kynurenic acid has been researched along with Autism Spectrum Disorder in 7 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Autism Spectrum Disorder: Wide continuum of associated cognitive and neurobehavioral disorders, including, but not limited to, three core-defining features: impairments in socialization, impairments in verbal and nonverbal communication, and restricted and repetitive patterns of behaviors. (from DSM-V)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Increasing literature highlighted alterations of tryptophan (TRP) metabolism and kynurenine (KYN) pathway in children with autism spectrum disorder (ASD)." | 8.31 | Kynurenine pathway and autism spectrum phenotypes: an investigation among adults with autism spectrum disorder and their first-degree relatives. ( Betti, L; Carmassi, C; Carpita, B; Cremone, IM; Dell'Osso, L; Giannaccini, G; Massimetti, G; Nardi, B; Palego, L, 2023) |
| "There are increasing reports about the potential role of kynurenine pathway metabolites in autism spectrum disorder (ASD)." | 8.12 | Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder. ( Abuşoğlu, S; Akça, ÖF; Baysal, T; Bilgiç, A; Oflaz, MB; Sadıç Çelikkol, Ç; Sivrikaya, A; Ünlü, A, 2022) |
| "Increasing literature highlighted alterations of tryptophan (TRP) metabolism and kynurenine (KYN) pathway in children with autism spectrum disorder (ASD)." | 4.31 | Kynurenine pathway and autism spectrum phenotypes: an investigation among adults with autism spectrum disorder and their first-degree relatives. ( Betti, L; Carmassi, C; Carpita, B; Cremone, IM; Dell'Osso, L; Giannaccini, G; Massimetti, G; Nardi, B; Palego, L, 2023) |
| "There are increasing reports about the potential role of kynurenine pathway metabolites in autism spectrum disorder (ASD)." | 4.12 | Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder. ( Abuşoğlu, S; Akça, ÖF; Baysal, T; Bilgiç, A; Oflaz, MB; Sadıç Çelikkol, Ç; Sivrikaya, A; Ünlü, A, 2022) |
| "To quantify the full range of tryptophan metabolites along the kynurenine pathway, a liquid chromatography - tandem mass spectrometry method was developed and used to analyse brain extracts of rodents treated with the kynurenine-3-mono-oxygenase (KMO) inhibitor Ro61-8048 during pregnancy." | 3.83 | Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2 ( Cobb, SR; Dalton, RN; Darlington, LG; Forrest, CM; Kennedy, PG; Rodgers, J; Stone, TW; Turner, C, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 3 (42.86) | 2.80 |
| Authors | Studies |
|---|---|
| Carpita, B | 1 |
| Nardi, B | 1 |
| Palego, L | 1 |
| Cremone, IM | 1 |
| Massimetti, G | 1 |
| Carmassi, C | 1 |
| Betti, L | 1 |
| Giannaccini, G | 1 |
| Dell'Osso, L | 1 |
| Yildirim, V | 1 |
| Simsek, S | 1 |
| Cetin, I | 1 |
| Dokuyucu, R | 1 |
| Bilgiç, A | 1 |
| Abuşoğlu, S | 1 |
| Sadıç Çelikkol, Ç | 1 |
| Oflaz, MB | 1 |
| Akça, ÖF | 1 |
| Sivrikaya, A | 1 |
| Baysal, T | 1 |
| Ünlü, A | 1 |
| Bryn, V | 2 |
| Verkerk, R | 2 |
| Skjeldal, OH | 2 |
| Saugstad, OD | 2 |
| Ormstad, H | 2 |
| Halvorsen, B | 1 |
| Isaksen, J | 1 |
| Maes, M | 1 |
| Forrest, CM | 1 |
| Kennedy, PG | 1 |
| Rodgers, J | 1 |
| Dalton, RN | 1 |
| Turner, C | 1 |
| Darlington, LG | 1 |
| Cobb, SR | 1 |
| Stone, TW | 1 |
| Gevi, F | 1 |
| Zolla, L | 1 |
| Gabriele, S | 1 |
| Persico, AM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Gut Mobilization With Oral Administration of Polyethylene Glycol (PEG) at the Dose of 6.9 g/d Once a Day for 6 Months in Chronically Constipated Autistic Children.[NCT05025553] | 21 participants (Actual) | Interventional | 2018-01-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for kynurenic acid and Autism Spectrum Disorder
| Article | Year |
|---|---|
Kynurenine pathway and autism spectrum phenotypes: an investigation among adults with autism spectrum disorder and their first-degree relatives.
Topics: Autism Spectrum Disorder; Autistic Disorder; Humans; Kynurenic Acid; Kynurenine; Phenotype; Tryptoph | 2023 |
Kynurenine, Kynurenic Acid, Quinolinic Acid and Interleukin-6 Levels in the Serum of Patients with Autism Spectrum Disorder.
Topics: Autism Spectrum Disorder; Child; Child, Preschool; Humans; Infant; Interleukin-6; Kynurenic Acid; Ky | 2023 |
Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder.
Topics: Autism Spectrum Disorder; Child, Preschool; Humans; Infant; Kynurenic Acid; Kynurenine; Tandem Mass | 2022 |
Kynurenine Pathway in Autism Spectrum Disorders in Children.
Topics: Autism Spectrum Disorder; Biomarkers; Child; Chromatography, High Pressure Liquid; Comorbidity; Fema | 2017 |
Serum Tryptophan, Tryptophan Catabolites and Brain-derived Neurotrophic Factor in Subgroups of Youngsters with Autism Spectrum Disorders.
Topics: 5-Hydroxytryptophan; Adolescent; Analysis of Variance; Autism Spectrum Disorder; Brain-Derived Neuro | 2018 |
Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2
Topics: Animals; Autism Spectrum Disorder; Brain; Chromatography, Liquid; Female; Kynurenic Acid; Kynurenine | 2016 |
Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism.
Topics: Autism Spectrum Disorder; Biomarkers; Case-Control Studies; Child; Child, Preschool; Chromatography, | 2016 |