kynurenic acid has been researched along with Aura in 33 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There was a statistically significant decrease of CSF kynurenic acid in patients with epileptic spasms compared to OND (p<0." | 8.12 | Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids. ( Antony, J; Ardern-Holmes, S; Bandodkar, S; Dale, RC; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Innes, EA; Jones, HF; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pires, AS; Tantsis, E; Troedson, C; Tsang, E; Webster, R; Wienholt, L; Yan, J, 2022) |
| "Kynurenic acid is an endogenous modulator of ionotropic glutamate receptors and a suppressor of the immune system." | 5.56 | Sensitivity of Rodent Microglia to Kynurenines in Models of Epilepsy and Inflammation In Vivo and In Vitro: Microglia Activation is Inhibited by Kynurenic Acid and the Synthetic Analogue SZR104. ( Dulka, K; Földesi, I; Fülöp, F; Gulya, K; Kata, D; Lajkó, N; Mátyás, A; Mihály, A; Szabó, M; Vécsei, L, 2020) |
| "There was a statistically significant decrease of CSF kynurenic acid in patients with epileptic spasms compared to OND (p<0." | 4.12 | Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids. ( Antony, J; Ardern-Holmes, S; Bandodkar, S; Dale, RC; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Innes, EA; Jones, HF; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pires, AS; Tantsis, E; Troedson, C; Tsang, E; Webster, R; Wienholt, L; Yan, J, 2022) |
| "Clinical studies indicate that phenytoin prevents acute post-traumatic seizures but not subsequent post-traumatic epilepsy." | 3.78 | Interictal spikes, seizures and ictal cell death are not necessary for post-traumatic epileptogenesis in vitro. ( Berdichevsky, Y; Dzhala, V; Mail, M; Staley, KJ, 2012) |
| "As a first step in the exploration of this approach, we examined the effect of 4-chloro-kynurenine (4-Cl-KYN), which is converted by astrocytes to the potent NMDA glycine-site antagonist 7-chloro-kynurenic acid (7-Cl-KYNA), on the in vivo epileptiform evoked potentials in the CA1 region of rats with chronic limbic epilepsy (CLE)." | 3.73 | In situ-produced 7-chlorokynurenate has different effects on evoked responses in rats with limbic epilepsy in comparison to naive controls. ( Bertram, EH; Schwarcz, R; Williamson, JM; Wu, HQ; Zhang, DX, 2005) |
| " Continuous microperfusion of the antagonist for the glycine binding site in NMDA receptors 5,7-dichlorokynurenic acid (100 microM) reversed the effect of both glutamate (1 mM) and glycine (1 mM) and suppressed seizures completely in 90% of the animals." | 3.71 | Effect of extracellular long-time microperfusion of high concentrations of glutamate and glycine on picrotoxin seizure thresholds in the hippocampus of freely moving rats. ( Senra-Vidal, A; Sierra-Marcuño, G; Sierra-Paredes, G, 2001) |
| "Kynurenic acid is an endogenous modulator of ionotropic glutamate receptors and a suppressor of the immune system." | 1.56 | Sensitivity of Rodent Microglia to Kynurenines in Models of Epilepsy and Inflammation In Vivo and In Vitro: Microglia Activation is Inhibited by Kynurenic Acid and the Synthetic Analogue SZR104. ( Dulka, K; Földesi, I; Fülöp, F; Gulya, K; Kata, D; Lajkó, N; Mátyás, A; Mihály, A; Szabó, M; Vécsei, L, 2020) |
| "Neuronal loss and gliosis in these animals were examined immunohistochemically." | 1.33 | Kynurenate and 7-chlorokynurenate formation in chronically epileptic rats. ( Bertram, EH; Goodman, JH; Rassoulpour, A; Scharfman, HE; Schwarcz, R; Wu, HQ, 2005) |
| "Kynurenic acid (KYNA) is an antagonist of (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors and it blocks the glycine site of the NMDA receptor preferentially (IC50 = 7." | 1.30 | Quantitative differences in the effects of de novo produced and exogenous kynurenic acid in rat brain slices. ( Hodgkins, PS; Lee, SC; Scharfman, HE; Schwarcz, R, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (12.12) | 18.7374 |
| 1990's | 14 (42.42) | 18.2507 |
| 2000's | 8 (24.24) | 29.6817 |
| 2010's | 5 (15.15) | 24.3611 |
| 2020's | 2 (6.06) | 2.80 |
| Authors | Studies |
|---|---|
| Yan, J | 1 |
| Kothur, K | 1 |
| Innes, EA | 1 |
| Han, VX | 1 |
| Jones, HF | 1 |
| Patel, S | 1 |
| Tsang, E | 1 |
| Webster, R | 1 |
| Gupta, S | 1 |
| Troedson, C | 1 |
| Menezes, MP | 1 |
| Antony, J | 1 |
| Ardern-Holmes, S | 1 |
| Tantsis, E | 1 |
| Mohammad, S | 1 |
| Wienholt, L | 1 |
| Pires, AS | 1 |
| Heng, B | 1 |
| Guillemin, GJ | 1 |
| Guller, A | 1 |
| Gill, D | 1 |
| Bandodkar, S | 1 |
| Dale, RC | 1 |
| Lajkó, N | 1 |
| Kata, D | 1 |
| Szabó, M | 1 |
| Mátyás, A | 1 |
| Dulka, K | 1 |
| Földesi, I | 1 |
| Fülöp, F | 1 |
| Gulya, K | 1 |
| Vécsei, L | 1 |
| Mihály, A | 1 |
| Wu, X | 1 |
| Muthuchamy, M | 1 |
| Reddy, DS | 1 |
| Maciejak, P | 1 |
| Szyndler, J | 1 |
| Turzyńska, D | 1 |
| Sobolewska, A | 1 |
| Kołosowska, K | 1 |
| Krząścik, P | 1 |
| Płaźnik, A | 1 |
| Berdichevsky, Y | 1 |
| Dzhala, V | 1 |
| Mail, M | 1 |
| Staley, KJ | 1 |
| Yamamura, S | 1 |
| Hoshikawa, M | 1 |
| Dai, K | 1 |
| Saito, H | 1 |
| Suzuki, N | 1 |
| Niwa, O | 1 |
| Okada, M | 1 |
| Russo, E | 1 |
| Scicchitano, F | 1 |
| Citraro, R | 1 |
| Aiello, R | 1 |
| Camastra, C | 1 |
| Mainardi, P | 1 |
| Chimirri, S | 1 |
| Perucca, E | 1 |
| Donato, G | 1 |
| De Sarro, G | 1 |
| KAWAMURA, M | 1 |
| MINOJIMA, A | 1 |
| MIZUNO, T | 1 |
| HAYASHI, H | 1 |
| SATO, I | 1 |
| OKINAKA, T | 1 |
| Rho, JM | 1 |
| Wu, HQ | 2 |
| Rassoulpour, A | 1 |
| Goodman, JH | 1 |
| Scharfman, HE | 3 |
| Bertram, EH | 2 |
| Schwarcz, R | 3 |
| Zhang, DX | 1 |
| Williamson, JM | 1 |
| Padmashri, R | 1 |
| Ganguly, A | 1 |
| Mondal, PP | 1 |
| Rajan, K | 1 |
| Sikdar, SK | 1 |
| Mikhaĭlov, IB | 1 |
| Guzeva, VI | 1 |
| Mel'nikova, NV | 1 |
| Rundfeldt, C | 1 |
| Wlaź, P | 1 |
| Löscher, W | 1 |
| Domenici, MR | 1 |
| Longo, R | 1 |
| Sagratella, S | 2 |
| Ofer, A | 1 |
| Muñóz-Hoyos, A | 1 |
| Molina-Carballo, A | 1 |
| Rodríguez-Cabezas, T | 1 |
| Uberos-Fernández, J | 1 |
| Ruiz-Cosano, C | 1 |
| Acuña-Castroviejo, D | 1 |
| Demir, R | 2 |
| Haberly, LB | 2 |
| Jackson, MB | 2 |
| Hodgkins, PS | 1 |
| Lee, SC | 1 |
| Tancredi, V | 1 |
| Biagini, G | 1 |
| D'Antuono, M | 1 |
| Louvel, J | 1 |
| Pumain, R | 1 |
| Avoli, M | 1 |
| Sierra-Paredes, G | 1 |
| Senra-Vidal, A | 1 |
| Sierra-Marcuño, G | 1 |
| Stone, TW | 3 |
| Wu, J | 1 |
| Javedan, SP | 1 |
| Ellsworth, K | 1 |
| Smith, K | 1 |
| Fisher, RS | 1 |
| Namba, T | 1 |
| Morimoto, K | 1 |
| Katayama, K | 1 |
| Inoue, K | 1 |
| Yamada, N | 1 |
| Otsuki, S | 1 |
| Wuarin, JP | 1 |
| Kim, YI | 1 |
| Cepeda, C | 1 |
| Tasker, JG | 1 |
| Walsh, JP | 1 |
| Peacock, WJ | 1 |
| Buchwald, NA | 1 |
| Dudek, FE | 1 |
| Frank, C | 1 |
| de Carolis, AS | 1 |
| Segal, MM | 1 |
| Furshpan, EJ | 1 |
| Malouf, AT | 1 |
| Robbins, CA | 1 |
| Schwartzkroin, PA | 1 |
| Schneiderman, JH | 1 |
| MacDonald, JF | 1 |
| Foster, AC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prednisolone vs. Vigabatrin in the First-line Treatment of Infantile Spasms[NCT02299115] | Phase 3 | 0 participants (Actual) | Interventional | 2017-09-05 | Withdrawn (stopped due to Most centres are now using oral steroids as 1st line treatment so question of efficacy is no longer of high interest.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for kynurenic acid and Aura
| Article | Year |
|---|---|
Basic science behind the catastrophic epilepsies.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Corticotropin-Releasing Hormone; Epilepsies | 2004 |
Kynurenic acid antagonists and kynurenine pathway inhibitors.
Topics: Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Neu | 2001 |
31 other studies available for kynurenic acid and Aura
| Article | Year |
|---|---|
Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids.
Topics: 3-Hydroxyanthranilic Acid; Adrenal Cortex Hormones; Animals; Biomarkers; Chromatography, Liquid; Epi | 2022 |
Sensitivity of Rodent Microglia to Kynurenines in Models of Epilepsy and Inflammation In Vivo and In Vitro: Microglia Activation is Inhibited by Kynurenic Acid and the Synthetic Analogue SZR104.
Topics: Animals; Calcium-Binding Proteins; Cells, Cultured; Epilepsy; Excitatory Amino Acid Antagonists; Kyn | 2020 |
Atomic force microscopy investigations of fibronectin and α5β1-integrin signaling in neuroplasticity and seizure susceptibility in experimental epilepsy.
Topics: 4-Aminopyridine; Action Potentials; Animals; Disease Models, Animal; Epilepsy; Excitatory Amino Acid | 2017 |
Is the interaction between fatty acids and tryptophan responsible for the efficacy of a ketogenic diet in epilepsy? The new hypothesis of action.
Topics: Animals; Brain; Diet, Ketogenic; Epilepsy; Fatty Acids; Hypnotics and Sedatives; Implantable Neurost | 2016 |
Interictal spikes, seizures and ictal cell death are not necessary for post-traumatic epileptogenesis in vitro.
Topics: Action Potentials; Animals; Anticonvulsants; Brain Injuries; Cell Death; Epilepsy; Excitatory Amino | 2012 |
ONO-2506 inhibits spike-wave discharges in a genetic animal model without affecting traditional convulsive tests via gliotransmission regulation.
Topics: Animals; Anticonvulsants; Astrocytes; Caprylates; Cells, Cultured; Convulsants; Disease Models, Anim | 2013 |
Protective activity of α-lactoalbumin (ALAC), a whey protein rich in tryptophan, in rodent models of epileptogenesis.
Topics: Animals; Convulsants; Epilepsy; Epilepsy, Absence; Excitatory Amino Acid Agonists; Excitatory Amino | 2012 |
[CASES OF EPILEPSY WITH SPLENOMEGALY; A NEW CONGENITAL METABOLIC DISORDER].
Topics: Adolescent; Child; Electroencephalography; Epilepsy; Humans; Kynurenic Acid; Lyases; Metabolic Disea | 1964 |
Kynurenate and 7-chlorokynurenate formation in chronically epileptic rats.
Topics: Animals; Astrocytes; Disease Models, Animal; Entorhinal Cortex; Epilepsy; Epilepsy, Temporal Lobe; E | 2005 |
In situ-produced 7-chlorokynurenate has different effects on evoked responses in rats with limbic epilepsy in comparison to naive controls.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Electroencephalography | 2005 |
Kynurenate treatment of autaptic hippocampal microcultures affect localized voltage-dependent calcium diffusion in the dendrites.
Topics: Animals; Calcium; Calcium Channels; Cells, Cultured; Dendrites; Diffusion; Epilepsy; Evoked Potentia | 2006 |
[Retardation of an experimental epileptogenic focus in the rat hippocampus by kynurenic acid].
Topics: Animals; Electrodes; Epilepsy; Excitatory Amino Acid Antagonists; Hippocampus; Kynurenic Acid; Male; | 1995 |
Anticonvulsant activity of antagonists and partial agonists for the NMDA receptor-associated glycine site in the kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Cycloserine; Differential Threshold; Epilepsy; Female; Glycine; Kindling, | 1994 |
7-chlorokynurenic acid prevents in vitro epileptiform and neurotoxic effects due to kainic acid.
Topics: Animals; Electrophysiology; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniqu | 1996 |
Pretreatment with L-kynurenine, the precursor to the excitatory amino acid antagonist kynurenic acid, suppresses epileptiform activity in combined entorhinal/hippocampal slices.
Topics: Animals; Anticonvulsants; Buffers; Electrophysiology; Entorhinal Cortex; Epilepsy; Excitatory Amino | 1997 |
Relationships between methoxyindole and kynurenine pathway metabolites in plasma and urine in children suffering from febrile and epileptic seizures.
Topics: 3-Hydroxyanthranilic Acid; Child; Child, Preschool; Circadian Rhythm; Epilepsy; Female; Humans; Infa | 1997 |
Sustained and accelerating activity at two discrete sites generate epileptiform discharges in slices of piriform cortex.
Topics: Animals; Electric Stimulation; Electrophysiology; Epilepsy; Excitatory Amino Acid Antagonists; Fluor | 1999 |
Quantitative differences in the effects of de novo produced and exogenous kynurenic acid in rat brain slices.
Topics: Animals; Buffers; Entorhinal Cortex; Epilepsy; Evoked Potentials; Excitatory Amino Acid Antagonists; | 1999 |
Sustained plateau activity precedes and can generate ictal-like discharges in low-Cl(-) medium in slices from rat piriform cortex.
Topics: Animals; Cerebral Cortex; Chlorides; Culture Media; Electric Stimulation; Electrophysiology; Epileps | 1999 |
Spindle-like thalamocortical synchronization in a rat brain slice preparation.
Topics: 4-Aminopyridine; Animals; Barbiturates; Cerebral Cortex; Cortical Synchronization; Electric Stimulat | 2000 |
Effect of extracellular long-time microperfusion of high concentrations of glutamate and glycine on picrotoxin seizure thresholds in the hippocampus of freely moving rats.
Topics: Animals; Epilepsy; Excitatory Amino Acid Antagonists; Extracellular Space; GABA Antagonists; Glutami | 2001 |
Gamma oscillation underlies hyperthermia-induced epileptiform-like spikes in immature rat hippocampal slices.
Topics: Action Potentials; Anesthetics, Local; Animals; Biological Clocks; Cortical Spreading Depression; El | 2001 |
Effects of strychnine-insensitive glycine receptor antagonist (7-chlorokynurenic acid) on amygdala kindling in rats.
Topics: Amygdala; Analysis of Variance; Animals; Epilepsy; Kindling, Neurologic; Kynurenic Acid; Male; Rats; | 1992 |
Sensitivity of hippocampal neurones to kainic acid, and antagonism by kynurenate.
Topics: Animals; Colchicine; Epilepsy; Hippocampus; In Vitro Techniques; Iontophoresis; Kainic Acid; Kynuren | 1990 |
Synaptic transmission in human neocortex removed for treatment of intractable epilepsy in children.
Topics: 2-Amino-5-phosphonovalerate; Adolescent; Bicuculline; Child; Child, Preschool; Epilepsy; Female; GAB | 1990 |
Inhibitory influence of excitatory amino acid antagonists on penicillin-induced epileptiform bursting in rat hippocampal slices.
Topics: Amino Acids; Animals; Anticonvulsants; Dibenzocycloheptenes; Dizocilpine Maleate; Electric Stimulati | 1990 |
Epileptiform activity in microcultures containing small numbers of hippocampal neurons.
Topics: Animals; Animals, Newborn; Baclofen; Bicuculline; Cells, Cultured; Epilepsy; Evoked Potentials; Hipp | 1990 |
Epileptiform activity in hippocampal slice cultures with normal inhibitory synaptic drive.
Topics: Action Potentials; Animals; Epilepsy; Hippocampus; In Vitro Techniques; Kynurenic Acid; Neural Inhib | 1990 |
Excitatory amino acid blockers differentially affect bursting of in vitro hippocampal neurons in two pharmacological models of epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Epilepsy; Guinea Pigs; Hippocampus; In Vitr | 1989 |
Comparison of kynurenic acid and 2-APV suppression of epileptiform activity in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dose-Response Relationship, Drug; Electrophysiology; Epilepsy; | 1988 |
Involvement of excitatory amino acid receptors in the mechanisms underlying excitotoxic phenomena.
Topics: Action Potentials; Amino Acids, Dicarboxylic; Animals; Cell Survival; Dendrites; Epilepsy; Kynurenic | 1986 |