kynurenic acid has been researched along with Pregnancy in 56 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study examined the diagnostic ability of tryptophan catabolites (TRYCATs) and insulin resistance (IR) parameters in women with PE." | 8.31 | Maternal Tryptophan Catabolites and Insulin Resistance Parameters in Preeclampsia. ( Al-Hakeim, HK; Jasim, ZA; Stanek, A; Zolghadri, S, 2023) |
| "Higher estimated tryptophan intake was cross-sectionally independently associated with a lower prevalence of depressive symptoms during pregnancy in Japanese women." | 8.12 | Tryptophan intake is related to a lower prevalence of depressive symptoms during pregnancy in Japan: baseline data from the Kyushu Okinawa Maternal and Child Health Study. ( Arakawa, M; Miyake, Y; Okubo, H; Sasaki, S; Tanaka, K, 2022) |
| " Tryptophan (TRP) metabolism has attracted considerable attention due to its influence on the onset of depression via induction of inflammation." | 7.91 | Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms. ( Kubo, H; Morikawa, M; Mouri, A; Nabeshima, T; Nakamura, Y; Okada, T; Ozaki, N; Saito, K; Shiino, T; Teshigawara, T; Yamamoto, Y, 2019) |
| "Several studies suggest a pathophysiologically relevant association between increased brain levels of the neuroinhibitory tryptophan metabolite kynurenic acid and cognitive dysfunctions in people with schizophrenia." | 7.88 | Maternal genotype determines kynurenic acid levels in the fetal brain: Implications for the pathophysiology of schizophrenia. ( Beggiato, S; Giorgini, F; Notarangelo, FM; Sathyasaikumar, KV; Schwarcz, R, 2018) |
| "The levels of kynurenic acid (KYNA), an endogenous negative modulator of alpha7 nicotinic acetylcholine receptors (α7nAChRs), are elevated in the brains of patients with schizophrenia (SZ)." | 7.81 | Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: implications for schizophrenia. ( Bortz, DM; Bruno, JP; Fredericks, PJ; Jørgensen, CV; Leuner, B; Pershing, ML; Pocivavsek, A; Schwarcz, R; Vunck, SA, 2015) |
| "The aim of the study was to evaluate the influence of premature rupture of fetal membranes on kynurenic acid (KYNA) levels in venous and arterial umbilical cord blood of neonates." | 7.71 | [Influence of premature rupture of fetal membranes on kynurenic acid concentration in umbilical cord blood]. ( Milart, P; Paszkowski, T; Radomański, T; Sikorski, R, 2001) |
| "The aim of the study was to evaluate the concentrations of kynurenic acid (KYNA) in blood and urine during the normal pregnancy." | 7.70 | [Kynurenic acid concentration in blood and urine during normal pregnancy]. ( Milart, P; Sikorski, R, 1998) |
| "Tryptophan breakdown metabolites formed along the kynurenine pathway play a significant role in pregnancy and fetal development." | 4.31 | LC-MS/MS-based quantification of tryptophan, kynurenine, and kynurenic acid in human placental, fetal membranes, and umbilical cord samples. ( Deuschle, M; Fornal, E; Gilles, M; Kozub, A; Lamadé, EK; Marszalek-Grabska, M; Pedraz-Petrozzi, B; Stachniuk, A; Szalaj, K; Trzpil, A; Turski, WA, 2023) |
| " The present study examined the diagnostic ability of tryptophan catabolites (TRYCATs) and insulin resistance (IR) parameters in women with PE." | 4.31 | Maternal Tryptophan Catabolites and Insulin Resistance Parameters in Preeclampsia. ( Al-Hakeim, HK; Jasim, ZA; Stanek, A; Zolghadri, S, 2023) |
| "Higher estimated tryptophan intake was cross-sectionally independently associated with a lower prevalence of depressive symptoms during pregnancy in Japanese women." | 4.12 | Tryptophan intake is related to a lower prevalence of depressive symptoms during pregnancy in Japan: baseline data from the Kyushu Okinawa Maternal and Child Health Study. ( Arakawa, M; Miyake, Y; Okubo, H; Sasaki, S; Tanaka, K, 2022) |
| " As KP metabolism during pregnancy is still insufficiently understood, we designed this study to examine the de novo synthesis of KYNA and 3-hydroxykynurenine (3-HK), an alternative biologically active product of kynurenine degradation, in tissue slices obtained from pregnant mice on gestational day (GD) 18." | 3.91 | Assessment of Prenatal Kynurenine Metabolism Using Tissue Slices: Focus on the Neosynthesis of Kynurenic Acid in Mice. ( Beggiato, S; Notarangelo, FM; Schwarcz, R, 2019) |
| " Tryptophan (TRP) metabolism has attracted considerable attention due to its influence on the onset of depression via induction of inflammation." | 3.91 | Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms. ( Kubo, H; Morikawa, M; Mouri, A; Nabeshima, T; Nakamura, Y; Okada, T; Ozaki, N; Saito, K; Shiino, T; Teshigawara, T; Yamamoto, Y, 2019) |
| "Several studies suggest a pathophysiologically relevant association between increased brain levels of the neuroinhibitory tryptophan metabolite kynurenic acid and cognitive dysfunctions in people with schizophrenia." | 3.88 | Maternal genotype determines kynurenic acid levels in the fetal brain: Implications for the pathophysiology of schizophrenia. ( Beggiato, S; Giorgini, F; Notarangelo, FM; Sathyasaikumar, KV; Schwarcz, R, 2018) |
| "Levels of kynurenic acid (KYNA), an endogenous negative modulator of alpha 7 nicotinic acetylcholine receptors (α7nAChRs) and antagonist at glutamatergic N-methyl-D-aspartate receptors (NMDARs), are elevated in the brain of patients with schizophrenia (SZ)." | 3.83 | Prenatal kynurenine exposure in rats: age-dependent changes in NMDA receptor expression and conditioned fear responding. ( Bruno, JP; Lindquist, DH; Pershing, ML; Phenis, D; Pocivavsek, A; Schwarcz, R; Valentini, V, 2016) |
| "To quantify the full range of tryptophan metabolites along the kynurenine pathway, a liquid chromatography - tandem mass spectrometry method was developed and used to analyse brain extracts of rodents treated with the kynurenine-3-mono-oxygenase (KMO) inhibitor Ro61-8048 during pregnancy." | 3.83 | Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2 ( Cobb, SR; Dalton, RN; Darlington, LG; Forrest, CM; Kennedy, PG; Rodgers, J; Stone, TW; Turner, C, 2016) |
| "The levels of kynurenic acid (KYNA), an endogenous negative modulator of alpha7 nicotinic acetylcholine receptors (α7nAChRs), are elevated in the brains of patients with schizophrenia (SZ)." | 3.81 | Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: implications for schizophrenia. ( Bortz, DM; Bruno, JP; Fredericks, PJ; Jørgensen, CV; Leuner, B; Pershing, ML; Pocivavsek, A; Schwarcz, R; Vunck, SA, 2015) |
| "The aim of the study was to evaluate the influence of premature rupture of fetal membranes on kynurenic acid (KYNA) levels in venous and arterial umbilical cord blood of neonates." | 3.71 | [Influence of premature rupture of fetal membranes on kynurenic acid concentration in umbilical cord blood]. ( Milart, P; Paszkowski, T; Radomański, T; Sikorski, R, 2001) |
| "Quinolinic acid was positively associated with sSAT at birth." | 1.72 | The Kynurenine Pathway Metabolites in Cord Blood Positively Correlate With Early Childhood Adiposity. ( Cameron-Smith, D; Chong, MFF; Chong, YS; Eriksson, JG; Fortier, MV; Gluckman, PD; Godfrey, KM; Kothandaraman, N; Lee, YS; Michael, N; Sadananthan, SA; Tan, KH; Tan, KM; Tint, MT; Velan, SS; Yap, F, 2022) |
| "Kynurenic acid (KYNA) is a KP metabolite synthesized by kynurenine aminotransferases (KATs) from its biological precursor kynurenine and acts as an endogenous antagonist of N-methyl-D-aspartate and α7-nicotinic acetylcholine receptors." | 1.62 | Prenatal Kynurenine Elevation Elicits Sex-Dependent Changes in Sleep and Arousal During Adulthood: Implications for Psychotic Disorders. ( Baratta, AM; Ditty, AL; Milosavljevic, S; Mong, JA; Pocivavsek, A; Rentschler, KM; Wagner, NTJ; Wright, CJ, 2021) |
| "PDS was determined by an Edinburgh Postnatal Depression Scale (EPDS) score ≥ 13." | 1.56 | The role of kynurenine pathway and kynurenic aminotransferase alleles in postpartum depression following cesarean section in Chinese women. ( Duan, K; Hu, N; Huang, Z; Long, G; Ma, J; Quan, C; Wang, S; Yang, M; Yu, H; Zeng, G, 2020) |
| "PPD was diagnosed with an Edinburgh Postnatal Depression Scale (EPDS) score ≥13." | 1.48 | [Correlation between kynurenine metabolites and postpartum depression]. ( Duan, K; Quan, C; Tan, Y; Wang, S; Wen, S; Zhang, J, 2018) |
| "These results show that early protein deficiency induces selective and long-lasting changes in brain kynurenine metabolism." | 1.46 | Maternal protein restriction during gestation and lactation in the rat results in increased brain levels of kynurenine and kynurenic acid in their adult offspring. ( Aguesse, A; Bolaños-Jiménez, F; Croyal, M; de Sa Braga Oliveira, A; Ferchaud-Roucher, V; Grit, I; Honório de Melo Martimiano, P; Kaeffer, B; Lopes de Souza, S; Ouguerram, K, 2017) |
| "Kynurenic acid is a tryptophan metabolite that is synthesized and released in the brain by astrocytes and acts as an antagonist of nicotinic acetylcholine receptors and N-methyl-d-aspartate glutamate receptors, both of which are critically involved in cognition as well as neural plasticity and brain development." | 1.39 | The effect of transient increases in kynurenic acid and quinolinic acid levels early in life on behavior in adulthood: Implications for schizophrenia. ( Bucci, DJ; Iaccarino, HF; Suckow, RF; Xie, S, 2013) |
| "l-Kynurenine treatment raised forebrain KYNA levels ∼3-fold at PD2 and ∼2." | 1.39 | Early developmental elevations of brain kynurenic acid impair cognitive flexibility in adults: reversal with galantamine. ( Alexander, KS; Bruno, JP; Pershing, ML; Pocivavsek, A; Schwarcz, R; Wu, HQ, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (12.50) | 18.7374 |
| 1990's | 10 (17.86) | 18.2507 |
| 2000's | 10 (17.86) | 29.6817 |
| 2010's | 18 (32.14) | 24.3611 |
| 2020's | 11 (19.64) | 2.80 |
| Authors | Studies |
|---|---|
| Kimmel, M | 1 |
| Jin, W | 1 |
| Xia, K | 1 |
| Lun, K | 1 |
| Azcarate-Peril, A | 1 |
| Plantinga, A | 1 |
| Wu, M | 1 |
| Ataei, S | 1 |
| Rackers, H | 1 |
| Carroll, I | 1 |
| Meltzer-Brody, S | 1 |
| Fransson, E | 1 |
| Knickmeyer, R | 1 |
| Tan, KM | 1 |
| Tint, MT | 1 |
| Kothandaraman, N | 1 |
| Michael, N | 1 |
| Sadananthan, SA | 1 |
| Velan, SS | 1 |
| Fortier, MV | 1 |
| Yap, F | 1 |
| Tan, KH | 1 |
| Gluckman, PD | 1 |
| Chong, YS | 1 |
| Chong, MFF | 1 |
| Lee, YS | 1 |
| Godfrey, KM | 1 |
| Eriksson, JG | 1 |
| Cameron-Smith, D | 1 |
| Szabo, M | 1 |
| Lajkó, N | 1 |
| Dulka, K | 1 |
| Szatmári, I | 1 |
| Fülöp, F | 1 |
| Mihály, A | 1 |
| Vécsei, L | 2 |
| Gulya, K | 1 |
| Miyake, Y | 1 |
| Tanaka, K | 1 |
| Okubo, H | 1 |
| Sasaki, S | 1 |
| Arakawa, M | 1 |
| Pedraz-Petrozzi, B | 1 |
| Marszalek-Grabska, M | 1 |
| Kozub, A | 1 |
| Szalaj, K | 1 |
| Trzpil, A | 1 |
| Stachniuk, A | 1 |
| Lamadé, EK | 1 |
| Gilles, M | 1 |
| Deuschle, M | 1 |
| Turski, WA | 1 |
| Fornal, E | 1 |
| Bjørke-Monsen, AL | 1 |
| Varsi, K | 1 |
| Sakkestad, ST | 1 |
| Ulvik, A | 1 |
| Ebbing, C | 1 |
| Ueland, PM | 1 |
| Jasim, ZA | 1 |
| Al-Hakeim, HK | 1 |
| Zolghadri, S | 1 |
| Stanek, A | 1 |
| Beggiato, S | 4 |
| Ieraci, A | 1 |
| Tomasini, MC | 1 |
| Schwarcz, R | 14 |
| Ferraro, L | 1 |
| Quan, C | 2 |
| Wang, S | 2 |
| Duan, K | 2 |
| Ma, J | 1 |
| Yu, H | 1 |
| Yang, M | 1 |
| Hu, N | 1 |
| Long, G | 1 |
| Zeng, G | 1 |
| Huang, Z | 1 |
| Rentschler, KM | 1 |
| Baratta, AM | 1 |
| Ditty, AL | 1 |
| Wagner, NTJ | 1 |
| Wright, CJ | 1 |
| Milosavljevic, S | 1 |
| Mong, JA | 1 |
| Pocivavsek, A | 7 |
| Notarangelo, FM | 5 |
| Goeden, N | 1 |
| Bonnin, A | 1 |
| Tan, Y | 1 |
| Wen, S | 1 |
| Zhang, J | 1 |
| Sathyasaikumar, KV | 1 |
| Giorgini, F | 1 |
| Teshigawara, T | 1 |
| Mouri, A | 1 |
| Kubo, H | 1 |
| Nakamura, Y | 1 |
| Shiino, T | 1 |
| Okada, T | 1 |
| Morikawa, M | 1 |
| Nabeshima, T | 1 |
| Ozaki, N | 1 |
| Yamamoto, Y | 1 |
| Saito, K | 1 |
| Feng, C | 1 |
| Gao, J | 1 |
| Zhen, Q | 1 |
| Fan, Z | 1 |
| Zhu, M | 1 |
| Yang, X | 1 |
| Ding, M | 1 |
| Iaccarino, HF | 1 |
| Suckow, RF | 1 |
| Xie, S | 1 |
| Bucci, DJ | 1 |
| Thomas, MA | 1 |
| Elmer, GI | 2 |
| Bruno, JP | 5 |
| Zavitsanou, K | 1 |
| Lim, CK | 1 |
| Purves-Tyson, T | 1 |
| Karl, T | 1 |
| Kassiou, M | 1 |
| Banister, SD | 1 |
| Guillemin, GJ | 1 |
| Weickert, CS | 1 |
| Grozdics, E | 1 |
| Berta, L | 1 |
| Bajnok, A | 1 |
| Veres, G | 1 |
| Ilisz, I | 1 |
| Klivényi, P | 1 |
| Rigó, J | 1 |
| Tulassay, T | 1 |
| Toldi, G | 1 |
| Pershing, ML | 3 |
| Bortz, DM | 1 |
| Fredericks, PJ | 1 |
| Jørgensen, CV | 1 |
| Vunck, SA | 1 |
| Leuner, B | 1 |
| Phenis, D | 1 |
| Valentini, V | 1 |
| Lindquist, DH | 1 |
| Forrest, CM | 1 |
| Kennedy, PG | 1 |
| Rodgers, J | 1 |
| Dalton, RN | 1 |
| Turner, C | 1 |
| Darlington, LG | 1 |
| Cobb, SR | 1 |
| Stone, TW | 1 |
| Honório de Melo Martimiano, P | 1 |
| de Sa Braga Oliveira, A | 1 |
| Ferchaud-Roucher, V | 1 |
| Croyal, M | 1 |
| Aguesse, A | 1 |
| Grit, I | 1 |
| Ouguerram, K | 1 |
| Lopes de Souza, S | 1 |
| Kaeffer, B | 1 |
| Bolaños-Jiménez, F | 1 |
| Crozier, RA | 1 |
| Bi, C | 1 |
| Han, YR | 1 |
| Plummer, MR | 1 |
| Kvochina, L | 1 |
| Hasser, EM | 1 |
| Heesch, CM | 1 |
| Alkondon, M | 1 |
| Pereira, EF | 1 |
| Eisenberg, HM | 1 |
| Kajii, Y | 1 |
| Albuquerque, EX | 1 |
| Wu, HQ | 2 |
| Alexander, KS | 1 |
| Yu, P | 1 |
| Di Prospero, NA | 1 |
| Sapko, MT | 1 |
| Cai, T | 1 |
| Chen, A | 1 |
| Melendez-Ferro, M | 1 |
| Du, F | 1 |
| Whetsell, WO | 1 |
| Guidetti, P | 2 |
| Tagle, DA | 1 |
| Ceresoli-Borroni, G | 1 |
| Amori, L | 1 |
| Pellicciari, R | 1 |
| Bermond, P | 1 |
| Stella, N | 1 |
| Pellerin, L | 1 |
| Magistretti, PJ | 1 |
| Becquet, D | 1 |
| Héry, M | 1 |
| Deprez, P | 1 |
| Faudon, M | 1 |
| Fache, MP | 1 |
| Giraud, P | 1 |
| Héry, F | 1 |
| Parsons, CG | 1 |
| Zong, X | 1 |
| Lux, HD | 1 |
| Birrell, GJ | 1 |
| Marcoux, FW | 1 |
| Couratier, P | 1 |
| Lesort, M | 1 |
| Terro, F | 1 |
| Dussartre, C | 1 |
| Hugon, J | 1 |
| Berger, R | 1 |
| Jensen, A | 1 |
| Hossmann, KA | 1 |
| Paschen, W | 1 |
| Milart, P | 3 |
| Sikorski, R | 3 |
| Walker, DW | 3 |
| Curtis, B | 1 |
| Lacey, B | 2 |
| Nitsos, I | 3 |
| Młynarczyk, M | 1 |
| Nicholls, T | 2 |
| Smythe, G | 2 |
| Kankofer, M | 1 |
| Paszkowski, T | 1 |
| Radomański, T | 1 |
| Homma, Y | 1 |
| Skinner, RD | 1 |
| Garcia-Rill, E | 1 |
| Jones, CT | 1 |
| Ashton, IK | 1 |
| El-Kholy, ZA | 1 |
| Saad, AA | 1 |
| Mostafa, MH | 1 |
| Abdel-Tawab, GA | 1 |
| El-Dardiri, N | 1 |
| El-Kabariti, H | 1 |
| Abdel-Rafea, A | 1 |
| Korkhov, VV | 1 |
| Jouanen, A | 1 |
| Tremblet, AM | 1 |
| Massardier, D | 1 |
| Haesslein, JL | 1 |
| Hunt, PF | 1 |
| Tapia-Arancibia, L | 1 |
| Astier, H | 1 |
| Jahr, CE | 1 |
| Jessell, TM | 1 |
| Price, JM | 1 |
| Brown, RR | 1 |
| Yess, N | 1 |
| Heilmann, HH | 1 |
| Knapp, A | 1 |
| Stolp, A | 1 |
| von Sudhodoletz, O | 1 |
1 review available for kynurenic acid and Pregnancy
| Article | Year |
|---|---|
Testing the functional capacity of the tryptophan-niacin pathway in man by analysis of urinary metabolites.
Topics: Adult; Amides; Amines; Chromatography, Ion Exchange; Equipment and Supplies; Female; Hormones; Human | 1965 |
55 other studies available for kynurenic acid and Pregnancy
| Article | Year |
|---|---|
Metabolite trajectories across the perinatal period and mental health: A preliminary study of tryptophan-related metabolites, bile acids and microbial composition.
Topics: Adult; Anxiety; Bile Acids and Salts; Chromatography, Liquid; Depression; Dietary Fiber; Fatty Acids | 2022 |
The Kynurenine Pathway Metabolites in Cord Blood Positively Correlate With Early Childhood Adiposity.
Topics: Adiposity; Adult; Birth Weight; Cesarean Section; Child; Child, Preschool; Female; Fetal Blood; Huma | 2022 |
Kynurenic Acid and Its Analog SZR104 Exhibit Strong Antiinflammatory Effects and Alter the Intracellular Distribution and Methylation Patterns of H3 Histones in Immunochallenged Microglia-Enriched Cultures of Newborn Rat Brains.
Topics: Amides; Animals; Animals, Newborn; Anti-Inflammatory Agents; Cells, Cultured; Chemokine CXCL10; Dise | 2022 |
Tryptophan intake is related to a lower prevalence of depressive symptoms during pregnancy in Japan: baseline data from the Kyushu Okinawa Maternal and Child Health Study.
Topics: Calcium; Child; Child Health; Cross-Sectional Studies; Depression; Docosahexaenoic Acids; Eicosapent | 2022 |
LC-MS/MS-based quantification of tryptophan, kynurenine, and kynurenic acid in human placental, fetal membranes, and umbilical cord samples.
Topics: Chromatography, Liquid; Extraembryonic Membranes; Female; Humans; Kynurenic Acid; Kynurenine; Placen | 2023 |
Lower levels of the neuroprotective tryptophan metabolite, kynurenic acid, in users of estrogen contraceptives.
Topics: Contraceptives, Oral, Hormonal; Estrogens; Female; Humans; Kynurenic Acid; Kynurenine; Pregnancy; Py | 2023 |
Maternal Tryptophan Catabolites and Insulin Resistance Parameters in Preeclampsia.
Topics: Case-Control Studies; Female; Humans; Insulin Resistance; Kynurenic Acid; Kynurenine; Pre-Eclampsia; | 2023 |
Prenatal THC exposure raises kynurenic acid levels in the prefrontal cortex of adult rats.
Topics: Animals; Biomarkers; Dronabinol; Female; Hallucinogens; Kynurenic Acid; Male; Memory, Short-Term; Pr | 2020 |
The role of kynurenine pathway and kynurenic aminotransferase alleles in postpartum depression following cesarean section in Chinese women.
Topics: Adult; Alleles; Cesarean Section; Depression, Postpartum; Female; Genotype; Humans; Kynurenic Acid; | 2020 |
Prenatal Kynurenine Elevation Elicits Sex-Dependent Changes in Sleep and Arousal During Adulthood: Implications for Psychotic Disorders.
Topics: Animals; Disease Models, Animal; Electroencephalography; Electromyography; Female; Kynurenic Acid; M | 2021 |
A single prenatal lipopolysaccharide injection has acute, but not long-lasting, effects on cerebral kynurenine pathway metabolism in mice.
Topics: Animals; Female; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Male; Mice; Placenta; Pregnancy; Q | 2021 |
Prenatal Dynamics of Kynurenine Pathway Metabolism in Mice: Focus on Kynurenic Acid.
Topics: Animals; Brain; Female; Kynurenic Acid; Kynurenine; Mice; Placenta; Pregnancy; Tryptophan | 2017 |
[Correlation between kynurenine metabolites and postpartum depression].
Topics: Biomarkers; Cesarean Section; China; Depression, Postpartum; Female; Humans; Incidence; Kynurenic Ac | 2018 |
Maternal genotype determines kynurenic acid levels in the fetal brain: Implications for the pathophysiology of schizophrenia.
Topics: Animals; Brain; Cognitive Dysfunction; Female; Genotype; Kynurenic Acid; Kynurenine; Kynurenine 3-Mo | 2018 |
Assessment of Prenatal Kynurenine Metabolism Using Tissue Slices: Focus on the Neosynthesis of Kynurenic Acid in Mice.
Topics: Animals; Brain; Female; Fetus; Kynurenic Acid; Kynurenine; Liver; Mice; Mice, Knockout; Organ Cultur | 2019 |
Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms.
Topics: Adult; Depression; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Postpartum Period; Preg | 2019 |
[Simultaneous determination of tryptophan and its metabolites in plasma by high performance liquid chromatography with on-column derivatization].
Topics: Acetonitriles; Chromatography, High Pressure Liquid; Female; Fluorescence; Humans; Hydroxyindoleacet | 2013 |
The effect of transient increases in kynurenic acid and quinolinic acid levels early in life on behavior in adulthood: Implications for schizophrenia.
Topics: Analysis of Variance; Animals; Animals, Newborn; Attention; Behavior, Animal; Brain Chemistry; Cohor | 2013 |
Continuous kynurenine administration during the prenatal period, but not during adolescence, causes learning and memory deficits in adult rats.
Topics: Age Factors; Animals; Avoidance Learning; Behavior, Animal; Cognition Disorders; Female; Hippocampus | 2014 |
Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: amelioration by COX-2 inhibition.
Topics: Animals; Brain; Celecoxib; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dizocilpine Maleate; | 2014 |
B7 costimulation and intracellular indoleamine-2,3-dioxygenase (IDO) expression in peripheral blood of healthy pregnant and non-pregnant women.
Topics: Adult; B7 Antigens; CD28 Antigens; CD4 Lymphocyte Count; CTLA-4 Antigen; Female; Flow Cytometry; Hum | 2014 |
Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: implications for schizophrenia.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Brain; Cognition; Dendritic Spines; Die | 2015 |
Prenatal kynurenine exposure in rats: age-dependent changes in NMDA receptor expression and conditioned fear responding.
Topics: Age Factors; alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Cognition; Conditioning, Psych | 2016 |
Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2
Topics: Animals; Autism Spectrum Disorder; Brain; Chromatography, Liquid; Female; Kynurenic Acid; Kynurenine | 2016 |
Maternal protein restriction during gestation and lactation in the rat results in increased brain levels of kynurenine and kynurenic acid in their adult offspring.
Topics: Age Factors; Animals; Brain; Dietary Proteins; Female; Kynurenic Acid; Kynurenine; Lactation; Male; | 2017 |
Restraint Stress during Pregnancy Rapidly Raises Kynurenic Acid Levels in Mouse Placenta and Fetal Brain.
Topics: Animals; Brain; Female; Fetus; Kynurenic Acid; Mice; Placenta; Pregnancy; Prenatal Exposure Delayed | 2016 |
BDNF modulation of NMDA receptors is activity dependent.
Topics: Animals; Biophysics; Brain-Derived Neurotrophic Factor; Calcium; Cells, Cultured; Chelating Agents; | 2008 |
Pregnancy decreases GABAergic inhibition of the hypothalamic paraventricular nucleus.
Topics: Action Potentials; Analysis of Variance; Angiotensin II; Animals; Antihypertensive Agents; Bicuculli | 2009 |
Age dependency of inhibition of alpha7 nicotinic receptors and tonically active N-methyl-D-aspartate receptors by endogenously produced kynurenic acid in the brain.
Topics: Adult; Aging; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bicuculline; Choline; Female; GABA-A | 2011 |
Pre- and postnatal exposure to kynurenine causes cognitive deficits in adulthood.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Chromatography, High Pressure Liquid; | 2012 |
Early developmental elevations of brain kynurenic acid impair cognitive flexibility in adults: reversal with galantamine.
Topics: Animals; Attention; Brain; Cognition; Female; Galantamine; Glutamic Acid; Kynurenic Acid; Kynurenine | 2013 |
Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice.
Topics: Animals; Behavior, Animal; Blood Chemical Analysis; Brain; Brain Chemistry; Female; Humans; Kidney; | 2004 |
Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications.
Topics: Animals; Animals, Newborn; Brain Chemistry; Cyclopropanes; Deoxycholic Acid; Drug Administration Sch | 2007 |
Therapy of side effects of oral contraceptive agents with vitamin B6.
Topics: Contraceptives, Oral; Contraceptives, Oral, Hormonal; Depressive Disorder; Dose-Response Relationshi | 1982 |
Modulation of the glutamate-evoked release of arachidonic acid from mouse cortical neurons: involvement of a pH-sensitive membrane phospholipase A2.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amiloride; A | 1995 |
N-methyl-D-aspartic acid/glycine interactions on the control of 5-hydroxytryptamine release in raphe primary cultures.
Topics: Animals; Cells, Cultured; Embryo, Mammalian; Female; Gestational Age; Glutamates; Glutamic Acid; Gly | 1993 |
Whole cell and single channel analysis of the kinetics of glycine-sensitive N-methyl-D-aspartate receptor desensitization.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Cells, Cultured; Female; Glycine; Kinetics; Kynur | 1993 |
Excitatory amino acid receptor-stimulated phosphoinositide turnover in primary cerebrocortical cultures.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Cycloleucine; Female; GTP-Binding Proteins; Kynu | 1993 |
NMDA antagonist blockade of AT8 tau immunoreactive changes in neuronal cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Dizocilpine M | 1996 |
No effect of glutamate on metabolic disturbances in hippocampal slices of mature fetal guinea pigs after transient in vitro ischemia.
Topics: Adenosine Triphosphate; Animals; Dizocilpine Maleate; Energy Metabolism; Excitatory Amino Acid Antag | 1997 |
[Kynurenic acid concentration in blood and urine during normal pregnancy].
Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Female; Humans; Kynurenic Acid; Pregnancy | 1998 |
Kynurenic acid in brain and cerebrospinal fluid of fetal, newborn, and adult sheep and effects of placental embolization.
Topics: Animals; Animals, Newborn; Brain; Brain Injuries; Embolism; Female; Fetal Hypoxia; Fetus; Kynurenic | 1999 |
[Influence of maternal smoking on kynurenic acid concentrations in umbilical cord blood].
Topics: Adult; Female; Fetal Blood; Humans; Hypoxia-Ischemia, Brain; Kynurenic Acid; Maternal Behavior; Preg | 2000 |
Regional changes in kynurenic acid, quinolinic acid, and glial fibrillary acidic protein concentrations in the fetal sheep brain after experimentally induced placental insufficiency.
Topics: Animals; Brain; Brain Chemistry; Embolism; Female; Femoral Artery; Gestational Age; Glial Fibrillary | 2001 |
Protein peroxidation processes in bovine retained and not-retained placenta.
Topics: Animals; Case-Control Studies; Cattle; Cattle Diseases; Female; Kynurenic Acid; Placenta; Placenta, | 2001 |
Kynurenine production and catabolism in fetal sheep with embolized or nonembolized placentas.
Topics: Animals; Disease Models, Animal; Embolism; Female; Fetal Blood; Fetal Diseases; Fetal Growth Retarda | 2001 |
[Influence of premature rupture of fetal membranes on kynurenic acid concentration in umbilical cord blood].
Topics: Adult; Case-Control Studies; Female; Fetal Blood; Fetal Membranes, Premature Rupture; Humans; Infant | 2001 |
Effects of pedunculopontine nucleus (PPN) stimulation on caudal pontine reticular formation (PnC) neurons in vitro.
Topics: Action Potentials; Anesthetics, Local; Animals; Carbachol; Cholinergic Agonists; Electric Stimulatio | 2002 |
Lipid biosynthesis in liver slices of the foetal guinea pig.
Topics: Acetates; Acetyl-CoA Carboxylase; Animals; ATP Citrate (pro-S)-Lyase; Fatty Acid Synthases; Fatty Ac | 1976 |
The effect of environment on tryptophan metabolism "via kynurenine" in oral contraceptives users.
Topics: Aminohippuric Acids; Contraceptives, Oral; Contraceptives, Oral, Combined; Environment; Ethinyl Estr | 1978 |
[State of interstitial metabolism of tryptophan during pregnancy and labor in women having received estrogen-progestagenic preparations].
Topics: Adult; Contraceptives, Oral; Estradiol Congeners; Female; Humans; Kynurenic Acid; Kynurenine; Labor, | 1975 |
GABA release from mouse striatal neurons in primary culture as a test for the functional activity of N-methyl-D-aspartate (NMDA) antagonists.
Topics: Animals; Cells, Cultured; Corpus Striatum; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Gly | 1991 |
Pharmacological properties of the NMDA receptor involved in somatostatin release from cortical neurons.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Female; Glutamates; Kainic Acid; Kynurenic Acid; Neurons; | 1990 |
Synaptic transmission between dorsal root ganglion and dorsal horn neurons in culture: antagonism of monosynaptic excitatory postsynaptic potentials and glutamate excitation by kynurenate.
Topics: Animals; Aspartic Acid; Cells, Cultured; Evoked Potentials; Female; Ganglia, Spinal; Glutamates; Glu | 1985 |
[On the influence of ovulation inhibitors on tryptophan metabolism in relation to vitamin B6].
Topics: Adult; Contraceptives, Oral; Female; Gestational Age; Humans; Kynurenic Acid; Kynurenine; Pregnancy; | 1968 |