Page last updated: 2024-10-19

kynurenine and Cancer of Pancreas

kynurenine has been researched along with Cancer of Pancreas in 13 studies

Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.

Research Excerpts

ExcerptRelevanceReference
"In this study, a new mathematical model was established and validated to forecast and define sensitive targets in the kynurenine pathway (Kynp) in pancreatic adenocarcinoma (PDAC)."8.02Forecasting sensitive targets of the kynurenine pathway in pancreatic adenocarcinoma using mathematical modeling. ( Alahdal, M; Duan, L; Ouyang, H; Sun, D; Wang, D; Wang, M; Xiong, J, 2021)
"Metabolomic profiling identified glucose and kynurenine to have potential clinical utility for differentiating mucinous from nonmucinous pancreatic cysts."7.79Metabolomic-derived novel cyst fluid biomarkers for pancreatic cysts: glucose and kynurenine. ( Banerjee, S; Bowen, R; Chen, AM; Fitch, WL; Friedland, S; Lowe, AW; Norton, JA; Pai, RK; Park, WG; Pasricha, PJ; Peltz, G; Poultsides, GA; Scott, BA; Visser, BC; Wodziak, D; Wu, M; Zheng, M, 2013)
" Herein, we study the role of indoleamine 2,3-dioxygenase 1 (IDO1), an enzyme important in the conversion of tryptophan to kynurenine, in a murine model of pancreatic cancer-associated depression."4.12IDO1 Is a Therapeutic Target for Pancreatic Cancer-Associated Depression. ( Graor, HJ; Hajihassani, O; Hue, JJ; Ji, K; Katayama, ES; Loftus, AW; Vaziri-Gohar, A; Winter, JM; Zarei, M, 2022)
"In this study, a new mathematical model was established and validated to forecast and define sensitive targets in the kynurenine pathway (Kynp) in pancreatic adenocarcinoma (PDAC)."4.02Forecasting sensitive targets of the kynurenine pathway in pancreatic adenocarcinoma using mathematical modeling. ( Alahdal, M; Duan, L; Ouyang, H; Sun, D; Wang, D; Wang, M; Xiong, J, 2021)
"17 patients with pancreatic adenocarcinoma were recruited and completed mood questionnaires (Functional Assessment of Cancer Therapy -Pancreatic Cancer, Beck Depression Inventory and the Beck Anxiety Inventory) and blood testing for serum levels of tryptophan, kynurenine, kynurenic acid and quinolinic acid."3.80A biological basis for depression in pancreatic cancer. ( Botwinick, IC; Chabot, JA; Cooper, T; Mann, JJ; Pursell, L; Yu, G, 2014)
"Metabolomic profiling identified glucose and kynurenine to have potential clinical utility for differentiating mucinous from nonmucinous pancreatic cysts."3.79Metabolomic-derived novel cyst fluid biomarkers for pancreatic cysts: glucose and kynurenine. ( Banerjee, S; Bowen, R; Chen, AM; Fitch, WL; Friedland, S; Lowe, AW; Norton, JA; Pai, RK; Park, WG; Pasricha, PJ; Peltz, G; Poultsides, GA; Scott, BA; Visser, BC; Wodziak, D; Wu, M; Zheng, M, 2013)
"In the SUPPORT study, adult pancreatic cancer patients were randomized to intervention programs of 6-month (1) a Supervised moderate-to-high-intensity progressive resistance training or (2) unsupervised Home-based resistance training, or (3) to a standard care patient Control group."3.01Resistance Exercise Modulates Kynurenine Pathway in Pancreatic Cancer Patients. ( Clauss, D; Pal, A; Schmidt, ME; Steindorf, K; Ulrich, CM; Wiskemann, J; Zimmer, P, 2021)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.69)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (38.46)24.3611
2020's7 (53.85)2.80

Authors

AuthorsStudies
Liang, H1
Li, T1
Fang, X1
Xing, Z1
Zhang, S1
Shi, L1
Li, W1
Guo, L1
Kuang, C1
Liu, H1
Yang, Q1
Korac, K1
Rajasekaran, D1
Sniegowski, T1
Schniers, BK1
Ibrahim, AF1
Bhutia, YD2
Hue, JJ1
Graor, HJ1
Zarei, M1
Katayama, ES1
Ji, K1
Hajihassani, O1
Loftus, AW1
Vaziri-Gohar, A1
Winter, JM1
Yang, T1
Li, QQ1
Liu, YM1
Yang, B1
Jonescheit, H1
Oberg, HH1
Gonnermann, D1
Hermes, M1
Sulaj, V1
Peters, C1
Kabelitz, D1
Wesch, D1
Pal, A1
Zimmer, P1
Clauss, D1
Schmidt, ME1
Ulrich, CM1
Wiskemann, J1
Steindorf, K1
Alahdal, M1
Sun, D1
Duan, L1
Ouyang, H1
Wang, M1
Xiong, J1
Wang, D1
Ogura, J1
Miyauchi, S1
Shimono, K1
Yang, S1
Gonchigar, S1
Ganapathy, V1
Huang, JY1
Butler, LM1
Midttun, Ø1
Ulvik, A1
Wang, R1
Jin, A1
Gao, YT1
Ueland, PM1
Koh, WP1
Yuan, JM1
Leja-Szpak, A1
Góralska, M1
Link-Lenczowski, P1
Czech, U1
Nawrot-Porąbka, K1
Bonior, J1
Jaworek, J1
Park, WG1
Wu, M1
Bowen, R1
Zheng, M1
Fitch, WL1
Pai, RK1
Wodziak, D1
Visser, BC1
Poultsides, GA1
Norton, JA1
Banerjee, S1
Chen, AM1
Friedland, S1
Scott, BA1
Pasricha, PJ1
Lowe, AW1
Peltz, G1
Botwinick, IC1
Pursell, L1
Yu, G1
Cooper, T1
Mann, JJ1
Chabot, JA1
Ehrhart, H1
Ried, W1
Benoit, W1
Dörfler, H1

Trials

1 trial available for kynurenine and Cancer of Pancreas

ArticleYear
Resistance Exercise Modulates Kynurenine Pathway in Pancreatic Cancer Patients.
    International journal of sports medicine, 2021, Volume: 42, Issue:1

    Topics: Biomarkers; Disease Progression; Down-Regulation; Humans; Interleukin-6; Kynurenine; Metabolic Netwo

2021

Other Studies

12 other studies available for kynurenine and Cancer of Pancreas

ArticleYear
IDO1/TDO dual inhibitor RY103 targets Kyn-AhR pathway and exhibits preclinical efficacy on pancreatic cancer.
    Cancer letters, 2021, 12-01, Volume: 522

    Topics: Animals; Cell Movement; Cell Proliferation; Disease Models, Animal; Enzyme Inhibitors; Gene Expressi

2021
IDO1/TDO dual inhibitor RY103 targets Kyn-AhR pathway and exhibits preclinical efficacy on pancreatic cancer.
    Cancer letters, 2021, 12-01, Volume: 522

    Topics: Animals; Cell Movement; Cell Proliferation; Disease Models, Animal; Enzyme Inhibitors; Gene Expressi

2021
IDO1/TDO dual inhibitor RY103 targets Kyn-AhR pathway and exhibits preclinical efficacy on pancreatic cancer.
    Cancer letters, 2021, 12-01, Volume: 522

    Topics: Animals; Cell Movement; Cell Proliferation; Disease Models, Animal; Enzyme Inhibitors; Gene Expressi

2021
IDO1/TDO dual inhibitor RY103 targets Kyn-AhR pathway and exhibits preclinical efficacy on pancreatic cancer.
    Cancer letters, 2021, 12-01, Volume: 522

    Topics: Animals; Cell Movement; Cell Proliferation; Disease Models, Animal; Enzyme Inhibitors; Gene Expressi

2021
Carbidopa, an activator of aryl hydrocarbon receptor, suppresses IDO1 expression in pancreatic cancer and decreases tumor growth.
    The Biochemical journal, 2022, 09-16, Volume: 479, Issue:17

    Topics: Animals; Carbidopa; Indoleamine-Pyrrole 2,3,-Dioxygenase; Janus Kinases; Kynurenine; Mice; Mice, Nud

2022
Carbidopa, an activator of aryl hydrocarbon receptor, suppresses IDO1 expression in pancreatic cancer and decreases tumor growth.
    The Biochemical journal, 2022, 09-16, Volume: 479, Issue:17

    Topics: Animals; Carbidopa; Indoleamine-Pyrrole 2,3,-Dioxygenase; Janus Kinases; Kynurenine; Mice; Mice, Nud

2022
Carbidopa, an activator of aryl hydrocarbon receptor, suppresses IDO1 expression in pancreatic cancer and decreases tumor growth.
    The Biochemical journal, 2022, 09-16, Volume: 479, Issue:17

    Topics: Animals; Carbidopa; Indoleamine-Pyrrole 2,3,-Dioxygenase; Janus Kinases; Kynurenine; Mice; Mice, Nud

2022
Carbidopa, an activator of aryl hydrocarbon receptor, suppresses IDO1 expression in pancreatic cancer and decreases tumor growth.
    The Biochemical journal, 2022, 09-16, Volume: 479, Issue:17

    Topics: Animals; Carbidopa; Indoleamine-Pyrrole 2,3,-Dioxygenase; Janus Kinases; Kynurenine; Mice; Mice, Nud

2022
IDO1 Is a Therapeutic Target for Pancreatic Cancer-Associated Depression.
    Molecular cancer therapeutics, 2022, 12-02, Volume: 21, Issue:12

    Topics: Animals; Depression; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Pancreatic Neoplasms; T

2022
IDO1 Is a Therapeutic Target for Pancreatic Cancer-Associated Depression.
    Molecular cancer therapeutics, 2022, 12-02, Volume: 21, Issue:12

    Topics: Animals; Depression; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Pancreatic Neoplasms; T

2022
IDO1 Is a Therapeutic Target for Pancreatic Cancer-Associated Depression.
    Molecular cancer therapeutics, 2022, 12-02, Volume: 21, Issue:12

    Topics: Animals; Depression; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Pancreatic Neoplasms; T

2022
IDO1 Is a Therapeutic Target for Pancreatic Cancer-Associated Depression.
    Molecular cancer therapeutics, 2022, 12-02, Volume: 21, Issue:12

    Topics: Animals; Depression; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Pancreatic Neoplasms; T

2022
T cells in pancreatic cancer stroma: Tryptophan metabolism plays an important role in immunoregulation.
    World journal of gastroenterology, 2023, May-07, Volume: 29, Issue:17

    Topics: Animals; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Pancreatic Neoplasms; Th17 Cells; T

2023
T cells in pancreatic cancer stroma: Tryptophan metabolism plays an important role in immunoregulation.
    World journal of gastroenterology, 2023, May-07, Volume: 29, Issue:17

    Topics: Animals; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Pancreatic Neoplasms; Th17 Cells; T

2023
T cells in pancreatic cancer stroma: Tryptophan metabolism plays an important role in immunoregulation.
    World journal of gastroenterology, 2023, May-07, Volume: 29, Issue:17

    Topics: Animals; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Pancreatic Neoplasms; Th17 Cells; T

2023
T cells in pancreatic cancer stroma: Tryptophan metabolism plays an important role in immunoregulation.
    World journal of gastroenterology, 2023, May-07, Volume: 29, Issue:17

    Topics: Animals; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Pancreatic Neoplasms; Th17 Cells; T

2023
Influence of Indoleamine-2,3-Dioxygenase and Its Metabolite Kynurenine on γδ T Cell Cytotoxicity against Ductal Pancreatic Adenocarcinoma Cells.
    Cells, 2020, 05-06, Volume: 9, Issue:5

    Topics: Adenocarcinoma; Adult; Carcinoma, Pancreatic Ductal; Cell Communication; Cell Cycle Checkpoints; Cel

2020
Forecasting sensitive targets of the kynurenine pathway in pancreatic adenocarcinoma using mathematical modeling.
    Cancer science, 2021, Volume: 112, Issue:4

    Topics: Adenocarcinoma; Cell Line, Tumor; Humans; Kynurenine; Models, Theoretical; Pancreatic Neoplasms; Rep

2021
Forecasting sensitive targets of the kynurenine pathway in pancreatic adenocarcinoma using mathematical modeling.
    Cancer science, 2021, Volume: 112, Issue:4

    Topics: Adenocarcinoma; Cell Line, Tumor; Humans; Kynurenine; Models, Theoretical; Pancreatic Neoplasms; Rep

2021
Forecasting sensitive targets of the kynurenine pathway in pancreatic adenocarcinoma using mathematical modeling.
    Cancer science, 2021, Volume: 112, Issue:4

    Topics: Adenocarcinoma; Cell Line, Tumor; Humans; Kynurenine; Models, Theoretical; Pancreatic Neoplasms; Rep

2021
Forecasting sensitive targets of the kynurenine pathway in pancreatic adenocarcinoma using mathematical modeling.
    Cancer science, 2021, Volume: 112, Issue:4

    Topics: Adenocarcinoma; Cell Line, Tumor; Humans; Kynurenine; Models, Theoretical; Pancreatic Neoplasms; Rep

2021
Carbidopa is an activator of aryl hydrocarbon receptor with potential for cancer therapy.
    The Biochemical journal, 2017, 09-28, Volume: 474, Issue:20

    Topics: Active Transport, Cell Nucleus; Aryl Hydrocarbon Hydroxylases; Carbidopa; Cell Nucleus; Hep G2 Cells

2017
A prospective evaluation of serum kynurenine metabolites and risk of pancreatic cancer.
    PloS one, 2018, Volume: 13, Issue:5

    Topics: 3-Hydroxyanthranilic Acid; Biomarkers; Case-Control Studies; China; Female; Humans; Kynurenine; Male

2018
The Opposite Effect of L-kynurenine and Ahr Inhibitor Ch223191 on Apoptotic Protein Expression in Pancreatic Carcinoma Cells (Panc-1).
    Anti-cancer agents in medicinal chemistry, 2019, Volume: 19, Issue:17

    Topics: Antineoplastic Agents; Apoptosis; Azo Compounds; Cell Proliferation; Cell Survival; Dose-Response Re

2019
The Opposite Effect of L-kynurenine and Ahr Inhibitor Ch223191 on Apoptotic Protein Expression in Pancreatic Carcinoma Cells (Panc-1).
    Anti-cancer agents in medicinal chemistry, 2019, Volume: 19, Issue:17

    Topics: Antineoplastic Agents; Apoptosis; Azo Compounds; Cell Proliferation; Cell Survival; Dose-Response Re

2019
The Opposite Effect of L-kynurenine and Ahr Inhibitor Ch223191 on Apoptotic Protein Expression in Pancreatic Carcinoma Cells (Panc-1).
    Anti-cancer agents in medicinal chemistry, 2019, Volume: 19, Issue:17

    Topics: Antineoplastic Agents; Apoptosis; Azo Compounds; Cell Proliferation; Cell Survival; Dose-Response Re

2019
The Opposite Effect of L-kynurenine and Ahr Inhibitor Ch223191 on Apoptotic Protein Expression in Pancreatic Carcinoma Cells (Panc-1).
    Anti-cancer agents in medicinal chemistry, 2019, Volume: 19, Issue:17

    Topics: Antineoplastic Agents; Apoptosis; Azo Compounds; Cell Proliferation; Cell Survival; Dose-Response Re

2019
Metabolomic-derived novel cyst fluid biomarkers for pancreatic cysts: glucose and kynurenine.
    Gastrointestinal endoscopy, 2013, Volume: 78, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Cohort Studies; Cys

2013
A biological basis for depression in pancreatic cancer.
    HPB : the official journal of the International Hepato Pancreato Biliary Association, 2014, Volume: 16, Issue:8

    Topics: Adenocarcinoma; Affect; Aged; Aged, 80 and over; Depression; Female; Humans; Kynurenine; Lymphatic M

2014
[Studies on experimental leukemias (VII). Adenocarcinomas, sarcomas and leukemias in mice following subcutaneous injections of 3-hydroxykynurenine].
    Zeitschrift fur Krebsforschung, 1968, Volume: 71, Issue:1

    Topics: Animals; Carcinogens; Carcinoma; Injections, Subcutaneous; Kynurenine; Leukemia, Experimental; Leuke

1968