kynurenine has been researched along with Alcoholism in 13 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "For this purpose, male and female abstinent AUD patients (N = 130) and healthy controls (N = 80) were clinically evaluated for substance use and mental disorders, and blood samples were collected to determine plasma concentrations of TRP, 5-HT, KYN and kynurenic acid (KA) using high performance liquid chromatography." | 3.96 | Plasma tryptophan and kynurenine pathway metabolites in abstinent patients with alcohol use disorder and high prevalence of psychiatric comorbidity. ( Araos, P; Colado, MI; Flores-López, M; García-Marchena, N; O'Shea, E; Pavón, FJ; Requena-Ocaña, N; Rodríguez de Fonseca, F; Rubio, G; Serrano, A; Suárez, J; Vidal, R, 2020) |
| "The role of the endogenous convulsant kynurenine (K) in the mechanisms of the development of epileptic seizures in alcoholic persons was studied on a clinical material of 63 patients suffering from alcoholism with the presence on the EEG of paroxysmal alterations without epileptic fits (n = 28) and alcoholic epilepsy (n = 35), epileptic patients not abusing alcohol (n = 20), and practically healthy subjects (n = 10)." | 3.68 | [Pathogenic role of the endogenous convulsant kynurenine in the mechanisms of development of epileptic attacks in alcoholics]. ( Eryshev, OF; Gromov, SA; Kartasheva, EV; Ryzhov, IV, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (53.85) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 5 (38.46) | 2.80 |
| Authors | Studies |
|---|---|
| Leclercq, S | 1 |
| Schwarz, M | 1 |
| Delzenne, NM | 1 |
| Stärkel, P | 1 |
| de Timary, P | 1 |
| Mechtcheriakov, S | 1 |
| Gleissenthall, GV | 1 |
| Geisler, S | 1 |
| Arnhard, K | 1 |
| Oberacher, H | 1 |
| Schurr, T | 1 |
| Kemmler, G | 1 |
| Unterberger, C | 1 |
| Fuchs, D | 1 |
| Wang, Z | 1 |
| Huang, S | 1 |
| Li, L | 1 |
| Wen, Y | 1 |
| Shang, D | 1 |
| Vidal, R | 1 |
| García-Marchena, N | 1 |
| O'Shea, E | 1 |
| Requena-Ocaña, N | 1 |
| Flores-López, M | 1 |
| Araos, P | 1 |
| Serrano, A | 1 |
| Suárez, J | 1 |
| Rubio, G | 1 |
| Rodríguez de Fonseca, F | 1 |
| Colado, MI | 1 |
| Pavón, FJ | 1 |
| Ho, MF | 1 |
| Zhang, C | 1 |
| Zhang, L | 1 |
| Wei, L | 1 |
| Zhou, Y | 1 |
| Moon, I | 1 |
| Geske, JR | 1 |
| Choi, DS | 1 |
| Biernacka, J | 1 |
| Frye, M | 1 |
| Wen, Z | 1 |
| Karpyak, VM | 1 |
| Li, H | 1 |
| Weinshilboum, R | 1 |
| PASQUARIELLO, G | 1 |
| QUADRI, A | 1 |
| TENCONI, LT | 1 |
| Krstulović, AM | 2 |
| Friedman, MJ | 2 |
| Colin, H | 1 |
| Guiochon, G | 1 |
| Gaspar, M | 1 |
| Pajer, KA | 1 |
| Branchey, L | 1 |
| Lieber, CS | 2 |
| Gromov, SA | 1 |
| Eryshev, OF | 1 |
| Kartasheva, EV | 1 |
| Ryzhov, IV | 1 |
| Buydens-Branchey, L | 1 |
| Branchey, M | 1 |
| Worner, TM | 1 |
| Zucker, D | 1 |
| Aramsombatdee, E | 1 |
| Severinghaus, JM | 1 |
| Brown, SJ | 1 |
| Payne, IR | 1 |
| Lu, GH | 1 |
| Meyer, K | 1 |
| Mainardi, L | 1 |
| Bissanti, A | 1 |
1 review available for kynurenine and Alcoholism
| Article | Year |
|---|---|
Kynurenine metabolite changes in individuals with alcohol use disorder: A systematic review and meta-analysis.
Topics: Alcoholism; Humans; Kynurenic Acid; Kynurenine; Tryptophan | 2023 |
12 other studies available for kynurenine and Alcoholism
| Article | Year |
|---|---|
Alterations of kynurenine pathway in alcohol use disorder and abstinence: a link with gut microbiota, peripheral inflammation and psychological symptoms.
Topics: Alcoholism; Gastrointestinal Microbiome; Humans; Inflammation; Kynurenic Acid; Kynurenine; Quinolini | 2021 |
Tryptophan-kynurenine metabolism during acute alcohol withdrawal in patients with alcohol use disorder: The role of immune activation.
Topics: Alcohol Drinking; Alcoholism; Biomarkers; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Ac | 2022 |
Plasma tryptophan and kynurenine pathway metabolites in abstinent patients with alcohol use disorder and high prevalence of psychiatric comorbidity.
Topics: Adolescent; Adult; Aged; Aging; Alcohol Abstinence; Alcoholism; Body Mass Index; Cross-Sectional Stu | 2020 |
TSPAN5 influences serotonin and kynurenine: pharmacogenomic mechanisms related to alcohol use disorder and acamprosate treatment response.
Topics: Acamprosate; Alcohol Drinking; Alcoholism; Depressive Disorder, Major; Humans; Induced Pluripotent S | 2021 |
TRYPTOPHAN-NICOTINIC ACID METABOLISM IN CHRONIC ALCOHOLICS.
Topics: Alcoholics; Alcoholism; Humans; Kynurenine; Liver Cirrhosis; Metabolism; Niacin; Nicotinic Acids; Tr | 1964 |
Analytical methodology for assays of serum tryptophan metabolites in control subjects and newly abstinent alcoholics: preliminary investigation by liquid chromatography with amperometric detection.
Topics: Adult; Aged; Alcoholism; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Humans | 1984 |
Activation of tryptophan pyrrolase after chronic alcohol administration.
Topics: Alcoholism; Animals; Enzyme Activation; Humans; Kynurenine; Liver; Rats; Rats, Inbred Strains; Trypt | 1982 |
[Pathogenic role of the endogenous convulsant kynurenine in the mechanisms of development of epileptic attacks in alcoholics].
Topics: Adult; Alcoholism; Cerebral Cortex; Electroencephalography; Epilepsy; Female; Humans; Kynurenine; Ma | 1991 |
Increase in tryptophan oxygenase activity in alcoholic patients.
Topics: Adult; Alcoholism; Humans; Hydrocortisone; Kinetics; Kynurenine; Liver Function Tests; Male; Middle | 1988 |
Altered conversion of tryptophan to kynurenine in newly abstinent alcoholics.
Topics: Adult; Alcoholism; Humans; Kynurenine; Liver; Male; Serotonin; Tryptophan; Tryptophan Oxygenase | 1988 |
Relationship of dietary tryptophan and niacin to tryptophan metabolism in alcoholics and nonalcoholics.
Topics: Acetates; Alcoholism; Aminohippuric Acids; Diet; Dietary Proteins; Female; Humans; Hydroxyindoleacet | 1974 |
[Various current findings in the problem of pellagra].
Topics: Alcoholism; Deficiency Diseases; Diet; Feeding Behavior; Hartnup Disease; Humans; Isoniazid; Isonico | 1968 |