kynurenic acid has been researched along with Stroke in 8 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The kynurenine pathway is the main metabolic pathway of tryptophan degradation and has been associated with stroke and impaired cognitive functioning, but studies on its role in post-stroke cognitive impairment (PSCI) are scarce." | 8.31 | The role of the kynurenine pathway in cognitive functioning after stroke: A prospective clinical study. ( Bakker, L; Choe, K; J P M Eussen, S; Kenis, G; Köhler, S; Ramakers, IHGB; Rutten, BPF; Staals, J; Ueland, PM; Ulvik, A; van den Hove, DLA; van Oostenbrugge, RJ; Verhey, FRJ, 2023) |
| "046), and neopterin was associated with the combined endpoint (recurrent ischemic stroke or death) (HR 1." | 8.02 | Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke. ( Alme, KN; Askim, T; Assmus, J; Knapskog, AB; Mollnes, TE; Naik, M; Næss, H; Saltvedt, I; Ueland, PM; Ulvik, A, 2021) |
| "To investigate if there is a correlation between serum kynurenines levels with poststroke anxiety and depression symptoms and disability scales." | 7.96 | Serum Kynurenines Correlate With Depressive Symptoms and Disability in Poststroke Patients: A Cross-sectional Study. ( Barajas-Martínez, K; Carrillo-Mora, P; Estrada-Cortés, B; Franyutti-Prado, K; Gamboa-Coria, G; Martínez-Cortéz, JA; Pérez-De la Cruz, V; Quinzaños-Fresnedo, J; Ramírez-Ortega, D; Ramos-Chávez, LA; Rangel-Caballero, F; Rodríguez-Barragán, M; Sánchez-Chapul, L; Sánchez-Vázquez, I; Toussaint-González, P, 2020) |
| "The kynurenine pathway is a complex enzymatic cascade of tryptophan catabolism, generating various neuroactive metabolites." | 6.58 | Ischemic Stroke and Kynurenines: Medicinal Chemistry Aspects. ( Fülöp, F; Hertelendy, P; Toldi, J; Vécsei, L, 2018) |
| "The kynurenine pathway is the main metabolic pathway of tryptophan degradation and has been associated with stroke and impaired cognitive functioning, but studies on its role in post-stroke cognitive impairment (PSCI) are scarce." | 4.31 | The role of the kynurenine pathway in cognitive functioning after stroke: A prospective clinical study. ( Bakker, L; Choe, K; J P M Eussen, S; Kenis, G; Köhler, S; Ramakers, IHGB; Rutten, BPF; Staals, J; Ueland, PM; Ulvik, A; van den Hove, DLA; van Oostenbrugge, RJ; Verhey, FRJ, 2023) |
| "046), and neopterin was associated with the combined endpoint (recurrent ischemic stroke or death) (HR 1." | 4.02 | Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke. ( Alme, KN; Askim, T; Assmus, J; Knapskog, AB; Mollnes, TE; Naik, M; Næss, H; Saltvedt, I; Ueland, PM; Ulvik, A, 2021) |
| "To investigate if there is a correlation between serum kynurenines levels with poststroke anxiety and depression symptoms and disability scales." | 3.96 | Serum Kynurenines Correlate With Depressive Symptoms and Disability in Poststroke Patients: A Cross-sectional Study. ( Barajas-Martínez, K; Carrillo-Mora, P; Estrada-Cortés, B; Franyutti-Prado, K; Gamboa-Coria, G; Martínez-Cortéz, JA; Pérez-De la Cruz, V; Quinzaños-Fresnedo, J; Ramírez-Ortega, D; Ramos-Chávez, LA; Rangel-Caballero, F; Rodríguez-Barragán, M; Sánchez-Chapul, L; Sánchez-Vázquez, I; Toussaint-González, P, 2020) |
| "The kynurenine pathway is a complex enzymatic cascade of tryptophan catabolism, generating various neuroactive metabolites." | 2.58 | Ischemic Stroke and Kynurenines: Medicinal Chemistry Aspects. ( Fülöp, F; Hertelendy, P; Toldi, J; Vécsei, L, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 5 (62.50) | 2.80 |
| Authors | Studies |
|---|---|
| Annus, Á | 1 |
| Tömösi, F | 1 |
| Rárosi, F | 1 |
| Fehér, E | 1 |
| Janáky, T | 1 |
| Kecskeméti, G | 1 |
| Toldi, J | 2 |
| Klivényi, P | 1 |
| Sztriha, L | 1 |
| Vécsei, L | 2 |
| Alme, KN | 1 |
| Ulvik, A | 2 |
| Askim, T | 1 |
| Assmus, J | 1 |
| Mollnes, TE | 1 |
| Naik, M | 1 |
| Næss, H | 1 |
| Saltvedt, I | 1 |
| Ueland, PM | 2 |
| Knapskog, AB | 1 |
| Bakker, L | 1 |
| Ramakers, IHGB | 1 |
| J P M Eussen, S | 1 |
| Choe, K | 1 |
| van den Hove, DLA | 1 |
| Kenis, G | 1 |
| Rutten, BPF | 1 |
| van Oostenbrugge, RJ | 1 |
| Staals, J | 1 |
| Verhey, FRJ | 1 |
| Köhler, S | 1 |
| Carrillo-Mora, P | 1 |
| Pérez-De la Cruz, V | 1 |
| Estrada-Cortés, B | 1 |
| Toussaint-González, P | 1 |
| Martínez-Cortéz, JA | 1 |
| Rodríguez-Barragán, M | 1 |
| Quinzaños-Fresnedo, J | 1 |
| Rangel-Caballero, F | 1 |
| Gamboa-Coria, G | 1 |
| Sánchez-Vázquez, I | 1 |
| Barajas-Martínez, K | 1 |
| Franyutti-Prado, K | 1 |
| Sánchez-Chapul, L | 1 |
| Ramírez-Ortega, D | 1 |
| Ramos-Chávez, LA | 1 |
| Chen, Y | 1 |
| Zelnick, LR | 1 |
| Huber, MP | 1 |
| Wang, K | 1 |
| Bansal, N | 1 |
| Hoofnagle, AN | 1 |
| Paranji, RK | 1 |
| Heckbert, SR | 1 |
| Weiss, NS | 1 |
| Go, AS | 1 |
| Hsu, CY | 1 |
| Feldman, HI | 1 |
| Waikar, SS | 1 |
| Mehta, RC | 1 |
| Srivastava, A | 1 |
| Seliger, SL | 1 |
| Lash, JP | 1 |
| Porter, AC | 1 |
| Raj, DS | 1 |
| Kestenbaum, BR | 1 |
| Hertelendy, P | 1 |
| Fülöp, F | 1 |
| Mangas, A | 1 |
| Yajeya, J | 1 |
| González, N | 1 |
| Ruiz, I | 1 |
| Duleu, S | 1 |
| Geffard, M | 1 |
| Coveñas, R | 1 |
| Nowicka-Stążka, P | 1 |
| Stążka, K | 1 |
| Dąbrowski, W | 1 |
| Turski, W | 1 |
| Majdan, M | 1 |
| Parada-Turska, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Norwegian COgnitive Impairment After STroke (NorCOAST) Study[NCT02650531] | 816 participants (Actual) | Observational | 2015-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for kynurenic acid and Stroke
| Article | Year |
|---|---|
Ischemic Stroke and Kynurenines: Medicinal Chemistry Aspects.
Topics: Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acids; Receptors, | 2018 |
[Kynurenic acid--a new tool in the treatment of hiperhomocysteinemia and its consequences?].
Topics: Atherosclerosis; Cardiovascular Diseases; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation; | 2012 |
6 other studies available for kynurenic acid and Stroke
| Article | Year |
|---|---|
Kynurenic acid and kynurenine aminotransferase are potential biomarkers of early neurological improvement after thrombolytic therapy: A pilot study.
Topics: Biomarkers; Brain Ischemia; Humans; Kynurenic Acid; Pilot Projects; Stroke; Thrombolytic Therapy; Tr | 2021 |
Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke.
Topics: Aged; Biomarkers; Brain Ischemia; Cohort Studies; Female; Humans; Inflammation; Ischemic Stroke; Kyn | 2021 |
The role of the kynurenine pathway in cognitive functioning after stroke: A prospective clinical study.
Topics: Biomarkers; Cognition; Female; Humans; Kynurenic Acid; Kynurenine; Male; Prospective Studies; Stroke | 2023 |
Serum Kynurenines Correlate With Depressive Symptoms and Disability in Poststroke Patients: A Cross-sectional Study.
Topics: Adult; Aged; Case-Control Studies; Cross-Sectional Studies; Depression; Female; Functional Status; H | 2020 |
Association Between Kidney Clearance of Secretory Solutes and Cardiovascular Events: The Chronic Renal Insufficiency Cohort (CRIC) Study.
Topics: Aged; Albuminuria; Chromatography, Liquid; Cohort Studies; Cresols; Female; Glomerular Filtration Ra | 2021 |
Overexpression of kynurenic acid in stroke: An endogenous neuroprotector?
Topics: Animals; Cerebral Cortex; Corpus Striatum; Kynurenic Acid; Male; Neuroprotection; Rats; Rats, Wistar | 2017 |