kynurenine has been researched along with Aging in 81 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The tryptophan metabolite kynurenine increases with aging and inflammation, and appears to contribute directly to the development and progression of several age-related conditions." | 9.05 | Kynurenine signaling through the aryl hydrocarbon receptor: Implications for aging and healthspan. ( Hamrick, MW; Kaiser, H; Parker, E, 2020) |
| "The kynurenine pathway is implicated in aging, longevity, and immune regulation, but longitudinal studies and assessment of the cerebrospinal fluid (CSF) are lacking." | 8.12 | Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging. ( Cabral-Marques, O; Dugué, PA; Giil, LM; Giles, GG; Halaas, NB; Hodge, A; Idland, AV; McCann, A; Midttun, Ø; Nordrehaug, JE; Nygård, O; Solvang, SH; Tell, GS; Ueland, PM; Ulvik, A; Watne, LO, 2022) |
| "Indoleamine 2,3 dioxygenase (Ido1), the first and rate-limiting enzyme of the kynurenine pathway (KP), is a striatally enriched gene with increased expression levels in the YAC128 mouse model of Huntington disease (HD)." | 7.79 | Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease. ( Adomat, H; Budac, DP; Leavitt, BR; Lu, G; Mazarei, G; Möller, T; Tomlinson Guns, ES, 2013) |
| "This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)-kynurenine (KYN) and guanine-tetrahydrobiopterin (BH4) metabolic pathways into inflammation cascade involved in aging and aging-associated medical and psychiatric disorders (AAMPD) (metabolic syndrome, depression, vascular cognitive impairment)." | 7.77 | Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders. ( Oxenkrug, GF, 2011) |
| "Proteins isolated from the nuclei of normal lenses and lenses with and types I to IV nuclear cataract were hydrolyzed in 6 M HCl, and the levels of kynurenine-lysine and kynurenine-histidine were determined by HPLC." | 7.72 | Protein-bound kynurenine decreases with the progression of age-related nuclear cataract. ( Parker, NR; Sheil, M; Truscott, RJ; Vazquez, S, 2004) |
| "A chronic low-grade inflammation is associated with the aging process, a state called inflammaging." | 6.82 | Role of indoleamine 2,3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process. ( Salminen, A, 2022) |
| "ARN cataract is also characterized by extensive oxidation, insolubilization, and cross-linking of polypeptides, particularly in the nucleus of the lens." | 5.33 | Identification of 3-hydroxykynurenine bound to proteins in the human lens. A possible role in age-related nuclear cataract. ( Korlimbinis, A; Truscott, RJ, 2006) |
| "The essential amino acid L-tryptophan (Trp) appears to play an important role in aging by acting as a general regulator of protein homeostasis." | 5.05 | Kynurenine pathway and human systems. ( Badawy, AA, 2020) |
| "The tryptophan metabolite kynurenine increases with aging and inflammation, and appears to contribute directly to the development and progression of several age-related conditions." | 5.05 | Kynurenine signaling through the aryl hydrocarbon receptor: Implications for aging and healthspan. ( Hamrick, MW; Kaiser, H; Parker, E, 2020) |
| "Although we are far from a complete understanding of the role of kynurenine pathway in the modulation of energy homeostasis, targeting kynurenine pathway harbors high potential to expand the range of therapies to prevent and treat metabolic diseases." | 5.01 | Emerging role for kynurenines in metabolic pathologies. ( Liu, JJ; Movassat, J; Portha, B, 2019) |
| "The kynurenine pathway is implicated in aging, longevity, and immune regulation, but longitudinal studies and assessment of the cerebrospinal fluid (CSF) are lacking." | 4.12 | Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging. ( Cabral-Marques, O; Dugué, PA; Giil, LM; Giles, GG; Halaas, NB; Hodge, A; Idland, AV; McCann, A; Midttun, Ø; Nordrehaug, JE; Nygård, O; Solvang, SH; Tell, GS; Ueland, PM; Ulvik, A; Watne, LO, 2022) |
| "For this purpose, male and female abstinent AUD patients (N = 130) and healthy controls (N = 80) were clinically evaluated for substance use and mental disorders, and blood samples were collected to determine plasma concentrations of TRP, 5-HT, KYN and kynurenic acid (KA) using high performance liquid chromatography." | 3.96 | Plasma tryptophan and kynurenine pathway metabolites in abstinent patients with alcohol use disorder and high prevalence of psychiatric comorbidity. ( Araos, P; Colado, MI; Flores-López, M; García-Marchena, N; O'Shea, E; Pavón, FJ; Requena-Ocaña, N; Rodríguez de Fonseca, F; Rubio, G; Serrano, A; Suárez, J; Vidal, R, 2020) |
| " Neuronal EAAT2 deletion leads to dysregulation of the kynurenine pathway, and astrocytic EAAT2 deficiency results in dysfunction of innate and adaptive immune pathways, which correlate with cognitive decline." | 3.91 | Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer's molecular signatures. ( Gray, JD; Kazim, SF; Larson, CS; McEwen, BS; Pereira, AC; Ramakrishnan, A; Rosenberg, PA; Sharma, A; Shen, L, 2019) |
| "These results suggest that increased kynurenine levels during aging may contribute to the bone fragility seen in the elderly through increased bone resorption, with a resultant imbalance in bone remodeling." | 3.91 | The Detrimental Effects of Kynurenine, a Tryptophan Metabolite, on Human Bone Metabolism. ( Hamrick, MW; Isales, CM; Kim, BJ; Kim, SJ; Koh, JM; Lee, SH; Yoo, HJ, 2019) |
| " Low xanthurenic acid occurred in both AD and with aging." | 3.85 | Kynurenine Pathway Metabolites in Alzheimer's Disease. ( Advani, R; Giil, LM; Midttun, Ø; Refsum, H; Smith, AD; Ueland, PM; Ulvik, A, 2017) |
| "Circulating neopterin and kynurenine/tryptophan ratio (KTR) increase during inflammation and serve as markers of cellular immune activation, but data are sparse on other determinants of these markers and metabolites of the kynurenine pathway." | 3.79 | A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study. ( Eussen, SJ; Midttun, Ø; Nygård, O; Tell, GS; Theofylaktopoulou, D; Ueland, PM; Ulvik, A; Vollset, SE, 2013) |
| "Indoleamine 2,3 dioxygenase (Ido1), the first and rate-limiting enzyme of the kynurenine pathway (KP), is a striatally enriched gene with increased expression levels in the YAC128 mouse model of Huntington disease (HD)." | 3.79 | Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease. ( Adomat, H; Budac, DP; Leavitt, BR; Lu, G; Mazarei, G; Möller, T; Tomlinson Guns, ES, 2013) |
| "This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)-kynurenine (KYN) and guanine-tetrahydrobiopterin (BH4) metabolic pathways into inflammation cascade involved in aging and aging-associated medical and psychiatric disorders (AAMPD) (metabolic syndrome, depression, vascular cognitive impairment)." | 3.77 | Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders. ( Oxenkrug, GF, 2011) |
| "The kynurenine pathway of tryptophan catabolism plays an important role in several biological systems affected by aging." | 3.77 | Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats. ( Braidy, N; Chan-Ling, T; Grant, R; Guillemin, GJ; Mansour, H, 2011) |
| "Proteins isolated from the nuclei of normal lenses and lenses with and types I to IV nuclear cataract were hydrolyzed in 6 M HCl, and the levels of kynurenine-lysine and kynurenine-histidine were determined by HPLC." | 3.72 | Protein-bound kynurenine decreases with the progression of age-related nuclear cataract. ( Parker, NR; Sheil, M; Truscott, RJ; Vazquez, S, 2004) |
| "Increasing neopterin concentrations and kyn/trp with older age are in line with the view that aging in healthy people is associated with immune activation especially of the T-cell/macrophage system." | 3.72 | Increasing production of homocysteine and neopterin and degradation of tryptophan with older age. ( Frick, B; Fuchs, D; Leblhuber, F; Neurauter, G; Schroecksnadel, K, 2004) |
| "A chronic low-grade inflammation is associated with the aging process, a state called inflammaging." | 2.82 | Role of indoleamine 2,3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process. ( Salminen, A, 2022) |
| "The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of nicotinamide adenine dinucleotide (NAD+)." | 2.66 | The kynurenine pathway: a finger in every pie. ( Savitz, J, 2020) |
| "Kynurenine (KYN) is a circulating tryptophan metabolite that is known to increase with age and is a ligand of the aryl hydrocarbon receptor (Ahr)." | 1.51 | Kynurenine, a Tryptophan Metabolite That Increases with Age, Induces Muscle Atrophy and Lipid Peroxidation. ( Fulzele, S; Hamrick, MW; Isales, CM; Johnson, M; Kaiser, H; McGee-Lawrence, ME; Mendhe, B; Pandya, C; Yu, K, 2019) |
| "The data indicate that, in mice with brain tumors, youth conveys an advantage to survival." | 1.43 | Advanced age negatively impacts survival in an experimental brain tumor model. ( Genet, M; Gritsina, G; James, CD; Ladomersky, E; Lauing, KL; Wainwright, DA; Wu, M; Zhai, L, 2016) |
| "Geriatric depression is a costly health issue, but little is known about its physiological underpinnings." | 1.39 | Aging leads to prolonged duration of inflammation-induced depression-like behavior caused by Bacillus Calmette-Guérin. ( Dantzer, R; Kelley, KW; Lawson, MA; McCusker, RH; O'Connor, JC; Rodriguez-Zas, SL, 2013) |
| "In patients with no apparent CNS disease, CSF PIC levels were 10-fold higher in samples taken between 20:00 and 16:00 h compared with those collected between 04:00 and 12:00 h." | 1.35 | Age and circadian influences on picolinic acid concentrations in human cerebrospinal fluid. ( Bilgin, A; Coggan, SE; Grant, RS; Smythe, GA, 2009) |
| "ARN cataract is also characterized by extensive oxidation, insolubilization, and cross-linking of polypeptides, particularly in the nucleus of the lens." | 1.33 | Identification of 3-hydroxykynurenine bound to proteins in the human lens. A possible role in age-related nuclear cataract. ( Korlimbinis, A; Truscott, RJ, 2006) |
| "L-kynurenine was also formed from the reaction of nitrite with free tryptophan." | 1.31 | The Nitrite/alpha crystallin reaction: a possible mechanism in lens matrix damage. ( Dillon, J; Paik, DC, 2000) |
| "Beta-benzoylacrylic acid was readily reduced in lenses." | 1.30 | UV filter compounds in human lenses: the origin of 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-beta-D-glucoside. ( Bova, LM; Jamie, JF; Truscott, RJ; Wood, AM, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (11.11) | 18.7374 |
| 1990's | 11 (13.58) | 18.2507 |
| 2000's | 18 (22.22) | 29.6817 |
| 2010's | 32 (39.51) | 24.3611 |
| 2020's | 11 (13.58) | 2.80 |
| Authors | Studies |
|---|---|
| Salminen, A | 1 |
| Solvang, SH | 1 |
| Hodge, A | 1 |
| Watne, LO | 1 |
| Cabral-Marques, O | 1 |
| Nordrehaug, JE | 1 |
| Giles, GG | 1 |
| Dugué, PA | 1 |
| Nygård, O | 3 |
| Ueland, PM | 4 |
| McCann, A | 1 |
| Idland, AV | 1 |
| Midttun, Ø | 4 |
| Ulvik, A | 4 |
| Halaas, NB | 1 |
| Tell, GS | 2 |
| Giil, LM | 2 |
| Shen, H | 1 |
| Xu, X | 1 |
| Bai, Y | 1 |
| Wang, X | 1 |
| Wu, Y | 2 |
| Zhong, J | 1 |
| Wu, Q | 1 |
| Luo, Y | 1 |
| Shang, T | 1 |
| Shen, R | 1 |
| Xi, M | 1 |
| Sun, H | 1 |
| Chung, T | 1 |
| Bopp, T | 1 |
| Ward, C | 1 |
| Notarangelo, FM | 1 |
| Schwarcz, R | 5 |
| Westbrook, R | 1 |
| Xue, QL | 1 |
| Walston, J | 1 |
| Hoke, A | 1 |
| Sharma, A | 1 |
| Kazim, SF | 1 |
| Larson, CS | 1 |
| Ramakrishnan, A | 1 |
| Gray, JD | 1 |
| McEwen, BS | 1 |
| Rosenberg, PA | 1 |
| Shen, L | 1 |
| Pereira, AC | 1 |
| Badawy, AA | 3 |
| Kaiser, H | 3 |
| Yu, K | 3 |
| Pandya, C | 1 |
| Mendhe, B | 1 |
| Isales, CM | 4 |
| McGee-Lawrence, ME | 3 |
| Johnson, M | 1 |
| Fulzele, S | 2 |
| Hamrick, MW | 5 |
| Kim, BJ | 2 |
| Lee, SH | 2 |
| Koh, JM | 2 |
| Parker, E | 1 |
| Pierce, JL | 2 |
| Roberts, RL | 1 |
| Kendall, RK | 1 |
| Davis, C | 1 |
| Johnson, MH | 2 |
| Hill, WD | 2 |
| Bollag, WB | 2 |
| Castro-Portuguez, R | 1 |
| Sutphin, GL | 1 |
| Vidal, R | 1 |
| García-Marchena, N | 1 |
| O'Shea, E | 1 |
| Requena-Ocaña, N | 1 |
| Flores-López, M | 1 |
| Araos, P | 1 |
| Serrano, A | 1 |
| Suárez, J | 1 |
| Rubio, G | 1 |
| Rodríguez de Fonseca, F | 1 |
| Colado, MI | 1 |
| Pavón, FJ | 1 |
| Song, P | 1 |
| Ramprasath, T | 1 |
| Wang, H | 1 |
| Zou, MH | 1 |
| Refaey, ME | 1 |
| Kennedy, EJ | 1 |
| Elsalanty, M | 1 |
| Zhong, Q | 1 |
| Ding, KH | 1 |
| Bendzunas, NG | 1 |
| Shi, XM | 1 |
| Xu, J | 1 |
| Hunter, M | 1 |
| Refsum, H | 1 |
| Advani, R | 1 |
| Smith, AD | 1 |
| Sas, K | 1 |
| Szabó, E | 1 |
| Vécsei, L | 2 |
| de Gomes, MG | 1 |
| Souza, LC | 1 |
| Goes, AR | 1 |
| Del Fabbro, L | 1 |
| Filho, CB | 1 |
| Donato, F | 1 |
| Prigol, M | 1 |
| Luchese, C | 1 |
| Roman, SS | 1 |
| Puntel, RL | 1 |
| Boeira, SP | 1 |
| Jesse, CR | 1 |
| Mai, N | 1 |
| Zhong, X | 1 |
| Wen, Y | 1 |
| Zhou, Y | 1 |
| Li, H | 1 |
| Shang, D | 1 |
| Hu, L | 1 |
| Chen, X | 1 |
| Chen, B | 1 |
| Zhang, M | 1 |
| Ning, Y | 1 |
| Liu, JJ | 1 |
| Movassat, J | 1 |
| Portha, B | 1 |
| Minhas, PS | 1 |
| Liu, L | 1 |
| Moon, PK | 1 |
| Joshi, AU | 1 |
| Dove, C | 1 |
| Mhatre, S | 1 |
| Contrepois, K | 1 |
| Wang, Q | 1 |
| Lee, BA | 1 |
| Coronado, M | 1 |
| Bernstein, D | 1 |
| Snyder, MP | 1 |
| Migaud, M | 1 |
| Majeti, R | 1 |
| Mochly-Rosen, D | 1 |
| Rabinowitz, JD | 1 |
| Andreasson, KI | 1 |
| Yoo, HJ | 1 |
| Kim, SJ | 1 |
| Savitz, J | 1 |
| Demarais, NJ | 1 |
| Donaldson, PJ | 1 |
| Grey, AC | 1 |
| Sorgdrager, FJH | 1 |
| Vermeiren, Y | 1 |
| Van Faassen, M | 1 |
| van der Ley, C | 1 |
| Nollen, EAA | 1 |
| Kema, IP | 1 |
| De Deyn, PP | 1 |
| Kelley, KW | 1 |
| O'Connor, JC | 1 |
| Lawson, MA | 1 |
| Dantzer, R | 1 |
| Rodriguez-Zas, SL | 1 |
| McCusker, RH | 1 |
| Theofylaktopoulou, D | 2 |
| Vollset, SE | 1 |
| Eussen, SJ | 2 |
| Mazarei, G | 1 |
| Budac, DP | 1 |
| Lu, G | 1 |
| Adomat, H | 1 |
| Tomlinson Guns, ES | 1 |
| Möller, T | 1 |
| Leavitt, BR | 1 |
| Reyes Ocampo, J | 1 |
| Lugo Huitrón, R | 1 |
| González-Esquivel, D | 1 |
| Ugalde-Muñiz, P | 1 |
| Jiménez-Anguiano, A | 1 |
| Pineda, B | 1 |
| Pedraza-Chaverri, J | 1 |
| Ríos, C | 1 |
| Pérez de la Cruz, V | 1 |
| de Bie, J | 1 |
| Guest, J | 1 |
| Guillemin, GJ | 3 |
| Grant, R | 3 |
| Török, N | 1 |
| Majláth, Z | 1 |
| Fülöp, F | 1 |
| Toldi, J | 1 |
| Rakete, S | 1 |
| Nagaraj, RH | 1 |
| Ladomersky, E | 1 |
| Zhai, L | 1 |
| Gritsina, G | 1 |
| Genet, M | 1 |
| Lauing, KL | 1 |
| Wu, M | 1 |
| James, CD | 1 |
| Wainwright, DA | 1 |
| Coggan, SE | 1 |
| Smythe, GA | 1 |
| Bilgin, A | 1 |
| Grant, RS | 1 |
| Snytnikova, OA | 1 |
| Kopylova, LV | 2 |
| Chernyak, EI | 1 |
| Morozov, SV | 1 |
| Kolosova, NG | 1 |
| Tsentalovich, YP | 2 |
| Oxenkrug, GF | 3 |
| Alkondon, M | 1 |
| Pereira, EF | 1 |
| Eisenberg, HM | 1 |
| Kajii, Y | 1 |
| Albuquerque, EX | 1 |
| Sherin, PS | 1 |
| Cherepanov, IV | 1 |
| Grilj, J | 1 |
| Vauthey, E | 1 |
| Trecartin, KV | 1 |
| Bucci, DJ | 1 |
| Braidy, N | 2 |
| Mansour, H | 1 |
| Chan-Ling, T | 1 |
| Massudi, H | 1 |
| Rejdak, R | 1 |
| Junemann, A | 1 |
| Grieb, P | 1 |
| Thaler, S | 1 |
| Schuettauf, F | 1 |
| Chorągiewicz, T | 1 |
| Zarnowski, T | 1 |
| Turski, WA | 1 |
| Zrenner, E | 1 |
| Tan, L | 2 |
| Yu, JT | 1 |
| Vazquez, S | 2 |
| Parker, NR | 2 |
| Sheil, M | 1 |
| Truscott, RJ | 10 |
| Savvateeva-Popova, EV | 1 |
| Popov, AV | 2 |
| Heinemann, T | 1 |
| Riederer, P | 2 |
| Frick, B | 1 |
| Schroecksnadel, K | 1 |
| Neurauter, G | 1 |
| Leblhuber, F | 1 |
| Fuchs, D | 1 |
| Korlimbinis, A | 3 |
| Pertovaara, M | 1 |
| Raitala, A | 1 |
| Lehtimäki, T | 1 |
| Karhunen, PJ | 1 |
| Oja, SS | 1 |
| Jylhä, M | 1 |
| Hervonen, A | 1 |
| Hurme, M | 1 |
| Aquilina, JA | 2 |
| Khan, JA | 1 |
| Forouhar, F | 1 |
| Tao, X | 1 |
| Tong, L | 1 |
| Jamie, JF | 3 |
| Davies, MJ | 1 |
| Miura, H | 1 |
| Ozaki, N | 1 |
| Shirokawa, T | 1 |
| Isobe, K | 1 |
| Dillon, J | 6 |
| Bando, M | 1 |
| Nakajima, A | 1 |
| Satoh, K | 1 |
| Allegri, G | 1 |
| Costa, C | 1 |
| De Antoni, A | 1 |
| Baccichetti, F | 1 |
| Vanzan, S | 1 |
| Rubaltelli, FF | 1 |
| Ceresoli, G | 3 |
| Fuller, MS | 1 |
| Guidetti, P | 2 |
| Malina, HZ | 1 |
| Martin, XD | 1 |
| Skonieczna, M | 1 |
| Mandal, K | 1 |
| Paik, D | 1 |
| Savvateeva, EV | 1 |
| Kamyshev, NG | 1 |
| Iliadi, KG | 1 |
| Bragina, JV | 1 |
| Heisenberg, M | 1 |
| Kornhuber, J | 1 |
| Garner, B | 3 |
| Griffith, R | 1 |
| Lindner, RA | 2 |
| Carver, JA | 2 |
| Hood, BD | 1 |
| Bova, LM | 2 |
| Wood, AM | 1 |
| Paik, DC | 1 |
| Shaw, DC | 1 |
| Gaillard, ER | 2 |
| Zheng, L | 1 |
| Merriam, JC | 1 |
| Sweeney, MH | 1 |
| Ervin, LA | 1 |
| Jospeh, MH | 1 |
| Baker, HF | 1 |
| Crow, TJ | 1 |
| Riley, GJ | 1 |
| Risby, D | 1 |
| Lapin, IP | 1 |
| Elderfield, A | 1 |
| Truscott, R | 1 |
| Atherton, SJ | 1 |
| Yu, NT | 1 |
| Barron, BC | 1 |
| Kuck, JF | 1 |
| Zigman, S | 1 |
| Paxhia, T | 1 |
| Guilarte, TR | 1 |
| Wagner, HN | 1 |
| Evans, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Investigating Brain Abnormalities in People With Knee Osteoarthritis Using MRI: a Nociplastic Pain Mechanism Based Assessment[NCT05986513] | 66 participants (Anticipated) | Interventional | 2023-09-01 | Not yet recruiting | |||
| Influence of 12 Weeks Vitamin D Supplementation Combined With Physical Activity on Blood and Functional Parameters and Quality of Life in Parkinson's Disease Patients Treated With Deep Brain Stimulation[NCT04768023] | 50 participants (Actual) | Interventional | 2019-11-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
19 reviews available for kynurenine and Aging
| Article | Year |
|---|---|
Role of indoleamine 2,3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process.
Topics: Aging; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Tryptophan | 2022 |
Therapeutic potential of targeting kynurenine pathway in neurodegenerative diseases.
Topics: Aging; Animals; Huntington Disease; Kynurenine; Mammals; Models, Animal; Neurodegenerative Diseases | 2023 |
Kynurenine pathway and human systems.
Topics: Aging; Cytokines; Humans; Kynurenine; Tryptophan | 2020 |
Clinical insights into the kynurenine pathway in age-related diseases.
Topics: Aged; Aging; Animals; Biomarkers; Frailty; Humans; Kynurenine; Metabolic Networks and Pathways; Tryp | 2020 |
Kynurenine signaling through the aryl hydrocarbon receptor: Implications for aging and healthspan.
Topics: Aging; Animals; Basic Helix-Loop-Helix Transcription Factors; Humans; Inflammation; Kynurenine; Long | 2020 |
Kynurenine pathway, NAD
Topics: Aging; Animals; Brain; Humans; Kynurenine; Longevity; Metabolic Networks and Pathways; Mice; Mitocho | 2020 |
Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases.
Topics: Aging; Animals; Blood Pressure; Cardiovascular Diseases; Diabetes Mellitus; Drug Discovery; Endothel | 2017 |
Mitochondria, Oxidative Stress and the Kynurenine System, with a Focus on Ageing and Neuroprotection.
Topics: Aging; Animals; Brain; Cellular Senescence; Disease Susceptibility; DNA Damage; DNA Repair; DNA, Mit | 2018 |
Emerging role for kynurenines in metabolic pathologies.
Topics: Aging; Animals; Atherosclerosis; Biomarkers; Diabetes Mellitus; Homeostasis; Humans; Islets of Lange | 2019 |
The kynurenine pathway: a finger in every pie.
Topics: Aging; Animals; Energy Metabolism; Humans; Kynurenine; Mental Disorders; NAD; Neurodegenerative Dise | 2020 |
Kynurenines with neuroactive and redox properties: relevance to aging and brain diseases.
Topics: Aging; Animals; Brain Diseases; Humans; Kynurenine; Metabolic Networks and Pathways; Neuroprotective | 2014 |
Tryptophan availability for kynurenine pathway metabolism across the life span: Control mechanisms and focus on aging, exercise, diet and nutritional supplements.
Topics: Aging; Animals; Diet; Dietary Supplements; Exercise; Humans; Kynurenine; Metabolic Networks and Path | 2017 |
Brain Aging and Disorders of the Central Nervous System: Kynurenines and Drug Metabolism.
Topics: Aging; Animals; Brain; Central Nervous System Diseases; Humans; Kynurenine; Pharmaceutical Preparati | 2016 |
Metabolic syndrome, age-associated neuroendocrine disorders, and dysregulation of tryptophan-kynurenine metabolism.
Topics: Aging; Animals; Endocrine System Diseases; Humans; Kynurenine; Metabolic Syndrome; Nervous System Di | 2010 |
NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns.
Topics: Aging; Animals; Cell Death; Cell Membrane; DNA Repair; Energy Metabolism; Enzyme Activation; Humans; | 2012 |
Kynurenic acid and kynurenine aminotransferases in retinal aging and neurodegeneration.
Topics: Aging; Animals; Humans; Kynurenic Acid; Kynurenine; Retina; Retinal Degeneration; Retinal Ganglion C | 2011 |
The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.
Topics: Aging; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Enzyme Inhibitors; Humans; Hunting | 2012 |
Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery.
Topics: Acrylamides; Adenosine Diphosphate Ribose; Aging; Animals; Antineoplastic Agents; Autoimmune Disease | 2007 |
Genetic and hormonal regulation of tryptophan kynurenine metabolism: implications for vascular cognitive impairment, major depressive disorder, and aging.
Topics: Aging; Animals; Cognition Disorders; Cytokines; Depressive Disorder, Major; Hormones; Humans; Kynure | 2007 |
1 trial available for kynurenine and Aging
| Article | Year |
|---|---|
Substrate product ratios of enzymes in the kynurenine pathway measured in plasma as indicators of functional vitamin B-6 status.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aging; Biomarkers; Cross-Sectional Studies; Female; Humans; Hydrola | 2013 |
61 other studies available for kynurenine and Aging
| Article | Year |
|---|---|
Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging.
Topics: Aged; Aging; Child, Preschool; Frailty; Humans; Kynurenine; Quinolinic Acid; Tryptophan | 2022 |
Deletion of quinolinate phosphoribosyltransferase gene accelerates frailty phenotypes and neuromuscular decline with aging in a sex-specific pattern.
Topics: Aging; Animals; Female; Frailty; Kynurenine; Male; Mice; Muscle Weakness; Phenotype | 2023 |
Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer's molecular signatures.
Topics: Adult; Aged, 80 and over; Aging; Alzheimer Disease; Animals; Astrocytes; Cognition; Cognitive Dysfun | 2019 |
Kynurenine, a Tryptophan Metabolite That Increases with Age, Induces Muscle Atrophy and Lipid Peroxidation.
Topics: Aging; Animals; Cells, Cultured; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; L | 2019 |
Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo.
Topics: Aging; Animals; Bone and Bones; Bone Density; Cell Differentiation; Female; Histone Deacetylases; Ky | 2020 |
Plasma tryptophan and kynurenine pathway metabolites in abstinent patients with alcohol use disorder and high prevalence of psychiatric comorbidity.
Topics: Adolescent; Adult; Aged; Aging; Alcohol Abstinence; Alcoholism; Body Mass Index; Cross-Sectional Stu | 2020 |
Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss.
Topics: Adiposity; Aging; Animals; Body Weight; Bone and Bones; Bone Resorption; Calcification, Physiologic; | 2017 |
Kynurenine Pathway Metabolites in Alzheimer's Disease.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Cognition Disorders; C | 2017 |
Fish oil ameliorates sickness behavior induced by lipopolysaccharide in aged mice through the modulation of kynurenine pathway.
Topics: Aging; Anhedonia; Animals; Behavior, Animal; Biomarkers; Body Weight; Brain; Cytokines; Fish Oils; I | 2018 |
Kynurenine pathway changes in late-life depression with memory deficit.
Topics: Aged; Aging; Biomarkers; Chromatography, Liquid; Depression; Female; Humans; Kynurenine; Male; Mass | 2018 |
Macrophage de novo NAD
Topics: Aging; Animals; Cells, Cultured; Homeostasis; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase | 2019 |
The Detrimental Effects of Kynurenine, a Tryptophan Metabolite, on Human Bone Metabolism.
Topics: Aged; Aged, 80 and over; Aging; Bone and Bones; Bone Density; Bone Marrow; Bone Remodeling; Case-Con | 2019 |
Age-related spatial differences of human lens UV filters revealed by negative ion mode MALDI imaging mass spectrometry.
Topics: Adult; Aged; Aged, 80 and over; Aging; Crystallins; Fourier Analysis; Glucosides; Glutathione; Human | 2019 |
Age- and disease-specific changes of the kynurenine pathway in Parkinson's and Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Female; Humans; Kynurenine; Male; Middle Aged; Parkinson Disease | 2019 |
Aging leads to prolonged duration of inflammation-induced depression-like behavior caused by Bacillus Calmette-Guérin.
Topics: Aging; Anhedonia; Animals; Behavior, Animal; Body Weight; Chronic Disease; Depression; Hindlimb Susp | 2013 |
A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aging; Biomarkers; Body Mass Index; Creatinine; Female; Humans; Inf | 2013 |
Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease.
Topics: Aging; Animals; Brain; Cerebellum; Corpus Striatum; Female; Genotype; Huntington Disease; Indoleamin | 2013 |
Central kynurenine pathway shift with age in women.
Topics: Adult; Aged; Aged, 80 and over; Aging; Brain; Female; Humans; Inflammation; Kynurenic Acid; Kynureni | 2016 |
Identification of Kynoxazine, a Novel Fluorescent Product of the Reaction between 3-Hydroxykynurenine and Erythrulose in the Human Lens, and Its Role in Protein Modification.
Topics: Aging; Eye Proteins; Humans; Kynurenine; Lens, Crystalline; Protein Processing, Post-Translational; | 2016 |
Advanced age negatively impacts survival in an experimental brain tumor model.
Topics: Aging; Animals; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; Glioblastoma; Indoleamine | 2016 |
Age and circadian influences on picolinic acid concentrations in human cerebrospinal fluid.
Topics: Aging; Analysis of Variance; C-Reactive Protein; Case-Control Studies; Central Nervous System Diseas | 2009 |
Tryptophan and kynurenine levels in lenses of Wistar and accelerated-senescence OXYS rats.
Topics: Aging; Animals; Chromatography, High Pressure Liquid; Kynurenine; Lens, Crystalline; Rats; Rats, Wis | 2009 |
Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders.
Topics: Aging; Animals; Humans; Inflammation; Interferon-gamma; Kynurenine; Mental Disorders; Metabolic Synd | 2011 |
Age dependency of inhibition of alpha7 nicotinic receptors and tonically active N-methyl-D-aspartate receptors by endogenously produced kynurenic acid in the brain.
Topics: Adult; Aging; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bicuculline; Choline; Female; GABA-A | 2011 |
Photochemical properties of UV Filter molecules of the human eye.
Topics: Aging; Chromatography, High Pressure Liquid; Glucosides; Glutathione; Humans; Kynurenine; Lens, Crys | 2011 |
Administration of kynurenine during adolescence, but not during adulthood, impairs social behavior in rats.
Topics: Aging; Animals; Disease Models, Animal; Interpersonal Relations; Kynurenine; Male; Motor Activity; R | 2011 |
Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats.
Topics: Aging; Animals; Brain; Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectro | 2011 |
Protein-bound kynurenine decreases with the progression of age-related nuclear cataract.
Topics: Aged; Aged, 80 and over; Aging; Cataract; Chromatography, High Pressure Liquid; Crystallins; Disease | 2004 |
Drosophila mutants of the kynurenine pathway as a model for ageing studies.
Topics: Aging; Animals; Apoptosis; Brain; Drosophila melanogaster; Kynurenine; Male; Models, Biological; Mut | 2003 |
Increasing production of homocysteine and neopterin and degradation of tryptophan with older age.
Topics: Adult; Aged; Aged, 80 and over; Aging; Dioxygenases; Enzyme-Linked Immunosorbent Assay; Female; Foli | 2004 |
Identification of 3-hydroxykynurenine bound to proteins in the human lens. A possible role in age-related nuclear cataract.
Topics: Aging; Animals; Butterflies; Cataract; Humans; Kynurenine; Lens, Crystalline; Moths; Oxidation-Reduc | 2006 |
Indoleamine 2,3-dioxygenase activity in nonagenarians is markedly increased and predicts mortality.
Topics: Adult; Aged, 80 and over; Aging; Female; Humans; Immune System; Indoleamine-Pyrrole 2,3,-Dioxygenase | 2006 |
Protein-bound UV filters in normal human lenses: the concentration of bound UV filters equals that of free UV filters in the center of older lenses.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Chromatography, High Pressure Liquid; Crystallins | 2007 |
Reversible binding of kynurenine to lens proteins: potential protection by glutathione in young lenses.
Topics: Aging; Animals; Binding, Competitive; Cattle; Crystallins; Cysteine; Glutathione; Histidine; Hydroge | 2007 |
Changes in brain tryptophan metabolism elicited by ageing, social environment, and psychological stress in mice.
Topics: Aging; Amygdala; Animals; Brain; Brain Chemistry; Hippocampus; Kynurenine; Male; Mice; Mice, Inbred | 2008 |
Photolytic changes in lens proteins.
Topics: Adolescent; Aged; Aging; Animals; Cataract; Cattle; Crystallins; Glucosides; Humans; In Vitro Techni | 1984 |
Spectrophotometric estimation of 3-OH L-kynurenine O-beta-glucoside in the human lens.
Topics: Adult; Aged; Aging; beta-Glucosidase; Child; Child, Preschool; Chromatography, Gas; Chromatography, | 1981 |
Effect of exposure to light in enzyme activities and tryptophan metabolites of the kynurenine pathway in Wistar, in heterozygous and homozygous adult and newborn Gunn rats.
Topics: Aging; Animals; Animals, Newborn; Female; Heterozygote; Hydrolases; Kynurenine; Light; Liver; Lyases | 1982 |
Excitotoxic lesions of the rat striatum: different responses of kynurenine pathway enzymes during ontogeny.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Aging; Animals; Animals, Newborn; Corpus Striatum; Dioxygenas | 1996 |
Kynurenine metabolism in the rat brain in vivo. Effect of acute excitotoxic insults.
Topics: Aging; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Ibotenic Acid; Infusions, Par | 1996 |
Xanthurenic acid derivative formation in the lens is responsible for senile cataract in humans.
Topics: Adult; Aging; Cataract; Chromatography, Thin Layer; Crystallins; Deamination; Electrophoresis, Polya | 1996 |
Metabolism of [5-(3)H]kynurenine in the developing rat brain in vivo: effect of intrastriatal ibotenate injections.
Topics: Aging; Animals; Brain; Corpus Striatum; Functional Laterality; Glutamate Decarboxylase; Ibotenic Aci | 1997 |
The photochemical attachment of the O-glucoside of 3-hydroxykynurenine to alpha-crystallin: a model for lenticular aging.
Topics: Aging; Chromatography, High Pressure Liquid; Crystallins; Glucosides; Humans; In Vitro Techniques; K | 1999 |
Age-dependent changes in memory and mushroom bodies in the Drosophila mutant vermilion deficient in the kynurenine pathway of tryptophan metabolism.
Topics: Aging; Animals; Brain; Conditioning, Classical; Drosophila; Kynurenine; Memory; Mutation; Sexual Beh | 1999 |
Identification of glutathionyl-3-hydroxykynurenine glucoside as a novel fluorophore associated with aging of the human lens.
Topics: Aging; Biomarkers; Glucosides; Glutathione; Humans; Kynurenine; Lens, Crystalline; Protein Conformat | 1999 |
Human lens coloration and aging. Evidence for crystallin modification by the major ultraviolet filter, 3-hydroxy-kynurenine O-beta-D-glucoside.
Topics: Age Factors; Aging; Animals; Cattle; Color; Crystallins; Glucosides; Humans; Kynurenine; Lens, Cryst | 1999 |
UV filter compounds in human lenses: the origin of 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-beta-D-glucoside.
Topics: Acrylates; Adult; Aging; Benzoates; Chromatography, High Pressure Liquid; Deamination; Fetus; Glucos | 1999 |
The Nitrite/alpha crystallin reaction: a possible mechanism in lens matrix damage.
Topics: Aging; Animals; Cataract; Cattle; Chromatography, High Pressure Liquid; Crystallins; Electrophoresis | 2000 |
Non-oxidative modification of lens crystallins by kynurenine: a novel post-translational protein modification with possible relevance to ageing and cataract.
Topics: Aging; Animals; Cataract; Cattle; Crystallins; Kynurenine; Lens, Crystalline; Oxidation-Reduction; P | 2000 |
Age-related changes in the absorption characteristics of the primate lens.
Topics: Absorption; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Child; Child, Preschool; Cry | 2000 |
Major changes in human ocular UV protection with age.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Chromatography, High Pressure Liquid; Glucosides; | 2001 |
Photochemically modified alpha-crystallin: a model system for aging in the primate lens.
Topics: Aging; Animals; Cattle; Crystallins; In Vitro Techniques; Kynurenine; Lens, Crystalline; Models, Bio | 2001 |
Kynurenine binds to the peptide binding region of the chaperone alphaB-crystallin.
Topics: Aging; Animals; Binding Sites; Cattle; Chromatography, High Pressure Liquid; Crystallins; Histidine; | 2001 |
Brain tryptophan metabolism in schizophrenia: a post mortem study of metabolites of the serotonin and kynurenine pathways in schizophrenic and control subjects.
Topics: Aged; Aging; Brain; Female; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; Middle Aged; Myocard | 1979 |
Convulsions and tremor in immature rats after intraperitoneal injection of kynurenine and its metabolites.
Topics: Aging; Animals; Body Weight; Injections, Intraperitoneal; Kynurenine; Nicotinic Acids; Quinolinic Ac | 1978 |
Tryptophan metabolism in senile cataract patients assessed by high-performance liquid chromatography.
Topics: Aging; Cataract; Chromatography, High Pressure Liquid; Humans; Kynurenic Acid; Kynurenine; Tryptopha | 1991 |
Time resolved spectroscopic studies on the intact human lens.
Topics: Aging; Crystallins; Humans; Kynurenine; Lens, Crystalline; Spectrometry, Fluorescence | 1990 |
Distribution of two metabolically related fluorophors in human lens measured by laser microprobe.
Topics: Adolescent; Aged; Aging; Child, Preschool; Glucosides; Glycosides; Humans; Infant; Kynurenine; Lens | 1989 |
The nature and properties of squirrel lens yellow pigment.
Topics: Aging; Animals; Chromatography, High Pressure Liquid; Kynurenine; Lens, Crystalline; Mass Spectromet | 1988 |
Increased concentrations of 3-hydroxykynurenine in vitamin B6 deficient neonatal rat brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Cerebellum; Cerebral Cortex; Chromatography, High Pressure | 1987 |
Guinea-pig liver tryptophan pyrrolase. Absence of detectable apoenzyme activity and of hormonal induction by cortisol and possible regulation by tryptophan.
Topics: Aging; Allopurinol; Animals; Apoproteins; Cycloheximide; Dactinomycin; Enzyme Induction; Enzyme Prec | 1974 |