kynurenic acid has been researched along with Amyotrophic Lateral Sclerosis in 3 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y | 1 |
| Meininger, V | 1 |
| Guillemin, GJ | 1 |
| Tan, L | 2 |
| Yu, JT | 1 |
| Iłzecka, J | 1 |
| Kocki, T | 1 |
| Stelmasiak, Z | 1 |
| Turski, WA | 1 |
1 review available for kynurenic acid and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.
Topics: Aging; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Enzyme Inhibitors; Humans; Hunting | 2012 |
2 other studies available for kynurenic acid and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Recent advances in the treatment of amyotrophic lateral sclerosis. Emphasis on kynurenine pathway inhibitors.
Topics: Adult; Amyotrophic Lateral Sclerosis; Animals; Brain; D-Aspartic Acid; Functional Laterality; Humans | 2009 |
Endogenous protectant kynurenic acid in amyotrophic lateral sclerosis.
Topics: Age Factors; Aged; Amyotrophic Lateral Sclerosis; Case-Control Studies; Chromatography, High Pressur | 2003 |