kynurenine has been researched along with Aura in 27 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There was a statistically significant decrease of CSF kynurenic acid in patients with epileptic spasms compared to OND (p<0." | 8.12 | Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids. ( Antony, J; Ardern-Holmes, S; Bandodkar, S; Dale, RC; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Innes, EA; Jones, HF; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pires, AS; Tantsis, E; Troedson, C; Tsang, E; Webster, R; Wienholt, L; Yan, J, 2022) |
| "Neurokynurenines (NK) possessing various neuroactivities, are involved in many abnormalities in stress, anxiety, depression, alcoholism, epilepsy, neurologic diseases." | 7.72 | Neurokynurenines--seizures or/and anxiety in children with epilepsy? ( Melnikova, NV, 2003) |
| "Seizure frequency was recorded using seizure diaries." | 6.79 | The effects of vagus nerve stimulation on tryptophan metabolites in children with intractable epilepsy. ( Aalbers, MW; Aldenkamp, AP; Kessels, AG; Klinkenberg, S; Leenen, L; Majoie, HJ; Rijkers, K; van den Borne, CJ; Verschuure, P; Vles, JS, 2014) |
| "The kynurenine pathway (KP) is the main path for tryptophan metabolism, and it represents a multitude of potential sites for drug discovery in neuroscience, including pain, stroke, and epilepsy." | 5.41 | Phase 1 study to access safety, tolerability, pharmacokinetics, and pharmacodynamics of kynurenine in healthy volunteers. ( Abou-Kassem, D; Al-Karagholi, MA; Ashina, M; Bergquist, J; Hansen, JM; Hansted, AK; Jansen-Olesen, I; Ubhayasekera, K; Vécsei, L, 2021) |
| " In both groups, they measure tryptophan metabolites before and after L-tryptophan overload, the dosage being 100/mg/kg of body weight." | 5.27 | [Tryptophan metabolism in children with epilepsy]. ( Bayés García, R; del Castillo, ML; Maldonado Lozano, J; Molina Font, JA; Narbona López, E; Núñez del Carril, J; Robles Vizcaíno, C, 1984) |
| "The kynurenine blood level was found to correlate with seizures." | 5.27 | [Elevated kynurenine concentration in the blood serum of children with epilepsy and bronchial asthma]. ( Buzdin, VV; Ivanova, NA; Nikitina, ZS; Ryzhov, IV, 1988) |
| "There was a statistically significant decrease of CSF kynurenic acid in patients with epileptic spasms compared to OND (p<0." | 4.12 | Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids. ( Antony, J; Ardern-Holmes, S; Bandodkar, S; Dale, RC; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Innes, EA; Jones, HF; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pires, AS; Tantsis, E; Troedson, C; Tsang, E; Webster, R; Wienholt, L; Yan, J, 2022) |
| "Neurokynurenines (NK) possessing various neuroactivities, are involved in many abnormalities in stress, anxiety, depression, alcoholism, epilepsy, neurologic diseases." | 3.72 | Neurokynurenines--seizures or/and anxiety in children with epilepsy? ( Melnikova, NV, 2003) |
| "The role of the endogenous convulsant kynurenine (K) in the mechanisms of the development of epileptic seizures in alcoholic persons was studied on a clinical material of 63 patients suffering from alcoholism with the presence on the EEG of paroxysmal alterations without epileptic fits (n = 28) and alcoholic epilepsy (n = 35), epileptic patients not abusing alcohol (n = 20), and practically healthy subjects (n = 10)." | 3.68 | [Pathogenic role of the endogenous convulsant kynurenine in the mechanisms of development of epileptic attacks in alcoholics]. ( Eryshev, OF; Gromov, SA; Kartasheva, EV; Ryzhov, IV, 1991) |
| "Seizure frequency was recorded using seizure diaries." | 2.79 | The effects of vagus nerve stimulation on tryptophan metabolites in children with intractable epilepsy. ( Aalbers, MW; Aldenkamp, AP; Kessels, AG; Klinkenberg, S; Leenen, L; Majoie, HJ; Rijkers, K; van den Borne, CJ; Verschuure, P; Vles, JS, 2014) |
| "The 18 patients had either West syndrome (12 patients) or Lennox-Gastaut syndrome (6 patients), which was intractable to antiepileptic drug therapy and to adrenocorticotrophic hormone." | 1.29 | Thyrotropin-releasing hormone in treatment of intractable epilepsy: neurochemical analysis of CSF monoamine metabolites. ( Kawase, S; Matsuo, S; Mitsufuji, N; Nishimura, A; Sawada, T; Takeuchi, Y; Tominaga, M; Yamazoe, I, 1995) |
| "The 5-hydroxytryptophan content was much higher in both El groups." | 1.28 | Regional distribution of tyrosine, tryptophan, and their metabolites in the brain of epileptic El mice. ( Mori, A; Suzuki, S, 1992) |
| " In both groups, they measure tryptophan metabolites before and after L-tryptophan overload, the dosage being 100/mg/kg of body weight." | 1.27 | [Tryptophan metabolism in children with epilepsy]. ( Bayés García, R; del Castillo, ML; Maldonado Lozano, J; Molina Font, JA; Narbona López, E; Núñez del Carril, J; Robles Vizcaíno, C, 1984) |
| "The kynurenine blood level was found to correlate with seizures." | 1.27 | [Elevated kynurenine concentration in the blood serum of children with epilepsy and bronchial asthma]. ( Buzdin, VV; Ivanova, NA; Nikitina, ZS; Ryzhov, IV, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (37.04) | 18.7374 |
| 1990's | 7 (25.93) | 18.2507 |
| 2000's | 6 (22.22) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Yan, J | 1 |
| Kothur, K | 1 |
| Innes, EA | 1 |
| Han, VX | 1 |
| Jones, HF | 1 |
| Patel, S | 1 |
| Tsang, E | 1 |
| Webster, R | 1 |
| Gupta, S | 1 |
| Troedson, C | 1 |
| Menezes, MP | 1 |
| Antony, J | 1 |
| Ardern-Holmes, S | 1 |
| Tantsis, E | 1 |
| Mohammad, S | 1 |
| Wienholt, L | 1 |
| Pires, AS | 1 |
| Heng, B | 1 |
| Guillemin, GJ | 1 |
| Guller, A | 1 |
| Gill, D | 1 |
| Bandodkar, S | 1 |
| Dale, RC | 1 |
| Al-Karagholi, MA | 1 |
| Hansen, JM | 1 |
| Abou-Kassem, D | 1 |
| Hansted, AK | 1 |
| Ubhayasekera, K | 1 |
| Bergquist, J | 1 |
| Vécsei, L | 2 |
| Jansen-Olesen, I | 1 |
| Ashina, M | 1 |
| Klinkenberg, S | 1 |
| van den Borne, CJ | 1 |
| Aalbers, MW | 1 |
| Verschuure, P | 1 |
| Kessels, AG | 1 |
| Leenen, L | 1 |
| Rijkers, K | 1 |
| Aldenkamp, AP | 1 |
| Vles, JS | 1 |
| Majoie, HJ | 1 |
| Vamos, E | 1 |
| Pardutz, A | 1 |
| Klivenyi, P | 1 |
| Toldi, J | 1 |
| Chugani, DC | 2 |
| Melnikova, NV | 1 |
| Rho, JM | 1 |
| Young, SN | 1 |
| Joseph, MH | 1 |
| Gauthier, S | 1 |
| Narbona López, E | 1 |
| Maldonado Lozano, J | 1 |
| del Castillo, ML | 1 |
| Bayés García, R | 1 |
| Robles Vizcaíno, C | 1 |
| Núñez del Carril, J | 1 |
| Molina Font, JA | 1 |
| Takeuchi, Y | 3 |
| Tominaga, M | 1 |
| Mitsufuji, N | 1 |
| Yamazoe, I | 1 |
| Kawase, S | 1 |
| Nishimura, A | 1 |
| Matsuo, S | 1 |
| Sawada, T | 2 |
| Du, F | 1 |
| Williamson, J | 1 |
| Bertram, E | 1 |
| Lothman, E | 1 |
| Okuno, E | 1 |
| Schwarcz, R | 1 |
| Scharfman, HE | 1 |
| Ofer, A | 1 |
| Muñóz-Hoyos, A | 1 |
| Molina-Carballo, A | 1 |
| Rodríguez-Cabezas, T | 1 |
| Uberos-Fernández, J | 1 |
| Ruiz-Cosano, C | 1 |
| Acuña-Castroviejo, D | 1 |
| Matsushita, H | 1 |
| Kawano, H | 1 |
| Sakai, H | 1 |
| Yoshimoto, K | 1 |
| Stone, TW | 1 |
| Takano, T | 1 |
| Abe, J | 1 |
| Takikita, S | 1 |
| Ohno, M | 1 |
| Grimm, U | 1 |
| Knapp, A | 1 |
| Schmitz, W | 1 |
| Smetan, M | 1 |
| Schmitz, KW | 1 |
| Reddemann, H | 1 |
| Schulz, M | 1 |
| Schlenzka, K | 1 |
| Suzuki, S | 1 |
| Mori, A | 1 |
| Gromov, SA | 1 |
| Eryshev, OF | 1 |
| Kartasheva, EV | 1 |
| Ryzhov, IV | 2 |
| Guilarte, TR | 1 |
| Wagner, HN | 1 |
| Ivanova, NA | 1 |
| Buzdin, VV | 1 |
| Nikitina, ZS | 1 |
| Raine, DN | 1 |
| Hansson, O | 4 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prednisolone vs. Vigabatrin in the First-line Treatment of Infantile Spasms[NCT02299115] | Phase 3 | 0 participants (Actual) | Interventional | 2017-09-05 | Withdrawn (stopped due to Most centres are now using oral steroids as 1st line treatment so question of efficacy is no longer of high interest.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for kynurenine and Aura
| Article | Year |
|---|---|
The role of kynurenines in disorders of the central nervous system: possibilities for neuroprotection.
Topics: Alzheimer Disease; Animals; Brain; Brain Diseases; Brain Ischemia; Epilepsy; Humans; Huntington Dise | 2009 |
α-methyl-L-tryptophan: mechanisms for tracer localization of epileptogenic brain regions.
Topics: Biomarkers; Brain; Epilepsy; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kinetics; Kynurenine; Pos | 2011 |
Basic science behind the catastrophic epilepsies.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Corticotropin-Releasing Hormone; Epilepsies | 2004 |
Serotonin in autism and pediatric epilepsies.
Topics: Animals; Autistic Disorder; Brain; Child; Electroencephalography; Epilepsy; Humans; Kynurenine; Magn | 2004 |
Kynurenic acid antagonists and kynurenine pathway inhibitors.
Topics: Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Neu | 2001 |
Thyrotropin-releasing hormone: role in the treatment of West syndrome and related epileptic encephalopathies.
Topics: Child; Epilepsy; Humans; Infant; Kynurenine; Spasms, Infantile; Thyrotropin-Releasing Hormone | 2001 |
2 trials available for kynurenine and Aura
| Article | Year |
|---|---|
Phase 1 study to access safety, tolerability, pharmacokinetics, and pharmacodynamics of kynurenine in healthy volunteers.
Topics: Adult; Animals; Blood Flow Velocity; Cerebrovascular Circulation; Cross-Over Studies; Dose-Response | 2021 |
The effects of vagus nerve stimulation on tryptophan metabolites in children with intractable epilepsy.
Topics: Adolescent; Affect; Biotransformation; Child; Child, Preschool; Double-Blind Method; Drug Resistance | 2014 |
19 other studies available for kynurenine and Aura
| Article | Year |
|---|---|
Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids.
Topics: 3-Hydroxyanthranilic Acid; Adrenal Cortex Hormones; Animals; Biomarkers; Chromatography, Liquid; Epi | 2022 |
Neurokynurenines--seizures or/and anxiety in children with epilepsy?
Topics: Adolescent; Anxiety; Child; Child, Preschool; Epilepsy; Humans; Kynurenine; Seizures; Xanthurenates | 2003 |
Studies on kynurenine in human cerebrospinal fluid: lowered levels in epilepsy.
Topics: Adolescent; Adult; Aged; Amino Acids; Anticonvulsants; Epilepsy; Epilepsy, Temporal Lobe; Humans; Hy | 1983 |
[Tryptophan metabolism in children with epilepsy].
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Kynurenine; Male; Pyridoxine; | 1984 |
Thyrotropin-releasing hormone in treatment of intractable epilepsy: neurochemical analysis of CSF monoamine metabolites.
Topics: Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Homovanillic Acid; Humans; Hydrox | 1995 |
Kynurenine pathway enzymes in a rat model of chronic epilepsy: immunohistochemical study of activated glial cells.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Astrocytes; Cell Death; Cerebral Cortex; Chronic Dis | 1993 |
Pretreatment with L-kynurenine, the precursor to the excitatory amino acid antagonist kynurenic acid, suppresses epileptiform activity in combined entorhinal/hippocampal slices.
Topics: Animals; Anticonvulsants; Buffers; Electrophysiology; Entorhinal Cortex; Epilepsy; Excitatory Amino | 1997 |
Relationships between methoxyindole and kynurenine pathway metabolites in plasma and urine in children suffering from febrile and epileptic seizures.
Topics: 3-Hydroxyanthranilic Acid; Child; Child, Preschool; Circadian Rhythm; Epilepsy; Female; Humans; Infa | 1997 |
TRH increases cerebrospinal fluid concentration of kynurenine.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Electrodes; Epilepsy; Female; Humans; Infant; | 1999 |
[Tryptophan metabolism and oligophrenia (author's transl)].
Topics: Amino Acid Metabolism, Inborn Errors; Down Syndrome; Epilepsy; Hartnup Disease; Humans; Intellectual | 1978 |
Regional distribution of tyrosine, tryptophan, and their metabolites in the brain of epileptic El mice.
Topics: 5-Hydroxytryptophan; Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Dopamine | 1992 |
[Pathogenic role of the endogenous convulsant kynurenine in the mechanisms of development of epileptic attacks in alcoholics].
Topics: Adult; Alcoholism; Cerebral Cortex; Electroencephalography; Epilepsy; Female; Humans; Kynurenine; Ma | 1991 |
3-Hydroxykynurenine as a possible mechanism of epileptic seizures associated with neonatal vitamin B6 deficiency.
Topics: Animals; Animals, Newborn; Brain; Epilepsy; Female; Kynurenine; Pregnancy; Rats; Synaptic Transmissi | 1986 |
[Elevated kynurenine concentration in the blood serum of children with epilepsy and bronchial asthma].
Topics: Adolescent; Asthma; Child; Child, Preschool; Chronic Disease; Epilepsy; Female; Humans; Kynurenine; | 1988 |
Effect of treatment on tryptophan metabolism in childhood epilepsy.
Topics: Adrenocorticotropic Hormone; Adult; Anticonvulsants; Central Nervous System Diseases; Child; Child, | 1969 |
Tryptophan loading and pyridoxine treatment in children with epilepsy.
Topics: Child; Epilepsy; Humans; Kynurenine; Pyridoxine; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1969 |
Tryptophan load test and pyridoxine treatment in epileptic children.
Topics: Epilepsy; Humans; Hydrolases; Kinetics; Kynurenine; ortho-Aminobenzoates; Pyridoxine; Tryptophan; Vi | 1967 |
Kinetics of urinary excretion of 3-hydroxykynurenine and 3-hydroxyanthranilic acid after tryptophan loading in man.
Topics: Adolescent; Adult; Child; Chromatography, Thin Layer; Epilepsy; Female; Humans; Hydrolases; Kynureni | 1968 |
Tryptophan load tests in children with epilepsy.
Topics: Adolescent; Adult; Child; Child, Preschool; Chromatography; Epilepsy; Female; Humans; Kynurenine; Ma | 1968 |