kynurenic acid has been researched along with Brain Injuries in 11 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clinical studies indicate that phenytoin prevents acute post-traumatic seizures but not subsequent post-traumatic epilepsy." | 3.78 | Interictal spikes, seizures and ictal cell death are not necessary for post-traumatic epileptogenesis in vitro. ( Berdichevsky, Y; Dzhala, V; Mail, M; Staley, KJ, 2012) |
| "Acute subdural hematoma (ASDH) gives rise to a mass effect not only by itself but also through unilateral hemispheric swelling." | 1.29 | Attenuation of hemispheric swelling associated with acute subdural hematomas by excitatory amino acid antagonist in rats. ( Hirayama, T; Kano, T; Katayama, Y; Kinoshita, K; Tsubokawa, T, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (81.82) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berdichevsky, Y | 1 |
| Dzhala, V | 1 |
| Mail, M | 1 |
| Staley, KJ | 1 |
| Suma, T | 1 |
| Koshinaga, M | 1 |
| Fukushima, M | 1 |
| Kano, T | 2 |
| Katayama, Y | 4 |
| Hicks, RR | 2 |
| Smith, DH | 3 |
| McIntosh, TK | 2 |
| Gennarelli, TA | 1 |
| McIntosh, T | 1 |
| Kinoshita, K | 1 |
| Hirayama, T | 1 |
| Tsubokawa, T | 1 |
| Okiyama, K | 1 |
| Thomas, MJ | 1 |
| Walker, DW | 1 |
| Curtis, B | 1 |
| Lacey, B | 1 |
| Nitsos, I | 1 |
| Dhillon, HS | 1 |
| Prasad, RM | 1 |
| D'Ambrosio, R | 1 |
| Maris, DO | 1 |
| Grady, MS | 1 |
| Winn, HR | 1 |
| Janigro, D | 1 |
| Becker, DP | 2 |
| Tamura, T | 1 |
| Ikezaki, K | 1 |
| Hovda, DA | 1 |
| Yoshino, A | 1 |
| Kawamata, T | 1 |
| Fineman, I | 1 |
11 other studies available for kynurenic acid and Brain Injuries
| Article | Year |
|---|---|
Interictal spikes, seizures and ictal cell death are not necessary for post-traumatic epileptogenesis in vitro.
Topics: Action Potentials; Animals; Anticonvulsants; Brain Injuries; Cell Death; Epilepsy; Excitatory Amino | 2012 |
Effects of in situ administration of excitatory amino acid antagonists on rapid microglial and astroglial reactions in rat hippocampus following traumatic brain injury.
Topics: Animals; Astrocytes; Brain Injuries; CD11b Antigen; Disease Models, Animal; Excitatory Amino Acid An | 2008 |
Temporal response and effects of excitatory amino acid antagonism on microtubule-associated protein 2 immunoreactivity following experimental brain injury in rats.
Topics: Animals; Brain Injuries; Cell Survival; Cerebral Cortex; Cytoskeleton; Excitatory Amino Acid Antagon | 1995 |
Kynurenate is neuroprotective following experimental brain injury in the rat.
Topics: Animals; Body Temperature; Brain Injuries; Cell Survival; Hippocampus; Kynurenic Acid; Male; Neurons | 1994 |
Attenuation of hemispheric swelling associated with acute subdural hematomas by excitatory amino acid antagonist in rats.
Topics: Animals; Brain Edema; Brain Injuries; Electron Transport Complex IV; Energy Metabolism; Excitatory A | 1994 |
Effects of the excitatory amino acid receptor antagonists kynurenate and indole-2-carboxylic acid on behavioral and neurochemical outcome following experimental brain injury.
Topics: Animals; Brain; Brain Injuries; Carboxylic Acids; Cations; Indoles; Kynurenic Acid; Male; Memory Dis | 1993 |
Kynurenic acid in brain and cerebrospinal fluid of fetal, newborn, and adult sheep and effects of placental embolization.
Topics: Animals; Animals, Newborn; Brain; Brain Injuries; Embolism; Female; Fetal Hypoxia; Fetus; Kynurenic | 1999 |
Kynurenate attenuates the accumulation of diacylglycerol and free fatty acids after experimental brain injury in the rat.
Topics: Analysis of Variance; Animals; Brain Injuries; Diglycerides; Drug Evaluation, Preclinical; Excitator | 1999 |
Impaired K(+) homeostasis and altered electrophysiological properties of post-traumatic hippocampal glia.
Topics: Animals; Astrocytes; Brain Injuries; Electric Stimulation; Glial Fibrillary Acidic Protein; Hippocam | 1999 |
Early cellular swelling in experimental traumatic brain injury: a phenomenon mediated by excitatory amino acids.
Topics: Amino Acids; Animals; Body Water; Brain Injuries; Female; Ions; Kynurenic Acid; Neurons; Potassium; | 1990 |
The increase in local cerebral glucose utilization following fluid percussion brain injury is prevented with kynurenic acid and is associated with an increase in calcium.
Topics: Animals; Brain; Brain Injuries; Calcium; Dialysis; Glucose; Kynurenic Acid; Male; Rats; Rats, Inbred | 1990 |