kynurenic acid has been researched along with Chronic Disease in 8 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| " This stimulation induces indoleamine 2,3-dioxygenase (IDO), an enzyme that reduces the tryptophan bioavailability to synthesize serotonin." | 1.51 | Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats. ( Caso, JR; García-Bueno, B; Leza, JC; Madrigal, JLM; Martín-Hernández, D; Tendilla-Beltrán, H, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Joisten, N | 1 |
| Ruas, JL | 1 |
| Braidy, N | 1 |
| Guillemin, GJ | 1 |
| Zimmer, P | 1 |
| Martín-Hernández, D | 1 |
| Tendilla-Beltrán, H | 1 |
| Madrigal, JLM | 1 |
| García-Bueno, B | 1 |
| Leza, JC | 1 |
| Caso, JR | 1 |
| Schwieler, L | 1 |
| Larsson, MK | 1 |
| Skogh, E | 1 |
| Kegel, ME | 1 |
| Orhan, F | 1 |
| Abdelmoaty, S | 1 |
| Finn, A | 1 |
| Bhat, M | 1 |
| Samuelsson, M | 1 |
| Lundberg, K | 1 |
| Dahl, ML | 1 |
| Sellgren, C | 1 |
| Schuppe-Koistinen, I | 1 |
| Svensson, C | 1 |
| Erhardt, S | 1 |
| Engberg, G | 1 |
| Wang, WZ | 1 |
| Gao, L | 1 |
| Wang, HJ | 1 |
| Zucker, IH | 1 |
| Wang, W | 1 |
| Sun, H | 1 |
| Wang, HL | 1 |
| Wang, S | 1 |
| Guseĭnova, RS | 1 |
| Pierce, HI | 1 |
| McGuffin, RG | 1 |
| Hillman, RS | 1 |
| Heeley, AF | 1 |
| Heeley, ME | 1 |
| Hardy, J | 1 |
| Soothill, JF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Longitudinal Study of Inflammatory Pathways in Depression[NCT04159207] | 160 participants (Anticipated) | Observational | 2019-10-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for kynurenic acid and Chronic Disease
| Article | Year |
|---|---|
The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?
Topics: Chronic Disease; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2021 |
7 other studies available for kynurenic acid and Chronic Disease
| Article | Year |
|---|---|
Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats.
Topics: Animals; Antidepressive Agents; Chronic Disease; Cytokines; Frontal Lobe; Glutamate Plasma Membrane | 2019 |
Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia--significance for activation of the kynurenine pathway.
Topics: Adult; Astrocytes; Cells, Cultured; Cerebral Cortex; Chronic Disease; Female; Humans; Interleukin-6; | 2015 |
Tonic glutamatergic input in the rostral ventrolateral medulla is increased in rats with chronic heart failure.
Topics: Animals; Blood Pressure; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; | 2009 |
D-serine relieves chronic lead exposure-impaired long-term potentiation in the CA1 region of the rat hippocampus in vitro.
Topics: Animals; Chronic Disease; Environmental Exposure; Excitatory Amino Acid Antagonists; Excitatory Post | 2007 |
[Tryptophan metabolic indices in allergic dermatoses].
Topics: Chronic Disease; Dermatitis, Atopic; Female; Humans; Kynurenic Acid; Kynurenine; Male; Prurigo; Pyri | 1979 |
Clinical studies in alcoholic sideroblastosis.
Topics: Adult; Aged; Alcoholism; Anemia, Sideroblastic; Chronic Disease; Diet; Erythropoiesis; Ethanol; Foli | 1976 |
A disorder of tryptophan metabolism in chronic granulomatous disease.
Topics: Child; Child, Preschool; Chromatography, Paper; Chronic Disease; Granuloma; Humans; Infant, Newborn; | 1970 |