kynurenic acid has been researched along with Cerebral Ischemia in 21 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "046), and neopterin was associated with the combined endpoint (recurrent ischemic stroke or death) (HR 1." | 8.02 | Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke. ( Alme, KN; Askim, T; Assmus, J; Knapskog, AB; Mollnes, TE; Naik, M; Næss, H; Saltvedt, I; Ueland, PM; Ulvik, A, 2021) |
| "046), and neopterin was associated with the combined endpoint (recurrent ischemic stroke or death) (HR 1." | 4.02 | Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke. ( Alme, KN; Askim, T; Assmus, J; Knapskog, AB; Mollnes, TE; Naik, M; Næss, H; Saltvedt, I; Ueland, PM; Ulvik, A, 2021) |
| "In order to determine the role of excitatory amino acids (EAAs) in free fatty acid (FFA) liberation during cerebral ischemia, we examined the effect of in situ administration of kynurenic acid, a broad-spectrum antagonist of EAA receptors, by microdialysis on the increase in FFA levels during ischemia in the rat hippocampus." | 3.69 | Inhibition of the early phase of free fatty acid liberation during cerebral ischemia by excitatory amino acid antagonist administered by microdialysis. ( Ishikawa, K; Katayama, Y; Kawamata, T; Maeda, T; Tsubokawa, T, 1994) |
| "Hypoxic-ischemic encephalopathy (HIE) remains to be a major cause of long-term neurodevelopmental deficits in term neonates." | 1.62 | The Kynurenic Acid Analog SZR72 Enhances Neuronal Activity after Asphyxia but Is Not Neuroprotective in a Translational Model of Neonatal Hypoxic Ischemic Encephalopathy. ( Berkecz, R; Domoki, F; Körmöczi, T; Kovács, V; Pénzes, A; Remzső, G; Tóth-Szűki, V; Vécsei, L, 2021) |
| " Agonists of the glycine recognition site of NMDA receptors (D-serine and D-alanine) did not have any toxic effect in hippocampal cultures, whereas competitive blockade of the glycine site by 7-chlorokynurenic acid was neuroprotective." | 1.33 | Glycine-induced neurotoxicity in organotypic hippocampal slice cultures. ( Barth, A; Barth, L; Newell, DW; Nguyen, LB, 2005) |
| "Ten minutes of global cerebral ischemia did not modify the interaction between KAIN and KYNA." | 1.33 | Kynurenic acid attenuates NMDA-induced pial arteriolar dilation in newborn pigs. ( Bari, F; Busija, DW; Domoki, F; Guidetti, P; Nagy, K; Schwarcz, R, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 10 (47.62) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 3 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Annus, Á | 1 |
| Tömösi, F | 1 |
| Rárosi, F | 1 |
| Fehér, E | 1 |
| Janáky, T | 1 |
| Kecskeméti, G | 1 |
| Toldi, J | 2 |
| Klivényi, P | 1 |
| Sztriha, L | 1 |
| Vécsei, L | 3 |
| Alme, KN | 1 |
| Ulvik, A | 1 |
| Askim, T | 1 |
| Assmus, J | 1 |
| Mollnes, TE | 1 |
| Naik, M | 1 |
| Næss, H | 1 |
| Saltvedt, I | 1 |
| Ueland, PM | 1 |
| Knapskog, AB | 1 |
| Kovács, V | 1 |
| Remzső, G | 1 |
| Körmöczi, T | 1 |
| Berkecz, R | 1 |
| Tóth-Szűki, V | 1 |
| Pénzes, A | 1 |
| Domoki, F | 2 |
| Gellért, L | 1 |
| Fuzik, J | 1 |
| Göblös, A | 1 |
| Sárközi, K | 1 |
| Marosi, M | 1 |
| Kis, Z | 1 |
| Farkas, T | 1 |
| Szatmári, I | 1 |
| Fülöp, F | 1 |
| Carpenedo, R | 1 |
| Meli, E | 1 |
| Peruginelli, F | 1 |
| Pellegrini-Giampietro, DE | 1 |
| Moroni, F | 2 |
| Barth, A | 2 |
| Nguyen, LB | 1 |
| Barth, L | 1 |
| Newell, DW | 2 |
| Bari, F | 1 |
| Nagy, K | 1 |
| Guidetti, P | 1 |
| Schwarcz, R | 1 |
| Busija, DW | 1 |
| Malouf, AT | 1 |
| Katayama, Y | 4 |
| Kawamata, T | 1 |
| Maeda, T | 1 |
| Ishikawa, K | 1 |
| Tsubokawa, T | 4 |
| Chen, J | 1 |
| Graham, S | 1 |
| Simon, R | 1 |
| Heary, RF | 1 |
| Maniker, AH | 1 |
| Krieger, AJ | 1 |
| Sapru, HN | 1 |
| Phillis, JW | 1 |
| Song, D | 1 |
| Guyot, LL | 1 |
| O'Regan, MH | 1 |
| Obeidat, AS | 1 |
| Jarvis, CR | 2 |
| Andrew, RD | 2 |
| Anderson, TR | 1 |
| Stone, TW | 1 |
| Tamura, T | 3 |
| Becker, DP | 3 |
| Lekieffre, D | 1 |
| Ghribi, O | 1 |
| Callebert, J | 1 |
| Allix, M | 1 |
| Plotkine, M | 1 |
| Boulu, RG | 1 |
| Nozaki, K | 1 |
| Beal, MF | 1 |
| Simon, RP | 1 |
| Young, RS | 1 |
| Stout, S | 1 |
| Cheng, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Norwegian COgnitive Impairment After STroke (NorCOAST) Study[NCT02650531] | 816 participants (Actual) | Observational | 2015-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for kynurenic acid and Cerebral Ischemia
| Article | Year |
|---|---|
Kynurenic acid antagonists and kynurenine pathway inhibitors.
Topics: Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Neu | 2001 |
20 other studies available for kynurenic acid and Cerebral Ischemia
| Article | Year |
|---|---|
Kynurenic acid and kynurenine aminotransferase are potential biomarkers of early neurological improvement after thrombolytic therapy: A pilot study.
Topics: Biomarkers; Brain Ischemia; Humans; Kynurenic Acid; Pilot Projects; Stroke; Thrombolytic Therapy; Tr | 2021 |
Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke.
Topics: Aged; Biomarkers; Brain Ischemia; Cohort Studies; Female; Humans; Inflammation; Ischemic Stroke; Kyn | 2021 |
The Kynurenic Acid Analog SZR72 Enhances Neuronal Activity after Asphyxia but Is Not Neuroprotective in a Translational Model of Neonatal Hypoxic Ischemic Encephalopathy.
Topics: Animals; Asphyxia Neonatorum; Brain Ischemia; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Dise | 2021 |
Neuroprotection with a new kynurenic acid analog in the four-vessel occlusion model of ischemia.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Carotid Arteries; Cell Count; Disease Models, Anim | 2011 |
Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures.
Topics: Alanine; Animals; Brain Ischemia; Cell Death; Cell Hypoxia; Culture Media, Conditioned; Enzyme Inhib | 2002 |
Glycine-induced neurotoxicity in organotypic hippocampal slice cultures.
Topics: Alanine; Animals; Animals, Newborn; Brain Ischemia; Dose-Response Relationship, Drug; Drug Resistanc | 2005 |
Kynurenic acid attenuates NMDA-induced pial arteriolar dilation in newborn pigs.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain Ischemia; Cerebral Arteries; Disease Models, | 2006 |
Glycine site NMDA receptor antagonists provide protection against ischemia-induced neuronal damage in hippocampal slice cultures.
Topics: Animals; Brain Ischemia; Cell Death; Dizocilpine Maleate; Glycine; Glycine Agents; Hippocampus; Kynu | 1995 |
Inhibition of the early phase of free fatty acid liberation during cerebral ischemia by excitatory amino acid antagonist administered by microdialysis.
Topics: Amino Acids; Animals; Brain Ischemia; Fatty Acids, Nonesterified; Hippocampus; Kynurenic Acid; Micro | 1994 |
A study of the dose dependency of a glycine receptor antagonist in focal ischemia.
Topics: Animals; Brain; Brain Chemistry; Brain Diseases; Brain Ischemia; Disease Models, Animal; Dizocilpine | 1993 |
Cardiovascular responses to global cerebral ischemia: role of excitatory amino acids in the ventrolateral medullary pressor area.
Topics: Acetylcholine; Amino Acids; Animals; Antidiuretic Hormone Receptor Antagonists; Atropine; Blood Pres | 1993 |
Failure of kynurenic acid to inhibit amino acid release from the ischemic rat cerebral cortex.
Topics: Amino Acids; Animals; Brain Ischemia; Carotid Arteries; Cerebral Cortex; Chromatography, High Pressu | 1999 |
Glutamate does not mediate acute neuronal damage after spreading depression induced by O2/glucose deprivation in the hippocampal slice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain Ischemia; Cortical | 2000 |
Anoxic depolarization mediates acute damage independent of glutamate in neocortical brain slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Brain Ischemia; Cortical Spreading | 2001 |
Early cellular swelling during cerebral ischemia in vivo is mediated by excitatory amino acids released from nerve terminals.
Topics: Amino Acids; Animals; Brain Ischemia; Calcium; Cobalt; Dialysis; Kynurenic Acid; Nerve Endings; Perf | 1992 |
Inhibition of glutamate release in rat hippocampus by kynurenic acid does not protect CA1 cells from forebrain ischemia.
Topics: Animals; Body Temperature; Brain Ischemia; Glutamates; Glutamic Acid; Hippocampus; Kynurenic Acid; M | 1992 |
Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Dose-Response Re | 1992 |
Inhibition of rapid potassium flux during cerebral ischemia in vivo with an excitatory amino acid antagonist.
Topics: Amino Acids; Animals; Brain Ischemia; Dialysis; Female; Hippocampus; Kinetics; Kynurenic Acid; Neuro | 1991 |
Cellular swelling during cerebral ischaemia demonstrated by microdialysis in vivo: preliminary data indicating the role of excitatory amino acids.
Topics: Amino Acids; Animals; Autoradiography; Brain; Brain Ischemia; Dialysis; Female; Kynurenic Acid; Perf | 1990 |
Inhibition of excitatory neurotransmission with kynurenate reduces brain edema in neonatal anoxia.
Topics: Animals; Animals, Newborn; Aspartic Acid; Brain Edema; Brain Ischemia; Glutamates; Glutamic Acid; Hy | 1986 |