kynurenine has been researched along with Behavior Disorders in 28 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)-kynurenine (KYN) and guanine-tetrahydrobiopterin (BH4) metabolic pathways into inflammation cascade involved in aging and aging-associated medical and psychiatric disorders (AAMPD) (metabolic syndrome, depression, vascular cognitive impairment)." | 7.77 | Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders. ( Oxenkrug, GF, 2011) |
| "Up to date study results on specific psychiatric disorders such as schizophrenia, bipolar disorder, Alzheimer's disease, autism spectrum disorders, depression and alcoholism are presented." | 6.72 | Gut microbiota, kynurenine pathway and mental disorders - Review. ( Janoska-Jaździk, M; Marcinowicz, P; Szulc, A; Więdłocha, M, 2021) |
| "For this purpose, male and female abstinent AUD patients (N = 130) and healthy controls (N = 80) were clinically evaluated for substance use and mental disorders, and blood samples were collected to determine plasma concentrations of TRP, 5-HT, KYN and kynurenic acid (KA) using high performance liquid chromatography." | 3.96 | Plasma tryptophan and kynurenine pathway metabolites in abstinent patients with alcohol use disorder and high prevalence of psychiatric comorbidity. ( Araos, P; Colado, MI; Flores-López, M; García-Marchena, N; O'Shea, E; Pavón, FJ; Requena-Ocaña, N; Rodríguez de Fonseca, F; Rubio, G; Serrano, A; Suárez, J; Vidal, R, 2020) |
| "This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)-kynurenine (KYN) and guanine-tetrahydrobiopterin (BH4) metabolic pathways into inflammation cascade involved in aging and aging-associated medical and psychiatric disorders (AAMPD) (metabolic syndrome, depression, vascular cognitive impairment)." | 3.77 | Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders. ( Oxenkrug, GF, 2011) |
| "Indeed, female sex bias in neuropsychiatric diseases is involved in a reduced availability of this amino acid pool and 5-HT synthesis." | 3.01 | Sex Differences in Tryptophan Metabolism: A Systematic Review Focused on Neuropsychiatric Disorders. ( Castelo-Branco, M; Gonçalves, J; Martins, J; Pais, ML, 2023) |
| "Up to date study results on specific psychiatric disorders such as schizophrenia, bipolar disorder, Alzheimer's disease, autism spectrum disorders, depression and alcoholism are presented." | 2.72 | Gut microbiota, kynurenine pathway and mental disorders - Review. ( Janoska-Jaździk, M; Marcinowicz, P; Szulc, A; Więdłocha, M, 2021) |
| "The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of nicotinamide adenine dinucleotide (NAD+)." | 2.66 | The kynurenine pathway: a finger in every pie. ( Savitz, J, 2020) |
| "In the field of psychiatric disorders, namely in schizophrenia and depression, the role of IDO is linked to immune dysregulation." | 2.52 | [Indoleamine 2,3-dioxygenase in oncology and psychiatry]. ( Horáček, J; Vonka, V, 2015) |
| "Kynurenines have been implicated in the neuroendocrine regulatory processes." | 2.52 | [Stress and the kynurenine pathway]. ( Majláth, Z; Vécsei, L, 2015) |
| "Cognitive dysfunction is a prominent feature of psychiatric disorders." | 1.56 | C-Reactive Protein as a Possible Predictor of Trail-Making Performance in Individuals with Psychiatric Disorders. ( Bengesser, SA; Birner, A; Dalkner, N; Falzberger, VS; Fellendorf, FT; Hamm, C; Lenger, M; Mangge, H; McIntyre, RS; Pilz, R; Platzer, M; Queissner, R; Reininghaus, B; Reininghaus, E; Rieger, A; Schwalsberger, K; Weiss, EM, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.57) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (10.71) | 29.6817 |
| 2010's | 15 (53.57) | 24.3611 |
| 2020's | 9 (32.14) | 2.80 |
| Authors | Studies |
|---|---|
| Skorobogatov, K | 1 |
| De Picker, L | 1 |
| Verkerk, R | 1 |
| Coppens, V | 1 |
| Leboyer, M | 1 |
| Müller, N | 1 |
| Morrens, M | 1 |
| Pais, ML | 1 |
| Martins, J | 1 |
| Castelo-Branco, M | 1 |
| Gonçalves, J | 1 |
| Sheibani, M | 1 |
| Shayan, M | 1 |
| Khalilzadeh, M | 1 |
| Soltani, ZE | 1 |
| Jafari-Sabet, M | 1 |
| Ghasemi, M | 1 |
| Dehpour, AR | 1 |
| Gheorghe, CE | 1 |
| Martin, JA | 1 |
| Manriquez, FV | 1 |
| Dinan, TG | 1 |
| Cryan, JF | 1 |
| Clarke, G | 2 |
| Vidal, R | 1 |
| García-Marchena, N | 1 |
| O'Shea, E | 1 |
| Requena-Ocaña, N | 1 |
| Flores-López, M | 1 |
| Araos, P | 1 |
| Serrano, A | 1 |
| Suárez, J | 1 |
| Rubio, G | 1 |
| Rodríguez de Fonseca, F | 1 |
| Colado, MI | 1 |
| Pavón, FJ | 1 |
| Fukuwatari, T | 1 |
| Dalkner, N | 1 |
| Reininghaus, E | 1 |
| Schwalsberger, K | 1 |
| Rieger, A | 1 |
| Hamm, C | 1 |
| Pilz, R | 1 |
| Lenger, M | 1 |
| Queissner, R | 1 |
| Falzberger, VS | 1 |
| Platzer, M | 1 |
| Fellendorf, FT | 1 |
| Birner, A | 1 |
| Bengesser, SA | 1 |
| Weiss, EM | 1 |
| McIntyre, RS | 1 |
| Mangge, H | 1 |
| Reininghaus, B | 1 |
| Więdłocha, M | 1 |
| Marcinowicz, P | 1 |
| Janoska-Jaździk, M | 1 |
| Szulc, A | 1 |
| Mithaiwala, MN | 1 |
| Santana-Coelho, D | 1 |
| Porter, GA | 1 |
| O'Connor, JC | 1 |
| Cervenka, I | 1 |
| Agudelo, LZ | 1 |
| Ruas, JL | 1 |
| Fazio, F | 1 |
| Ulivieri, M | 1 |
| Volpi, C | 1 |
| Gargaro, M | 1 |
| Fallarino, F | 1 |
| Hüfner, K | 1 |
| Fuchs, D | 2 |
| Blauth, M | 1 |
| Sperner-Unterweger, B | 1 |
| Savitz, J | 1 |
| Shilov, IuE | 1 |
| Bezrukov, MV | 1 |
| Obál, I | 1 |
| Majláth, Z | 2 |
| Toldi, J | 1 |
| Vécsei, L | 2 |
| Kubesova, A | 1 |
| Tejkalova, H | 1 |
| Syslova, K | 1 |
| Kacer, P | 1 |
| Vondrousova, J | 1 |
| Tyls, F | 1 |
| Fujakova, M | 1 |
| Palenicek, T | 1 |
| Horacek, J | 2 |
| Vonka, V | 1 |
| Anderson, G | 1 |
| Strasser, B | 1 |
| Becker, K | 1 |
| Gostner, JM | 1 |
| Douet, V | 1 |
| Tanizaki, N | 1 |
| Franke, A | 1 |
| Li, X | 1 |
| Chang, L | 1 |
| Fitzgerald, P | 1 |
| Cassidy Eugene, M | 1 |
| Scully, P | 1 |
| Barry, S | 1 |
| Quigley Eamonn, MM | 1 |
| Shanahan, F | 1 |
| Cryan, J | 1 |
| Dinan Timothy, G | 1 |
| Myint, AM | 1 |
| Schwarz, MJ | 1 |
| Steinbusch, HW | 2 |
| Leonard, BE | 1 |
| Erhardt, S | 2 |
| Olsson, SK | 1 |
| Engberg, G | 1 |
| Oxenkrug, GF | 1 |
| van Donkelaar, EL | 1 |
| Blokland, A | 1 |
| Ferrington, L | 1 |
| Kelly, PA | 1 |
| Prickaerts, J | 1 |
| Lim, CK | 1 |
| Linderholm, KR | 1 |
| Janelidze, S | 1 |
| Lindqvist, D | 1 |
| Samuelsson, M | 1 |
| Lundberg, K | 1 |
| Postolache, TT | 1 |
| Träskman-Bendz, L | 1 |
| Guillemin, GJ | 1 |
| Brundin, L | 1 |
| HEELEY, AF | 1 |
| ROBERTS, GE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Investigating Brain Abnormalities in People With Knee Osteoarthritis Using MRI: a Nociplastic Pain Mechanism Based Assessment[NCT05986513] | 66 participants (Anticipated) | Interventional | 2023-09-01 | Not yet recruiting | |||
| Kynurenine Pathway Metabolites as Novel Translational Biological Markers of Irritable Bowel Syndrome: Relationship to Gastrointestinal Function, Cognition and Co-morbid Depression[NCT01304355] | 85 participants (Anticipated) | Observational | 2011-01-31 | Recruiting | |||
| The Safety and Effectiveness of Probiotic Supplementation on Bipolar Depression: a Proof of Concept Randomized Controlled Trial[NCT02155972] | Phase 2 | 16 participants (Actual) | Interventional | 2013-05-31 | Terminated (stopped due to The trial was terminated because of inability to recruit the needed number of participants) | ||
| The Role of Kynurenine Pathway Metabolites in Perinatal Depression and Suicidality[NCT02566980] | 209 participants (Actual) | Observational | 2014-10-23 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
18 reviews available for kynurenine and Behavior Disorders
| Article | Year |
|---|---|
Brain
Topics: Animals; Biomarkers; Blood-Brain Barrier; Brain; Disease Models, Animal; Disease Susceptibility; Hum | 2021 |
Sex Differences in Tryptophan Metabolism: A Systematic Review Focused on Neuropsychiatric Disorders.
Topics: Amino Acids; Female; Humans; Kynurenine; Male; Mental Disorders; Serotonin; Sex Characteristics; Try | 2023 |
Kynurenine pathway and its role in neurologic, psychiatric, and inflammatory bowel diseases.
Topics: Humans; Inflammatory Bowel Diseases; Kynurenine; Mental Disorders; Metabolic Networks and Pathways; | 2023 |
Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis.
Topics: Animals; Brain; Gastrointestinal Microbiome; Humans; Indoles; Kynurenine; Mental Disorders; Tryptoph | 2019 |
Possibility of Amino Acid Treatment to Prevent the Psychiatric Disorders via Modulation of the Production of Tryptophan Metabolite Kynurenic Acid.
Topics: Amino Acids; Animals; Astrocytes; Brain; Brain Diseases; Humans; Kynurenic Acid; Kynurenine; Mental | 2020 |
Gut microbiota, kynurenine pathway and mental disorders - Review.
Topics: Animals; Brain; Brain-Gut Axis; Gastrointestinal Microbiome; Humans; Kynurenine; Mental Disorders; P | 2021 |
Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications.
Topics: Animals; Humans; Inflammation; Kynurenine; Mental Disorders; Neurodegenerative Diseases | 2021 |
Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health.
Topics: Brain; Depression; Exercise; Gastrointestinal Microbiome; Gastrointestinal Tract; Humans; Inflammati | 2017 |
Targeting metabotropic glutamate receptors for the treatment of neuroinflammation.
Topics: Animals; Central Nervous System Diseases; Humans; Inflammation; Kynurenine; Mental Disorders; Microg | 2018 |
The kynurenine pathway: a finger in every pie.
Topics: Aging; Animals; Energy Metabolism; Humans; Kynurenine; Mental Disorders; NAD; Neurodegenerative Dise | 2020 |
[Kynurenines in pathogenesis of endogenous psychiatric disorders].
Topics: Humans; Hydroxyindoleacetic Acid; Kynurenine; Mental Disorders; Psychotic Disorders; Tryptophan; Xan | 2013 |
Mental disturbances in Parkinson's disease and related disorders: the role of excitotoxins.
Topics: Dopamine; Glutamic Acid; Humans; Kynurenine; Mental Disorders; Neuroprotective Agents; Neurotoxins; | 2014 |
[Indoleamine 2,3-dioxygenase in oncology and psychiatry].
Topics: Brain; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Mental Disorders; | 2015 |
[Stress and the kynurenine pathway].
Topics: Animals; Humans; Intestines; Irritable Bowel Syndrome; Kynurenine; Mental Disorders; Microcirculatio | 2015 |
Kynurenine pathway metabolism and immune activation: Peripheral measurements in psychiatric and co-morbid conditions.
Topics: Animals; Humans; Immune System Diseases; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mental Di | 2017 |
Neuropsychiatric disorders related to interferon and interleukins treatment.
Topics: Animals; Brain; Brain Diseases, Metabolic; Cytokines; Encephalitis; Humans; Interferons; Interleukin | 2009 |
Pharmacological manipulation of kynurenic acid: potential in the treatment of psychiatric disorders.
Topics: Animals; Cognition Disorders; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; | 2009 |
Mechanism of acute tryptophan depletion: is it only serotonin?
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Cerebrovascular Disorders; Cognition; Eating; Hum | 2011 |
10 other studies available for kynurenine and Behavior Disorders
| Article | Year |
|---|---|
Plasma tryptophan and kynurenine pathway metabolites in abstinent patients with alcohol use disorder and high prevalence of psychiatric comorbidity.
Topics: Adolescent; Adult; Aged; Aging; Alcohol Abstinence; Alcoholism; Body Mass Index; Cross-Sectional Stu | 2020 |
C-Reactive Protein as a Possible Predictor of Trail-Making Performance in Individuals with Psychiatric Disorders.
Topics: Adult; Aged; Biomarkers; C-Reactive Protein; Cognitive Dysfunction; Female; Humans; Inflammation; In | 2020 |
How acute and chronic physical disease may influence mental health - An Analysis of neurotransmitter precursor amino acid levels.
Topics: Acute Disease; Adult; Aged; Amino Acids; Anxiety Disorders; C-Reactive Protein; Chronic Disease; Dep | 2019 |
Biochemical, histopathological and morphological profiling of a rat model of early immune stimulation: relation to psychopathology.
Topics: Animals; Astrocytes; Biogenic Monoamines; Body Weight; Brain; Disease Models, Animal; Kynurenine; Ma | 2015 |
Editorial: The Kynurenine and Melatonergic Pathways in Psychiatric and CNS Disorders.
Topics: Central Nervous System Diseases; Humans; Kynurenine; Melatonin; Mental Disorders; Signal Transductio | 2016 |
Polymorphism of Kynurenine Pathway-Related Genes, Kynurenic Acid, and Psychopathological Symptoms in HIV.
Topics: Adult; Female; HIV Infections; Humans; Kynurenic Acid; Kynurenine; Male; Mental Disorders; Middle Ag | 2016 |
Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity.
Topics: Adult; Anxiety Disorders; Chromatography, High Pressure Liquid; Comorbidity; Depressive Disorder, Ma | 2008 |
Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity.
Topics: Adult; Anxiety Disorders; Chromatography, High Pressure Liquid; Comorbidity; Depressive Disorder, Ma | 2008 |
Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity.
Topics: Adult; Anxiety Disorders; Chromatography, High Pressure Liquid; Comorbidity; Depressive Disorder, Ma | 2008 |
Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity.
Topics: Adult; Anxiety Disorders; Chromatography, High Pressure Liquid; Comorbidity; Depressive Disorder, Ma | 2008 |
Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders.
Topics: Aging; Animals; Humans; Inflammation; Interferon-gamma; Kynurenine; Mental Disorders; Metabolic Synd | 2011 |
Connecting inflammation with glutamate agonism in suicidality.
Topics: Adult; Aged; Encephalitis; Excitatory Amino Acid Agonists; Female; Follow-Up Studies; Humans; Interl | 2013 |
TRYPTOPHAN METABOLISM IN PSYCHOTIC CHILDREN. A PRELIMINARY REPORT.
Topics: Amino Acids; Child; Humans; Hydrolases; Kynurenine; Mental Disorders; Psychotic Disorders; Pyridoxin | 1965 |