kynurenine has been researched along with Autosomal Recessive Chronic Granulomatous Disease in 6 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here we show that a superoxide-dependent step in tryptophan metabolism along the kynurenine pathway is blocked in CGD mice with lethal pulmonary aspergillosis, leading to unrestrained Vgamma1(+) gammadelta T-cell reactivity, dominant production of interleukin (IL)-17, defective regulatory T-cell activity and acute inflammatory lung injury." | 7.74 | Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. ( Bistoni, F; D'Angelo, C; De Luca, A; Fallarino, F; Fioretti, MC; Grohmann, U; Montagnoli, C; Puccetti, P; Romani, L; Segal, BH; Vacca, C; Zelante, T, 2008) |
| " Here we show that a superoxide-dependent step in tryptophan metabolism along the kynurenine pathway is blocked in CGD mice with lethal pulmonary aspergillosis, leading to unrestrained Vgamma1(+) gammadelta T-cell reactivity, dominant production of interleukin (IL)-17, defective regulatory T-cell activity and acute inflammatory lung injury." | 3.74 | Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. ( Bistoni, F; D'Angelo, C; De Luca, A; Fallarino, F; Fioretti, MC; Grohmann, U; Montagnoli, C; Puccetti, P; Romani, L; Segal, BH; Vacca, C; Zelante, T, 2008) |
| "Kynurenine accumulation was dose- and time-dependent as was that of a downstream metabolite, anthranilic acid." | 1.36 | Tryptophan/kynurenine metabolism in human leukocytes is independent of superoxide and is fully maintained in chronic granulomatous disease. ( Chan, KC; De Ravin, SS; Fox, SD; Gallin, JI; Kuhns, DB; Long-Priel, D; Malech, HL; Zarember, KA, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maghzal, GJ | 1 |
| Winter, S | 1 |
| Wurzer, B | 1 |
| Chong, BH | 1 |
| Holmdahl, R | 1 |
| Stocker, R | 1 |
| Romani, L | 2 |
| Puccetti, P | 2 |
| De Ravin, SS | 1 |
| Zarember, KA | 1 |
| Long-Priel, D | 1 |
| Chan, KC | 1 |
| Fox, SD | 1 |
| Gallin, JI | 1 |
| Kuhns, DB | 1 |
| Malech, HL | 1 |
| Jürgens, B | 1 |
| Fuchs, D | 1 |
| Reichenbach, J | 1 |
| Heitger, A | 1 |
| Kuijpers, T | 1 |
| Lutter, R | 1 |
| Fallarino, F | 1 |
| De Luca, A | 1 |
| Montagnoli, C | 1 |
| D'Angelo, C | 1 |
| Zelante, T | 1 |
| Vacca, C | 1 |
| Bistoni, F | 1 |
| Fioretti, MC | 1 |
| Grohmann, U | 1 |
| Segal, BH | 1 |
1 review available for kynurenine and Autosomal Recessive Chronic Granulomatous Disease
| Article | Year |
|---|---|
Inflammation and repeated infections in CGD: two sides of a coin.
Topics: Animals; Female; Granulomatous Disease, Chronic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infla | 2012 |
5 other studies available for kynurenine and Autosomal Recessive Chronic Granulomatous Disease
| Article | Year |
|---|---|
Tryptophan catabolism is unaffected in chronic granulomatous disease.
Topics: Animals; Granulomatous Disease, Chronic; Inflammation; Kynurenine; Tryptophan | 2014 |
Romani & Puccetti reply.
Topics: Animals; Granulomatous Disease, Chronic; Inflammation; Kynurenine; Tryptophan | 2014 |
Tryptophan/kynurenine metabolism in human leukocytes is independent of superoxide and is fully maintained in chronic granulomatous disease.
Topics: Cells, Cultured; Chromatography, Liquid; Dose-Response Relationship, Drug; Granulomatous Disease, Ch | 2010 |
Intact indoleamine 2,3-dioxygenase activity in human chronic granulomatous disease.
Topics: Antigens, CD; Child; Child, Preschool; Dendritic Cells; Female; Granulomatous Disease, Chronic; HLA- | 2010 |
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease.
Topics: Animals; Aspergillosis; Aspergillus fumigatus; Chronic Disease; Disease Models, Animal; Granulomatou | 2008 |