kynurenic acid has been researched along with Sensitivity and Specificity in 16 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The time course and dose-response relationships for this effect were examined after treatment with two representative antidepressant drugs (imipramine and citalopram) and electriconvulsive shock (ECS)." | 1.29 | Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments. ( Layer, RT; Nowak, G; Paul, IA; Popik, P; Skolnick, P, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Chen, Y | 1 |
| Chen, H | 2 |
| Shi, G | 1 |
| Yang, M | 1 |
| Zheng, F | 1 |
| Zheng, Z | 1 |
| Zhang, S | 1 |
| Zhong, S | 1 |
| Tong, Q | 1 |
| Song, J | 1 |
| Yang, G | 1 |
| Fan, L | 1 |
| Xiong, W | 1 |
| Fang, J | 1 |
| Du, TT | 1 |
| Cui, T | 1 |
| Qiu, HM | 1 |
| Wang, NR | 1 |
| Huang, D | 1 |
| Jiang, XH | 1 |
| Hu, LJ | 1 |
| Li, XF | 1 |
| Hu, JQ | 1 |
| Ni, XJ | 1 |
| Lu, HY | 1 |
| Wang, JJ | 1 |
| Huang, XN | 1 |
| Lin, CX | 1 |
| Shang, DW | 1 |
| Wen, YG | 1 |
| Xiao, LD | 1 |
| Luo, XB | 2 |
| Pi, LG | 2 |
| Tang, AG | 2 |
| Mo, XM | 1 |
| Ao, X | 1 |
| Soto, ME | 1 |
| Ares, AM | 1 |
| Bernal, J | 1 |
| Nozal, MJ | 1 |
| Bernal, JL | 1 |
| Zhao, J | 1 |
| Ni, P | 1 |
| Xu, B | 1 |
| Luo, X | 1 |
| Zhan, Y | 1 |
| Gao, P | 1 |
| Zhu, D | 1 |
| Amirkhani, A | 1 |
| Heldin, E | 1 |
| Markides, KE | 1 |
| Bergquist, J | 1 |
| Rejdak, K | 1 |
| Petzold, A | 1 |
| Kocki, T | 1 |
| Kurzepa, J | 1 |
| Grieb, P | 1 |
| Turski, WA | 1 |
| Stelmasiak, Z | 1 |
| Kretschmer, BD | 1 |
| Bubser, M | 1 |
| Schmidt, WJ | 1 |
| Paul, IA | 1 |
| Nowak, G | 1 |
| Layer, RT | 1 |
| Popik, P | 1 |
| Skolnick, P | 1 |
| Furlanetto, S | 1 |
| Tognini, C | 1 |
| Carpenedo, R | 1 |
| La Porta, E | 1 |
| Pinzauti, S | 1 |
| Nicholls, T | 1 |
| Nitsos, I | 1 |
| Smythe, G | 1 |
| Walker, DW | 1 |
| Ikeda, H | 1 |
| Leyba, L | 1 |
| Bartolo, A | 1 |
| Wang, Y | 1 |
| Okada, YC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Intraoperative Low-dose Ketamine on Incidence of Postpartum Depression in Parturients With Prenatal Depression Undergoing Cesarean Delivery: Blind Test, Randomized, Placebo-controlled Trial[NCT03336541] | Phase 4 | 64 participants (Actual) | Interventional | 2017-11-23 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 other studies available for kynurenic acid and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Ultra-performance liquid chromatography-tandem mass spectrometry quantitative profiling of tryptophan metabolites in human plasma and its application to clinical study.
Topics: 3-Hydroxyanthranilic Acid; Adult; Chromatography, High Pressure Liquid; Female; Humans; Kynurenic Ac | 2019 |
Simultaneous determination of tryptophan, kynurenine, kynurenic acid, xanthurenic acid and 5-hydroxytryptamine in human plasma by LC-MS/MS and its application to acute myocardial infarction monitoring.
Topics: Case-Control Studies; Chromatography, Liquid; Humans; Kynurenic Acid; Kynurenine; Linear Models; Myo | 2018 |
Simultaneous determination of tryptophan, kynurenine, kynurenic acid and two monoamines in rat plasma by HPLC-ECD/DAD.
Topics: Amino Acids, Essential; Animals; Boron; Chemical Fractionation; Chromatography, High Pressure Liquid | 2018 |
A Simple HPLC-MS/MS Method for Determination of Tryptophan, Kynurenine and Kynurenic Acid in Human Serum and its Potential for Monitoring Antidepressant Therapy.
Topics: Antidepressive Agents; Case-Control Studies; Chromatography, High Pressure Liquid; Depression; Drug | 2017 |
Simultaneous determination of kynurenine and kynurenic acid concentrations in human serum by HPLC with dual wavelengths fluorescence detection.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Female; Humans; Kynurenic Acid; Kynurenine; Male; | 2008 |
More rapid and sensitive method for simultaneous determination of tryptophan and kynurenic acid by HPLC.
Topics: Acetonitriles; Adolescent; Adult; Asian People; Calibration; Chromatography, High Pressure Liquid; F | 2009 |
Simultaneous determination of tryptophan, kynurenine, kynurenic and xanthurenic acids in honey by liquid chromatography with diode array, fluorescence and tandem mass spectrometry detection.
Topics: Chromatography, Liquid; Formates; Honey; Kynurenic Acid; Kynurenine; Methanol; Reproducibility of Re | 2011 |
Simultaneous determination of urinary tryptophan, tryptophan-related metabolites and creatinine by high performance liquid chromatography with ultraviolet and fluorimetric detection.
Topics: Adult; Chromatography, High Pressure Liquid; Creatinine; Drug Stability; Female; Humans; Hydroxyindo | 2011 |
Quantitation of tryptophan, kynurenine and kynurenic acid in human plasma by capillary liquid chromatography-electrospray ionization tandem mass spectrometry.
Topics: Calibration; Chromatography, Liquid; Humans; Kynurenic Acid; Kynurenine; Sensitivity and Specificity | 2002 |
Astrocytic activation in relation to inflammatory markers during clinical exacerbation of relapsing-remitting multiple sclerosis.
Topics: Acute Disease; Adult; Astrocytes; Biomarkers; Brain; Encephalitis; Female; Gliosis; Humans; Kynureni | 2007 |
Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats.
Topics: Animals; Behavior, Animal; Corpus Striatum; Cycloserine; Dopamine; Drug Interactions; Excitatory Ami | 1995 |
Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments.
Topics: Adaptation, Physiological; Animals; Antidepressive Agents; Citalopram; Dose-Response Relationship, D | 1994 |
Set-up and validation of an adsorptive stripping voltammetric method for kynurenic acid determination in human urine.
Topics: Adsorption; Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Humans; Kynureni | 1998 |
Kynurenine production and catabolism in fetal sheep with embolized or nonembolized placentas.
Topics: Animals; Disease Models, Animal; Embolism; Female; Fetal Blood; Fetal Diseases; Fetal Growth Retarda | 2001 |
Synchronized spikes of thalamocortical axonal terminals and cortical neurons are detectable outside the pig brain with MEG.
Topics: Action Potentials; Animals; Biological Clocks; Brain; Electric Stimulation; Evoked Potentials, Somat | 2002 |