kynurenine has been researched along with Ache in 14 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This review summarizes current knowledge of the role of kynurenine signalling in trigeminal and central pain processing, including its therapeutic prospects in migraine treatment." | 8.87 | The L-kynurenine signalling pathway in trigeminal pain processing: a potential therapeutic target in migraine? ( Ashina, M; Guo, S; Vecsei, L, 2011) |
| "To investigate host and gut-microbiota related Tryptophan metabolism in hand osteoarthritis (HOA)." | 8.31 | Serum tryptophan metabolites are associated with erosive hand osteoarthritis and pain: results from the DIGICOD cohort. ( Berenbaum, F; Binvignat, M; Butte, AJ; Courties, A; Crema, MD; Emond, P; Klatzmann, D; Kloppenburg, M; Lefèvre, A; Maheu, E; Mariotti-Ferrandiz, E; Miao, B; Mifsud, F; Richette, P; Sellam, J; Sokol, H, 2023) |
| "To investigate the relationship between the tryptophan-kynurenine (TRP-KYN) pathway and painful physical symptoms (PPS) in major depressive disorder (MDD)." | 8.12 | Relationship between the tryptophan-kynurenine pathway and painful physical symptoms in patients with major depressive disorder. ( An, H; Bai, L; Fan, H; Ma, B; Ma, T; Qi, S; Wang, Z; Yang, F; Yun, Y; Zhang, Q; Zhao, W, 2022) |
| "Fibromyalgia (FM) is a prevalent syndrome with chronic pain and a hypothesised underlying disturbance of the tryptophan (TRP) metabolism." | 7.72 | Experimental evaluation of an altered tryptophan metabolism in fibromyalgia. ( Ackenheil, M; Neumeister, A; Offenbaecher, M; Schwarz, MJ, 2003) |
| "Fibromyalgia (FM) is a prevalent syndrome with chronic pain and a hypothesized underlying disturbance of the tryptophan (TRP) metabolism." | 7.71 | Evidence for an altered tryptophan metabolism in fibromyalgia. ( Ackenheil, M; Ewert, T; Lossau, K; Neumeister, A; Offenbaecher, M; Praschak-Rieder, N; Schwarz, MJ; Stucki, G; Weisser, R; Willeit, M; Zach, J; Zacherl, M, 2002) |
| " In recent years, migraine research focused on tryptophan, which is metabolized via two main pathways, the serotonin and kynurenine pathways, both of which produce neuroactive molecules that influence pain processing and stress response by disturbing neural and brain hypersensitivity and by interacting with molecules that control vascular and inflammatory actions." | 5.22 | Exploring the Tryptophan Metabolic Pathways in Migraine-Related Mechanisms. ( Körtési, T; Spekker, E; Vécsei, L, 2022) |
| "This review summarizes current knowledge of the role of kynurenine signalling in trigeminal and central pain processing, including its therapeutic prospects in migraine treatment." | 4.87 | The L-kynurenine signalling pathway in trigeminal pain processing: a potential therapeutic target in migraine? ( Ashina, M; Guo, S; Vecsei, L, 2011) |
| "To investigate host and gut-microbiota related Tryptophan metabolism in hand osteoarthritis (HOA)." | 4.31 | Serum tryptophan metabolites are associated with erosive hand osteoarthritis and pain: results from the DIGICOD cohort. ( Berenbaum, F; Binvignat, M; Butte, AJ; Courties, A; Crema, MD; Emond, P; Klatzmann, D; Kloppenburg, M; Lefèvre, A; Maheu, E; Mariotti-Ferrandiz, E; Miao, B; Mifsud, F; Richette, P; Sellam, J; Sokol, H, 2023) |
| "To investigate the relationship between the tryptophan-kynurenine (TRP-KYN) pathway and painful physical symptoms (PPS) in major depressive disorder (MDD)." | 4.12 | Relationship between the tryptophan-kynurenine pathway and painful physical symptoms in patients with major depressive disorder. ( An, H; Bai, L; Fan, H; Ma, B; Ma, T; Qi, S; Wang, Z; Yang, F; Yun, Y; Zhang, Q; Zhao, W, 2022) |
| "Fibromyalgia (FM) is a prevalent syndrome with chronic pain and a hypothesised underlying disturbance of the tryptophan (TRP) metabolism." | 3.72 | Experimental evaluation of an altered tryptophan metabolism in fibromyalgia. ( Ackenheil, M; Neumeister, A; Offenbaecher, M; Schwarz, MJ, 2003) |
| "Fibromyalgia (FM) is a prevalent syndrome with chronic pain and a hypothesized underlying disturbance of the tryptophan (TRP) metabolism." | 3.71 | Evidence for an altered tryptophan metabolism in fibromyalgia. ( Ackenheil, M; Ewert, T; Lossau, K; Neumeister, A; Offenbaecher, M; Praschak-Rieder, N; Schwarz, MJ; Stucki, G; Weisser, R; Willeit, M; Zach, J; Zacherl, M, 2002) |
| "Somatoform disorders are troubling to both patients and physicians." | 2.44 | A biological substrate for somatoform disorders: importance of pathophysiology. ( Dantzer, R; Dimsdale, JE, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 5 (35.71) | 2.80 |
| Authors | Studies |
|---|---|
| Yun, Y | 1 |
| Zhang, Q | 1 |
| Zhao, W | 1 |
| Ma, T | 1 |
| Fan, H | 1 |
| Bai, L | 1 |
| Ma, B | 1 |
| Qi, S | 1 |
| Wang, Z | 1 |
| An, H | 1 |
| Yang, F | 1 |
| Körtési, T | 2 |
| Spekker, E | 2 |
| Vécsei, L | 5 |
| Binvignat, M | 1 |
| Emond, P | 1 |
| Mifsud, F | 1 |
| Miao, B | 1 |
| Courties, A | 1 |
| Lefèvre, A | 1 |
| Maheu, E | 1 |
| Crema, MD | 1 |
| Klatzmann, D | 1 |
| Kloppenburg, M | 1 |
| Richette, P | 1 |
| Butte, AJ | 1 |
| Mariotti-Ferrandiz, E | 1 |
| Berenbaum, F | 1 |
| Sokol, H | 1 |
| Sellam, J | 1 |
| Pradeep, A | 1 |
| Birerdinc, A | 1 |
| Branigan, T | 1 |
| Phan, V | 1 |
| Morris, H | 1 |
| Shah, J | 1 |
| DeStefano, S | 1 |
| Sikdar, S | 1 |
| Srbely, J | 1 |
| Kumbhare, D | 1 |
| Stecco, A | 1 |
| Paik, J | 1 |
| Gerber, LH | 1 |
| Roth, W | 1 |
| Zadeh, K | 1 |
| Vekariya, R | 1 |
| Ge, Y | 1 |
| Mohamadzadeh, M | 1 |
| Vamos, E | 1 |
| Pardutz, A | 1 |
| Klivenyi, P | 1 |
| Toldi, J | 2 |
| Cosi, C | 1 |
| Mannaioni, G | 1 |
| Cozzi, A | 1 |
| Carlà, V | 1 |
| Sili, M | 1 |
| Cavone, L | 1 |
| Maratea, D | 1 |
| Moroni, F | 1 |
| Guo, S | 1 |
| Ashina, M | 1 |
| Szalárdy, L | 1 |
| Fülöp, F | 1 |
| Schwarz, MJ | 2 |
| Offenbaecher, M | 2 |
| Neumeister, A | 2 |
| Ewert, T | 1 |
| Willeit, M | 1 |
| Praschak-Rieder, N | 1 |
| Zach, J | 1 |
| Zacherl, M | 1 |
| Lossau, K | 1 |
| Weisser, R | 1 |
| Stucki, G | 1 |
| Ackenheil, M | 2 |
| Dimsdale, JE | 1 |
| Dantzer, R | 1 |
| Weil-Fugazza, J | 1 |
| Heyliger, SO | 1 |
| Goodman, CB | 1 |
| Ngong, JM | 1 |
| Soliman, KF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Exploration of the Role of Tryptophan Metabolites in Pediatric Migraine[NCT05969990] | 200 participants (Anticipated) | Observational | 2022-01-01 | Recruiting | |||
| Effect Of High Intensity Interval Upper Extremity Training On Biochemistry Parameters And Disease Symptoms In Patients With Fibromyalgia[NCT05502003] | 33 participants (Actual) | Interventional | 2022-08-25 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for kynurenine and Ache
| Article | Year |
|---|---|
Exploring the Tryptophan Metabolic Pathways in Migraine-Related Mechanisms.
Topics: Humans; Kynurenic Acid; Kynurenine; Metabolic Networks and Pathways; Migraine Disorders; Pain; Serot | 2022 |
Exploring the Tryptophan Metabolic Pathways in Migraine-Related Mechanisms.
Topics: Humans; Kynurenic Acid; Kynurenine; Metabolic Networks and Pathways; Migraine Disorders; Pain; Serot | 2022 |
Exploring the Tryptophan Metabolic Pathways in Migraine-Related Mechanisms.
Topics: Humans; Kynurenic Acid; Kynurenine; Metabolic Networks and Pathways; Migraine Disorders; Pain; Serot | 2022 |
Exploring the Tryptophan Metabolic Pathways in Migraine-Related Mechanisms.
Topics: Humans; Kynurenic Acid; Kynurenine; Metabolic Networks and Pathways; Migraine Disorders; Pain; Serot | 2022 |
Tryptophan Metabolism and Gut-Brain Homeostasis.
Topics: Brain; Colon; Enteric Nervous System; Gastrointestinal Microbiome; Homeostasis; Humans; Hunger; Kynu | 2021 |
The role of kynurenines in disorders of the central nervous system: possibilities for neuroprotection.
Topics: Alzheimer Disease; Animals; Brain; Brain Diseases; Brain Ischemia; Epilepsy; Humans; Huntington Dise | 2009 |
The L-kynurenine signalling pathway in trigeminal pain processing: a potential therapeutic target in migraine?
Topics: Animals; Humans; Kynurenine; Migraine Disorders; Pain; Pain Perception; Signal Transduction; Tryptop | 2011 |
Kynurenines in the CNS: recent advances and new questions.
Topics: Animals; Autoimmune Diseases; Central Nervous System Diseases; Drug Design; Drug Evaluation, Preclin | 2013 |
A biological substrate for somatoform disorders: importance of pathophysiology.
Topics: Acute-Phase Reaction; Animals; Brain; Depression; Diagnosis, Differential; Fatigue; Inflammation Med | 2007 |
Endogenous kynurenine derivatives and pain.
Topics: Analgesia; Animals; Brain; Humans; Kynurenine; Models, Neurological; Neurons; Nociceptors; Pain; Ser | 1996 |
7 other studies available for kynurenine and Ache
| Article | Year |
|---|---|
Relationship between the tryptophan-kynurenine pathway and painful physical symptoms in patients with major depressive disorder.
Topics: Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Pain; Quinolinic Acid; Serotonin; Ta | 2022 |
Serum tryptophan metabolites are associated with erosive hand osteoarthritis and pain: results from the DIGICOD cohort.
Topics: Cross-Sectional Studies; Humans; Kynurenine; Osteoarthritis; Pain; Serotonin; Tryptophan | 2023 |
Evidence for an association of serum microanalytes and myofascial pain syndrome.
Topics: Acetylcholine; Adult; Brain-Derived Neurotrophic Factor; Cytokines; Dehydroepiandrosterone; Female; | 2023 |
G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast.
Topics: Analgesics; Animals; Antidepressive Agents, Second-Generation; Dose-Response Relationship, Drug; Dru | 2011 |
Evidence for an altered tryptophan metabolism in fibromyalgia.
Topics: Adult; Case-Control Studies; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay | 2002 |
Experimental evaluation of an altered tryptophan metabolism in fibromyalgia.
Topics: Adult; Case-Control Studies; Cross-Over Studies; Double-Blind Method; Female; Fibromyalgia; Humans; | 2003 |
The analgesic effects of tryptophan and its metabolites in the rat.
Topics: Analgesics; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Antago | 1998 |