Page last updated: 2024-10-30

kynurenic acid and Aura

kynurenic acid has been researched along with Aura in 33 studies

Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.

Research Excerpts

ExcerptRelevanceReference
"There was a statistically significant decrease of CSF kynurenic acid in patients with epileptic spasms compared to OND (p<0."8.12Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids. ( Antony, J; Ardern-Holmes, S; Bandodkar, S; Dale, RC; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Innes, EA; Jones, HF; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pires, AS; Tantsis, E; Troedson, C; Tsang, E; Webster, R; Wienholt, L; Yan, J, 2022)
"Kynurenic acid is an endogenous modulator of ionotropic glutamate receptors and a suppressor of the immune system."5.56Sensitivity of Rodent Microglia to Kynurenines in Models of Epilepsy and Inflammation In Vivo and In Vitro: Microglia Activation is Inhibited by Kynurenic Acid and the Synthetic Analogue SZR104. ( Dulka, K; Földesi, I; Fülöp, F; Gulya, K; Kata, D; Lajkó, N; Mátyás, A; Mihály, A; Szabó, M; Vécsei, L, 2020)
"There was a statistically significant decrease of CSF kynurenic acid in patients with epileptic spasms compared to OND (p<0."4.12Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids. ( Antony, J; Ardern-Holmes, S; Bandodkar, S; Dale, RC; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Innes, EA; Jones, HF; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pires, AS; Tantsis, E; Troedson, C; Tsang, E; Webster, R; Wienholt, L; Yan, J, 2022)
"Clinical studies indicate that phenytoin prevents acute post-traumatic seizures but not subsequent post-traumatic epilepsy."3.78Interictal spikes, seizures and ictal cell death are not necessary for post-traumatic epileptogenesis in vitro. ( Berdichevsky, Y; Dzhala, V; Mail, M; Staley, KJ, 2012)
"As a first step in the exploration of this approach, we examined the effect of 4-chloro-kynurenine (4-Cl-KYN), which is converted by astrocytes to the potent NMDA glycine-site antagonist 7-chloro-kynurenic acid (7-Cl-KYNA), on the in vivo epileptiform evoked potentials in the CA1 region of rats with chronic limbic epilepsy (CLE)."3.73In situ-produced 7-chlorokynurenate has different effects on evoked responses in rats with limbic epilepsy in comparison to naive controls. ( Bertram, EH; Schwarcz, R; Williamson, JM; Wu, HQ; Zhang, DX, 2005)
" Continuous microperfusion of the antagonist for the glycine binding site in NMDA receptors 5,7-dichlorokynurenic acid (100 microM) reversed the effect of both glutamate (1 mM) and glycine (1 mM) and suppressed seizures completely in 90% of the animals."3.71Effect of extracellular long-time microperfusion of high concentrations of glutamate and glycine on picrotoxin seizure thresholds in the hippocampus of freely moving rats. ( Senra-Vidal, A; Sierra-Marcuño, G; Sierra-Paredes, G, 2001)
"Kynurenic acid is an endogenous modulator of ionotropic glutamate receptors and a suppressor of the immune system."1.56Sensitivity of Rodent Microglia to Kynurenines in Models of Epilepsy and Inflammation In Vivo and In Vitro: Microglia Activation is Inhibited by Kynurenic Acid and the Synthetic Analogue SZR104. ( Dulka, K; Földesi, I; Fülöp, F; Gulya, K; Kata, D; Lajkó, N; Mátyás, A; Mihály, A; Szabó, M; Vécsei, L, 2020)
"Neuronal loss and gliosis in these animals were examined immunohistochemically."1.33Kynurenate and 7-chlorokynurenate formation in chronically epileptic rats. ( Bertram, EH; Goodman, JH; Rassoulpour, A; Scharfman, HE; Schwarcz, R; Wu, HQ, 2005)
"Kynurenic acid (KYNA) is an antagonist of (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors and it blocks the glycine site of the NMDA receptor preferentially (IC50 = 7."1.30Quantitative differences in the effects of de novo produced and exogenous kynurenic acid in rat brain slices. ( Hodgkins, PS; Lee, SC; Scharfman, HE; Schwarcz, R, 1999)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19904 (12.12)18.7374
1990's14 (42.42)18.2507
2000's8 (24.24)29.6817
2010's5 (15.15)24.3611
2020's2 (6.06)2.80

Authors

AuthorsStudies
Yan, J1
Kothur, K1
Innes, EA1
Han, VX1
Jones, HF1
Patel, S1
Tsang, E1
Webster, R1
Gupta, S1
Troedson, C1
Menezes, MP1
Antony, J1
Ardern-Holmes, S1
Tantsis, E1
Mohammad, S1
Wienholt, L1
Pires, AS1
Heng, B1
Guillemin, GJ1
Guller, A1
Gill, D1
Bandodkar, S1
Dale, RC1
Lajkó, N1
Kata, D1
Szabó, M1
Mátyás, A1
Dulka, K1
Földesi, I1
Fülöp, F1
Gulya, K1
Vécsei, L1
Mihály, A1
Wu, X1
Muthuchamy, M1
Reddy, DS1
Maciejak, P1
Szyndler, J1
Turzyńska, D1
Sobolewska, A1
Kołosowska, K1
Krząścik, P1
Płaźnik, A1
Berdichevsky, Y1
Dzhala, V1
Mail, M1
Staley, KJ1
Yamamura, S1
Hoshikawa, M1
Dai, K1
Saito, H1
Suzuki, N1
Niwa, O1
Okada, M1
Russo, E1
Scicchitano, F1
Citraro, R1
Aiello, R1
Camastra, C1
Mainardi, P1
Chimirri, S1
Perucca, E1
Donato, G1
De Sarro, G1
KAWAMURA, M1
MINOJIMA, A1
MIZUNO, T1
HAYASHI, H1
SATO, I1
OKINAKA, T1
Rho, JM1
Wu, HQ2
Rassoulpour, A1
Goodman, JH1
Scharfman, HE3
Bertram, EH2
Schwarcz, R3
Zhang, DX1
Williamson, JM1
Padmashri, R1
Ganguly, A1
Mondal, PP1
Rajan, K1
Sikdar, SK1
Mikhaĭlov, IB1
Guzeva, VI1
Mel'nikova, NV1
Rundfeldt, C1
Wlaź, P1
Löscher, W1
Domenici, MR1
Longo, R1
Sagratella, S2
Ofer, A1
Muñóz-Hoyos, A1
Molina-Carballo, A1
Rodríguez-Cabezas, T1
Uberos-Fernández, J1
Ruiz-Cosano, C1
Acuña-Castroviejo, D1
Demir, R2
Haberly, LB2
Jackson, MB2
Hodgkins, PS1
Lee, SC1
Tancredi, V1
Biagini, G1
D'Antuono, M1
Louvel, J1
Pumain, R1
Avoli, M1
Sierra-Paredes, G1
Senra-Vidal, A1
Sierra-Marcuño, G1
Stone, TW3
Wu, J1
Javedan, SP1
Ellsworth, K1
Smith, K1
Fisher, RS1
Namba, T1
Morimoto, K1
Katayama, K1
Inoue, K1
Yamada, N1
Otsuki, S1
Wuarin, JP1
Kim, YI1
Cepeda, C1
Tasker, JG1
Walsh, JP1
Peacock, WJ1
Buchwald, NA1
Dudek, FE1
Frank, C1
de Carolis, AS1
Segal, MM1
Furshpan, EJ1
Malouf, AT1
Robbins, CA1
Schwartzkroin, PA1
Schneiderman, JH1
MacDonald, JF1
Foster, AC1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prednisolone vs. Vigabatrin in the First-line Treatment of Infantile Spasms[NCT02299115]Phase 30 participants (Actual)Interventional2017-09-05Withdrawn (stopped due to Most centres are now using oral steroids as 1st line treatment so question of efficacy is no longer of high interest.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for kynurenic acid and Aura

ArticleYear
Basic science behind the catastrophic epilepsies.
    Epilepsia, 2004, Volume: 45 Suppl 5

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Corticotropin-Releasing Hormone; Epilepsies

2004
Kynurenic acid antagonists and kynurenine pathway inhibitors.
    Expert opinion on investigational drugs, 2001, Volume: 10, Issue:4

    Topics: Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Neu

2001

Other Studies

31 other studies available for kynurenic acid and Aura

ArticleYear
Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids.
    EBioMedicine, 2022, Volume: 84

    Topics: 3-Hydroxyanthranilic Acid; Adrenal Cortex Hormones; Animals; Biomarkers; Chromatography, Liquid; Epi

2022
Sensitivity of Rodent Microglia to Kynurenines in Models of Epilepsy and Inflammation In Vivo and In Vitro: Microglia Activation is Inhibited by Kynurenic Acid and the Synthetic Analogue SZR104.
    International journal of molecular sciences, 2020, Dec-07, Volume: 21, Issue:23

    Topics: Animals; Calcium-Binding Proteins; Cells, Cultured; Epilepsy; Excitatory Amino Acid Antagonists; Kyn

2020
Atomic force microscopy investigations of fibronectin and α5β1-integrin signaling in neuroplasticity and seizure susceptibility in experimental epilepsy.
    Epilepsy research, 2017, Volume: 138

    Topics: 4-Aminopyridine; Action Potentials; Animals; Disease Models, Animal; Epilepsy; Excitatory Amino Acid

2017
Is the interaction between fatty acids and tryptophan responsible for the efficacy of a ketogenic diet in epilepsy? The new hypothesis of action.
    Neuroscience, 2016, Jan-28, Volume: 313

    Topics: Animals; Brain; Diet, Ketogenic; Epilepsy; Fatty Acids; Hypnotics and Sedatives; Implantable Neurost

2016
Interictal spikes, seizures and ictal cell death are not necessary for post-traumatic epileptogenesis in vitro.
    Neurobiology of disease, 2012, Volume: 45, Issue:2

    Topics: Action Potentials; Animals; Anticonvulsants; Brain Injuries; Cell Death; Epilepsy; Excitatory Amino

2012
ONO-2506 inhibits spike-wave discharges in a genetic animal model without affecting traditional convulsive tests via gliotransmission regulation.
    British journal of pharmacology, 2013, Volume: 168, Issue:5

    Topics: Animals; Anticonvulsants; Astrocytes; Caprylates; Cells, Cultured; Convulsants; Disease Models, Anim

2013
Protective activity of α-lactoalbumin (ALAC), a whey protein rich in tryptophan, in rodent models of epileptogenesis.
    Neuroscience, 2012, Dec-13, Volume: 226

    Topics: Animals; Convulsants; Epilepsy; Epilepsy, Absence; Excitatory Amino Acid Agonists; Excitatory Amino

2012
[CASES OF EPILEPSY WITH SPLENOMEGALY; A NEW CONGENITAL METABOLIC DISORDER].
    Nihon Shonika Gakkai zasshi. Acta paediatrica Japonica, 1964, Volume: 68

    Topics: Adolescent; Child; Electroencephalography; Epilepsy; Humans; Kynurenic Acid; Lyases; Metabolic Disea

1964
Kynurenate and 7-chlorokynurenate formation in chronically epileptic rats.
    Epilepsia, 2005, Volume: 46, Issue:7

    Topics: Animals; Astrocytes; Disease Models, Animal; Entorhinal Cortex; Epilepsy; Epilepsy, Temporal Lobe; E

2005
In situ-produced 7-chlorokynurenate has different effects on evoked responses in rats with limbic epilepsy in comparison to naive controls.
    Epilepsia, 2005, Volume: 46, Issue:11

    Topics: Animals; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Electroencephalography

2005
Kynurenate treatment of autaptic hippocampal microcultures affect localized voltage-dependent calcium diffusion in the dendrites.
    Cell calcium, 2006, Volume: 39, Issue:3

    Topics: Animals; Calcium; Calcium Channels; Cells, Cultured; Dendrites; Diffusion; Epilepsy; Evoked Potentia

2006
[Retardation of an experimental epileptogenic focus in the rat hippocampus by kynurenic acid].
    Biulleten' eksperimental'noi biologii i meditsiny, 1995, Volume: 119, Issue:5

    Topics: Animals; Electrodes; Epilepsy; Excitatory Amino Acid Antagonists; Hippocampus; Kynurenic Acid; Male;

1995
Anticonvulsant activity of antagonists and partial agonists for the NMDA receptor-associated glycine site in the kindling model of epilepsy.
    Brain research, 1994, Aug-08, Volume: 653, Issue:1-2

    Topics: Animals; Anticonvulsants; Cycloserine; Differential Threshold; Epilepsy; Female; Glycine; Kindling,

1994
7-chlorokynurenic acid prevents in vitro epileptiform and neurotoxic effects due to kainic acid.
    General pharmacology, 1996, Volume: 27, Issue:1

    Topics: Animals; Electrophysiology; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniqu

1996
Pretreatment with L-kynurenine, the precursor to the excitatory amino acid antagonist kynurenic acid, suppresses epileptiform activity in combined entorhinal/hippocampal slices.
    Neuroscience letters, 1997, Mar-14, Volume: 224, Issue:2

    Topics: Animals; Anticonvulsants; Buffers; Electrophysiology; Entorhinal Cortex; Epilepsy; Excitatory Amino

1997
Relationships between methoxyindole and kynurenine pathway metabolites in plasma and urine in children suffering from febrile and epileptic seizures.
    Clinical endocrinology, 1997, Volume: 47, Issue:6

    Topics: 3-Hydroxyanthranilic Acid; Child; Child, Preschool; Circadian Rhythm; Epilepsy; Female; Humans; Infa

1997
Sustained and accelerating activity at two discrete sites generate epileptiform discharges in slices of piriform cortex.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Feb-15, Volume: 19, Issue:4

    Topics: Animals; Electric Stimulation; Electrophysiology; Epilepsy; Excitatory Amino Acid Antagonists; Fluor

1999
Quantitative differences in the effects of de novo produced and exogenous kynurenic acid in rat brain slices.
    Neuroscience letters, 1999, Oct-22, Volume: 274, Issue:2

    Topics: Animals; Buffers; Entorhinal Cortex; Epilepsy; Evoked Potentials; Excitatory Amino Acid Antagonists;

1999
Sustained plateau activity precedes and can generate ictal-like discharges in low-Cl(-) medium in slices from rat piriform cortex.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Dec-15, Volume: 19, Issue:24

    Topics: Animals; Cerebral Cortex; Chlorides; Culture Media; Electric Stimulation; Electrophysiology; Epileps

1999
Spindle-like thalamocortical synchronization in a rat brain slice preparation.
    Journal of neurophysiology, 2000, Volume: 84, Issue:2

    Topics: 4-Aminopyridine; Animals; Barbiturates; Cerebral Cortex; Cortical Synchronization; Electric Stimulat

2000
Effect of extracellular long-time microperfusion of high concentrations of glutamate and glycine on picrotoxin seizure thresholds in the hippocampus of freely moving rats.
    Brain research, 2001, Jan-05, Volume: 888, Issue:1

    Topics: Animals; Epilepsy; Excitatory Amino Acid Antagonists; Extracellular Space; GABA Antagonists; Glutami

2001
Gamma oscillation underlies hyperthermia-induced epileptiform-like spikes in immature rat hippocampal slices.
    BMC neuroscience, 2001, Volume: 2

    Topics: Action Potentials; Anesthetics, Local; Animals; Biological Clocks; Cortical Spreading Depression; El

2001
Effects of strychnine-insensitive glycine receptor antagonist (7-chlorokynurenic acid) on amygdala kindling in rats.
    The Japanese journal of psychiatry and neurology, 1992, Volume: 46, Issue:2

    Topics: Amygdala; Analysis of Variance; Animals; Epilepsy; Kindling, Neurologic; Kynurenic Acid; Male; Rats;

1992
Sensitivity of hippocampal neurones to kainic acid, and antagonism by kynurenate.
    British journal of pharmacology, 1990, Volume: 101, Issue:4

    Topics: Animals; Colchicine; Epilepsy; Hippocampus; In Vitro Techniques; Iontophoresis; Kainic Acid; Kynuren

1990
Synaptic transmission in human neocortex removed for treatment of intractable epilepsy in children.
    Annals of neurology, 1990, Volume: 28, Issue:4

    Topics: 2-Amino-5-phosphonovalerate; Adolescent; Bicuculline; Child; Child, Preschool; Epilepsy; Female; GAB

1990
Inhibitory influence of excitatory amino acid antagonists on penicillin-induced epileptiform bursting in rat hippocampal slices.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 35, Issue:4

    Topics: Amino Acids; Animals; Anticonvulsants; Dibenzocycloheptenes; Dizocilpine Maleate; Electric Stimulati

1990
Epileptiform activity in microcultures containing small numbers of hippocampal neurons.
    Journal of neurophysiology, 1990, Volume: 64, Issue:5

    Topics: Animals; Animals, Newborn; Baclofen; Bicuculline; Cells, Cultured; Epilepsy; Evoked Potentials; Hipp

1990
Epileptiform activity in hippocampal slice cultures with normal inhibitory synaptic drive.
    Neuroscience letters, 1990, Jan-01, Volume: 108, Issue:1-2

    Topics: Action Potentials; Animals; Epilepsy; Hippocampus; In Vitro Techniques; Kynurenic Acid; Neural Inhib

1990
Excitatory amino acid blockers differentially affect bursting of in vitro hippocampal neurons in two pharmacological models of epilepsy.
    Neuroscience, 1989, Volume: 31, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Epilepsy; Guinea Pigs; Hippocampus; In Vitr

1989
Comparison of kynurenic acid and 2-APV suppression of epileptiform activity in rat hippocampal slices.
    Neuroscience letters, 1988, Jan-22, Volume: 84, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Dose-Response Relationship, Drug; Electrophysiology; Epilepsy;

1988
Involvement of excitatory amino acid receptors in the mechanisms underlying excitotoxic phenomena.
    Advances in experimental medicine and biology, 1986, Volume: 203

    Topics: Action Potentials; Amino Acids, Dicarboxylic; Animals; Cell Survival; Dendrites; Epilepsy; Kynurenic

1986