kynurenic acid has been researched along with Anoxemia in 29 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Activation of the kynurenine pathway (KP) has been reported in patients with pulmonary arterial hypertension (PAH) undergoing PAH therapy." | 8.12 | Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα. ( Boersma, E; Boomars, KA; Cai, Z; de Rijke, YB; Duncker, DJ; Geenen, LW; Guignabert, C; Kema, I; Klein, T; Koudstaal, T; Merkus, D; Reiss, IKM; Tian, S; Tran-Lundmark, K; Tu, L; van den Bosch, AE; van der Ley, C; Van Faassen, M, 2022) |
| "The neuroprotective potential of an antagonist (7-chlorokynurenic acid (7-CIKYNA)) and a low efficacy partial agonist (HA-966) for the glycine modulatory site on the N-methyl-D-aspartate (NMDA) receptor complex has been examined using a neuronal cell culture/hypoxia model of neurodegeneration." | 7.68 | The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures. ( Horne, AL; Kemp, JA; McKernan, RM; Priestley, T, 1990) |
| " Microinjection of kynurenic acid (an ionotropic receptor antagonist of excitatory amino acids) and l-NAME (a non-selective NO synthase inhibitor) elicited increases in the ventilatory response to hypoxia and hypercarbia." | 4.82 | Nucleus isthmi and control of breathing in amphibians. ( Branco, LG; Gargaglioni, LH, 2004) |
| "Activation of the kynurenine pathway (KP) has been reported in patients with pulmonary arterial hypertension (PAH) undergoing PAH therapy." | 4.12 | Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα. ( Boersma, E; Boomars, KA; Cai, Z; de Rijke, YB; Duncker, DJ; Geenen, LW; Guignabert, C; Kema, I; Klein, T; Koudstaal, T; Merkus, D; Reiss, IKM; Tian, S; Tran-Lundmark, K; Tu, L; van den Bosch, AE; van der Ley, C; Van Faassen, M, 2022) |
| " Since LC contains glutamatergic receptors and L-glutamate is known to participate in the ventilatory and thermoregulatory responses to hypoxia, the effects of kynurenic acid (KYN, a glutamatergic receptor antagonist) microinjected into the LC in the hypoxic hyperventilation and anapyrexia (a regulated drop in body temperature [Tb]) were examined." | 3.72 | Role of L-glutamate in the locus coeruleus of rats in hypoxia-induced hyperventilation and anapyrexia. ( Branco, LG; de Paula, PM; Ferreira, CM, 2004) |
| " During peripheral chemoreceptor stimulation by hypoxia (10% O2 for 30 min) or doxapram (Dox) infusion (2 mg kg-1 (30 min)-1), ventilation was recorded and successively, under the same conditions, the extracellular Glut concentration ([Glut]o) in the caudal NTS was measured by in vivo microdialysis." | 3.69 | In vivo release of glutamate in nucleus tractus solitarii of the rat during hypoxia. ( Hida, W; Kikuchi, Y; Kurosawa, H; Mizusawa, A; Ogawa, H; Okabe, S; Shirato, K; Takishima, T, 1994) |
| "The neuroprotective potential of an antagonist (7-chlorokynurenic acid (7-CIKYNA)) and a low efficacy partial agonist (HA-966) for the glycine modulatory site on the N-methyl-D-aspartate (NMDA) receptor complex has been examined using a neuronal cell culture/hypoxia model of neurodegeneration." | 3.68 | The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures. ( Horne, AL; Kemp, JA; McKernan, RM; Priestley, T, 1990) |
| "Brief anoxia (3 min) abolished EPSPs but reduced IPSPs by 64." | 1.29 | Anoxia selectively depresses excitatory synaptic transmission in hippocampal slices. ( Krnjević, K; Zhu, PJ, 1994) |
| " The dose-response effects of glutamate and serine were studied on the population spikes evoked in the granular cell layer." | 1.29 | Serine released from hippocampal slices during deprivation of oxygen and glucose enhances the effects of glutamate on neuronal function. ( Hirai, H; Okada, Y, 1993) |
| "Kynurenic acid (300 mg/kg) was administered i." | 1.27 | The excitatory amino acid antagonist kynurenic acid administered after hypoxic-ischemia in neonatal rats offers neuroprotection. ( Andiné, P; Ellrén, K; Hagberg, H; Kjellmer, I; Lehmann, A; Nielsen, T; Wennberg, E, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.45) | 18.7374 |
| 1990's | 9 (31.03) | 18.2507 |
| 2000's | 11 (37.93) | 29.6817 |
| 2010's | 5 (17.24) | 24.3611 |
| 2020's | 3 (10.34) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, Z | 1 |
| Tian, S | 1 |
| Klein, T | 1 |
| Tu, L | 1 |
| Geenen, LW | 1 |
| Koudstaal, T | 1 |
| van den Bosch, AE | 1 |
| de Rijke, YB | 1 |
| Reiss, IKM | 1 |
| Boersma, E | 1 |
| van der Ley, C | 1 |
| Van Faassen, M | 1 |
| Kema, I | 1 |
| Duncker, DJ | 1 |
| Boomars, KA | 1 |
| Tran-Lundmark, K | 1 |
| Guignabert, C | 1 |
| Merkus, D | 1 |
| Bigelman, E | 1 |
| Pasmanik-Chor, M | 1 |
| Dassa, B | 1 |
| Itkin, M | 1 |
| Malitsky, S | 1 |
| Dorot, O | 1 |
| Pichinuk, E | 1 |
| Kleinberg, Y | 1 |
| Keren, G | 1 |
| Entin-Meer, M | 1 |
| Malheiros-Lima, MR | 1 |
| Silva, JN | 1 |
| Souza, FC | 1 |
| Takakura, AC | 1 |
| Moreira, TS | 1 |
| Garcia-Contreras, M | 1 |
| Tamayo-Garcia, A | 1 |
| Pappan, KL | 1 |
| Michelotti, GA | 1 |
| Stabler, CL | 1 |
| Ricordi, C | 1 |
| Buchwald, P | 1 |
| Kakall, ZM | 1 |
| Pilowsky, PM | 1 |
| Farnham, MMJ | 1 |
| Mandel, DA | 1 |
| Schreihofer, AM | 1 |
| Nucci, TB | 1 |
| Dias, MB | 1 |
| Branco, LG | 6 |
| Gargaglioni, LH | 3 |
| Costa-Silva, JH | 1 |
| Zoccal, DB | 1 |
| Machado, BH | 1 |
| Osaka, T | 1 |
| Hong, LZ | 1 |
| Chai, CY | 1 |
| Solomon, IC | 2 |
| Ferreira, CM | 1 |
| de Paula, PM | 3 |
| Mutolo, D | 1 |
| Bongianni, F | 1 |
| Nardone, F | 1 |
| Pantaleo, T | 1 |
| Sun, MK | 2 |
| Reis, DJ | 2 |
| Zhu, PJ | 1 |
| Krnjević, K | 1 |
| Mizusawa, A | 1 |
| Ogawa, H | 1 |
| Kikuchi, Y | 1 |
| Hida, W | 1 |
| Kurosawa, H | 1 |
| Okabe, S | 1 |
| Takishima, T | 1 |
| Shirato, K | 1 |
| Hirai, H | 1 |
| Okada, Y | 1 |
| Jarvis, CR | 1 |
| Anderson, TR | 1 |
| Andrew, RD | 1 |
| Heyman, S | 1 |
| Spokes, K | 1 |
| Rosen, S | 1 |
| Epstein, FH | 1 |
| el-Asrar, AM | 1 |
| Morse, PH | 1 |
| Maimone, D | 1 |
| Torczynski, E | 1 |
| Reder, AT | 1 |
| Dillon, GH | 1 |
| Welsh, DE | 1 |
| Waldrop, TG | 1 |
| Priestley, T | 1 |
| Horne, AL | 1 |
| McKernan, RM | 1 |
| Kemp, JA | 1 |
| Andiné, P | 1 |
| Lehmann, A | 1 |
| Ellrén, K | 1 |
| Wennberg, E | 1 |
| Kjellmer, I | 1 |
| Nielsen, T | 1 |
| Hagberg, H | 1 |
1 review available for kynurenic acid and Anoxemia
| Article | Year |
|---|---|
Nucleus isthmi and control of breathing in amphibians.
Topics: Amphibians; Animals; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hypercapnia; Hypoxia; Kyn | 2004 |
28 other studies available for kynurenic acid and Anoxemia
| Article | Year |
|---|---|
Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα.
Topics: Animals; Endothelial Cells; Humans; Hypoxia; Interleukin-6; Kynurenic Acid; Kynurenine; Monocrotalin | 2022 |
Kynurenic acid, a key L-tryptophan-derived metabolite, protects the heart from an ischemic damage.
Topics: Acute Kidney Injury; Animals; Heart; Hypoxia; Kynurenic Acid; Mitochondria, Heart; Rats; Tryptophan | 2023 |
C1 neurons are part of the circuitry that recruits active expiration in response to the activation of peripheral chemoreceptors.
Topics: Animals; Catecholamines; Chemoreceptor Cells; Excitatory Amino Acid Antagonists; Exhalation; Glutama | 2020 |
Metabolomics Study of the Effects of Inflammation, Hypoxia, and High Glucose on Isolated Human Pancreatic Islets.
Topics: Biomarkers; Humans; Hyperglycemia; Hypoxia; Inflammation; Insulin; Insulin Secretion; Islets of Lang | 2017 |
PACAP-(6-38) or kynurenate microinjections in the RVLM prevent the development of sympathetic long-term facilitation after acute intermittent hypoxia.
Topics: Acute Disease; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Hypertension | 2018 |
Modulation of the sympathetic response to acute hypoxia by the caudal ventrolateral medulla in rats.
Topics: Animals; Bicuculline; Blood Pressure; Excitatory Amino Acid Antagonists; GABA Agonists; GABA-A Recep | 2009 |
Ionotropic glutamatergic receptors in the rostral medullary raphe modulate hypoxia and hypercapnia-induced hyperpnea.
Topics: Analysis of Variance; Animals; Body Temperature; Excitatory Amino Acid Antagonists; Hypercapnia; Hyp | 2011 |
Chronic intermittent hypoxia alters glutamatergic control of sympathetic and respiratory activities in the commissural NTS of rats.
Topics: Animals; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia; Kynurenic Acid; Male; Microinjec | 2012 |
Hypoxia-induced hypothermia mediated by the glutamatergic transmission in the lateral preoptic area.
Topics: Anesthesia; Animals; Body Temperature; Carbon Dioxide; Excitatory Amino Acid Antagonists; Glutamic A | 2012 |
Role of glutamate in the nucleus isthmi on the hypoxia- and hypercarbia-induced hyperventilation of toads.
Topics: Animals; Bufonidae; Carbon Dioxide; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hyperc | 2003 |
Involvement of N-methyl-D-aspartate receptors in post-hypoxic depression of the dorsomedial medulla in cats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4- | 2003 |
Ionotropic excitatory amino acid receptors in pre-Botzinger complex play a modulatory role in hypoxia-induced gasping in vivo.
Topics: Animals; Cats; Excitatory Amino Acid Antagonists; Hypoxia; Kynurenic Acid; Microinjections; Phrenic | 2004 |
Role of L-glutamate in the locus coeruleus of rats in hypoxia-induced hyperventilation and anapyrexia.
Topics: Animals; Blood Pressure; Body Temperature; Body Temperature Regulation; Glutamic Acid; Heart Rate; H | 2004 |
Glutamatergic neurotransmission modulates hypoxia-induced hyperventilation but not anapyrexia.
Topics: Animals; Benzoates; Body Temperature; Body Temperature Regulation; Excitatory Amino Acid Antagonists | 2004 |
Glutamate neurotransmission is not required for, but may modulate, hypoxic sensitivity of pre-Bötzinger complex in vivo.
Topics: Action Potentials; Animals; Cats; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Aci | 2005 |
Respiratory responses evoked by blockades of ionotropic glutamate receptors within the Bötzinger complex and the pre-Bötzinger complex of the rabbit.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Bl | 2005 |
Glutamatergic receptors of the rostral ventrolateral medulla are involved in the ventilatory response to hypoxia.
Topics: Animals; Benzoates; Body Temperature; Body Temperature Regulation; Drug Interactions; Excitatory Ami | 2005 |
NMDA receptor-mediated sympathetic chemoreflex excitation of RVL-spinal vasomotor neurones in rats.
Topics: Adrenergic Fibers; Animals; Carotid Sinus; Chemoreceptor Cells; Hypoxia; Injections, Intra-Arterial; | 1995 |
Intrathecal kynurenate but not benextramine blocks hypoxic sympathoexcitation in chemodenervated anesthetized rats.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Blood Pressure; Catecholamines; Cystamine; Hypoxi | 1994 |
Anoxia selectively depresses excitatory synaptic transmission in hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Evoked Pote | 1994 |
In vivo release of glutamate in nucleus tractus solitarii of the rat during hypoxia.
Topics: Animals; Blood Pressure; Carotid Body; Chemoreceptor Cells; Denervation; Dizocilpine Maleate; Doxapr | 1994 |
Serine released from hippocampal slices during deprivation of oxygen and glucose enhances the effects of glutamate on neuronal function.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Dizocilpine Maleate; Glucose; Glutamates; Glutamic Aci | 1993 |
Anoxic depolarization mediates acute damage independent of glutamate in neocortical brain slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Brain Ischemia; Cortical Spreading | 2001 |
Mechanism of glycine protection in hypoxic injury: analogies with glycine receptor.
Topics: Animals; Dose-Response Relationship, Drug; Glycine; Hypoxia; In Vitro Techniques; Kidney; Kynurenic | 1992 |
MK-801 protects retinal neurons from hypoxia and the toxicity of glutamate and aspartate.
Topics: Animals; Culture Techniques; Dextromethorphan; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hypox | 1992 |
Modulation of respiratory reflexes by an excitatory amino acid mechanism in the ventrolateral medulla.
Topics: Amino Acids; Animals; Chemoreceptor Cells; Hypercapnia; Hypoxia; Kynurenic Acid; Medulla Oblongata; | 1991 |
The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures.
Topics: Animals; Binding Sites; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Fetus; Glycine; Hypox | 1990 |
The excitatory amino acid antagonist kynurenic acid administered after hypoxic-ischemia in neonatal rats offers neuroprotection.
Topics: Animals; Brain; Brain Edema; Cerebrovascular Disorders; Female; Hypoxia; Ischemic Attack, Transient; | 1988 |