Page last updated: 2024-10-18

kynurenine and Affective Disorders

kynurenine has been researched along with Affective Disorders in 9 studies

Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.

Research Excerpts

ExcerptRelevanceReference
"Weight loss diet lowered leptin levels in both groups by 46%, although not reaching significance."9.20Effects of a caloric restriction weight loss diet on tryptophan metabolism and inflammatory biomarkers in overweight adults. ( Berger, K; Fuchs, D; Strasser, B, 2015)
" In this systematic review, we examine the relationship between kynurenine metabolites (kynurenine, kynurenic acid, tryptophan, quinolinic acid, the ratio of kynurenine and tryptophan) and mood disorders by conducting a meta-analysis."8.98Role of Kynurenine pathway and its metabolites in mood disorders: A systematic review and meta-analysis of clinical studies. ( Arnone, D; Dantzer, R; Salem, H; Saraykar, S; Selvaraj, S; Teixeira, AL, 2018)
"The role of serotonin in the pathogenesis of depression is well-documented, while the involvement of other tryptophan (TRP) metabolites generated in the kynurenine pathway is less known."7.96Tryptophan Intake and Metabolism in Older Adults with Mood Disorders. ( Blasiak, J; Chojnacki, C; Chojnacki, J; Fila, M; Konrad, P; Popławski, T, 2020)
"Mood disorders were evaluated by the Hamilton Anxiety Rating Scale (HAM-A) and the Hamilton Depression Rating Scale (HAM-D)."5.91Reduced Intake of Dietary Tryptophan Improves Beneficial Action of Budesonide in Patients with Lymphocytic Colitis and Mood Disorders. ( Blasiak, J; Błońska, A; Chojnacki, C; Chojnacki, J; Gąsiorowska, A; Konrad, P; Popławski, T; Zajdler, R, 2023)
"Weight loss diet lowered leptin levels in both groups by 46%, although not reaching significance."5.20Effects of a caloric restriction weight loss diet on tryptophan metabolism and inflammatory biomarkers in overweight adults. ( Berger, K; Fuchs, D; Strasser, B, 2015)
" In this systematic review, we examine the relationship between kynurenine metabolites (kynurenine, kynurenic acid, tryptophan, quinolinic acid, the ratio of kynurenine and tryptophan) and mood disorders by conducting a meta-analysis."4.98Role of Kynurenine pathway and its metabolites in mood disorders: A systematic review and meta-analysis of clinical studies. ( Arnone, D; Dantzer, R; Salem, H; Saraykar, S; Selvaraj, S; Teixeira, AL, 2018)
"The role of serotonin in the pathogenesis of depression is well-documented, while the involvement of other tryptophan (TRP) metabolites generated in the kynurenine pathway is less known."3.96Tryptophan Intake and Metabolism in Older Adults with Mood Disorders. ( Blasiak, J; Chojnacki, C; Chojnacki, J; Fila, M; Konrad, P; Popławski, T, 2020)
"Aprepitant treatment offers an opportunity to target inflammation and mood disorders frequently co-existing in chronic HIV infection."3.01Effect of aprepitant on kynurenine to tryptophan ratio in cART treated and cART naïve adults living with HIV. ( Douglas, SD; Evans, DL; Kinder, A; Pappa, V; Rappaport, J; Spitsin, S, 2021)
"Mood disorders were evaluated by the Hamilton Anxiety Rating Scale (HAM-A) and the Hamilton Depression Rating Scale (HAM-D)."1.91Reduced Intake of Dietary Tryptophan Improves Beneficial Action of Budesonide in Patients with Lymphocytic Colitis and Mood Disorders. ( Blasiak, J; Błońska, A; Chojnacki, C; Chojnacki, J; Gąsiorowska, A; Konrad, P; Popławski, T; Zajdler, R, 2023)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's0 (0.00)29.6817
2010's4 (44.44)24.3611
2020's4 (44.44)2.80

Authors

AuthorsStudies
Chojnacki, C2
Gąsiorowska, A1
Popławski, T2
Błońska, A1
Konrad, P2
Zajdler, R1
Chojnacki, J2
Blasiak, J2
Fila, M1
Spitsin, S1
Pappa, V1
Kinder, A1
Evans, DL1
Rappaport, J1
Douglas, SD1
Arnone, D1
Saraykar, S1
Salem, H1
Teixeira, AL1
Dantzer, R1
Selvaraj, S1
Maget, A1
Platzer, M1
Bengesser, SA1
Fellendorf, FT1
Birner, A1
Queissner, R1
Hamm, C1
Reininghaus, B1
Hecker, A1
Tomberger, L1
Pilz, R1
Dalkner, N1
Moll, N1
Schütze, G1
Schwarz, M1
Kapfhammer, HP1
Reininghaus, EZ1
Strasser, B1
Berger, K1
Fuchs, D2
Singh, R1
Savitz, J1
Teague, TK1
Polanski, DW1
Mayer, AR1
Bellgowan, PS1
Meier, TB1
Bechter, K1
Reiber, H1
Herzog, S1
Tumani, H1
Maxeiner, HG1
Lapin, IP1

Reviews

2 reviews available for kynurenine and Affective Disorders

ArticleYear
Role of Kynurenine pathway and its metabolites in mood disorders: A systematic review and meta-analysis of clinical studies.
    Neuroscience and biobehavioral reviews, 2018, Volume: 92

    Topics: Humans; Kynurenic Acid; Kynurenine; Mood Disorders; Quinolinic Acid; Serotonin; Signal Transduction;

2018
Kynurenines and anxiety.
    Advances in experimental medicine and biology, 1996, Volume: 398

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Humans; Kynurenine; Maze Learning; Mice; Moo

1996

Trials

2 trials available for kynurenine and Affective Disorders

ArticleYear
Effect of aprepitant on kynurenine to tryptophan ratio in cART treated and cART naïve adults living with HIV.
    Medicine, 2021, Jun-11, Volume: 100, Issue:23

    Topics: Adult; Anti-HIV Agents; Aprepitant; CD4 Lymphocyte Count; Double-Blind Method; Drug Therapy, Combina

2021
Effects of a caloric restriction weight loss diet on tryptophan metabolism and inflammatory biomarkers in overweight adults.
    European journal of nutrition, 2015, Volume: 54, Issue:1

    Topics: Austria; Biomarkers; Body Mass Index; Caloric Restriction; Diet, Reducing; Female; Humans; Inflammat

2015

Other Studies

5 other studies available for kynurenine and Affective Disorders

ArticleYear
Reduced Intake of Dietary Tryptophan Improves Beneficial Action of Budesonide in Patients with Lymphocytic Colitis and Mood Disorders.
    Nutrients, 2023, Mar-30, Volume: 15, Issue:7

    Topics: Budesonide; Colitis, Lymphocytic; Diet; Humans; Hydroxyindoleacetic Acid; Kynurenine; Mood Disorders

2023
Tryptophan Intake and Metabolism in Older Adults with Mood Disorders.
    Nutrients, 2020, Oct-18, Volume: 12, Issue:10

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Depression; Dietary Supplements; Eating; Female; Humans

2020
Differences in Kynurenine Metabolism During Depressive, Manic, and Euthymic Phases of Bipolar Affective Disorder.
    Current topics in medicinal chemistry, 2020, Volume: 20, Issue:15

    Topics: Adult; Bipolar Disorder; Depression; Female; Humans; Kynurenine; Male; Middle Aged; Mood Disorders

2020
Mood symptoms correlate with kynurenine pathway metabolites following sports-related concussion.
    Journal of neurology, neurosurgery, and psychiatry, 2016, Volume: 87, Issue:6

    Topics: Athletic Injuries; Brain Concussion; Follow-Up Studies; Football; Humans; Kynurenine; Male; Mood Dis

2016
Cerebrospinal fluid analysis in affective and schizophrenic spectrum disorders: identification of subgroups with immune responses and blood-CSF barrier dysfunction.
    Journal of psychiatric research, 2010, Volume: 44, Issue:5

    Topics: Adult; Cohort Studies; Female; Humans; Immunoglobulins; International Classification of Diseases; Ky

2010
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