kynurenine has been researched along with Adrenal Insufficiency in 2 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Adrenal Insufficiency: Conditions in which the production of adrenal CORTICOSTEROIDS falls below the requirement of the body. Adrenal insufficiency can be caused by defects in the ADRENAL GLANDS, the PITUITARY GLAND, or the HYPOTHALAMUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metabolism of tryptophan through the kynurenine pathway is reduced after a 10-week treatment with a higher dose HC and plays a role in the effect of HC on fatigue and physical functioning in patients with secondary AI." | 9.27 | Hydrocortisone Affects Fatigue and Physical Functioning Through Metabolism of Tryptophan: A Randomized Controlled Trial. ( Bos, EH; Kema, IP; Sorgdrager, FJH; Van Beek, AP; Werumeus Buning, J, 2018) |
| "Metabolism of tryptophan through the kynurenine pathway is reduced after a 10-week treatment with a higher dose HC and plays a role in the effect of HC on fatigue and physical functioning in patients with secondary AI." | 5.27 | Hydrocortisone Affects Fatigue and Physical Functioning Through Metabolism of Tryptophan: A Randomized Controlled Trial. ( Bos, EH; Kema, IP; Sorgdrager, FJH; Van Beek, AP; Werumeus Buning, J, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vulto, A | 1 |
| van Faassen, M | 1 |
| Kerstens, MN | 1 |
| van Beek, AP | 2 |
| Sorgdrager, FJH | 1 |
| Werumeus Buning, J | 1 |
| Bos, EH | 1 |
| Kema, IP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Double Blind Cross-over Study of the Effects of Low Dose and High Dose Hydrocortisone Replacement Therapy on Cognition, Quality of Life, Metabolic Profile and Somatosensation in Patients With Secondary Adrenal Insufficiency[NCT01546922] | Phase 4 | 63 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Cognitive domains to be tested: memory, executive functioning, attention and social cognition.~The psychological tests consist of oral and written questions or computer tasks.~Data is given as Z-scores based on normative data. Higher Z-scores represent a better performance." (NCT01546922)
Timeframe: After completion of treatment period 1 (that is after 10 weeks from baseline) and after treatment period 2 (that is after 20 weeks from baseline).
| Intervention | Z-scores based on normative data. (Mean) | |||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RBMT-Immediate Memory | RBMT-Delayed Memory | RBMT-Delayed corrected for immediate memory | 15 Words Test-Short-term memory | 15 Words Test-Total immediate memory | 15 Words Test - Learning Score | 15 Words Test - Delayed Memory | 15 Words Test - Delayed corrected for total memory | 15 Words Test-Recognition | Digit Span forward - Short term memory | Rey Complex Figure - Immediate memory | Rey Complex Figure - Delayed memory | Divided attention-reaction time auditory response | Divided attention-reaction time visual response | Divided attention - Number of omission errors | Divided attention - Number of commission errors | Visual scanning - Reaction time for target stimuli | Visual scanning - Number of omission errors | Visual scanning - Number of commission errors | Alertness - Reaction time tonic alertness | Alertness - Reaction time phasic alertness | Semantic fluency | Phonemic fluency | Digit Span backwards-Working memory | Trail Making Test - Time condition A | Trail Making Test - Time condition B | Trail Making Test - Condition B/A | Social Cognition | |
| High Dose of Hydrocortisone | -0.42 | 0.10 | 0.89 | -0.03 | 0.25 | 0.38 | 0.23 | -0.16 | 0.08 | 0.56 | 1.40 | 1.28 | -0.89 | 0.03 | -0.14 | 0.34 | -0.36 | 0.08 | -0.70 | -0.99 | -1.10 | 0.09 | 0.21 | -0.01 | -0.26 | 0.18 | 0.36 | -0.71 |
| Low Dose of Hydrocortisone | -0.41 | 0.07 | 0.85 | 0.36 | 0.43 | 0.08 | 0.02 | -0.30 | -0.11 | 0.49 | 1.14 | 1.11 | -0.87 | -0.06 | -0.02 | 0.30 | -0.38 | -0.03 | -0.72 | -0.90 | -1.03 | 0.02 | 0.32 | 0.05 | -0.32 | 0.16 | 0.37 | -0.67 |
2 trials available for kynurenine and Adrenal Insufficiency
| Article | Year |
|---|---|
Susceptibility to Adrenal Crisis Is Associated With Differences in Cortisol Excretion in Patients With Secondary Adrenal Insufficiency.
Topics: Acute Disease; Adrenal Insufficiency; Cortisone; Glucocorticoids; Humans; Hydrocortisone; Kynurenine | 2022 |
Hydrocortisone Affects Fatigue and Physical Functioning Through Metabolism of Tryptophan: A Randomized Controlled Trial.
Topics: Adrenal Insufficiency; Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Met | 2018 |