Page last updated: 2024-10-30

kynurenic acid and Sepsis

kynurenic acid has been researched along with Sepsis in 4 studies

Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.

Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.

Research Excerpts

ExcerptRelevanceReference
"Thirty-six patients with severe sepsis/septic shock and sepsis-associated immunosuppression (assessed using monocytic human leukocyte antigen-DR (mHLA-DR) expression) were assessed in a controlled trial of GM-CSF or placebo treatment for 8 days."6.75Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock. ( Fotopoulou, C; Fusch, G; Hammoud, B; Hasper, D; Meisel, C; Pschowski, R; Reinke, P; Schefold, JC; Schütt, C; Volk, HD; Von Haehling, S; Zeden, JP, 2010)
"Sepsis was characterized by significantly elevated ROFA scores, while the increased BBB permeability and plasma S100B levels demonstrated brain damage."5.62Kynurenic Acid and Its Synthetic Derivatives Protect Against Sepsis-Associated Neutrophil Activation and Brain Mitochondrial Dysfunction in Rats. ( Boros, M; Czakó, BL; Dookhun, D; Fülöp, F; Gál, KG; Glenz, RJ; Gulácsi, L; Juhász, L; Kaszaki, J; Lőrinczi, B; Nászai, A; Poles, MZ; Rutai, A; Szabó, A; Szatmári, I; Tallósy, SP; Vécsei, L, 2021)
"Thirty-six patients with severe sepsis/septic shock and sepsis-associated immunosuppression (assessed using monocytic human leukocyte antigen-DR (mHLA-DR) expression) were assessed in a controlled trial of GM-CSF or placebo treatment for 8 days."2.75Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock. ( Fotopoulou, C; Fusch, G; Hammoud, B; Hasper, D; Meisel, C; Pschowski, R; Reinke, P; Schefold, JC; Schütt, C; Volk, HD; Von Haehling, S; Zeden, JP, 2010)
"Kynurenic acid is a common differential metabolite that could be used as a candidate for both diagnosis and prognosis for septic patients with cardiac dysfunction."1.91Untargeted metabolomic profiling of sepsis-induced cardiac dysfunction. ( Cao, Y; Fang, C; Han, X; Huang, J; Jing, Y; Liu, Z; Ma, W; Pei, Y; Xiao, W, 2023)
"Sepsis was characterized by significantly elevated ROFA scores, while the increased BBB permeability and plasma S100B levels demonstrated brain damage."1.62Kynurenic Acid and Its Synthetic Derivatives Protect Against Sepsis-Associated Neutrophil Activation and Brain Mitochondrial Dysfunction in Rats. ( Boros, M; Czakó, BL; Dookhun, D; Fülöp, F; Gál, KG; Glenz, RJ; Gulácsi, L; Juhász, L; Kaszaki, J; Lőrinczi, B; Nászai, A; Poles, MZ; Rutai, A; Szabó, A; Szatmári, I; Tallósy, SP; Vécsei, L, 2021)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's0 (0.00)29.6817
2010's1 (25.00)24.3611
2020's2 (50.00)2.80

Authors

AuthorsStudies
Poles, MZ1
Nászai, A1
Gulácsi, L1
Czakó, BL1
Gál, KG1
Glenz, RJ1
Dookhun, D1
Rutai, A1
Tallósy, SP1
Szabó, A1
Lőrinczi, B1
Szatmári, I1
Fülöp, F1
Vécsei, L1
Boros, M1
Juhász, L1
Kaszaki, J1
Cao, Y1
Liu, Z1
Ma, W1
Fang, C1
Pei, Y1
Jing, Y1
Huang, J1
Han, X1
Xiao, W1
Schefold, JC1
Zeden, JP1
Pschowski, R1
Hammoud, B1
Fotopoulou, C1
Hasper, D1
Fusch, G1
Von Haehling, S1
Volk, HD1
Meisel, C1
Schütt, C1
Reinke, P1
Heyes, MP1
Lackner, A1

Trials

1 trial available for kynurenic acid and Sepsis

ArticleYear
Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock.
    Scandinavian journal of infectious diseases, 2010, Volume: 42, Issue:3

    Topics: Aged; Calcitonin; Calcitonin Gene-Related Peptide; Granulocyte-Macrophage Colony-Stimulating Factor;

2010

Other Studies

3 other studies available for kynurenic acid and Sepsis

ArticleYear
Kynurenic Acid and Its Synthetic Derivatives Protect Against Sepsis-Associated Neutrophil Activation and Brain Mitochondrial Dysfunction in Rats.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Kynurenic Acid; Male; Mitochondria; Neuroprote

2021
Untargeted metabolomic profiling of sepsis-induced cardiac dysfunction.
    Frontiers in endocrinology, 2023, Volume: 14

    Topics: Chromatography, Liquid; Discriminant Analysis; Humans; Kynurenic Acid; Metabolomics; Sepsis

2023
Increased cerebrospinal fluid quinolinic acid, kynurenic acid, and L-kynurenine in acute septicemia.
    Journal of neurochemistry, 1990, Volume: 55, Issue:1

    Topics: Acute Disease; Animals; Female; Kynurenic Acid; Kynurenine; Macaca mulatta; Male; Pyridines; Quinoli

1990