kynurenic acid has been researched along with Down Syndrome in 2 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Uberos, J | 1 |
| Romero, J | 1 |
| Molina-Carballo, A | 1 |
| Muñoz-Hoyos, A | 1 |
| Baran, H | 1 |
| Cairns, N | 1 |
| Lubec, B | 1 |
| Lubec, G | 1 |
2 other studies available for kynurenic acid and Down Syndrome
| Article | Year |
|---|---|
Melatonin and elimination of kynurenines in children with Down's syndrome.
Topics: Child; Child, Preschool; Circadian Rhythm; Down Syndrome; Female; Humans; Kynurenic Acid; Kynurenine | 2010 |
Increased kynurenic acid levels and decreased brain kynurenine aminotransferase I in patients with Down syndrome.
Topics: Adult; Aged; Down Syndrome; Female; Frontal Lobe; Humans; Kynurenic Acid; Lyases; Male; Middle Aged; | 1996 |