kynurenic acid has been researched along with Brain Ischemia in 21 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "046), and neopterin was associated with the combined endpoint (recurrent ischemic stroke or death) (HR 1." | 8.02 | Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke. ( Alme, KN; Askim, T; Assmus, J; Knapskog, AB; Mollnes, TE; Naik, M; Næss, H; Saltvedt, I; Ueland, PM; Ulvik, A, 2021) |
| "046), and neopterin was associated with the combined endpoint (recurrent ischemic stroke or death) (HR 1." | 4.02 | Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke. ( Alme, KN; Askim, T; Assmus, J; Knapskog, AB; Mollnes, TE; Naik, M; Næss, H; Saltvedt, I; Ueland, PM; Ulvik, A, 2021) |
| "In order to determine the role of excitatory amino acids (EAAs) in free fatty acid (FFA) liberation during cerebral ischemia, we examined the effect of in situ administration of kynurenic acid, a broad-spectrum antagonist of EAA receptors, by microdialysis on the increase in FFA levels during ischemia in the rat hippocampus." | 3.69 | Inhibition of the early phase of free fatty acid liberation during cerebral ischemia by excitatory amino acid antagonist administered by microdialysis. ( Ishikawa, K; Katayama, Y; Kawamata, T; Maeda, T; Tsubokawa, T, 1994) |
| "Hypoxic-ischemic encephalopathy (HIE) remains to be a major cause of long-term neurodevelopmental deficits in term neonates." | 1.62 | The Kynurenic Acid Analog SZR72 Enhances Neuronal Activity after Asphyxia but Is Not Neuroprotective in a Translational Model of Neonatal Hypoxic Ischemic Encephalopathy. ( Berkecz, R; Domoki, F; Körmöczi, T; Kovács, V; Pénzes, A; Remzső, G; Tóth-Szűki, V; Vécsei, L, 2021) |
| " Agonists of the glycine recognition site of NMDA receptors (D-serine and D-alanine) did not have any toxic effect in hippocampal cultures, whereas competitive blockade of the glycine site by 7-chlorokynurenic acid was neuroprotective." | 1.33 | Glycine-induced neurotoxicity in organotypic hippocampal slice cultures. ( Barth, A; Barth, L; Newell, DW; Nguyen, LB, 2005) |
| "Ten minutes of global cerebral ischemia did not modify the interaction between KAIN and KYNA." | 1.33 | Kynurenic acid attenuates NMDA-induced pial arteriolar dilation in newborn pigs. ( Bari, F; Busija, DW; Domoki, F; Guidetti, P; Nagy, K; Schwarcz, R, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 10 (47.62) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 3 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Annus, Á | 1 |
| Tömösi, F | 1 |
| Rárosi, F | 1 |
| Fehér, E | 1 |
| Janáky, T | 1 |
| Kecskeméti, G | 1 |
| Toldi, J | 2 |
| Klivényi, P | 1 |
| Sztriha, L | 1 |
| Vécsei, L | 3 |
| Alme, KN | 1 |
| Ulvik, A | 1 |
| Askim, T | 1 |
| Assmus, J | 1 |
| Mollnes, TE | 1 |
| Naik, M | 1 |
| Næss, H | 1 |
| Saltvedt, I | 1 |
| Ueland, PM | 1 |
| Knapskog, AB | 1 |
| Kovács, V | 1 |
| Remzső, G | 1 |
| Körmöczi, T | 1 |
| Berkecz, R | 1 |
| Tóth-Szűki, V | 1 |
| Pénzes, A | 1 |
| Domoki, F | 2 |
| Gellért, L | 1 |
| Fuzik, J | 1 |
| Göblös, A | 1 |
| Sárközi, K | 1 |
| Marosi, M | 1 |
| Kis, Z | 1 |
| Farkas, T | 1 |
| Szatmári, I | 1 |
| Fülöp, F | 1 |
| Carpenedo, R | 1 |
| Meli, E | 1 |
| Peruginelli, F | 1 |
| Pellegrini-Giampietro, DE | 1 |
| Moroni, F | 2 |
| Barth, A | 2 |
| Nguyen, LB | 1 |
| Barth, L | 1 |
| Newell, DW | 2 |
| Bari, F | 1 |
| Nagy, K | 1 |
| Guidetti, P | 1 |
| Schwarcz, R | 1 |
| Busija, DW | 1 |
| Malouf, AT | 1 |
| Katayama, Y | 4 |
| Kawamata, T | 1 |
| Maeda, T | 1 |
| Ishikawa, K | 1 |
| Tsubokawa, T | 4 |
| Chen, J | 1 |
| Graham, S | 1 |
| Simon, R | 1 |
| Heary, RF | 1 |
| Maniker, AH | 1 |
| Krieger, AJ | 1 |
| Sapru, HN | 1 |
| Phillis, JW | 1 |
| Song, D | 1 |
| Guyot, LL | 1 |
| O'Regan, MH | 1 |
| Obeidat, AS | 1 |
| Jarvis, CR | 2 |
| Andrew, RD | 2 |
| Anderson, TR | 1 |
| Stone, TW | 1 |
| Tamura, T | 3 |
| Becker, DP | 3 |
| Lekieffre, D | 1 |
| Ghribi, O | 1 |
| Callebert, J | 1 |
| Allix, M | 1 |
| Plotkine, M | 1 |
| Boulu, RG | 1 |
| Nozaki, K | 1 |
| Beal, MF | 1 |
| Simon, RP | 1 |
| Young, RS | 1 |
| Stout, S | 1 |
| Cheng, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Norwegian COgnitive Impairment After STroke (NorCOAST) Study[NCT02650531] | 816 participants (Actual) | Observational | 2015-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for kynurenic acid and Brain Ischemia
| Article | Year |
|---|---|
Kynurenic acid antagonists and kynurenine pathway inhibitors.
Topics: Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Neu | 2001 |
20 other studies available for kynurenic acid and Brain Ischemia
| Article | Year |
|---|---|
Kynurenic acid and kynurenine aminotransferase are potential biomarkers of early neurological improvement after thrombolytic therapy: A pilot study.
Topics: Biomarkers; Brain Ischemia; Humans; Kynurenic Acid; Pilot Projects; Stroke; Thrombolytic Therapy; Tr | 2021 |
Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke.
Topics: Aged; Biomarkers; Brain Ischemia; Cohort Studies; Female; Humans; Inflammation; Ischemic Stroke; Kyn | 2021 |
The Kynurenic Acid Analog SZR72 Enhances Neuronal Activity after Asphyxia but Is Not Neuroprotective in a Translational Model of Neonatal Hypoxic Ischemic Encephalopathy.
Topics: Animals; Asphyxia Neonatorum; Brain Ischemia; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Dise | 2021 |
Neuroprotection with a new kynurenic acid analog in the four-vessel occlusion model of ischemia.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Carotid Arteries; Cell Count; Disease Models, Anim | 2011 |
Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures.
Topics: Alanine; Animals; Brain Ischemia; Cell Death; Cell Hypoxia; Culture Media, Conditioned; Enzyme Inhib | 2002 |
Glycine-induced neurotoxicity in organotypic hippocampal slice cultures.
Topics: Alanine; Animals; Animals, Newborn; Brain Ischemia; Dose-Response Relationship, Drug; Drug Resistanc | 2005 |
Kynurenic acid attenuates NMDA-induced pial arteriolar dilation in newborn pigs.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain Ischemia; Cerebral Arteries; Disease Models, | 2006 |
Glycine site NMDA receptor antagonists provide protection against ischemia-induced neuronal damage in hippocampal slice cultures.
Topics: Animals; Brain Ischemia; Cell Death; Dizocilpine Maleate; Glycine; Glycine Agents; Hippocampus; Kynu | 1995 |
Inhibition of the early phase of free fatty acid liberation during cerebral ischemia by excitatory amino acid antagonist administered by microdialysis.
Topics: Amino Acids; Animals; Brain Ischemia; Fatty Acids, Nonesterified; Hippocampus; Kynurenic Acid; Micro | 1994 |
A study of the dose dependency of a glycine receptor antagonist in focal ischemia.
Topics: Animals; Brain; Brain Chemistry; Brain Diseases; Brain Ischemia; Disease Models, Animal; Dizocilpine | 1993 |
Cardiovascular responses to global cerebral ischemia: role of excitatory amino acids in the ventrolateral medullary pressor area.
Topics: Acetylcholine; Amino Acids; Animals; Antidiuretic Hormone Receptor Antagonists; Atropine; Blood Pres | 1993 |
Failure of kynurenic acid to inhibit amino acid release from the ischemic rat cerebral cortex.
Topics: Amino Acids; Animals; Brain Ischemia; Carotid Arteries; Cerebral Cortex; Chromatography, High Pressu | 1999 |
Glutamate does not mediate acute neuronal damage after spreading depression induced by O2/glucose deprivation in the hippocampal slice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain Ischemia; Cortical | 2000 |
Anoxic depolarization mediates acute damage independent of glutamate in neocortical brain slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Brain Ischemia; Cortical Spreading | 2001 |
Early cellular swelling during cerebral ischemia in vivo is mediated by excitatory amino acids released from nerve terminals.
Topics: Amino Acids; Animals; Brain Ischemia; Calcium; Cobalt; Dialysis; Kynurenic Acid; Nerve Endings; Perf | 1992 |
Inhibition of glutamate release in rat hippocampus by kynurenic acid does not protect CA1 cells from forebrain ischemia.
Topics: Animals; Body Temperature; Brain Ischemia; Glutamates; Glutamic Acid; Hippocampus; Kynurenic Acid; M | 1992 |
Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Dose-Response Re | 1992 |
Inhibition of rapid potassium flux during cerebral ischemia in vivo with an excitatory amino acid antagonist.
Topics: Amino Acids; Animals; Brain Ischemia; Dialysis; Female; Hippocampus; Kinetics; Kynurenic Acid; Neuro | 1991 |
Cellular swelling during cerebral ischaemia demonstrated by microdialysis in vivo: preliminary data indicating the role of excitatory amino acids.
Topics: Amino Acids; Animals; Autoradiography; Brain; Brain Ischemia; Dialysis; Female; Kynurenic Acid; Perf | 1990 |
Inhibition of excitatory neurotransmission with kynurenate reduces brain edema in neonatal anoxia.
Topics: Animals; Animals, Newborn; Aspartic Acid; Brain Edema; Brain Ischemia; Glutamates; Glutamic Acid; Hy | 1986 |