kynurenic acid has been researched along with Brain Diseases in 13 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Brain Diseases: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quinolinic acid (QUIN) is an endogenous N-methyl-D-aspartate receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction." | 1.28 | Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. ( Crowley, JS; Davis, LE; Demitrack, MA; Der, M; Dilling, LA; Elia, J; Heyes, MP; Kruesi, MJ; Lackner, A; Saito, K, 1992) |
| " The antagonistic properties of kynurenate were dose-dependent: equimolar kynurenate had no effect on quinolinate but attenuated the actions of ibotenate, kainate and NMDA; 2 x equimolar kynurenate had no effect on quinolinate or ibotenate but attenuated the toxicity of kainate and NMDA; and 3 x equimolar kynurenate had no effect on the toxicity of kainate or ibotenate, attenuated the actions of NMDA and abolished the toxic action of quinolinate." | 1.28 | A comparison of excitotoxic lesions of the basal forebrain by kainate, quinolinate, ibotenate, N-methyl-D-aspartate or quisqualate, and the effects on toxicity of 2-amino-5-phosphonovaleric acid and kynurenic acid in the rat. ( Clark, AJ; Hastings, MH; Latimer, M; Stone, TW; Winn, P, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (76.92) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Fukuwatari, T | 1 |
| Lehmann, JC | 1 |
| Procureur, D | 1 |
| Wood, PL | 1 |
| Chen, J | 1 |
| Graham, S | 1 |
| Moroni, F | 1 |
| Simon, R | 1 |
| Schwarcz, R | 6 |
| Wu, HQ | 3 |
| Ungerstedt, U | 2 |
| Lee, SC | 1 |
| Ravikumar, A | 1 |
| Deepadevi, KV | 1 |
| Arun, P | 1 |
| Manojkumar, V | 1 |
| Kurup, PA | 1 |
| Du, F | 2 |
| Schmidt, W | 1 |
| Turski, WA | 1 |
| Gramsbergen, JB | 1 |
| Okuno, E | 1 |
| Roberts, RC | 1 |
| Heyes, MP | 1 |
| Saito, K | 1 |
| Crowley, JS | 1 |
| Davis, LE | 1 |
| Demitrack, MA | 1 |
| Der, M | 1 |
| Dilling, LA | 1 |
| Elia, J | 1 |
| Kruesi, MJ | 1 |
| Lackner, A | 1 |
| Winn, P | 1 |
| Stone, TW | 1 |
| Latimer, M | 1 |
| Hastings, MH | 1 |
| Clark, AJ | 1 |
| Akaoka, H | 1 |
| Aston-Jones, G | 1 |
4 reviews available for kynurenic acid and Brain Diseases
| Article | Year |
|---|---|
Possibility of Amino Acid Treatment to Prevent the Psychiatric Disorders via Modulation of the Production of Tryptophan Metabolite Kynurenic Acid.
Topics: Amino Acids; Animals; Astrocytes; Brain; Brain Diseases; Humans; Kynurenic Acid; Kynurenine; Mental | 2020 |
Metabolism and function of brain kynurenines.
Topics: Animals; Brain; Brain Diseases; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Receptors, N-Me | 1993 |
Kynurenic acid: a potential pathogen in brain disorders.
Topics: Animals; Brain; Brain Diseases; Humans; Kynurenic Acid; Kynurenine; Lyases; Models, Neurological; Re | 1992 |
Quinolinic acid and kynurenic acid in the mammalian brain.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; AIDS Dementia Complex; Animals; Aspartic Acid; Biological Tra | 1991 |
9 other studies available for kynurenic acid and Brain Diseases
| Article | Year |
|---|---|
7-Chlorokynurenate prevents NMDA-induced and kainate-induced striatal lesions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Diseases; Choline O-Acetylt | 1993 |
A study of the dose dependency of a glycine receptor antagonist in focal ischemia.
Topics: Animals; Brain; Brain Chemistry; Brain Diseases; Brain Ischemia; Disease Models, Animal; Dizocilpine | 1993 |
L-alpha-aminoadipic acid as a regulator of kynurenic acid production in the hippocampus: a microdialysis study in freely moving rats.
Topics: 2-Aminoadipic Acid; Animals; Brain Diseases; Dialysis; Hippocampus; Kynurenic Acid; Kynurenine; Male | 1995 |
Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus.
Topics: Animals; Brain Diseases; Dialysis Solutions; Hippocampus; Injections, Intraperitoneal; Kynurenic Aci | 2000 |
Tryptophan and tyrosine catabolic pattern in neuropsychiatric disorders.
Topics: Adult; Biogenic Monoamines; Brain Diseases; Brain Neoplasms; Digoxin; Epilepsy, Generalized; Erythro | 2000 |
Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease.
Topics: Aged; Animals; Brain Diseases; Encephalitis; Female; HIV Infections; Humans; Kynurenic Acid; Kynuren | 1992 |
Regulation of kynurenic acid synthesis studied by microdialysis in the dorsal hippocampus of unanesthetized rats.
Topics: Aminooxyacetic Acid; Animals; Brain Diseases; Dialysis; Drug Interactions; Hippocampus; Kynurenic Ac | 1992 |
A comparison of excitotoxic lesions of the basal forebrain by kainate, quinolinate, ibotenate, N-methyl-D-aspartate or quisqualate, and the effects on toxicity of 2-amino-5-phosphonovaleric acid and kynurenic acid in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Diseases; Ibotenic Acid; Kainic Acid; Kynurenic A | 1991 |
Opiate withdrawal-induced hyperactivity of locus coeruleus neurons is substantially mediated by augmented excitatory amino acid input.
Topics: Amino Acids; Animals; Brain Diseases; Electric Stimulation; Glutamates; Glutamic Acid; Infusion Pump | 1991 |