Page last updated: 2024-10-30

kynurenic acid and Stroke

kynurenic acid has been researched along with Stroke in 8 studies

Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.

Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)

Research Excerpts

ExcerptRelevanceReference
"The kynurenine pathway is the main metabolic pathway of tryptophan degradation and has been associated with stroke and impaired cognitive functioning, but studies on its role in post-stroke cognitive impairment (PSCI) are scarce."8.31The role of the kynurenine pathway in cognitive functioning after stroke: A prospective clinical study. ( Bakker, L; Choe, K; J P M Eussen, S; Kenis, G; Köhler, S; Ramakers, IHGB; Rutten, BPF; Staals, J; Ueland, PM; Ulvik, A; van den Hove, DLA; van Oostenbrugge, RJ; Verhey, FRJ, 2023)
"046), and neopterin was associated with the combined endpoint (recurrent ischemic stroke or death) (HR 1."8.02Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke. ( Alme, KN; Askim, T; Assmus, J; Knapskog, AB; Mollnes, TE; Naik, M; Næss, H; Saltvedt, I; Ueland, PM; Ulvik, A, 2021)
"To investigate if there is a correlation between serum kynurenines levels with poststroke anxiety and depression symptoms and disability scales."7.96Serum Kynurenines Correlate With Depressive Symptoms and Disability in Poststroke Patients: A Cross-sectional Study. ( Barajas-Martínez, K; Carrillo-Mora, P; Estrada-Cortés, B; Franyutti-Prado, K; Gamboa-Coria, G; Martínez-Cortéz, JA; Pérez-De la Cruz, V; Quinzaños-Fresnedo, J; Ramírez-Ortega, D; Ramos-Chávez, LA; Rangel-Caballero, F; Rodríguez-Barragán, M; Sánchez-Chapul, L; Sánchez-Vázquez, I; Toussaint-González, P, 2020)
"The kynurenine pathway is a complex enzymatic cascade of tryptophan catabolism, generating various neuroactive metabolites."6.58Ischemic Stroke and Kynurenines: Medicinal Chemistry Aspects. ( Fülöp, F; Hertelendy, P; Toldi, J; Vécsei, L, 2018)
"The kynurenine pathway is the main metabolic pathway of tryptophan degradation and has been associated with stroke and impaired cognitive functioning, but studies on its role in post-stroke cognitive impairment (PSCI) are scarce."4.31The role of the kynurenine pathway in cognitive functioning after stroke: A prospective clinical study. ( Bakker, L; Choe, K; J P M Eussen, S; Kenis, G; Köhler, S; Ramakers, IHGB; Rutten, BPF; Staals, J; Ueland, PM; Ulvik, A; van den Hove, DLA; van Oostenbrugge, RJ; Verhey, FRJ, 2023)
"046), and neopterin was associated with the combined endpoint (recurrent ischemic stroke or death) (HR 1."4.02Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke. ( Alme, KN; Askim, T; Assmus, J; Knapskog, AB; Mollnes, TE; Naik, M; Næss, H; Saltvedt, I; Ueland, PM; Ulvik, A, 2021)
"To investigate if there is a correlation between serum kynurenines levels with poststroke anxiety and depression symptoms and disability scales."3.96Serum Kynurenines Correlate With Depressive Symptoms and Disability in Poststroke Patients: A Cross-sectional Study. ( Barajas-Martínez, K; Carrillo-Mora, P; Estrada-Cortés, B; Franyutti-Prado, K; Gamboa-Coria, G; Martínez-Cortéz, JA; Pérez-De la Cruz, V; Quinzaños-Fresnedo, J; Ramírez-Ortega, D; Ramos-Chávez, LA; Rangel-Caballero, F; Rodríguez-Barragán, M; Sánchez-Chapul, L; Sánchez-Vázquez, I; Toussaint-González, P, 2020)
"The kynurenine pathway is a complex enzymatic cascade of tryptophan catabolism, generating various neuroactive metabolites."2.58Ischemic Stroke and Kynurenines: Medicinal Chemistry Aspects. ( Fülöp, F; Hertelendy, P; Toldi, J; Vécsei, L, 2018)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (37.50)24.3611
2020's5 (62.50)2.80

Authors

AuthorsStudies
Annus, Á1
Tömösi, F1
Rárosi, F1
Fehér, E1
Janáky, T1
Kecskeméti, G1
Toldi, J2
Klivényi, P1
Sztriha, L1
Vécsei, L2
Alme, KN1
Ulvik, A2
Askim, T1
Assmus, J1
Mollnes, TE1
Naik, M1
Næss, H1
Saltvedt, I1
Ueland, PM2
Knapskog, AB1
Bakker, L1
Ramakers, IHGB1
J P M Eussen, S1
Choe, K1
van den Hove, DLA1
Kenis, G1
Rutten, BPF1
van Oostenbrugge, RJ1
Staals, J1
Verhey, FRJ1
Köhler, S1
Carrillo-Mora, P1
Pérez-De la Cruz, V1
Estrada-Cortés, B1
Toussaint-González, P1
Martínez-Cortéz, JA1
Rodríguez-Barragán, M1
Quinzaños-Fresnedo, J1
Rangel-Caballero, F1
Gamboa-Coria, G1
Sánchez-Vázquez, I1
Barajas-Martínez, K1
Franyutti-Prado, K1
Sánchez-Chapul, L1
Ramírez-Ortega, D1
Ramos-Chávez, LA1
Chen, Y1
Zelnick, LR1
Huber, MP1
Wang, K1
Bansal, N1
Hoofnagle, AN1
Paranji, RK1
Heckbert, SR1
Weiss, NS1
Go, AS1
Hsu, CY1
Feldman, HI1
Waikar, SS1
Mehta, RC1
Srivastava, A1
Seliger, SL1
Lash, JP1
Porter, AC1
Raj, DS1
Kestenbaum, BR1
Hertelendy, P1
Fülöp, F1
Mangas, A1
Yajeya, J1
González, N1
Ruiz, I1
Duleu, S1
Geffard, M1
Coveñas, R1
Nowicka-Stążka, P1
Stążka, K1
Dąbrowski, W1
Turski, W1
Majdan, M1
Parada-Turska, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Norwegian COgnitive Impairment After STroke (NorCOAST) Study[NCT02650531]816 participants (Actual)Observational2015-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for kynurenic acid and Stroke

ArticleYear
Ischemic Stroke and Kynurenines: Medicinal Chemistry Aspects.
    Current medicinal chemistry, 2018, Volume: 25, Issue:42

    Topics: Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acids; Receptors,

2018
[Kynurenic acid--a new tool in the treatment of hiperhomocysteinemia and its consequences?].
    Postepy higieny i medycyny doswiadczalnej (Online), 2012, Jun-22, Volume: 66

    Topics: Atherosclerosis; Cardiovascular Diseases; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation;

2012

Other Studies

6 other studies available for kynurenic acid and Stroke

ArticleYear
Kynurenic acid and kynurenine aminotransferase are potential biomarkers of early neurological improvement after thrombolytic therapy: A pilot study.
    Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 2021, Volume: 30, Issue:12

    Topics: Biomarkers; Brain Ischemia; Humans; Kynurenic Acid; Pilot Projects; Stroke; Thrombolytic Therapy; Tr

2021
Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke.
    BMC neurology, 2021, Dec-08, Volume: 21, Issue:1

    Topics: Aged; Biomarkers; Brain Ischemia; Cohort Studies; Female; Humans; Inflammation; Ischemic Stroke; Kyn

2021
The role of the kynurenine pathway in cognitive functioning after stroke: A prospective clinical study.
    Journal of the neurological sciences, 2023, Nov-15, Volume: 454

    Topics: Biomarkers; Cognition; Female; Humans; Kynurenic Acid; Kynurenine; Male; Prospective Studies; Stroke

2023
Serum Kynurenines Correlate With Depressive Symptoms and Disability in Poststroke Patients: A Cross-sectional Study.
    Neurorehabilitation and neural repair, 2020, Volume: 34, Issue:10

    Topics: Adult; Aged; Case-Control Studies; Cross-Sectional Studies; Depression; Female; Functional Status; H

2020
Association Between Kidney Clearance of Secretory Solutes and Cardiovascular Events: The Chronic Renal Insufficiency Cohort (CRIC) Study.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2021, Volume: 78, Issue:2

    Topics: Aged; Albuminuria; Chromatography, Liquid; Cohort Studies; Cresols; Female; Glomerular Filtration Ra

2021
Overexpression of kynurenic acid in stroke: An endogenous neuroprotector?
    Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 2017, Volume: 211

    Topics: Animals; Cerebral Cortex; Corpus Striatum; Kynurenic Acid; Male; Neuroprotection; Rats; Rats, Wistar

2017