kynurenic acid has been researched along with Hypertension in 23 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aim To compare serum concentrations of tryptophane (Trp) and its metabolites in subjects with no cardiovascular disease (CVD) and patients with СVD, including arterial hypertension (AH) and ischemic heart disease (IHD)." | 8.12 | Comparative analysis of tryptophan and downstream metabolites of the kynurenine and serotonin pathways in patients with arterial hypertension and coronary artery disease. ( Ageev, AA; Appolonova, SA; Belenkov, YN; Korobkova, EO; Kozhevnikova, MV; Krivova, AV; Moskaleva, NE; Privalova, EV; Shestakova, KM, 2022) |
| "A chronic increase in circulating angiotensin II (Ang II) activates an aldosterone-mineralocorticoid receptor-ouabain neuromodulatory pathway in the brain that increases neuronal activation in hypothalamic nuclei, such as the paraventricular nucleus (PVN) and causes progressive hypertension." | 7.79 | Central mineralocorticoid receptors and the role of angiotensin II and glutamate in the paraventricular nucleus of rats with angiotensin II-induced hypertension. ( Gabor, A; Leenen, FH, 2013) |
| "Aim To compare serum concentrations of tryptophane (Trp) and its metabolites in subjects with no cardiovascular disease (CVD) and patients with СVD, including arterial hypertension (AH) and ischemic heart disease (IHD)." | 4.12 | Comparative analysis of tryptophan and downstream metabolites of the kynurenine and serotonin pathways in patients with arterial hypertension and coronary artery disease. ( Ageev, AA; Appolonova, SA; Belenkov, YN; Korobkova, EO; Kozhevnikova, MV; Krivova, AV; Moskaleva, NE; Privalova, EV; Shestakova, KM, 2022) |
| "A chronic increase in circulating angiotensin II (Ang II) activates an aldosterone-mineralocorticoid receptor-ouabain neuromodulatory pathway in the brain that increases neuronal activation in hypothalamic nuclei, such as the paraventricular nucleus (PVN) and causes progressive hypertension." | 3.79 | Central mineralocorticoid receptors and the role of angiotensin II and glutamate in the paraventricular nucleus of rats with angiotensin II-induced hypertension. ( Gabor, A; Leenen, FH, 2013) |
| "In the present study, we investigated the effects of pretreatment with NG-nitro-L-arginine methyl ester (L-NAME) (nitric oxide synthase inhibitor) injected intravenously (IV) on the hypotension, bradycardia, and vasodilation produced by moxonidine (alpha2-adrenergic/imidazoline receptor agonist) injected into the fourth brain ventricle (4th V) in rats submitted to acute hypertension that results from baroreflex blockade by bilateral injections of kynurenic acid (kyn, glutamatergic receptor antagonist) into the nucleus of the solitary tract (NTS) or in normotensive rats." | 3.73 | Antihypertensive responses elicited by central moxonidine in rats: possible role of nitric oxide. ( Colombari, E; Menani, JV; Moreira, TS; Sato, MA; Takakura, AC, 2006) |
| "Obesity is intimately associated with hypertension; increases in blood pressure are closely related to the magnitude of weight gain." | 1.36 | Role of excitatory amino acid input in rostral ventrolateral medulla neurons in rats with obesity-induced hypertension. ( Dewa, A; Suhaimi, FW; Yusof, AP; Yusoff, NH, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (26.09) | 18.2507 |
| 2000's | 8 (34.78) | 29.6817 |
| 2010's | 8 (34.78) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Kozhevnikova, MV | 2 |
| Krivova, AV | 2 |
| Korobkova, EO | 2 |
| Ageev, AA | 2 |
| Shestakova, KM | 2 |
| Moskaleva, NE | 2 |
| Appolonova, SA | 2 |
| Privalova, EV | 2 |
| Belenkov, YN | 2 |
| Kakall, ZM | 1 |
| Pilowsky, PM | 1 |
| Farnham, MMJ | 1 |
| Gabor, A | 1 |
| Leenen, FH | 1 |
| Zhao, J | 1 |
| Wang, YK | 1 |
| Shen, D | 1 |
| Hao, Q | 1 |
| Yu, Q | 1 |
| Wu, ZT | 1 |
| Deng, Y | 1 |
| Chen, YF | 1 |
| Yuan, WJ | 1 |
| Hu, QK | 1 |
| Su, DF | 1 |
| Wang, WZ | 1 |
| Bądzyńska, B | 1 |
| Zakrocka, I | 1 |
| Sadowski, J | 1 |
| Turski, WA | 1 |
| Kompanowska-Jezierska, E | 1 |
| Suhaimi, FW | 1 |
| Yusoff, NH | 1 |
| Dewa, A | 1 |
| Yusof, AP | 1 |
| Shinohara, K | 1 |
| Hirooka, Y | 1 |
| Kishi, T | 1 |
| Sunagawa, K | 1 |
| Veitenheimer, B | 1 |
| Osborn, JW | 1 |
| Ito, S | 5 |
| Komatsu, K | 4 |
| Tsukamoto, K | 4 |
| Kanmatsuse, K | 1 |
| Sved, AF | 5 |
| Sved, JC | 1 |
| Kido, H | 1 |
| Sasaki, S | 1 |
| Oguni, A | 1 |
| Harada, S | 1 |
| Morimoto, S | 1 |
| Takeda, K | 1 |
| Nakagawa, M | 1 |
| Moreira, TS | 1 |
| Takakura, AC | 1 |
| Sato, MA | 1 |
| Menani, JV | 1 |
| Colombari, E | 1 |
| Li, DP | 1 |
| Pan, HL | 1 |
| Nakai, M | 2 |
| Tamaki, K | 2 |
| Ogata, J | 1 |
| Maeda, M | 2 |
| Amano, M | 1 |
| Asari, T | 1 |
| Kubo, T | 1 |
| Kapoor, V | 1 |
| Kapoor, R | 1 |
| Chalmers, JP | 1 |
| Bergamaschi, CT | 1 |
| Campos, RR | 1 |
| Lopes, OU | 1 |
| Mills, E | 1 |
| Minson, J | 1 |
| Drolet, G | 1 |
| Chalmers, J | 1 |
1 review available for kynurenic acid and Hypertension
| Article | Year |
|---|---|
Brainstem mechanisms of hypertension: role of the rostral ventrolateral medulla.
Topics: Angiotensin II; Animals; Baroreflex; Blood Pressure; Humans; Hypertension; Kynurenic Acid; Medulla O | 2003 |
1 trial available for kynurenic acid and Hypertension
| Article | Year |
|---|---|
Plasma kynurenic acid/tryptophan ratio: a sensitive and reliable biomarker for the assessment of renal function.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Female; Humans; Hypertension; Kidney Function Tes | 2013 |
21 other studies available for kynurenic acid and Hypertension
| Article | Year |
|---|---|
Comparative analysis of tryptophan and downstream metabolites of the kynurenine and serotonin pathways in patients with arterial hypertension and coronary artery disease.
Topics: Atherosclerosis; Coronary Artery Disease; Humans; Hydroxyindoleacetic Acid; Hypertension; Kynurenic | 2022 |
Comparative analysis of tryptophan and downstream metabolites of the kynurenine and serotonin pathways in patients with arterial hypertension and coronary artery disease.
Topics: Atherosclerosis; Coronary Artery Disease; Humans; Hydroxyindoleacetic Acid; Hypertension; Kynurenic | 2022 |
Comparative analysis of tryptophan and downstream metabolites of the kynurenine and serotonin pathways in patients with arterial hypertension and coronary artery disease.
Topics: Atherosclerosis; Coronary Artery Disease; Humans; Hydroxyindoleacetic Acid; Hypertension; Kynurenic | 2022 |
Comparative analysis of tryptophan and downstream metabolites of the kynurenine and serotonin pathways in patients with arterial hypertension and coronary artery disease.
Topics: Atherosclerosis; Coronary Artery Disease; Humans; Hydroxyindoleacetic Acid; Hypertension; Kynurenic | 2022 |
PACAP-(6-38) or kynurenate microinjections in the RVLM prevent the development of sympathetic long-term facilitation after acute intermittent hypoxia.
Topics: Acute Disease; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Hypertension | 2018 |
Central mineralocorticoid receptors and the role of angiotensin II and glutamate in the paraventricular nucleus of rats with angiotensin II-induced hypertension.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds | 2013 |
Overexpression of angiotensin-converting enzyme 2 attenuates tonically active glutamatergic input to the rostral ventrolateral medulla in hypertensive rats.
Topics: Angiotensin-Converting Enzyme 2; Animals; Blood Pressure; Disease Models, Animal; Excitatory Amino A | 2014 |
Effects of systemic administration of kynurenic acid and glycine on renal haemodynamics and excretion in normotensive and spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Diuresis; Glycine; Hemodynamics; Hypertension; Kidney; Kynurenic Acid; Male | 2014 |
Role of excitatory amino acid input in rostral ventrolateral medulla neurons in rats with obesity-induced hypertension.
Topics: Adiposity; Analysis of Variance; Animals; Blood Pressure; Body Weight; Disease Models, Animal; Dose- | 2010 |
Reduction of nitric oxide-mediated γ-amino butyric acid release in rostral ventrolateral medulla is involved in superoxide-induced sympathoexcitation of hypertensive rats.
Topics: Animals; Arterial Pressure; Bicuculline; Cyclic N-Oxides; Disease Models, Animal; Down-Regulation; E | 2012 |
Effects of intrathecal kynurenate on arterial pressure during chronic osmotic stress in conscious rats.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Blood Pressure Monitoring, Ambulatory; Consciou | 2013 |
Ventrolateral medulla AT1 receptors support blood pressure in hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Brain Stem; Dose-Response | 2002 |
Effects of angiotensin II type 1 receptor antagonist on pressor responses to pulsatile compression of the rostral ventrolateral medulla in rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Benzimida | 2004 |
Antihypertensive responses elicited by central moxonidine in rats: possible role of nitric oxide.
Topics: Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Bradycardia; Drug Interactions; Endoth | 2006 |
Glutamatergic inputs in the hypothalamic paraventricular nucleus maintain sympathetic vasomotor tone in hypertension.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Blood Pressure; Excitato | 2007 |
Metabolic and non-metabolic cerebrovasomotor mechanisms operational during hypertensive states of different origin in rats.
Topics: Animals; Baroreflex; Brain Chemistry; Cerebrovascular Circulation; Cold Temperature; Hypertension; K | 1994 |
Excitatory amino acid receptors in the rostral ventrolateral medulla mediate hypertension induced by carotid body chemoreceptor stimulation.
Topics: Animals; Blood Pressure; Carotid Body; Cordotomy; Excitatory Amino Acid Antagonists; Heart Rate; Hex | 1994 |
Altered responsiveness of medullary depressor neurones to L-glutamate and D-serine in SHR rats.
Topics: Animals; Blood Pressure; Glutamic Acid; Hypertension; Kynurenic Acid; Medulla Oblongata; Microinject | 1996 |
Rostral ventrolateral medulla : A source of sympathetic activation in rats subjected to long-term treatment with L-NAME.
Topics: Animals; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hypertension; | 1999 |
Excitatory amino acids in the rostral ventrolateral medulla support blood pressure in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Excitatory Amino Acid Antagonists; GABA Agonists; Glutamic Acid; Heart Rate | 2000 |
Tonic excitatory input to the rostral ventrolateral medulla in Dahl salt-sensitive rats.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitator | 2001 |
Tonic excitatory input to the rostral ventrolateral medulla in Dahl salt-sensitive rats.
Topics: Analysis of Variance; Animals; Blood Pressure; Brain; Excitatory Amino Acid Antagonists; Excitatory | 2001 |
Sympathetic and metabolic mechanisms of the cerebrovasomotor function of the caudal ventrolateral medulla in rats.
Topics: Animals; Blood Gas Analysis; Brain Chemistry; Cerebrovascular Circulation; Cross Circulation; Hypert | 1992 |
Effect of intrathecal amino acid receptor antagonists on basal blood pressure and pressor responses to brainstem stimulation in normotensive and hypertensive rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Blood Pressure; Brain Stem; Cerebrovascular Disor | 1990 |