kynurenine has been researched along with Adipocere in 5 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The levels of kynurenic acid (KYNA), an astrocyte-derived metabolite of the branched kynurenine pathway (KP) of tryptophan degradation and antagonist of α7 nicotinic acetylcholine and N-methyl-D-aspartate receptors, are elevated in the prefrontal cortex (PFC) of individuals with schizophrenia (SZ)." | 7.77 | Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia. ( McMahon, RP; Rassoulpour, A; Roberts, RC; Sathyasaikumar, KV; Schwarcz, R; Stachowski, EK; Wonodi, I, 2011) |
| "Prior studies of mRNA expression, protein expression, and pathway metabolite levels have implicated dysregulation of the kynurenine pathway in the etiology of schizophrenia and bipolar disorder." | 7.75 | Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder. ( Leonard, S; Miller, CL; Murakami, P; Ross, RG; Ruczinski, I; Sinkus, M; Sullivan, B, 2009) |
| "The levels of kynurenic acid (KYNA), an astrocyte-derived metabolite of the branched kynurenine pathway (KP) of tryptophan degradation and antagonist of α7 nicotinic acetylcholine and N-methyl-D-aspartate receptors, are elevated in the prefrontal cortex (PFC) of individuals with schizophrenia (SZ)." | 3.77 | Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia. ( McMahon, RP; Rassoulpour, A; Roberts, RC; Sathyasaikumar, KV; Schwarcz, R; Stachowski, EK; Wonodi, I, 2011) |
| "Prior studies of mRNA expression, protein expression, and pathway metabolite levels have implicated dysregulation of the kynurenine pathway in the etiology of schizophrenia and bipolar disorder." | 3.75 | Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder. ( Leonard, S; Miller, CL; Murakami, P; Ross, RG; Ruczinski, I; Sinkus, M; Sullivan, B, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sathyasaikumar, KV | 2 |
| Tararina, M | 1 |
| Wu, HQ | 1 |
| Neale, SA | 1 |
| Weisz, F | 1 |
| Salt, TE | 1 |
| Schwarcz, R | 2 |
| Miller, CL | 2 |
| Murakami, P | 1 |
| Ruczinski, I | 1 |
| Ross, RG | 1 |
| Sinkus, M | 1 |
| Sullivan, B | 1 |
| Leonard, S | 1 |
| Stachowski, EK | 1 |
| Wonodi, I | 1 |
| Roberts, RC | 1 |
| Rassoulpour, A | 1 |
| McMahon, RP | 1 |
| Llenos, IC | 1 |
| Dulay, JR | 1 |
| Weis, S | 1 |
| Jospeh, MH | 1 |
| Baker, HF | 1 |
| Crow, TJ | 1 |
| Riley, GJ | 1 |
| Risby, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Vortioxetine Monotherapy for Major Depressive Disorder in Type 2 Diabetes: Role of Inflammation, Kynurenine Pathway, and Structural and Functional Brain Connectivity as Biomarkers[NCT03580967] | Phase 4 | 0 participants (Actual) | Interventional | 2019-07-01 | Withdrawn (stopped due to COVID-19 Pandemic interfered with Pt recruitment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for kynurenine and Adipocere
| Article | Year |
|---|---|
Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological Effects.
Topics: Aged; Animals; Brain; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Fluoroquinolones; | 2017 |
Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder.
Topics: Adult; Aged; Aged, 80 and over; Bipolar Disorder; Black or African American; Databases, Genetic; Fem | 2009 |
Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia.
Topics: Adult; Aged; Animals; Antipsychotic Agents; Case-Control Studies; Female; Humans; Kynurenine; Kynure | 2011 |
Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder.
Topics: Adult; Analysis of Variance; Bipolar Disorder; Chromatography, High Pressure Liquid; Demography; Dep | 2006 |
Brain tryptophan metabolism in schizophrenia: a post mortem study of metabolites of the serotonin and kynurenine pathways in schizophrenic and control subjects.
Topics: Aged; Aging; Brain; Female; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; Middle Aged; Myocard | 1979 |