kynurenine has been researched along with Cancer of Colon in 13 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixty-six patients with colorectal cancer were studied (39 males; median age 66 years) of whom 25 had colorectal liver metastases only (17 males; median age 62 years; median liver metastasis volume 208 ml; median survival 234 days)." | 5.31 | Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer. ( Allen-Mersh, TG; Fuchs, D; Glover, C; Henderson, DC; Huang, A; Widner, B, 2002) |
| "Tryptophan metabolism, via the kynurenine (Kyn) pathway, and microbial transformation of tryptophan to indolic compounds are fundamental for host health; both of which are altered in colon carcinogenesis." | 5.12 | Targeting Dietary and Microbial Tryptophan-Indole Metabolism as Therapeutic Approaches to Colon Cancer. ( Greathouse, KL; Wyatt, M, 2021) |
| "C57Bl6 wild-type (control), IDO1-/-, Rag1-/-, and Rag1/IDO1 double-knockout mice were exposed to azoxymethane and dextran sodium sulfate to induce colitis and tumorigenesis." | 3.79 | IDO1 metabolites activate β-catenin signaling to promote cancer cell proliferation and colon tumorigenesis in mice. ( Bishnupuri, KS; Ciorba, MA; Foster, L; Kerr, TA; Marinshaw, JM; Newberry, RD; Rao, MS; Stenson, WF; Thaker, AI, 2013) |
| "In a mouse colon cancer model, TDO2 expression substantially enhanced liver metastasis, induced AHR-mediated PD-L1 transactivation, and dampened immune responses; these changes were all abolished by PD-L1 knockout." | 1.72 | Stemness and immune evasion conferred by the TDO2-AHR pathway are associated with liver metastasis of colon cancer. ( Aoki, K; Chung, S; Ichikawa, H; Kubo, T; Miyazaki, T; Mizoguchi, Y; Nakagama, H; Obata, Y; Ohata, H; Okamoto, K; Sakai, H; Shiokawa, D; Soga, T; Taniguchi, H, 2022) |
| "Kynurenine was inversely associated with colon cancer in ColoCare (OR per 1-SD = 0." | 1.62 | Circulating tryptophan metabolites and risk of colon cancer: Results from case-control and prospective cohort studies. ( Achaintre, D; Ardanaz, E; Baierl, A; Brezina, S; Bueno-de-Mesquita, B; Colorado-Yohar, SM; Geijsen, AJMR; Gicquiau, A; Gigic, B; Gsur, A; Gumpenberger, T; Gunter, MJ; Habermann, N; Kaaks, R; Kampman, E; Katzke, V; Keski-Rahkonen, P; Krogh, V; Murphy, N; Ose, J; Papadimitriou, N; Sánchez, MJ; Scalbert, A; Schulze, MB; Travis, RC; Ueland, PM; Ulrich, CM; van Roekel, EH; Weiderpass, E; Weijenberg, MP, 2021) |
| "Celastrol was found to inhibit the growth of colon cancer cells and induce apoptosis." | 1.48 | Celastrol Suppresses Tryptophan Catabolism in Human Colon Cancer Cells as Revealed by Metabolic Profiling and Targeted Metabolite Analysis. ( Duan, G; Lu, F; Lv, L; Qi, Y; Wang, R; Yan, H; Zhang, T; Zhao, L; Zhou, F, 2018) |
| "Sixty-six patients with colorectal cancer were studied (39 males; median age 66 years) of whom 25 had colorectal liver metastases only (17 males; median age 62 years; median liver metastasis volume 208 ml; median survival 234 days)." | 1.31 | Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer. ( Allen-Mersh, TG; Fuchs, D; Glover, C; Henderson, DC; Huang, A; Widner, B, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 6 (46.15) | 2.80 |
| Authors | Studies |
|---|---|
| Miyazaki, T | 1 |
| Chung, S | 1 |
| Sakai, H | 1 |
| Ohata, H | 1 |
| Obata, Y | 1 |
| Shiokawa, D | 1 |
| Mizoguchi, Y | 1 |
| Kubo, T | 1 |
| Ichikawa, H | 1 |
| Taniguchi, H | 1 |
| Aoki, K | 1 |
| Soga, T | 1 |
| Nakagama, H | 1 |
| Okamoto, K | 1 |
| Perez-Castro, L | 2 |
| Venkateswaran, N | 2 |
| Garcia, R | 1 |
| Hao, YH | 2 |
| Lafita-Navarro, MC | 2 |
| Kim, J | 1 |
| Segal, D | 1 |
| Saponzik, E | 1 |
| Chang, BJ | 1 |
| Fiolka, R | 1 |
| Danuser, G | 1 |
| Xu, L | 1 |
| Brabletz, T | 2 |
| Conacci-Sorrell, M | 2 |
| Nozawa, H | 1 |
| Taira, T | 1 |
| Sonoda, H | 1 |
| Sasaki, K | 1 |
| Murono, K | 1 |
| Emoto, S | 1 |
| Yokoyama, Y | 1 |
| Nagai, Y | 1 |
| Abe, S | 1 |
| Ishihara, S | 1 |
| Kilgore, JA | 1 |
| Braverman, J | 1 |
| Borenstein-Auerbach, N | 1 |
| Kim, M | 1 |
| Lesner, NP | 1 |
| Mishra, P | 1 |
| Shay, JW | 1 |
| DeBerardinis, RJ | 1 |
| Williams, NS | 1 |
| Yilmaz, OH | 1 |
| Schramme, F | 1 |
| Crosignani, S | 1 |
| Frederix, K | 1 |
| Hoffmann, D | 1 |
| Pilotte, L | 1 |
| Stroobant, V | 1 |
| Preillon, J | 1 |
| Driessens, G | 1 |
| Van den Eynde, BJ | 1 |
| Wyatt, M | 1 |
| Greathouse, KL | 1 |
| Papadimitriou, N | 1 |
| Gunter, MJ | 1 |
| Murphy, N | 1 |
| Gicquiau, A | 1 |
| Achaintre, D | 1 |
| Brezina, S | 1 |
| Gumpenberger, T | 1 |
| Baierl, A | 1 |
| Ose, J | 1 |
| Geijsen, AJMR | 1 |
| van Roekel, EH | 1 |
| Gsur, A | 1 |
| Gigic, B | 1 |
| Habermann, N | 1 |
| Ulrich, CM | 1 |
| Kampman, E | 1 |
| Weijenberg, MP | 1 |
| Ueland, PM | 1 |
| Kaaks, R | 1 |
| Katzke, V | 1 |
| Krogh, V | 1 |
| Bueno-de-Mesquita, B | 1 |
| Ardanaz, E | 1 |
| Travis, RC | 1 |
| Schulze, MB | 1 |
| Sánchez, MJ | 1 |
| Colorado-Yohar, SM | 1 |
| Weiderpass, E | 1 |
| Scalbert, A | 1 |
| Keski-Rahkonen, P | 1 |
| Park, JH | 1 |
| Lee, JM | 1 |
| Lee, EJ | 1 |
| Kim, DJ | 1 |
| Hwang, WB | 1 |
| Qi, Y | 1 |
| Wang, R | 1 |
| Zhao, L | 1 |
| Lv, L | 1 |
| Zhou, F | 1 |
| Zhang, T | 1 |
| Lu, F | 1 |
| Yan, H | 1 |
| Duan, G | 1 |
| Bishnupuri, KS | 2 |
| Alvarado, DM | 1 |
| Khouri, AN | 1 |
| Shabsovich, M | 1 |
| Chen, B | 1 |
| Dieckgraefe, BK | 1 |
| Ciorba, MA | 2 |
| Thaker, AI | 1 |
| Rao, MS | 1 |
| Kerr, TA | 1 |
| Foster, L | 1 |
| Marinshaw, JM | 1 |
| Newberry, RD | 1 |
| Stenson, WF | 1 |
| García-Navarro, A | 1 |
| González-Puga, C | 1 |
| Escames, G | 1 |
| López, LC | 1 |
| López, A | 1 |
| López-Cantarero, M | 1 |
| Camacho, E | 1 |
| Espinosa, A | 1 |
| Gallo, MA | 1 |
| Acuña-Castroviejo, D | 1 |
| Huang, A | 1 |
| Fuchs, D | 1 |
| Widner, B | 1 |
| Glover, C | 1 |
| Henderson, DC | 1 |
| Allen-Mersh, TG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis[NCT02328677] | 5,000 participants (Anticipated) | Observational | 2007-03-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for kynurenine and Cancer of Colon
| Article | Year |
|---|---|
Targeting Dietary and Microbial Tryptophan-Indole Metabolism as Therapeutic Approaches to Colon Cancer.
Topics: Basic Helix-Loop-Helix Transcription Factors; Carcinogenesis; Colon; Colonic Neoplasms; Combined Mod | 2021 |
12 other studies available for kynurenine and Cancer of Colon
| Article | Year |
|---|---|
Stemness and immune evasion conferred by the TDO2-AHR pathway are associated with liver metastasis of colon cancer.
Topics: Animals; B7-H1 Antigen; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Colonic Neop | 2022 |
The AHR target gene scinderin activates the WNT pathway by facilitating the nuclear translocation of β-catenin.
Topics: Actins; beta Catenin; Colonic Neoplasms; Cytochrome P-450 CYP1A1; Environmental Pollutants; Humans; | 2022 |
Enhancement of radiation therapy by indoleamine 2,3 dioxygenase 1 inhibition through multimodal mechanisms.
Topics: Animals; beta Catenin; Bromodeoxyuridine; Colonic Neoplasms; HT29 Cells; Humans; Indoleamine-Pyrrole | 2023 |
MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer.
Topics: Amino Acid Transport System ASC; Antineoplastic Agents; Arylformamidase; Cell Line; Cell Line, Tumor | 2019 |
Inhibition of Tryptophan-Dioxygenase Activity Increases the Antitumor Efficacy of Immune Checkpoint Inhibitors.
Topics: Animals; Antineoplastic Agents, Immunological; Cell Line, Tumor; Colonic Neoplasms; CTLA-4 Antigen; | 2020 |
Circulating tryptophan metabolites and risk of colon cancer: Results from case-control and prospective cohort studies.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Colonic Neoplasms; Female; Humans; Kynurenine; | 2021 |
Kynurenine promotes the goblet cell differentiation of HT-29 colon carcinoma cells by modulating Wnt, Notch and AhR signals.
Topics: Basic Helix-Loop-Helix Transcription Factors; beta Catenin; Cell Differentiation; Cell Proliferation | 2018 |
Celastrol Suppresses Tryptophan Catabolism in Human Colon Cancer Cells as Revealed by Metabolic Profiling and Targeted Metabolite Analysis.
Topics: Antineoplastic Agents; Cell Survival; Colonic Neoplasms; HCT116 Cells; Humans; Indoleamine-Pyrrole 2 | 2018 |
IDO1 and Kynurenine Pathway Metabolites Activate PI3K-Akt Signaling in the Neoplastic Colon Epithelium to Promote Cancer Cell Proliferation and Inhibit Apoptosis.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Colon; Colonic Neoplasms; Colorectal Neop | 2019 |
IDO1 metabolites activate β-catenin signaling to promote cancer cell proliferation and colon tumorigenesis in mice.
Topics: Animals; Azoxymethane; beta Catenin; Carcinogens; Cell Proliferation; Colitis; Colitis, Ulcerative; | 2013 |
Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture.
Topics: Cell Proliferation; Colonic Neoplasms; Glutathione; Glutathione Peroxidase; Glutathione Reductase; H | 2007 |
Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer.
Topics: Adenocarcinoma; Aged; Colonic Neoplasms; Colorectal Neoplasms; Humans; Interleukin-6; Kynurenine; Li | 2002 |