kynurenine has been researched along with Age-Related Memory Disorders in 13 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Utilising the acute tryptophan depletion (ATD) protocol, the aim of this study was to examine if manipulating peripheral levels of tryptophan regulates cognitive performance in irritable bowel syndrome and also to determine for the first time if the ATD protocol alters kynurenine supply to the central nervous system." | 9.20 | Acute tryptophan depletion reduces kynurenine levels: implications for treatment of impaired visuospatial memory performance in irritable bowel syndrome. ( Allen, AP; Clarke, G; Cryan, JF; Dinan, TG; Kennedy, PJ; O'Neill, A; Quigley, EM, 2015) |
| "Obesity is associated with impaired learning, but the mechanisms underlying this cognitive dysfunction are poorly understood." | 5.91 | Obesity-Induced Memory Deficits in Female Rats Are Oestrous Cycle Dependent and Linked to Impaired Brain Kynurenine Pathway Metabolism. ( Bolaños-Jiménez, F; Croyal, M; García Santillán, JA; Gourdel, M; Mezo-González, CE; Reyes-Castro, LA, 2023) |
| "Utilising the acute tryptophan depletion (ATD) protocol, the aim of this study was to examine if manipulating peripheral levels of tryptophan regulates cognitive performance in irritable bowel syndrome and also to determine for the first time if the ATD protocol alters kynurenine supply to the central nervous system." | 5.20 | Acute tryptophan depletion reduces kynurenine levels: implications for treatment of impaired visuospatial memory performance in irritable bowel syndrome. ( Allen, AP; Clarke, G; Cryan, JF; Dinan, TG; Kennedy, PJ; O'Neill, A; Quigley, EM, 2015) |
| " Neuronal EAAT2 deletion leads to dysregulation of the kynurenine pathway, and astrocytic EAAT2 deficiency results in dysfunction of innate and adaptive immune pathways, which correlate with cognitive decline." | 3.91 | Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer's molecular signatures. ( Gray, JD; Kazim, SF; Larson, CS; McEwen, BS; Pereira, AC; Ramakrishnan, A; Rosenberg, PA; Sharma, A; Shen, L, 2019) |
| " Increasing evidence has been proposed the activation of the tryptophan-degrading indoleamine-2,3-dyoxigenase (IDO), the rate-limiting enzyme of kynurerine pathway (KP), as a pathogenic factor of amyloid-beta (Aβ)-related inflammation in AD." | 3.83 | Indoleamine-2,3-dioxygenase mediates neurobehavioral alterations induced by an intracerebroventricular injection of amyloid-β1-42 peptide in mice. ( Antunes, MS; Boeira, SP; de Oliveira Espinosa, D; Donato, F; Giacomeli, R; Gomes, NS; Jesse, CR; Ruff, JR; Souza, LC, 2016) |
| "Obesity is associated with impaired learning, but the mechanisms underlying this cognitive dysfunction are poorly understood." | 1.91 | Obesity-Induced Memory Deficits in Female Rats Are Oestrous Cycle Dependent and Linked to Impaired Brain Kynurenine Pathway Metabolism. ( Bolaños-Jiménez, F; Croyal, M; García Santillán, JA; Gourdel, M; Mezo-González, CE; Reyes-Castro, LA, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 10 (76.92) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Mezo-González, CE | 1 |
| García Santillán, JA | 1 |
| Reyes-Castro, LA | 1 |
| Gourdel, M | 1 |
| Croyal, M | 1 |
| Bolaños-Jiménez, F | 1 |
| Sharma, A | 1 |
| Kazim, SF | 1 |
| Larson, CS | 1 |
| Ramakrishnan, A | 1 |
| Gray, JD | 1 |
| McEwen, BS | 1 |
| Rosenberg, PA | 1 |
| Shen, L | 1 |
| Pereira, AC | 1 |
| Quist-Paulsen, E | 1 |
| Ormaasen, V | 1 |
| Kran, AB | 1 |
| Dunlop, O | 1 |
| Ueland, PM | 1 |
| Ueland, T | 1 |
| Eikeland, R | 1 |
| Aukrust, P | 1 |
| Nordenmark, TH | 1 |
| Ramirez Ortega, D | 1 |
| Ovalle Rodríguez, P | 1 |
| Pineda, B | 1 |
| González Esquivel, DF | 1 |
| Ramos Chávez, LA | 1 |
| Vázquez Cervantes, GI | 1 |
| Roldán Roldán, G | 1 |
| Pérez de la Cruz, G | 1 |
| Díaz Ruiz, A | 1 |
| Méndez Armenta, M | 1 |
| Marcial Quino, J | 1 |
| Gómez Manzo, S | 1 |
| Ríos, C | 1 |
| Pérez de la Cruz, V | 1 |
| Wu, Y | 1 |
| Mai, N | 1 |
| Zhong, X | 1 |
| Wen, Y | 1 |
| Zhou, Y | 1 |
| Li, H | 1 |
| Shang, D | 1 |
| Hu, L | 1 |
| Chen, X | 1 |
| Chen, B | 1 |
| Zhang, M | 1 |
| Ning, Y | 1 |
| Pocivavsek, A | 2 |
| Elmer, GI | 2 |
| Schwarcz, R | 2 |
| Quagliato, LA | 1 |
| Freire, RC | 1 |
| Nardi, AE | 1 |
| Thomas, MA | 1 |
| Bruno, JP | 1 |
| Kennedy, PJ | 1 |
| Allen, AP | 1 |
| O'Neill, A | 1 |
| Quigley, EM | 1 |
| Cryan, JF | 1 |
| Dinan, TG | 1 |
| Clarke, G | 1 |
| Heisler, JM | 1 |
| O'Connor, JC | 1 |
| Souza, LC | 1 |
| Jesse, CR | 1 |
| Antunes, MS | 1 |
| Ruff, JR | 1 |
| de Oliveira Espinosa, D | 1 |
| Gomes, NS | 1 |
| Donato, F | 1 |
| Giacomeli, R | 1 |
| Boeira, SP | 1 |
| Akagbosu, CO | 1 |
| Evans, GC | 1 |
| Gulick, D | 1 |
| Suckow, RF | 1 |
| Bucci, DJ | 1 |
| Savvateeva, E | 1 |
| Popov, A | 1 |
| Kamyshev, N | 1 |
| Bragina, J | 1 |
| Heisenberg, M | 1 |
| Senitz, D | 1 |
| Kornhuber, J | 1 |
| Riederer, P | 1 |
1 trial available for kynurenine and Age-Related Memory Disorders
| Article | Year |
|---|---|
Acute tryptophan depletion reduces kynurenine levels: implications for treatment of impaired visuospatial memory performance in irritable bowel syndrome.
Topics: Adolescent; Adult; Cross-Over Studies; Double-Blind Method; Female; Hippocampus; Humans; Irritable B | 2015 |
12 other studies available for kynurenine and Age-Related Memory Disorders
| Article | Year |
|---|---|
Obesity-Induced Memory Deficits in Female Rats Are Oestrous Cycle Dependent and Linked to Impaired Brain Kynurenine Pathway Metabolism.
Topics: Animals; Brain; Female; Kynurenic Acid; Kynurenine; Memory Disorders; NAD; Obesity; Rats; Tryptophan | 2023 |
Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer's molecular signatures.
Topics: Adult; Aged, 80 and over; Aging; Alzheimer Disease; Animals; Astrocytes; Cognition; Cognitive Dysfun | 2019 |
Encephalitis and aseptic meningitis: short-term and long-term outcome, quality of life and neuropsychological functioning.
Topics: Adult; Aged; Biomarkers; Brain Damage, Chronic; Encephalitis; Female; Follow-Up Studies; Humans; Kyn | 2019 |
Kynurenine Pathway as a New Target of Cognitive Impairment Induced by Lead Toxicity During the Lactation.
Topics: Animals; Brain; Cognitive Dysfunction; Environmental Exposure; Female; Kynurenine; Lactation; Lead; | 2020 |
Kynurenine pathway changes in late-life depression with memory deficit.
Topics: Aged; Aging; Biomarkers; Chromatography, Liquid; Depression; Female; Humans; Kynurenine; Male; Mass | 2018 |
Inhibition of kynurenine aminotransferase II attenuates hippocampus-dependent memory deficit in adult rats treated prenatally with kynurenine.
Topics: Age Factors; Animals; Female; Heterocyclic Compounds, 3-Ring; Hippocampus; Kynurenine; Male; Memory | 2019 |
Elevated peripheral kynurenine/tryptophan ratio predicts poor short-term auditory memory in panic disorder patients.
Topics: Adolescent; Adult; Auditory Perception; Biomarkers; Female; Humans; Kynurenine; Male; Memory Disorde | 2019 |
Continuous kynurenine administration during the prenatal period, but not during adolescence, causes learning and memory deficits in adult rats.
Topics: Age Factors; Animals; Avoidance Learning; Behavior, Animal; Cognition Disorders; Female; Hippocampus | 2014 |
Indoleamine 2,3-dioxygenase-dependent neurotoxic kynurenine metabolism mediates inflammation-induced deficit in recognition memory.
Topics: Animals; Cytokines; Depression; Encephalitis; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lipo | 2015 |
Indoleamine-2,3-dioxygenase mediates neurobehavioral alterations induced by an intracerebroventricular injection of amyloid-β1-42 peptide in mice.
Topics: Amyloid beta-Peptides; Animals; Anxiety; Behavior, Animal; Depression; Disease Models, Animal; Hippo | 2016 |
Exposure to kynurenic acid during adolescence produces memory deficits in adulthood.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Excitatory Amino Acid Antagonists; Fear; Kynurenic | 2012 |
Age-dependent memory loss, synaptic pathology and altered brain plasticity in the Drosophila mutant cardinal accumulating 3-hydroxykynurenine.
Topics: Age Factors; Animals; Courtship; Drosophila; Kynurenic Acid; Kynurenine; Learning; Male; Memory Diso | 2000 |