kynurenic acid has been researched along with Deficiency, Pyridoxine in 33 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether functional vitamin B-6 insufficiency occurs in OC users and is attributable to OCs, we investigated the associations of PLP with metabolites of one-carbon metabolism, tryptophan catabolism, and inflammation in OC users, and evaluated the effects of OCs on these metabolites." | 9.20 | Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives o ( Chi, YY; Coats, B; Gregory, JF; Midttun, Ø; Rios-Avila, L; Stacpoole, PW; Ueland, PM, 2015) |
| "To determine whether functional vitamin B-6 insufficiency occurs in OC users and is attributable to OCs, we investigated the associations of PLP with metabolites of one-carbon metabolism, tryptophan catabolism, and inflammation in OC users, and evaluated the effects of OCs on these metabolites." | 5.20 | Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives o ( Chi, YY; Coats, B; Gregory, JF; Midttun, Ø; Rios-Avila, L; Stacpoole, PW; Ueland, PM, 2015) |
| "Xanthurenic acid (XA) has been quantified in the serum of normal and vitamin B6-deficient rabbits using high performance liquid chromatography." | 1.27 | Quantitation of xanthurenic acid in rabbit serum using high performance liquid chromatography. ( Boots, LR; Cornwell, PE; Monti, JA; Williams, SA, 1984) |
| "Xanthurenic acid excretion was greater before and after a tryptophan load in -B6 than in B6R." | 1.27 | The effects of vitamin B6 deprivation with 4-deoxypyridoxine in meal-fed rats. ( Hoover-Plow, JL; Sinha, YN, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (87.88) | 18.7374 |
| 1990's | 1 (3.03) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rios-Avila, L | 3 |
| Nijhout, HF | 1 |
| Reed, MC | 1 |
| Sitren, HS | 1 |
| Gregory, JF | 3 |
| da Silva, VR | 1 |
| Lamers, Y | 1 |
| Ralat, MA | 1 |
| Midttun, Ø | 2 |
| Quinlivan, EP | 1 |
| Garrett, TJ | 1 |
| Coats, B | 2 |
| Shankar, MN | 1 |
| Percival, SS | 1 |
| Chi, YY | 2 |
| Muller, KE | 1 |
| Ueland, PM | 2 |
| Stacpoole, PW | 2 |
| KNAPP, A | 1 |
| KOWLESSAR, OD | 1 |
| HAEFFNER, LJ | 1 |
| BENSON, GD | 1 |
| ASATOOR, AM | 1 |
| Linkswiler, H | 3 |
| Miller, LT | 1 |
| Wirth, JC | 1 |
| Lohman, TG | 1 |
| Williams, SA | 1 |
| Monti, JA | 1 |
| Boots, LR | 1 |
| Cornwell, PE | 1 |
| Bermond, P | 1 |
| Shibata, K | 1 |
| Mushiage, M | 1 |
| Kondo, T | 1 |
| Hayakawa, T | 1 |
| Tsuge, H | 1 |
| Donald, EA | 1 |
| Bossé, TR | 1 |
| Jones, CL | 1 |
| Gonzalez, V | 1 |
| Yeh, JK | 1 |
| Brown, RR | 2 |
| Pierce, HI | 1 |
| McGuffin, RG | 1 |
| Hillman, RS | 1 |
| Leklem, JE | 1 |
| Rose, DP | 1 |
| Arend, RA | 1 |
| Takeuchi, F | 1 |
| Tsubouchi, R | 1 |
| Izuta, S | 1 |
| Shibata, Y | 1 |
| Okayama, A | 1 |
| Ogawa, Y | 1 |
| Goto, S | 1 |
| Yamatodani, A | 1 |
| Wada, H | 1 |
| Okuno, E | 1 |
| Takikawa, O | 1 |
| Kido, R | 2 |
| Hoover-Plow, JL | 1 |
| Sinha, YN | 1 |
| Bowman, AL | 1 |
| Travis, HF | 1 |
| Warner, RG | 1 |
| Hogue, DE | 1 |
| Shin, HK | 1 |
| Linkswiler, HM | 1 |
| Allegri, G | 1 |
| De Antoni, A | 1 |
| Chen, NC | 1 |
| Gholson, RK | 1 |
| Barlow, GB | 1 |
| Wilkinson, AW | 1 |
| Kochen, W | 1 |
| Byrd, D | 1 |
| Bühner, R | 1 |
| Bührlen, E | 1 |
| Payne, IR | 1 |
| Walsh, EM | 1 |
| Whittenburg, EJ | 1 |
| Zinsser, HH | 1 |
| Stern, F | 1 |
| Marshall, S | 1 |
| Karp, F | 1 |
| Seneca, E | 1 |
| Gursel, E | 1 |
| Yang, SS | 1 |
| Ling, KH | 1 |
| Gibbs, DA | 1 |
| Watts, RW | 1 |
| Abdel-Tawab, GA | 1 |
| Saad, AA | 1 |
| Ibrahim, EK | 1 |
| Moustafa, MH | 1 |
| Mousa, AH | 1 |
| Abdel-Wahab, AF | 1 |
| Drenick, EJ | 1 |
| Vinyard, E | 1 |
| Swendseid, ME | 1 |
| Noguchi, T | 1 |
| Kawamoto, M | 1 |
| Matsumura, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Vitamin B6 Effects on One-Carbon Metabolism[NCT01128244] | Phase 2/Phase 3 | 13 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| Vitamin B6 Dependence of One-Carbon Metabolism[NCT00877812] | 45 participants (Actual) | Interventional | 2008-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
For all subjects, the concentration of plasma cystathionine in fasting blood samples taken before and after the supplementation period will provide a functional measure of vitamin B6 nutritional status. (NCT01128244)
Timeframe: Fasting blood samples will be taken at baseline and after 28 days of vitamin B6 supplementation.
| Intervention | micromol/L (Mean) | |
|---|---|---|
| Baseline prior to vitamin supplementation | After 28-days of vitamin supplementation | |
| Plasma Cystathionine Concentration | 0.14 | 0.13 |
For all subjects, the concentration of plasma pyridoxal phosphate in fasting blood samples taken before and after the supplementation period will provide a direct measure of vitamin B6 nutritional status. (NCT01128244)
Timeframe: Fasting blood samples will be taken at baseline and after 28 days of vitamin B6 supplementation.
| Intervention | nmol/L (Mean) | |
|---|---|---|
| Baseline prior to vitamin supplementation | After 28-days of vitamin supplementation | |
| Plasma Pyridoxal Phosphate Concentration | 25.8 | 143 |
Data from analysis of serine, methionine and leucine in the timed blood samples of all subjects will provide a measurement of the metabolic rate of homocysteine remethylation from serine-derived carbon before and after vitamin B6 supplementation. These flux values may be slightly higher than flux of total homocysteine remethylation in Outcome Measure 1 because of the small contribution of methionine salvage to the flux measured in Outcome Measure 2. (NCT01128244)
Timeframe: Blood samples will be taken prior to infusion and at 0, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7.5, and 9h. Infusions will be conducted at baseline and after 28 days
| Intervention | micromol/(kg x hr) (Mean) | |
|---|---|---|
| Baseline prior to vitamin supplementation | After 28-days of vitamin supplementation | |
| Homocysteine Remethylation Flux From Serine | 6.60 | 6.92 |
For all subjects, analysis of blood samples before and after vitamin B6 supplementation will allow evaluation of discriminating biomarkers using targeted metabolite profile analysis of one-carbon metabolism and tryptophan catabolism constituents. Also, we will conduct exploratory evaluation and potential identification of new biomarkers using metabolomics analysis on subjects before and after vitamin B6 supplementation. (NCT01128244)
Timeframe: April, 2010 - June, 2014
| Intervention | microl/L (Mean) | |
|---|---|---|
| Baseline prior to vitamin supplementation | After 28-days of vitamin supplementation | |
| Secondary Analysis: Plasma 3-hydroxykynurenine Concentration | 25.9 | 27.3 |
Data from analysis of serine, methionine and leucine in the timed blood samples of all subjects will provide a measurement of the metabolic rate of total remethylation of homocysteine before and after vitamin B6 supplementation. (NCT01128244)
Timeframe: Blood samples will be taken prior to infusion and at 0, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7.5, and 9h. Infusions will be conducted at baseline and after 28 days
| Intervention | micromol/(kg x hr) (Mean) | |
|---|---|---|
| Baseline prior to vitamin supplementation | After 28-days of vitamin supplementation | |
| Total Homocysteine Remethylation Flux | 6.07 | 5.63 |
3 trials available for kynurenic acid and Deficiency, Pyridoxine
30 other studies available for kynurenic acid and Deficiency, Pyridoxine
| Article | Year |
|---|---|
A mathematical model of tryptophan metabolism via the kynurenine pathway provides insights into the effects of vitamin B-6 deficiency, tryptophan loading, and induction of tryptophan 2,3-dioxygenase on tryptophan metabolites.
Topics: Animals; Brain; Contraceptives, Oral; Female; Humans; Hydrolases; Intestines; Kynurenic Acid; Kynure | 2013 |
Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women.
Topics: Adult; Biomarkers; Creatine; Cystathionine; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine | 2013 |
[Tryptophan loading and vitamin B6 deficiency. I. Excretion of xanthurenic acid, kynurenine, trigonelline amide, and 5-hydroxyindoleacetic acid in various diseases].
Topics: Alkaloids; Amides; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kynurenic Acid; Kynurenine; | 1961 |
ABNORMAL TRYPTOPHAN METABOLISM IN PATIENTS WITH ADULT CELIAC DISEASE, WITH EVIDENCE FOR DEFICIENCY OF VITAMIN B6.
Topics: Adult; Biochemical Phenomena; Biochemistry; Celiac Disease; Dietary Proteins; Glutens; Humans; Hydro | 1964 |
PYRIDOXINE DEFICIENCY IN THE RAT PRODUCED BY D-PENICILLAMINE.
Topics: Chromatography; Kynurenic Acid; Penicillamine; Pharmacology; Rats; Research; Toxicology; Urine; Vita | 1964 |
Biochemical and physiological changes in vitamin B6 deficiency.
Topics: Alanine Transaminase; Anemia, Hypochromic; Central Nervous System Diseases; Cysteine; Erythrocytes; | 1967 |
Effect of protein intake on the development of abnormal tryptophan metabolism by men during vitamin B6 depletion.
Topics: Adult; Body Weight; Dietary Proteins; Humans; Kynurenic Acid; Kynurenine; Male; Tryptophan; Vitamin | 1967 |
Quantitation of xanthurenic acid in rabbit serum using high performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectrometry; Kynuren | 1984 |
Therapy of side effects of oral contraceptive agents with vitamin B6.
Topics: Contraceptives, Oral; Contraceptives, Oral, Hormonal; Depressive Disorder; Dose-Response Relationshi | 1982 |
Effects of vitamin B6 deficiency on the conversion ratio of tryptophan to niacin.
Topics: Animals; Diet; Feeding Behavior; Kynurenic Acid; Niacin; Niacinamide; Rats; Rats, Wistar; Tryptophan | 1995 |
The vitamin B6 requirement in oral contraceptive users. II. Assessment by tryptophan metabolites, vitamin B6, and pyridoxic acid levels in urine.
Topics: Adolescent; Adult; Contraceptives, Oral; Contraceptives, Oral, Synthetic; Female; Humans; Isonicotin | 1979 |
Pyridoxine deficiency: a new factor in diabetic neuropathy.
Topics: Adult; Aged; Diabetic Neuropathies; Female; Humans; Kynurenic Acid; Male; Middle Aged; Tryptophan; V | 1978 |
Effects of vitamin B-6 deficiency and tryptophan loading on urinary excretion of tryptophan metabolites in mammals.
Topics: Adult; Animals; Cricetinae; Diet; Female; Guinea Pigs; Humans; Kynurenic Acid; Kynurenine; Pyridoxin | 1977 |
Clinical studies in alcoholic sideroblastosis.
Topics: Adult; Aged; Alcoholism; Anemia, Sideroblastic; Chronic Disease; Diet; Erythropoiesis; Ethanol; Foli | 1976 |
Kynurenine metabolism and xanthurenic acid formation in vitamin B6-deficient rat after tryptophan injection.
Topics: Animals; Hydrolases; Kidney; Kynurenic Acid; Kynurenine; Liver; Lyases; Male; Rats; Rats, Inbred Str | 1989 |
Enzymatic studies on tryptophan metabolism disorder in rats chronically exposed to carbon disulfide.
Topics: Animals; Body Weight; Carbon Disulfide; Female; Kynurenic Acid; Lyases; Rats; Rats, Inbred Strains; | 1988 |
The effects of vitamin B6 deprivation with 4-deoxypyridoxine in meal-fed rats.
Topics: Animals; Blood Glucose; Body Weight; Feeding Behavior; Growth Hormone; Kynurenic Acid; Liver; Male; | 1985 |
Vitamin B6 requirement of the mink.
Topics: Animal Nutritional Physiological Phenomena; Animals; Diet; Female; Growth; Kynurenic Acid; Male; Min | 1968 |
Tryptophan and methionine metabolism of adult females as affected by vitamin B-6 deficiency.
Topics: Adult; Body Weight; Cystathionine; Cysteine; Dietary Proteins; Female; Homocystine; Humans; Kynureni | 1974 |
Transamination of kynurenines.
Topics: Animals; Chickens; Grasshoppers; Horses; Humans; Kidney; Kynurenic Acid; Kynurenine; Liver; Neurospo | 1974 |
An improved column chromatographic method for isolation of tryptophan metabolites.
Topics: 5-Hydroxytryptophan; Aldehydes; Amides; Animals; Chromatography, DEAE-Cellulose; Colorimetry; Hydrox | 1972 |
The effect of burns on the metabolism of tryptophan in children.
Topics: Burns; Child; Child, Preschool; Creatinine; Humans; Kynurenic Acid; Kynurenine; Oxalates; Tryptophan | 1972 |
[Proceedings: Tryptophan metabolism in untreated phenylketonuria and in vitamin B6 dependent cramps].
Topics: 3-Hydroxyanthranilic Acid; Adolescent; Adult; Carboxylic Acids; Child; Child, Preschool; Humans; Hyd | 1972 |
Relationship of dietary tryptophan and niacin to tryptophan metabolism in schizophrenics and nonschizophrenics.
Topics: Acetates; Aminohippuric Acids; Diet; Female; Humans; Hydroxyindoleacetic Acid; Indican; Indoles; Kyn | 1974 |
Urinary organic acids found in B6-deficient rats and calcium oxalate calculus patients.
Topics: Acids; Amino Acids; Animals; Calcium; Chromatography, Paper; Citrates; Coenzyme A; Folic Acid Defici | 1971 |
Excretion of kynurenic and xanthurenic acid of the mimosine intoxicatted rats after loading L-tryptophan.
Topics: Animals; Fluorometry; Kynurenic Acid; Male; Propionates; Rats; Tryptophan; Vitamin B 6 Deficiency; X | 1968 |
The action of pyridoxine in primary hyperoxaluria.
Topics: Adolescent; Adult; Child; Female; Humans; Kynurenic Acid; Kynurenine; Male; Metabolic Diseases; Mixe | 1970 |
Tryptophan metabolism in some intestinal helminthiases.
Topics: Adolescent; Adult; Aminohippuric Acids; Ancylostomiasis; Ascariasis; Humans; Indican; Intestinal Dis | 1968 |
Vitamin B6 requirements in starving obese males.
Topics: Fasting; Humans; Kynurenic Acid; Male; Obesity; Pyridoxine; Time Factors; Tryptophan; Vitamin B 6 De | 1969 |
The occurrence of 6-hydroxykynurenic acid in pyridoxine-deficient rats.
Topics: Animals; Chemical Phenomena; Chemistry; Kynurenic Acid; Rats; Vitamin B 6 Deficiency | 1966 |