kynurenic acid has been researched along with Seizures in 63 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our study demonstrated that the development of seizures during the electrically induced kindling of seizures is associated with significant changes in the concentration of kynurenic acid (KYNA) and its precursor, tryptophan (TRP)." | 7.78 | The effects of electrical hippocampal kindling of seizures on amino acids and kynurenic acid concentrations in brain structures. ( Maciejak, P; Płaźnik, A; Sobolewska, A; Szyndler, J; Turzyńska, D; Walkowiak, J, 2012) |
| " In this study, we tested the hypothesis that a new KYNA analog administered systemically in a sufficient dose results in a decreased population spike activity recorded from the pyramidal layer of area CA1 of the hippocampus, and also provides protection against pentylenetetrazole-induced epileptiform seizures." | 7.78 | A novel kynurenic acid analog (SZR104) inhibits pentylenetetrazole-induced epileptiform seizures. An electrophysiological study : special issue related to kynurenine. ( Demeter, I; Fülöp, F; Gellért, L; Nagy, K; Toldi, J; Vécsei, L, 2012) |
| "This study evaluated a possible mechanism by which glycine potentiates the activity of diazepam (DZP) and valproic acid (VAL) against the clonic seizures induced by pentylenetetrazol (PTZ) in rats." | 7.69 | Diazepam potentiation by glycine in pentylenetetrazol seizures is antagonized by 7-chlorokynurenic acid. ( Peterson, SL, 1994) |
| "This study evaluated a possible mechanism by which glycine potentiates the activity of anticonvulsant drugs against maximal electroshock seizures in rats." | 7.68 | Anticonvulsant drug potentiation by glycine in maximal electroshock seizures is mimicked by D-serine and antagonized by 7-chlorokynurenic acid. ( Peterson, SL, 1991) |
| " In the present investigation, kynurenate (KYN), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist and 2-amino-5-phosphonovalerate (APV), a competitive NMDA receptor antagonist, were tested in the pattern, latency and duration of the spinal seizures." | 7.68 | Kynurenate and 2-amino-5-phosphonovalerate alter the spinal seizures evoked by sudden cooling of toad isolated cords. ( Daló, NL; Piña, JC, 1990) |
| "One-fourth of children with cerebral malaria (CM) retain cognitive sequelae up to 2 years after acute disease." | 5.46 | Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria. ( Bangirana, P; Engberg, G; Färnert, A; Franzén-Röhl, E; Holmberg, D; Idro, R; John, CC; Opoka, RO; Schwieler, L; Sellgren, CM; Wickström, R, 2017) |
| "In animals with high seizure susceptibility the decrease in norepinephrine content and the increase in the coefficient ratio between dopamine and norepinephrine have been found in the most of the regions investigated." | 5.31 | [Effect of kynurenic acid on catecholamine content in the brain of rats with different susceptibility to seizures]. ( Popova, LD, 2002) |
| "However, they do not affect clonic seizures with preserved righting reflexes." | 5.29 | Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis: III. The action of kynurenic acid and glutamic acid diethylester. ( Kusá, R; Mares, P; Roztocilová, L; Velísek, L, 1995) |
| "Kynurenine is a direct precursor of kynurenic acid, the only known endogenous antagonist of excitatory amino acid receptors in the brain." | 5.28 | Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain. ( Beal, MF; MacGarvey, U; Miller, J; Vécsei, L, 1992) |
| "It also prevented pentylenetetrazol seizures in rats in a four times lower dose." | 5.27 | Antagonism of seizures induced by the administration of the endogenous convulsant quinolinic acid into rat brain ventricles. ( Kiseleva, IP; Lapin, IP; Prakhie, IB, 1986) |
| "Kynurenic acid (KYNA) was tested as an antagonist of the neurotoxic and epileptogenic effects of the metabolically related brain constituent quinolinic acid (QUIN)." | 5.27 | Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid. ( Foster, AC; French, ED; Schwarcz, R; Vezzani, A, 1984) |
| "Picolinic acid completely prevented seizures." | 5.27 | Antagonism of kynurenine-induced seizures by picolinic, kynurenic and xanthurenic acids. ( Lapin, IP, 1983) |
| "Clinical studies indicate that phenytoin prevents acute post-traumatic seizures but not subsequent post-traumatic epilepsy." | 3.78 | Interictal spikes, seizures and ictal cell death are not necessary for post-traumatic epileptogenesis in vitro. ( Berdichevsky, Y; Dzhala, V; Mail, M; Staley, KJ, 2012) |
| "Our study demonstrated that the development of seizures during the electrically induced kindling of seizures is associated with significant changes in the concentration of kynurenic acid (KYNA) and its precursor, tryptophan (TRP)." | 3.78 | The effects of electrical hippocampal kindling of seizures on amino acids and kynurenic acid concentrations in brain structures. ( Maciejak, P; Płaźnik, A; Sobolewska, A; Szyndler, J; Turzyńska, D; Walkowiak, J, 2012) |
| " In this study, we tested the hypothesis that a new KYNA analog administered systemically in a sufficient dose results in a decreased population spike activity recorded from the pyramidal layer of area CA1 of the hippocampus, and also provides protection against pentylenetetrazole-induced epileptiform seizures." | 3.78 | A novel kynurenic acid analog (SZR104) inhibits pentylenetetrazole-induced epileptiform seizures. An electrophysiological study : special issue related to kynurenine. ( Demeter, I; Fülöp, F; Gellért, L; Nagy, K; Toldi, J; Vécsei, L, 2012) |
| "The time response of changes in the brain concentration of kynurenic acid (KYNA) was examined in rats subjected to the pentylenetetrazol (PTZ)-induced kindling of seizures (n=32)." | 3.75 | Time course of changes in the concentration of kynurenic acid in the brain of pentylenetetrazol-kindled rats. ( Bidziński, A; Lehner, M; Maciejak, P; Płaźnik, A; Skórzewska, A; Sobolewska, A; Szyndler, J; Taracha, E; Turzyńska, D, 2009) |
| " Continuous microperfusion of the antagonist for the glycine binding site in NMDA receptors 5,7-dichlorokynurenic acid (100 microM) reversed the effect of both glutamate (1 mM) and glycine (1 mM) and suppressed seizures completely in 90% of the animals." | 3.71 | Effect of extracellular long-time microperfusion of high concentrations of glutamate and glycine on picrotoxin seizure thresholds in the hippocampus of freely moving rats. ( Senra-Vidal, A; Sierra-Marcuño, G; Sierra-Paredes, G, 2001) |
| " We tested this hypothesis by examining the influence of gamma-aminobutyric acid (GABA) ergic and glutamatergic transmission in the NTS on seizures evoked by systemic and focal bicuculline and systemic pentylenetetrazol (PTZ) in rats." | 3.70 | Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius. ( Easton, A; Gale, K; Walker, BR, 1999) |
| "1-10 nmol; direct GABA(A) agonist); (3) YM90K (3-10 mg/kg; AMPA receptor antagonist); and (4) diazepam (2 and 5 mg/kg) and carbamazepine (5 and 20 mg/kg), two standard anticonvulsants, using the partially-kindled hippocampal model for epileptic seizures in freely moving rats." | 3.70 | Acute effects of various GABA receptor agonists and glutamate antagonists on focal hippocampal seizures in freely moving rats elicited by low-frequency stimulation. ( Ashby, CR; Katsumori, H; Minabe, Y; Osawa, M, 1998) |
| "The anticonvulsant activity of felbamate against sound-induced seizures was studied in the DBA/2 mouse model." | 3.69 | Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice. ( Aguglia, U; Bertorelli, R; De Sarro, A; De Sarro, G; Ongini, E, 1994) |
| " The GABAA receptor agonist, muscimol (390 pmol) was microinjected unilaterally into the posterior piriform cortex and adjacent regions in the same hemisphere from which seizures were evoked by focal application of bicuculline into AT." | 3.69 | Posterior piriform and perirhinal cortex relay seizures evoked from the area tempestas: role of excitatory and inhibitory amino acid receptors. ( Gale, K; Halonen, T; Tortorella, A; Zrebeet, H, 1994) |
| "This study evaluated a possible mechanism by which glycine potentiates the activity of diazepam (DZP) and valproic acid (VAL) against the clonic seizures induced by pentylenetetrazol (PTZ) in rats." | 3.69 | Diazepam potentiation by glycine in pentylenetetrazol seizures is antagonized by 7-chlorokynurenic acid. ( Peterson, SL, 1994) |
| " In the present investigation, kynurenate (KYN), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist and 2-amino-5-phosphonovalerate (APV), a competitive NMDA receptor antagonist, were tested in the pattern, latency and duration of the spinal seizures." | 3.68 | Kynurenate and 2-amino-5-phosphonovalerate alter the spinal seizures evoked by sudden cooling of toad isolated cords. ( Daló, NL; Piña, JC, 1990) |
| "This study evaluated a possible mechanism by which glycine potentiates the activity of anticonvulsant drugs against maximal electroshock seizures in rats." | 3.68 | Anticonvulsant drug potentiation by glycine in maximal electroshock seizures is mimicked by D-serine and antagonized by 7-chlorokynurenic acid. ( Peterson, SL, 1991) |
| "Quinolinic acid appeared to be the only kynurenine metabolite among tested (L- and DL-kynurenine sulfate, kynurenic and nicotinic acids, nicotinamide) which induced locomotor excitation and clonic seizures in rats whereas all of them exerted convulsant action in mice." | 3.66 | [Stimulatory effects of intraventricular administration of kynurenines, amino acids, and convulsants: differences between rats and mice]. ( Kiseleva, IP; Lapin, IP; Prakh'e, IB, 1982) |
| "One-fourth of children with cerebral malaria (CM) retain cognitive sequelae up to 2 years after acute disease." | 1.46 | Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria. ( Bangirana, P; Engberg, G; Färnert, A; Franzén-Röhl, E; Holmberg, D; Idro, R; John, CC; Opoka, RO; Schwieler, L; Sellgren, CM; Wickström, R, 2017) |
| "Since seizures trigger intracellular calcium overload, it has been presumed that the intrinsic cell death pathway mediated by mitochondrial dysfunction would modulate cell death following seizures." | 1.33 | Activation of the caspase 8 pathway mediates seizure-induced cell death in cultured hippocampal neurons. ( Cameron, JA; Chu, XP; Clayton, C; Henshall, DC; Lan, JQ; Meller, R; Schindler, CK; Simon, RP; Torrey, DJ; Xiong, ZG, 2006) |
| "In animals with high seizure susceptibility the decrease in norepinephrine content and the increase in the coefficient ratio between dopamine and norepinephrine have been found in the most of the regions investigated." | 1.31 | [Effect of kynurenic acid on catecholamine content in the brain of rats with different susceptibility to seizures]. ( Popova, LD, 2002) |
| "Furthermore, the seizure threshold of DMCM was increased by intracerebroventricular (i." | 1.30 | Role of the NMDA receptor complex in DMCM-induced seizure in mice. ( Misawa, M; Suzuki, T; Tsuda, M, 1997) |
| "Animals developed severe limbic seizures between 1 and 6 h after L-AAA injection, characterized by generalized convulsions." | 1.30 | L-alpha-aminoadipate inhibits kynurenate synthesis in rat brain hippocampus and tissue culture. ( Cauley, RK; Chang, JD; Chang, YF; Rao, VV, 1997) |
| "The decrease in the seizure threshold for pentylenetetrazole during diazepam withdrawal was inhibited by pretreatment with MK-801 ((+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cycloheptan-5,10-imine maleate), 7-chlorokynurenic acid and ifenprodil." | 1.30 | Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists. ( Misawa, M; Suzuki, T; Tsuda, M, 1997) |
| "However, they do not affect clonic seizures with preserved righting reflexes." | 1.29 | Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis: III. The action of kynurenic acid and glutamic acid diethylester. ( Kusá, R; Mares, P; Roztocilová, L; Velísek, L, 1995) |
| "El mouse convulsions were inhibited by oral administration of citalopram for 2 weeks." | 1.29 | The anticonvulsant effect of citalopram on El mice, and the levels of tryptophan and tyrosine and their metabolites in the brain. ( Kabuto, H; Kurimoto, T; Mori, A; Takei, M; Yokoi, I, 1994) |
| "GSA potentiated NMDA-induced convulsions significantly, but not L-glutamate- or kainate-induced convulsions." | 1.29 | N-methyl-D-aspartate receptors contribute to guanidinosuccinate-induced convulsions in mice. ( D'Hooge, R; De Deyn, PP; Pei, YQ, 1993) |
| "Kynurenic acid was determined 3 h after kainate injection in various brain regions (olfactory bulb, frontal cortex, piriform cortex, amygdala, hippocampus, nucleus accumbens, caudate/putamen, thalamus, superior and inferior colliculus, pons and medulla, and cerebellar cortex) and in plasma, using a sensitive high-performance liquid chromatographic method." | 1.29 | Systemic administration of kainate induces marked increases of endogenous kynurenic acid in various brain regions and plasma of rats. ( Baran, H; Gramer, M; Hönack, D; Löscher, W, 1995) |
| "In all seizure paradigms, KYNA levels in the dialysate began to rise within 1 h and gradually reached a plateau approximately 4 h after administration of the convulsants." | 1.29 | Seizure activity causes elevation of endogenous extracellular kynurenic acid in the rat brain. ( Schwarcz, R; Wu, HQ, 1996) |
| "7CKA did not affect NMDA-induced convulsions but reduced the D-serine potentiation of NMDA responses." | 1.28 | In vitro and in vivo characterization of the NMDA receptor-linked strychnine-insensitive glycine site. ( Peeters, BW; Vanderheyden, PM, 1992) |
| "Cocaine HCl (90 mg/kg, IP) induced seizures in 95% and death within 24 h in 68% (n = 135) of the animals." | 1.28 | Glutamate receptor antagonists block cocaine-induced convulsions and death. ( Andrew, M; Farley, JM; Ho, IK; Oden, G; Rockhold, RW, 1991) |
| "Prolonged periods of intense seizure-like activity usually killed most neurons in the culture." | 1.28 | Seizure-like activity and cellular damage in rat hippocampal neurons in cell culture. ( Furshpan, EJ; Potter, DD, 1989) |
| " Greatest protection was observed when the antidote was administered between 30 and 90 min after injection of the toxic extract." | 1.28 | Kynurenic acid protects against neurotoxicity and lethality of toxic extracts from contaminated Atlantic coast mussels. ( Bose, R; Glavin, GB; Pinsky, C, 1989) |
| "Kynurenine is a direct precursor of kynurenic acid, the only known endogenous antagonist of excitatory amino acid receptors in the brain." | 1.28 | Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain. ( Beal, MF; MacGarvey, U; Miller, J; Vécsei, L, 1992) |
| "Picolinic acid completely prevented seizures." | 1.27 | Antagonism of kynurenine-induced seizures by picolinic, kynurenic and xanthurenic acids. ( Lapin, IP, 1983) |
| "Kynurenic acid (KYNA) was tested as an antagonist of the neurotoxic and epileptogenic effects of the metabolically related brain constituent quinolinic acid (QUIN)." | 1.27 | Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid. ( Foster, AC; French, ED; Schwarcz, R; Vezzani, A, 1984) |
| "It also prevented pentylenetetrazol seizures in rats in a four times lower dose." | 1.27 | Antagonism of seizures induced by the administration of the endogenous convulsant quinolinic acid into rat brain ventricles. ( Kiseleva, IP; Lapin, IP; Prakhie, IB, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (15.87) | 18.7374 |
| 1990's | 37 (58.73) | 18.2507 |
| 2000's | 10 (15.87) | 29.6817 |
| 2010's | 6 (9.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Salituro, FG | 1 |
| Harrison, BL | 1 |
| Baron, BM | 1 |
| Nyce, PL | 1 |
| Stewart, KT | 1 |
| Kehne, JH | 1 |
| White, HS | 1 |
| McDonald, IA | 1 |
| Holmberg, D | 1 |
| Franzén-Röhl, E | 1 |
| Idro, R | 1 |
| Opoka, RO | 1 |
| Bangirana, P | 1 |
| Sellgren, CM | 1 |
| Wickström, R | 1 |
| Färnert, A | 1 |
| Schwieler, L | 1 |
| Engberg, G | 1 |
| John, CC | 1 |
| Maciejak, P | 3 |
| Szyndler, J | 3 |
| Turzyńska, D | 3 |
| Sobolewska, A | 3 |
| Taracha, E | 1 |
| Skórzewska, A | 1 |
| Lehner, M | 1 |
| Bidziński, A | 1 |
| Płaźnik, A | 3 |
| Prigol, M | 1 |
| Brüning, CA | 1 |
| Nogueira, CW | 1 |
| Zeni, G | 1 |
| Walkowiak, J | 1 |
| Berdichevsky, Y | 1 |
| Dzhala, V | 1 |
| Mail, M | 1 |
| Staley, KJ | 1 |
| Demeter, I | 1 |
| Nagy, K | 1 |
| Gellért, L | 1 |
| Vécsei, L | 2 |
| Fülöp, F | 1 |
| Toldi, J | 1 |
| Popova, LD | 1 |
| Meller, R | 2 |
| Schindler, CK | 2 |
| Chu, XP | 2 |
| Xiong, ZG | 2 |
| Cameron, JA | 2 |
| Simon, RP | 2 |
| Henshall, DC | 2 |
| FRENCH, JH | 1 |
| GRUETER, BB | 1 |
| DRUCKMAN, R | 1 |
| O'BRIEN, D | 1 |
| Clayton, C | 1 |
| Torrey, DJ | 1 |
| Lan, JQ | 1 |
| Foster, AC | 1 |
| Vezzani, A | 2 |
| French, ED | 2 |
| Schwarcz, R | 4 |
| Lapin, IP | 3 |
| Prakh'e, IB | 1 |
| Kiseleva, IP | 2 |
| Kabuto, H | 1 |
| Yokoi, I | 1 |
| Takei, M | 1 |
| Kurimoto, T | 1 |
| Mori, A | 1 |
| De Sarro, G | 2 |
| Ongini, E | 1 |
| Bertorelli, R | 1 |
| Aguglia, U | 1 |
| De Sarro, A | 2 |
| Ammendola, D | 1 |
| Nava, F | 1 |
| Swann, JW | 1 |
| Smith, KL | 1 |
| Brady, RJ | 1 |
| D'Hooge, R | 1 |
| Pei, YQ | 1 |
| De Deyn, PP | 1 |
| Halonen, T | 1 |
| Tortorella, A | 1 |
| Zrebeet, H | 1 |
| Gale, K | 4 |
| Pellicciari, R | 1 |
| Natalini, B | 1 |
| Costantino, G | 1 |
| Mahmoud, MR | 1 |
| Mattoli, L | 1 |
| Sadeghpour, BM | 1 |
| Moroni, F | 1 |
| Chiarugi, A | 1 |
| Carpenedo, R | 1 |
| Peterson, SL | 2 |
| Velísek, L | 1 |
| Roztocilová, L | 1 |
| Kusá, R | 1 |
| Mares, P | 1 |
| Baran, H | 1 |
| Gramer, M | 1 |
| Hönack, D | 1 |
| Löscher, W | 1 |
| Doyle, KM | 1 |
| Shaw, GG | 1 |
| Wu, HQ | 2 |
| Guzeva, VI | 1 |
| Mikhailov, IB | 1 |
| Melnikova, NV | 1 |
| Tsuda, M | 2 |
| Suzuki, T | 2 |
| Misawa, M | 2 |
| Chang, YF | 1 |
| Cauley, RK | 1 |
| Chang, JD | 1 |
| Rao, VV | 1 |
| Katsumori, H | 1 |
| Minabe, Y | 1 |
| Osawa, M | 1 |
| Ashby, CR | 1 |
| Micheli, F | 1 |
| Cugola, A | 1 |
| Donati, D | 1 |
| Missio, A | 1 |
| Pecunioso, A | 1 |
| Reggiani, A | 2 |
| Tarzia, G | 1 |
| Murray, B | 1 |
| Alessandrini, A | 1 |
| Cole, AJ | 1 |
| Yee, AG | 1 |
| Furshpan, EJ | 2 |
| Walker, BR | 1 |
| Easton, A | 1 |
| Min, MY | 1 |
| Melyan, Z | 1 |
| Kullmann, DM | 1 |
| Bonina, FP | 1 |
| Arenare, L | 1 |
| Ippolito, R | 1 |
| Boatto, G | 1 |
| Battaglia, G | 1 |
| Bruno, V | 1 |
| de Caprariis, P | 1 |
| Dybdal, D | 1 |
| Haberek, G | 1 |
| Tomczyk, T | 1 |
| Zuchora, B | 1 |
| Wielosz, M | 1 |
| Turski, WA | 2 |
| Urbanska, EM | 1 |
| Sierra-Paredes, G | 1 |
| Senra-Vidal, A | 1 |
| Sierra-Marcuño, G | 1 |
| Manfredini, S | 1 |
| Pavan, B | 1 |
| Vertuani, S | 1 |
| Scaglianti, M | 1 |
| Compagnone, D | 1 |
| Biondi, C | 1 |
| Scatturin, A | 1 |
| Tanganelli, S | 1 |
| Ferraro, L | 1 |
| Prasad, P | 1 |
| Dalpiaz, A | 1 |
| Ohtani, K | 1 |
| Tanaka, H | 1 |
| Yoneda, Y | 1 |
| Yasuda, H | 1 |
| Ito, A | 1 |
| Nagata, R | 1 |
| Nakamura, M | 1 |
| Rockhold, RW | 2 |
| Surrett, RS | 1 |
| Oden, G | 2 |
| Acuff, CG | 1 |
| Zhang, T | 1 |
| Farley, JM | 2 |
| Hoskins, B | 1 |
| Ho, IK | 2 |
| Wood, ER | 1 |
| Bussey, TJ | 1 |
| Phillips, AG | 1 |
| Peeters, BW | 1 |
| Vanderheyden, PM | 1 |
| Miller, J | 1 |
| MacGarvey, U | 1 |
| Beal, MF | 1 |
| Connick, JH | 1 |
| Heywood, GC | 1 |
| Sills, GJ | 1 |
| Thompson, GG | 1 |
| Brodie, MJ | 1 |
| Stone, TW | 1 |
| Croucher, MJ | 2 |
| Bradford, HF | 2 |
| Andrew, M | 1 |
| Singh, L | 1 |
| Oles, RJ | 1 |
| Tricklebank, MD | 1 |
| Chiamulera, C | 1 |
| Costa, S | 1 |
| Daló, NL | 1 |
| Piña, JC | 1 |
| Ungerstedt, U | 1 |
| Koek, W | 1 |
| Colpaert, FC | 1 |
| Wardas, J | 1 |
| Graham, J | 1 |
| Potter, DD | 1 |
| Pinsky, C | 1 |
| Glavin, GB | 1 |
| Bose, R | 1 |
| Prakhie, IB | 1 |
| Whetsell, WO | 1 |
| Kochen, W | 1 |
| Yokoyama, Y | 1 |
| Tada, K | 1 |
| Yoshida, T | 1 |
| Nakagawa, H | 1 |
| Arakawa, T | 1 |
63 other studies available for kynurenic acid and Seizures
| Article | Year |
|---|---|
3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-methyl-D-aspartic acid receptor associated glycine binding site.
Topics: Animals; Binding Sites; Cerebral Cortex; Glycine; Hippocampus; Indoles; Mice; Mice, Inbred DBA; Prop | 1992 |
Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria.
Topics: Child; Child, Preschool; Cognition; Coma; Female; Humans; Infant; Kynurenic Acid; Kynurenine; Malari | 2017 |
Time course of changes in the concentration of kynurenic acid in the brain of pentylenetetrazol-kindled rats.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Kindling, Neurologic; Kynurenic Acid; Male; Pe | 2009 |
The role of the glutathione system in seizures induced by diphenyl diselenide in rat pups.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Benzene Derivatives; Buthionine Sulfoximine; | 2011 |
The effects of electrical hippocampal kindling of seizures on amino acids and kynurenic acid concentrations in brain structures.
Topics: Amino Acids; Animals; Brain Chemistry; Electric Stimulation; Electrodes, Implanted; Hippocampus; Kin | 2012 |
Interictal spikes, seizures and ictal cell death are not necessary for post-traumatic epileptogenesis in vitro.
Topics: Action Potentials; Animals; Anticonvulsants; Brain Injuries; Cell Death; Epilepsy; Excitatory Amino | 2012 |
A novel kynurenic acid analog (SZR104) inhibits pentylenetetrazole-induced epileptiform seizures. An electrophysiological study : special issue related to kynurenine.
Topics: Action Potentials; Animals; Kynurenic Acid; Kynurenine; Male; Pentylenetetrazole; Rats; Rats, Spragu | 2012 |
Kynurenic acid: a new effector of valproate action?
Topics: Animals; Anticonvulsants; Hippocampus; Kindling, Neurologic; Kynurenic Acid; Male; Neurons; Pentylen | 2011 |
[Effect of kynurenic acid on catecholamine content in the brain of rats with different susceptibility to seizures].
Topics: Animals; Brain; Brain Chemistry; Catecholamines; Disease Susceptibility; Kynurenic Acid; Rats; Rats, | 2002 |
Seizure-like activity leads to the release of BAD from 14-3-3 protein and cell death in hippocampal neurons in vitro.
Topics: 14-3-3 Proteins; Animals; Animals, Newborn; Apoptosis; bcl-Associated Death Protein; bcl-X Protein; | 2003 |
PYRIDOXINE AND INFANTILE MYOCLONIC SEIZURES.
Topics: Amino Acids; Drug Therapy; Electroencephalography; Epilepsies, Myoclonic; Humans; Infant; Kynurenic | 1965 |
Activation of the caspase 8 pathway mediates seizure-induced cell death in cultured hippocampal neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Caspase 8; Caspase 9; Caspases; Cell Death; Cells, Cu | 2006 |
Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid.
Topics: Animals; Choline O-Acetyltransferase; Corpus Striatum; Hippocampus; Kynurenic Acid; Male; Nerve Dege | 1984 |
Antagonism of kynurenine-induced seizures by picolinic, kynurenic and xanthurenic acids.
Topics: Animals; Dose-Response Relationship, Drug; Female; Kynurenic Acid; Kynurenine; Male; Muridae; Picoli | 1983 |
[Stimulatory effects of intraventricular administration of kynurenines, amino acids, and convulsants: differences between rats and mice].
Topics: Amino Acids; Animals; Convulsants; Injections, Intraventricular; Kynurenic Acid; Kynurenine; Male; M | 1982 |
The anticonvulsant effect of citalopram on El mice, and the levels of tryptophan and tyrosine and their metabolites in the brain.
Topics: Animals; Anticonvulsants; Brain; Cerebral Cortex; Citalopram; Corpus Striatum; Hippocampus; Homovani | 1994 |
Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 1994 |
Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Anticonvuls | 1995 |
Localized excitatory synaptic interactions mediate the sustained depolarization of electrographic seizures in developing hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dendrites; Evoked Potentials; GABA Antagonists; Hippo | 1993 |
N-methyl-D-aspartate receptors contribute to guanidinosuccinate-induced convulsions in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Drug Interactions; Female; Glutamates; Glutam | 1993 |
Posterior piriform and perirhinal cortex relay seizures evoked from the area tempestas: role of excitatory and inhibitory amino acid receptors.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cerebral Cortex; Entorhinal Cort | 1994 |
Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl)alanine, a potent inhibitor of kynurenine-3-hydroxylase.
Topics: Alanine; Animals; Anticonvulsants; Binding, Competitive; Brain; Hippocampus; Hydrolases; Kynurenic A | 1994 |
Diazepam potentiation by glycine in pentylenetetrazol seizures is antagonized by 7-chlorokynurenic acid.
Topics: Animals; Diazepam; Drug Synergism; Glycine; Injections, Intraventricular; Kynurenic Acid; Male; Pent | 1994 |
Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis: III. The action of kynurenic acid and glutamic acid diethylester.
Topics: Age Factors; Animals; Disease Models, Animal; Glutamic Acid; Kynurenic Acid; Male; Pentylenetetrazol | 1995 |
Systemic administration of kainate induces marked increases of endogenous kynurenic acid in various brain regions and plasma of rats.
Topics: Animals; Anticonvulsants; Brain; Excitatory Amino Acid Agonists; Female; Kainic Acid; Kynurenic Acid | 1995 |
Investigation of the involvement of the N-methyl-D-aspartate receptor macrocomplex in the development of spermine-induced CNS excitation in vivo.
Topics: Animals; Brain; Cerebral Ventricles; Dizocilpine Maleate; Female; Kynurenic Acid; Mice; Neuroprotect | 1996 |
Seizure activity causes elevation of endogenous extracellular kynurenic acid in the rat brain.
Topics: Animals; Brain; Hippocampus; Kynurenic Acid; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Seizur | 1996 |
The kynurenines and the seizures.
Topics: Animals; Cerebral Ventricles; Electroencephalography; Hippocampus; Kynurenic Acid; Kynurenine; Micro | 1996 |
Role of the NMDA receptor complex in DMCM-induced seizure in mice.
Topics: Animals; Carbolines; Cerebral Ventricles; Convulsants; Dizocilpine Maleate; Excitatory Amino Acid An | 1997 |
Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Dizocilpine Maleate; Drug I | 1997 |
L-alpha-aminoadipate inhibits kynurenate synthesis in rat brain hippocampus and tissue culture.
Topics: 2-Aminoadipic Acid; Animals; Astrocytes; Cells, Cultured; Drug Evaluation, Preclinical; Hippocampus; | 1997 |
Acute effects of various GABA receptor agonists and glutamate antagonists on focal hippocampal seizures in freely moving rats elicited by low-frequency stimulation.
Topics: Animals; Anticonvulsants; Ataxia; Carbamazepine; Diazepam; Dizocilpine Maleate; Excitatory Amino Aci | 1998 |
2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as selective glycine antagonist with in vivo activity.
Topics: Animals; Avoidance Learning; Binding Sites; Cyclic N-Oxides; Dizocilpine Maleate; Excitatory Amino A | 1997 |
Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Death; Cells, Cultured; Enzyme Inhibitor | 1998 |
Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius.
Topics: Animals; Bicuculline; Electric Stimulation Therapy; Excitatory Amino Acid Antagonists; GABA Agonists | 1999 |
Synaptically released glutamate reduces gamma-aminobutyric acid (GABA)ergic inhibition in the hippocampus via kainate receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; GABA-B | 1999 |
Synthesis, pharmacokinetics and anticonvulsant activity of 7-chlorokynurenic acid prodrugs.
Topics: Animals; Blood-Brain Barrier; Cells, Cultured; Esters; Excitatory Amino Acid Agonists; Excitatory Am | 2000 |
Postural and anticonvulsant effects of inhibition of the rat subthalamic nucleus.
Topics: Animals; Anticonvulsants; Bicuculline; Functional Laterality; GABA-A Receptor Agonists; Kynurenic Ac | 2000 |
Proconvulsive effects of the mitochondrial respiratory chain inhibitor--3-nitropropionic acid.
Topics: Acetylcholine; Animals; Convulsants; Drug Interactions; Electric Stimulation; Electron Transport; El | 2000 |
Effect of extracellular long-time microperfusion of high concentrations of glutamate and glycine on picrotoxin seizure thresholds in the hippocampus of freely moving rats.
Topics: Animals; Epilepsy; Excitatory Amino Acid Antagonists; Extracellular Space; GABA Antagonists; Glutami | 2001 |
Design, synthesis and activity of ascorbic acid prodrugs of nipecotic, kynurenic and diclophenamic acids, liable to increase neurotropic activity.
Topics: Animals; Ascorbic Acid; Biological Transport; Cell Line; Central Nervous System Agents; Diclofenac; | 2002 |
In vitro and in vivo antagonistic activities of SM-31900 for the NMDA receptor glycine-binding site.
Topics: Aminoquinolines; Animals; Binding, Competitive; Brain; Cells, Cultured; Dizocilpine Maleate; Dose-Re | 2002 |
Inhibition of cocaine intoxication by excitatory amino acid receptor antagonists.
Topics: Animals; Anticonvulsants; Cocaine; Death; Dextrorphan; Dizocilpine Maleate; Glutamates; Kynurenic Ac | 1992 |
A glycine antagonist reduces ischemia-induced CA1 cell loss in vivo.
Topics: Animals; Glycine; Hippocampus; Injections, Intraventricular; Ischemic Attack, Transient; Kynurenic A | 1992 |
In vitro and in vivo characterization of the NMDA receptor-linked strychnine-insensitive glycine site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Dizocilpine Maleate; Glycine; Kynurenic Acid | 1992 |
Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain.
Topics: Analysis of Variance; Animals; Brain; Cerebral Cortex; Corpus Striatum; Diazepam; Dose-Response Rela | 1992 |
Nicotinylalanine increases cerebral kynurenic acid content and has anticonvulsant activity.
Topics: Alanine; Animals; Anticonvulsants; Brain Chemistry; Electroshock; In Vitro Techniques; Kidney; Kynur | 1992 |
The influence of strychnine-insensitive glycine receptor agonists and antagonists on generalized seizure thresholds.
Topics: Alanine; Amygdala; Animals; Glycine; Kindling, Neurologic; Kynurenic Acid; Male; Pyrrolidinones; Rat | 1991 |
Anticonvulsant drug potentiation by glycine in maximal electroshock seizures is mimicked by D-serine and antagonized by 7-chlorokynurenic acid.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Synergism; Electroshock; Glycine; Kynurenic Acid; Male | 1991 |
Glutamate receptor antagonists block cocaine-induced convulsions and death.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anticonvulsants; Cocaine; Death; Dextrorphan; Dizocil | 1991 |
Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor/ion channel complex.
Topics: Acoustic Stimulation; Animals; Aspartic Acid; Diazepam; Injections, Intraventricular; Ion Channels; | 1990 |
Effect of NMDA- and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Injections, Intraventricular; Kynurenic A | 1990 |
Kynurenate and 2-amino-5-phosphonovalerate alter the spinal seizures evoked by sudden cooling of toad isolated cords.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bufo marinus; Cold Temperature; Kynurenic Acid; Muscle Contrac | 1990 |
Systemic kainic acid administration in rats: effects on kynurenic acid production in vitro and in vivo.
Topics: Animals; Cerebral Cortex; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; Olfactory Pathways | 1991 |
Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; Kainic Acid; Kynurenic Acid; Male | 1990 |
7-Chlorokynurenic acid, a strychnine-insensitive glycine receptor antagonist, inhibits limbic seizure kindling.
Topics: Amygdala; Animals; Anticonvulsants; Electric Stimulation; Kindling, Neurologic; Kynurenic Acid; Limb | 1990 |
Evidence for a role of glycine in area tempestas for triggering convulsive seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Carbachol; Cerebral Cortex; Glycine; Kainic Acid; Kynurenic A | 1990 |
Seizure-like activity and cellular damage in rat hippocampal neurons in cell culture.
Topics: Animals; Cell Survival; Cells, Cultured; Electric Conductivity; Hippocampus; Kynurenic Acid; Magnesi | 1989 |
Kynurenic acid protects against neurotoxicity and lethality of toxic extracts from contaminated Atlantic coast mussels.
Topics: Animals; Bivalvia; Food Contamination; Kynurenic Acid; Male; Mice; Neurotoxins; Seizures; Shellfish; | 1989 |
Antagonism of seizures induced by the administration of the endogenous convulsant quinolinic acid into rat brain ventricles.
Topics: Animals; Anticonvulsants; Diazepam; gamma-Aminobutyric Acid; Glycine; Injections, Intraventricular; | 1986 |
Anti-excitotoxic actions of taurine in the rat hippocampus studied in vivo and in vitro.
Topics: Action Potentials; Animals; Dialysis; Hippocampus; Kynurenic Acid; Organ Culture Techniques; Pyridin | 1986 |
[Tryptophan metabolism in pyridoxine-dependent convulsions].
Topics: Chemistry, Clinical; Child; Child, Preschool; Chromatography, Thin Layer; Epilepsy, Tonic-Clonic; Hu | 1971 |
Liver kynureninase activity of an infant with infantile spasm.
Topics: Aspartate Aminotransferases; Cerebral Palsy; Child; Child, Preschool; Erythrocytes; Female; Humans; | 1968 |