kynurenic acid has been researched along with Spasms, Infantile in 5 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Spasms, Infantile: An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| CAREDDU, P | 1 |
| FRENCH, JH | 1 |
| GRUETER, BB | 1 |
| DRUCKMAN, R | 1 |
| O'BRIEN, D | 1 |
| Rho, JM | 1 |
| Yamamoto, H | 1 |
| Shindo, I | 1 |
| Egawa, B | 1 |
| Horiguchi, K | 1 |
| Wuarin, JP | 1 |
| Kim, YI | 1 |
| Cepeda, C | 1 |
| Tasker, JG | 1 |
| Walsh, JP | 1 |
| Peacock, WJ | 1 |
| Buchwald, NA | 1 |
| Dudek, FE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prednisolone vs. Vigabatrin in the First-line Treatment of Infantile Spasms[NCT02299115] | Phase 3 | 0 participants (Actual) | Interventional | 2017-09-05 | Withdrawn (stopped due to Most centres are now using oral steroids as 1st line treatment so question of efficacy is no longer of high interest.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for kynurenic acid and Spasms, Infantile
| Article | Year |
|---|---|
Basic science behind the catastrophic epilepsies.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Corticotropin-Releasing Hormone; Epilepsies | 2004 |
4 other studies available for kynurenic acid and Spasms, Infantile
| Article | Year |
|---|---|
[CHANGES IN TRYPTOPHAN METABOLISM IN THE WINKING-NODDING SPASM IN INFANTS].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Blinking; Blood Chemical Analysis; Chromatogra | 1963 |
PYRIDOXINE AND INFANTILE MYOCLONIC SEIZURES.
Topics: Amino Acids; Drug Therapy; Electroencephalography; Epilepsies, Myoclonic; Humans; Infant; Kynurenic | 1965 |
Kynurenic acid is decreased in cerebrospinal fluid of patients with infantile spasms.
Topics: Asphyxia Neonatorum; Brain; Chromatography, High Pressure Liquid; Electroencephalography; Female; Hu | 1994 |
Synaptic transmission in human neocortex removed for treatment of intractable epilepsy in children.
Topics: 2-Amino-5-phosphonovalerate; Adolescent; Bicuculline; Child; Child, Preschool; Epilepsy; Female; GAB | 1990 |