kynurenic acid has been researched along with Mental Disorders in 7 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Mental Disorders: Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "For this purpose, male and female abstinent AUD patients (N = 130) and healthy controls (N = 80) were clinically evaluated for substance use and mental disorders, and blood samples were collected to determine plasma concentrations of TRP, 5-HT, KYN and kynurenic acid (KA) using high performance liquid chromatography." | 3.96 | Plasma tryptophan and kynurenine pathway metabolites in abstinent patients with alcohol use disorder and high prevalence of psychiatric comorbidity. ( Araos, P; Colado, MI; Flores-López, M; García-Marchena, N; O'Shea, E; Pavón, FJ; Requena-Ocaña, N; Rodríguez de Fonseca, F; Rubio, G; Serrano, A; Suárez, J; Vidal, R, 2020) |
| "Kynurenic acid (KYNA) is an antagonist to the α-7nACh and NMDA receptors." | 2.58 | Galantamine-Memantine Combination for Cognitive Impairments Due to Electroconvulsive Therapy, Traumatic Brain Injury, and Neurologic and Psychiatric Disorders: Kynurenic Acid and Mismatch Negativity Target Engagement. ( Koola, MM, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Araos, P | 2 |
| Vidal, R | 2 |
| O'Shea, E | 2 |
| Pedraz, M | 1 |
| García-Marchena, N | 2 |
| Serrano, A | 2 |
| Suárez, J | 2 |
| Castilla-Ortega, E | 1 |
| Ruiz, JJ | 1 |
| Campos-Cloute, R | 1 |
| Santín, LJ | 1 |
| Rodríguez de Fonseca, F | 2 |
| Pavón, FJ | 2 |
| Colado, MI | 2 |
| Requena-Ocaña, N | 1 |
| Flores-López, M | 1 |
| Rubio, G | 1 |
| Fukuwatari, T | 1 |
| Koola, MM | 1 |
| Douet, V | 1 |
| Tanizaki, N | 1 |
| Franke, A | 1 |
| Li, X | 1 |
| Chang, L | 1 |
| Erhardt, S | 2 |
| Olsson, SK | 1 |
| Engberg, G | 1 |
| Lim, CK | 1 |
| Linderholm, KR | 1 |
| Janelidze, S | 1 |
| Lindqvist, D | 1 |
| Samuelsson, M | 1 |
| Lundberg, K | 1 |
| Postolache, TT | 1 |
| Träskman-Bendz, L | 1 |
| Guillemin, GJ | 1 |
| Brundin, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of Kynurenine Pathway Metabolites in Perinatal Depression and Suicidality[NCT02566980] | 209 participants (Actual) | Observational | 2014-10-23 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for kynurenic acid and Mental Disorders
| Article | Year |
|---|---|
Possibility of Amino Acid Treatment to Prevent the Psychiatric Disorders via Modulation of the Production of Tryptophan Metabolite Kynurenic Acid.
Topics: Amino Acids; Animals; Astrocytes; Brain; Brain Diseases; Humans; Kynurenic Acid; Kynurenine; Mental | 2020 |
Galantamine-Memantine Combination for Cognitive Impairments Due to Electroconvulsive Therapy, Traumatic Brain Injury, and Neurologic and Psychiatric Disorders: Kynurenic Acid and Mismatch Negativity Target Engagement.
Topics: Animals; Cognitive Dysfunction; Drug Therapy, Combination; Electroconvulsive Therapy; Galantamine; H | 2018 |
Pharmacological manipulation of kynurenic acid: potential in the treatment of psychiatric disorders.
Topics: Animals; Cognition Disorders; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; | 2009 |
4 other studies available for kynurenic acid and Mental Disorders
| Article | Year |
|---|---|
Serotonin is the main tryptophan metabolite associated with psychiatric comorbidity in abstinent cocaine-addicted patients.
Topics: Adult; Case-Control Studies; Cocaine-Related Disorders; Comorbidity; Cross-Sectional Studies; Female | 2019 |
Plasma tryptophan and kynurenine pathway metabolites in abstinent patients with alcohol use disorder and high prevalence of psychiatric comorbidity.
Topics: Adolescent; Adult; Aged; Aging; Alcohol Abstinence; Alcoholism; Body Mass Index; Cross-Sectional Stu | 2020 |
Polymorphism of Kynurenine Pathway-Related Genes, Kynurenic Acid, and Psychopathological Symptoms in HIV.
Topics: Adult; Female; HIV Infections; Humans; Kynurenic Acid; Kynurenine; Male; Mental Disorders; Middle Ag | 2016 |
Connecting inflammation with glutamate agonism in suicidality.
Topics: Adult; Aged; Encephalitis; Excitatory Amino Acid Agonists; Female; Follow-Up Studies; Humans; Interl | 2013 |