kynurenine has been researched along with Brain Disorders in 23 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quinolinic acid is an agonist at the population of glutamate receptors which are sensitive to N-methyl-D-aspartate (NMDA), and kynurenic acid is an antagonist at several glutamate receptors." | 6.42 | Tryptophan metabolites and brain disorders. ( Clark, CJ; Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW, 2003) |
| "Although some ITES syndromes have recognisable MRI neuroimaging phenotypes, there are otherwise few biomarkers of disease." | 5.91 | CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection-triggered encephalopathy syndromes. ( Andrews, PI; Ardern-Holmes, S; Bandodkar, S; Calvert, S; Dale, RC; Gill, D; Gupta, S; Han, VX; Kandula, T; Kothur, K; Malone, S; Menezes, MP; Mohammad, S; Patel, S; Subramanian, G; Thomas, T; Troedson, C; Waak, M; Yan, J, 2023) |
| "Quinolinic acid is an agonist at the population of glutamate receptors which are sensitive to N-methyl-D-aspartate (NMDA), and kynurenic acid is an antagonist at several glutamate receptors." | 2.42 | Tryptophan metabolites and brain disorders. ( Clark, CJ; Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW, 2003) |
| "Although some ITES syndromes have recognisable MRI neuroimaging phenotypes, there are otherwise few biomarkers of disease." | 1.91 | CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection-triggered encephalopathy syndromes. ( Andrews, PI; Ardern-Holmes, S; Bandodkar, S; Calvert, S; Dale, RC; Gill, D; Gupta, S; Han, VX; Kandula, T; Kothur, K; Malone, S; Menezes, MP; Mohammad, S; Patel, S; Subramanian, G; Thomas, T; Troedson, C; Waak, M; Yan, J, 2023) |
| "3-Hydroxykynurenine (3-HK) is a tryptophan metabolite whose level in the brain is elevated under several pathological states including Huntington's disease." | 1.29 | 3-Hydroxykynurenine toxicity on the rat striatum in vivo. ( Katsuki, H; Nakagami, Y; Saito, H, 1996) |
| "Quinolinic acid (QUIN) is an endogenous N-methyl-D-aspartate receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction." | 1.28 | Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. ( Crowley, JS; Davis, LE; Demitrack, MA; Der, M; Dilling, LA; Elia, J; Heyes, MP; Kruesi, MJ; Lackner, A; Saito, K, 1992) |
| "In patients with encephalopathy, serum QUIN was elevated with corresponding increments in CSF QUIN." | 1.28 | Neuroactive kynurenines in Lyme borreliosis. ( Halperin, JJ; Heyes, MP, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (52.17) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 3 (13.04) | 24.3611 |
| 2020's | 3 (13.04) | 2.80 |
| Authors | Studies |
|---|---|
| Phing, AH | 1 |
| Makpol, S | 1 |
| Nasaruddin, ML | 1 |
| Wan Zaidi, WA | 1 |
| Ahmad, NS | 1 |
| Embong, H | 1 |
| Dale, RC | 1 |
| Thomas, T | 1 |
| Patel, S | 1 |
| Han, VX | 1 |
| Kothur, K | 1 |
| Troedson, C | 1 |
| Gupta, S | 1 |
| Gill, D | 1 |
| Malone, S | 1 |
| Waak, M | 1 |
| Calvert, S | 1 |
| Subramanian, G | 1 |
| Andrews, PI | 1 |
| Kandula, T | 1 |
| Menezes, MP | 1 |
| Ardern-Holmes, S | 1 |
| Mohammad, S | 1 |
| Bandodkar, S | 1 |
| Yan, J | 1 |
| Fukuwatari, T | 1 |
| Reyes Ocampo, J | 1 |
| Lugo Huitrón, R | 1 |
| González-Esquivel, D | 1 |
| Ugalde-Muñiz, P | 1 |
| Jiménez-Anguiano, A | 1 |
| Pineda, B | 1 |
| Pedraza-Chaverri, J | 1 |
| Ríos, C | 2 |
| Pérez de la Cruz, V | 1 |
| Vamos, E | 1 |
| Pardutz, A | 1 |
| Klivenyi, P | 1 |
| Toldi, J | 1 |
| Vecsei, L | 1 |
| Adams Wilson, JR | 1 |
| Morandi, A | 1 |
| Girard, TD | 1 |
| Thompson, JL | 1 |
| Boomershine, CS | 1 |
| Shintani, AK | 1 |
| Ely, EW | 1 |
| Pandharipande, PP | 1 |
| Devlin, JW | 1 |
| Skrobik, Y | 1 |
| Stone, TW | 1 |
| Mackay, GM | 1 |
| Forrest, CM | 1 |
| Clark, CJ | 1 |
| Darlington, LG | 1 |
| Pérez-De La Cruz, V | 1 |
| Königsberg, M | 1 |
| Santamaría, A | 2 |
| Altagracia, M | 1 |
| Solís, F | 1 |
| Kravzov, J | 1 |
| Ordaz, H | 1 |
| Gonzalez, L | 1 |
| Schwarcz, R | 6 |
| Schapira, AH | 1 |
| Wu, HQ | 3 |
| Ungerstedt, U | 2 |
| Cheminal, R | 1 |
| Echenne, B | 1 |
| Bellet, H | 1 |
| Duran, M | 1 |
| Nakagami, Y | 1 |
| Saito, H | 1 |
| Katsuki, H | 1 |
| Sanni, LA | 1 |
| Thomas, SR | 1 |
| Tattam, BN | 1 |
| Moore, DE | 1 |
| Chaudhri, G | 1 |
| Stocker, R | 1 |
| Hunt, NH | 1 |
| Lee, SC | 1 |
| Myśliwiec, P | 1 |
| Pawlak, D | 1 |
| Du, F | 2 |
| Schmidt, W | 1 |
| Turski, WA | 1 |
| Gramsbergen, JB | 1 |
| Okuno, E | 1 |
| Roberts, RC | 1 |
| Heyes, MP | 2 |
| Saito, K | 1 |
| Crowley, JS | 1 |
| Davis, LE | 1 |
| Demitrack, MA | 1 |
| Der, M | 1 |
| Dilling, LA | 1 |
| Elia, J | 1 |
| Kruesi, MJ | 1 |
| Lackner, A | 1 |
| Halperin, JJ | 1 |
11 reviews available for kynurenine and Brain Disorders
| Article | Year |
|---|---|
Altered Tryptophan-Kynurenine Pathway in Delirium: A Review of the Current Literature.
Topics: Aged; Brain Diseases; Delirium; Humans; Immune System; Kynurenine; Quinolinic Acid; Tryptophan | 2023 |
Possibility of Amino Acid Treatment to Prevent the Psychiatric Disorders via Modulation of the Production of Tryptophan Metabolite Kynurenic Acid.
Topics: Amino Acids; Animals; Astrocytes; Brain; Brain Diseases; Humans; Kynurenic Acid; Kynurenine; Mental | 2020 |
Kynurenines with neuroactive and redox properties: relevance to aging and brain diseases.
Topics: Aging; Animals; Brain Diseases; Humans; Kynurenine; Metabolic Networks and Pathways; Neuroprotective | 2014 |
The role of kynurenines in disorders of the central nervous system: possibilities for neuroprotection.
Topics: Alzheimer Disease; Animals; Brain; Brain Diseases; Brain Ischemia; Epilepsy; Humans; Huntington Dise | 2009 |
Tryptophan metabolites and brain disorders.
Topics: AIDS Dementia Complex; Brain Diseases; Central Nervous System Diseases; Humans; Huntington Disease; | 2003 |
Kynurenine pathway and disease: an overview.
Topics: Animals; Brain Diseases; Humans; Kynurenine; Signal Transduction | 2007 |
Metabolism and function of brain kynurenines.
Topics: Animals; Brain; Brain Diseases; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Receptors, N-Me | 1993 |
The use of toxins to elucidate neural function and disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Brain; Brain Diseases; Disease Models, Animal; Humans; | 1993 |
[Kynurenic pathway in health and disease].
Topics: Animals; Brain; Brain Diseases; Humans; Kidney Diseases; Kynurenine; Liver Diseases; Nervous System; | 2000 |
Kynurenic acid: a potential pathogen in brain disorders.
Topics: Animals; Brain; Brain Diseases; Humans; Kynurenic Acid; Kynurenine; Lyases; Models, Neurological; Re | 1992 |
Quinolinic acid and kynurenic acid in the mammalian brain.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; AIDS Dementia Complex; Animals; Aspartic Acid; Biological Tra | 1991 |
12 other studies available for kynurenine and Brain Disorders
| Article | Year |
|---|---|
CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection-triggered encephalopathy syndromes.
Topics: Biomarkers; Brain Diseases; Chromatography, Liquid; Encephalitis; Humans; Kynurenine; Neopterin; Neu | 2023 |
The association of the kynurenine pathway of tryptophan metabolism with acute brain dysfunction during critical illness*.
Topics: Acute Disease; Aged; Brain Diseases; Critical Illness; Female; Humans; Kynurenine; Male; Metabolic N | 2012 |
The kynurenine pathway: a metabolinomic pathway for intensive care unit delirium?*.
Topics: Brain Diseases; Female; Humans; Kynurenine; Male; Tryptophan | 2012 |
Kynurenine and probenecid prevent quinolinic acid-induced neurotoxicity in rat corpus striatum.
Topics: Animals; Brain Diseases; gamma-Aminobutyric Acid; Kynurenine; Male; Neostriatum; Probenecid; Quinoli | 1994 |
L-alpha-aminoadipic acid as a regulator of kynurenic acid production in the hippocampus: a microdialysis study in freely moving rats.
Topics: 2-Aminoadipic Acid; Animals; Brain Diseases; Dialysis; Hippocampus; Kynurenic Acid; Kynurenine; Male | 1995 |
Congenital non-progressive encephalopathy and deafness with intermittent episodes of coma and hyperkynureninuria.
Topics: Algeria; Brain Diseases; Child; Child, Preschool; Coma; Deafness; Female; Humans; Infant; Intellectu | 1996 |
3-Hydroxykynurenine toxicity on the rat striatum in vivo.
Topics: Acetylcysteine; Animals; Brain Diseases; Corpus Striatum; Free Radical Scavengers; Injections, Intra | 1996 |
Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria.
Topics: Animals; Aspartic Acid; Brain; Brain Diseases; Female; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxy | 1998 |
Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus.
Topics: Animals; Brain Diseases; Dialysis Solutions; Hippocampus; Injections, Intraperitoneal; Kynurenic Aci | 2000 |
Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease.
Topics: Aged; Animals; Brain Diseases; Encephalitis; Female; HIV Infections; Humans; Kynurenic Acid; Kynuren | 1992 |
Neuroactive kynurenines in Lyme borreliosis.
Topics: Brain Diseases; Humans; Kynurenine; Lyme Disease; Lymphokines; Multiple Sclerosis; Nervous System Di | 1992 |
Regulation of kynurenic acid synthesis studied by microdialysis in the dorsal hippocampus of unanesthetized rats.
Topics: Aminooxyacetic Acid; Animals; Brain Diseases; Dialysis; Drug Interactions; Hippocampus; Kynurenic Ac | 1992 |