kynurenic acid has been researched along with Uremia in 6 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Increased oxidative stress (SOX), inflammation and accelerated atherosclerosis have been reported in end-stage renal disease (ESRD), but their associations with kynurenine pathway activation remain unknown." | 3.75 | Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease. ( Brzosko, S; Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| "Plasma concentrations of four substances, a pyridine derivative (S7a), uric acid (UA), hippuric acid (HA) and kynurenic acid (KA), suspected as uremic toxins in dogs were determined in dogs with experimentally induced uremia by the ligations of renal arteries, spontaneous uremic dog patients and normal dogs." | 3.69 | Plasma concentrations of substances suspected as uremic toxins in experimentally induced and spontaneous uremic dogs. ( Kawamura, M; Nishimura, R; Ohashi, F; Sasaki, N; Takeuchi, A, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Prokopienko, AJ | 1 |
| West, RE | 1 |
| Stubbs, JR | 1 |
| Nolin, TD | 1 |
| Pawlak, K | 2 |
| Brzosko, S | 1 |
| Mysliwiec, M | 2 |
| Pawlak, D | 2 |
| Schefold, JC | 1 |
| Zeden, JP | 1 |
| Fotopoulou, C | 1 |
| von Haehling, S | 1 |
| Pschowski, R | 1 |
| Hasper, D | 1 |
| Volk, HD | 1 |
| Schuett, C | 1 |
| Reinke, P | 1 |
| Kawamura, M | 1 |
| Ohashi, F | 1 |
| Nishimura, R | 1 |
| Sasaki, N | 1 |
| Takeuchi, A | 1 |
| Malyszko, J | 1 |
| Buczko, W | 1 |
| Tavares-Almeida, I | 1 |
| Gulyassy, PF | 1 |
| Depner, TA | 1 |
| Jarrard, EA | 1 |
6 other studies available for kynurenic acid and Uremia
| Article | Year |
|---|---|
Development and validation of a UHPLC-MS/MS method for measurement of a gut-derived uremic toxin panel in human serum: An application in patients with kidney disease.
Topics: Blood Chemical Analysis; Chromatography, High Pressure Liquid; Cresols; Hippurates; Humans; Hydrogen | 2019 |
Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease.
Topics: Adult; Age Factors; Biomarkers; C-Reactive Protein; Carotid Artery Diseases; Cross-Sectional Studies | 2009 |
Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms.
Topics: 5-Hydroxytryptophan; Adult; Aged; C-Reactive Protein; Case-Control Studies; Creatinine; Female; Huma | 2009 |
Plasma concentrations of substances suspected as uremic toxins in experimentally induced and spontaneous uremic dogs.
Topics: Animals; Biomarkers; Blood Urea Nitrogen; Creatinine; Dog Diseases; Dogs; Female; Glomerulonephritis | 1994 |
Accumulation of toxic products degradation of kynurenine in hemodialyzed patients.
Topics: Female; Humans; Kidney; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Quinoli | 2001 |
Aromatic amino acid metabolites as potential protein binding inhibitors in human uremic plasma.
Topics: Amino Acids; Blood Proteins; Hippurates; Humans; Indoles; Kynurenic Acid; Protein Binding; Quinoline | 1985 |