaudhury, A; Sebastian, N; Singh, R; Thirumoorthy, K, 2016) |
| "The expression of TDO2 in ovarian cancer tissues, normal ovarian tissues and fallopian tube tissues were analyzed using the gene expression data from The Cancer Genome Atlas and Genotype‑Tissue Expression project." | 1.62 | Tryptophan 2, 3‑dioxygenase promotes proliferation, migration and invasion of ovarian cancer cells. ( Chen, L; Chen, W; Cheng, X; Du, J; He, Q; Jiang, J; Ou, R; Tang, KF; Tao, F; Wu, X; Xu, Y; Zhao, Y; Zhong, S, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 5 (62.50) | 2.80 |
| Authors | Studies |
|---|---|
| Trézéguet, V | 1 |
| Fatrouni, H | 1 |
| Merched, AJ | 1 |
| Mathsyaraja, H | 1 |
| Freie, B | 1 |
| Cheng, PF | 1 |
| Babaeva, E | 1 |
| Catchpole, JT | 1 |
| Janssens, D | 1 |
| Henikoff, S | 1 |
| Eisenman, RN | 1 |
| Du, L | 1 |
| Xing, Z | 1 |
| Tao, B | 1 |
| Li, T | 1 |
| Yang, D | 1 |
| Li, W | 1 |
| Zheng, Y | 1 |
| Kuang, C | 1 |
| Yang, Q | 1 |
| Xiong, J | 1 |
| Zhang, X | 1 |
| Zhang, Y | 1 |
| Wu, B | 1 |
| Fang, L | 1 |
| Wang, N | 1 |
| Yi, H | 1 |
| Chang, N | 1 |
| Chen, L | 2 |
| Zhang, J | 1 |
| Zhao, Y | 1 |
| Tao, F | 1 |
| Jiang, J | 1 |
| Du, J | 1 |
| Cheng, X | 1 |
| He, Q | 1 |
| Zhong, S | 1 |
| Chen, W | 1 |
| Wu, X | 1 |
| Ou, R | 1 |
| Xu, Y | 1 |
| Tang, KF | 1 |
| Wyatt, M | 1 |
| Greathouse, KL | 1 |
| Duan, ZQ | 1 |
| Li, Y | 1 |
| Li, L | 1 |
| Palanichamy, K | 1 |
| Thirumoorthy, K | 1 |
| Kanji, S | 1 |
| Gordon, N | 1 |
| Singh, R | 1 |
| Jacob, JR | 1 |
| Sebastian, N | 1 |
| Litzenberg, KT | 1 |
| Patel, D | 1 |
| Bassett, E | 1 |
| Ramasubramanian, B | 1 |
| Lautenschlaeger, T | 1 |
| Fischer, SM | 1 |
| Ray-Chaudhury, A | 1 |
| Chakravarti, A | 1 |
2 reviews available for kynurenine and Carcinogenesis
| Article | Year |
|---|---|
Immuno-Metabolic Modulation of Liver Oncogenesis by the Tryptophan Metabolism.
Topics: Carcinogenesis; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Liver; L | 2021 |
Targeting Dietary and Microbial Tryptophan-Indole Metabolism as Therapeutic Approaches to Colon Cancer.
Topics: Basic Helix-Loop-Helix Transcription Factors; Carcinogenesis; Colon; Colonic Neoplasms; Combined Mod | 2021 |
6 other studies available for kynurenine and Carcinogenesis
| Article | Year |
|---|---|
Topics: Active Transport, Cell Nucleus; Animals; Basic-Leucine Zipper Transcription Factors; Carcinogenesis; | 2019 |
Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn-AhR-AQP4 signaling pathway.
Topics: Animals; Aquaporin 4; Carcinogenesis; Female; Glioma; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; | 2020 |
Aryl hydrocarbon receptor mediates Jak2/STAT3 signaling for non-small cell lung cancer stem cell maintenance.
Topics: Adult; Aged; Animals; Azo Compounds; Basic Helix-Loop-Helix Transcription Factors; Carcinogenesis; C | 2020 |
Tryptophan 2, 3‑dioxygenase promotes proliferation, migration and invasion of ovarian cancer cells.
Topics: Carcinogenesis; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Movement; Cell Proliferation; | 2021 |
Experimental evidences for miR-30b as a negative regulator of FOXO3 upregulated by kynurenine.
Topics: Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Forkhead Box Protein O3; Gene E | 2017 |
Methionine and Kynurenine Activate Oncogenic Kinases in Glioblastoma, and Methionine Deprivation Compromises Proliferation.
Topics: Astrocytes; Biomarkers, Tumor; Carcinogenesis; Cell Line; Cell Proliferation; Chromatography, High P | 2016 |