kynurenic acid has been researched along with Delayed Effects, Prenatal Exposure in 11 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The levels of kynurenic acid (KYNA), an endogenous negative modulator of alpha7 nicotinic acetylcholine receptors (α7nAChRs), are elevated in the brains of patients with schizophrenia (SZ)." | 7.81 | Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: implications for schizophrenia. ( Bortz, DM; Bruno, JP; Fredericks, PJ; Jørgensen, CV; Leuner, B; Pershing, ML; Pocivavsek, A; Schwarcz, R; Vunck, SA, 2015) |
| "Levels of kynurenic acid (KYNA), an endogenous negative modulator of alpha 7 nicotinic acetylcholine receptors (α7nAChRs) and antagonist at glutamatergic N-methyl-D-aspartate receptors (NMDARs), are elevated in the brain of patients with schizophrenia (SZ)." | 3.83 | Prenatal kynurenine exposure in rats: age-dependent changes in NMDA receptor expression and conditioned fear responding. ( Bruno, JP; Lindquist, DH; Pershing, ML; Phenis, D; Pocivavsek, A; Schwarcz, R; Valentini, V, 2016) |
| "The levels of kynurenic acid (KYNA), an endogenous negative modulator of alpha7 nicotinic acetylcholine receptors (α7nAChRs), are elevated in the brains of patients with schizophrenia (SZ)." | 3.81 | Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: implications for schizophrenia. ( Bortz, DM; Bruno, JP; Fredericks, PJ; Jørgensen, CV; Leuner, B; Pershing, ML; Pocivavsek, A; Schwarcz, R; Vunck, SA, 2015) |
| "Kynurenic acid (KYNA) is a KP metabolite synthesized by kynurenine aminotransferases (KATs) from its biological precursor kynurenine and acts as an endogenous antagonist of N-methyl-D-aspartate and α7-nicotinic acetylcholine receptors." | 1.62 | Prenatal Kynurenine Elevation Elicits Sex-Dependent Changes in Sleep and Arousal During Adulthood: Implications for Psychotic Disorders. ( Baratta, AM; Ditty, AL; Milosavljevic, S; Mong, JA; Pocivavsek, A; Rentschler, KM; Wagner, NTJ; Wright, CJ, 2021) |
| "These results show that early protein deficiency induces selective and long-lasting changes in brain kynurenine metabolism." | 1.46 | Maternal protein restriction during gestation and lactation in the rat results in increased brain levels of kynurenine and kynurenic acid in their adult offspring. ( Aguesse, A; Bolaños-Jiménez, F; Croyal, M; de Sa Braga Oliveira, A; Ferchaud-Roucher, V; Grit, I; Honório de Melo Martimiano, P; Kaeffer, B; Lopes de Souza, S; Ouguerram, K, 2017) |
| "l-Kynurenine treatment raised forebrain KYNA levels ∼3-fold at PD2 and ∼2." | 1.39 | Early developmental elevations of brain kynurenic acid impair cognitive flexibility in adults: reversal with galantamine. ( Alexander, KS; Bruno, JP; Pershing, ML; Pocivavsek, A; Schwarcz, R; Wu, HQ, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 8 (72.73) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Beggiato, S | 1 |
| Ieraci, A | 1 |
| Tomasini, MC | 1 |
| Schwarcz, R | 8 |
| Ferraro, L | 1 |
| Rentschler, KM | 1 |
| Baratta, AM | 1 |
| Ditty, AL | 1 |
| Wagner, NTJ | 1 |
| Wright, CJ | 1 |
| Milosavljevic, S | 1 |
| Mong, JA | 1 |
| Pocivavsek, A | 6 |
| Thomas, MA | 1 |
| Elmer, GI | 2 |
| Bruno, JP | 5 |
| Zavitsanou, K | 1 |
| Lim, CK | 1 |
| Purves-Tyson, T | 1 |
| Karl, T | 1 |
| Kassiou, M | 1 |
| Banister, SD | 1 |
| Guillemin, GJ | 1 |
| Weickert, CS | 1 |
| Pershing, ML | 3 |
| Bortz, DM | 1 |
| Fredericks, PJ | 1 |
| Jørgensen, CV | 1 |
| Vunck, SA | 1 |
| Leuner, B | 1 |
| Phenis, D | 1 |
| Valentini, V | 1 |
| Lindquist, DH | 1 |
| Honório de Melo Martimiano, P | 1 |
| de Sa Braga Oliveira, A | 1 |
| Ferchaud-Roucher, V | 1 |
| Croyal, M | 1 |
| Aguesse, A | 1 |
| Grit, I | 1 |
| Ouguerram, K | 1 |
| Lopes de Souza, S | 1 |
| Kaeffer, B | 1 |
| Bolaños-Jiménez, F | 1 |
| Notarangelo, FM | 1 |
| Wu, HQ | 2 |
| Alexander, KS | 1 |
| Ceresoli-Borroni, G | 1 |
| Guidetti, P | 1 |
| Amori, L | 1 |
| Pellicciari, R | 1 |
11 other studies available for kynurenic acid and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Prenatal THC exposure raises kynurenic acid levels in the prefrontal cortex of adult rats.
Topics: Animals; Biomarkers; Dronabinol; Female; Hallucinogens; Kynurenic Acid; Male; Memory, Short-Term; Pr | 2020 |
Prenatal Kynurenine Elevation Elicits Sex-Dependent Changes in Sleep and Arousal During Adulthood: Implications for Psychotic Disorders.
Topics: Animals; Disease Models, Animal; Electroencephalography; Electromyography; Female; Kynurenic Acid; M | 2021 |
Continuous kynurenine administration during the prenatal period, but not during adolescence, causes learning and memory deficits in adult rats.
Topics: Age Factors; Animals; Avoidance Learning; Behavior, Animal; Cognition Disorders; Female; Hippocampus | 2014 |
Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: amelioration by COX-2 inhibition.
Topics: Animals; Brain; Celecoxib; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dizocilpine Maleate; | 2014 |
Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: implications for schizophrenia.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Brain; Cognition; Dendritic Spines; Die | 2015 |
Prenatal kynurenine exposure in rats: age-dependent changes in NMDA receptor expression and conditioned fear responding.
Topics: Age Factors; alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Cognition; Conditioning, Psych | 2016 |
Maternal protein restriction during gestation and lactation in the rat results in increased brain levels of kynurenine and kynurenic acid in their adult offspring.
Topics: Age Factors; Animals; Brain; Dietary Proteins; Female; Kynurenic Acid; Kynurenine; Lactation; Male; | 2017 |
Restraint Stress during Pregnancy Rapidly Raises Kynurenic Acid Levels in Mouse Placenta and Fetal Brain.
Topics: Animals; Brain; Female; Fetus; Kynurenic Acid; Mice; Placenta; Pregnancy; Prenatal Exposure Delayed | 2016 |
Pre- and postnatal exposure to kynurenine causes cognitive deficits in adulthood.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Chromatography, High Pressure Liquid; | 2012 |
Early developmental elevations of brain kynurenic acid impair cognitive flexibility in adults: reversal with galantamine.
Topics: Animals; Attention; Brain; Cognition; Female; Galantamine; Glutamic Acid; Kynurenic Acid; Kynurenine | 2013 |
Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications.
Topics: Animals; Animals, Newborn; Brain Chemistry; Cyclopropanes; Deoxycholic Acid; Drug Administration Sch | 2007 |