kynurenic acid has been researched along with Aging in 27 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "For this purpose, male and female abstinent AUD patients (N = 130) and healthy controls (N = 80) were clinically evaluated for substance use and mental disorders, and blood samples were collected to determine plasma concentrations of TRP, 5-HT, KYN and kynurenic acid (KA) using high performance liquid chromatography." | 3.96 | Plasma tryptophan and kynurenine pathway metabolites in abstinent patients with alcohol use disorder and high prevalence of psychiatric comorbidity. ( Araos, P; Colado, MI; Flores-López, M; García-Marchena, N; O'Shea, E; Pavón, FJ; Requena-Ocaña, N; Rodríguez de Fonseca, F; Rubio, G; Serrano, A; Suárez, J; Vidal, R, 2020) |
| "Circulating neopterin and kynurenine/tryptophan ratio (KTR) increase during inflammation and serve as markers of cellular immune activation, but data are sparse on other determinants of these markers and metabolites of the kynurenine pathway." | 3.79 | A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study. ( Eussen, SJ; Midttun, Ø; Nygård, O; Tell, GS; Theofylaktopoulou, D; Ueland, PM; Ulvik, A; Vollset, SE, 2013) |
| "Kynurenic acid (KYNA) is an endogenous metabolite in the kynurenine pathway of tryptophan degradation and is an antagonist at the glycine site of the N-methyl-D-aspartate as well as at the alpha 7 nicotinic cholinergic receptors." | 1.33 | Age-related increase of kynurenic acid in human cerebrospinal fluid - IgG and beta2-microglobulin changes. ( Baran, H; Ferraz-Leite, H; Kainz, A; Kalina, P; Kepplinger, B; Newcombe, J, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 9 (33.33) | 18.2507 |
| 2000's | 9 (33.33) | 29.6817 |
| 2010's | 7 (25.93) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Vidal, R | 1 |
| García-Marchena, N | 1 |
| O'Shea, E | 1 |
| Requena-Ocaña, N | 1 |
| Flores-López, M | 1 |
| Araos, P | 1 |
| Serrano, A | 1 |
| Suárez, J | 1 |
| Rubio, G | 1 |
| Rodríguez de Fonseca, F | 1 |
| Colado, MI | 1 |
| Pavón, FJ | 1 |
| Vohra, M | 1 |
| Lemieux, GA | 1 |
| Lin, L | 1 |
| Ashrafi, K | 1 |
| Theofylaktopoulou, D | 1 |
| Midttun, Ø | 1 |
| Ulvik, A | 1 |
| Ueland, PM | 1 |
| Tell, GS | 1 |
| Vollset, SE | 1 |
| Nygård, O | 1 |
| Eussen, SJ | 1 |
| de Bie, J | 1 |
| Guest, J | 1 |
| Guillemin, GJ | 1 |
| Grant, R | 1 |
| Alkondon, M | 1 |
| Pereira, EF | 1 |
| Eisenberg, HM | 1 |
| Kajii, Y | 1 |
| Schwarcz, R | 5 |
| Albuquerque, EX | 1 |
| Żarnowski, T | 2 |
| Chorągiewicz, T | 2 |
| Tulidowicz-Bielak, M | 1 |
| Thaler, S | 2 |
| Rejdak, R | 3 |
| Żarnowski, I | 1 |
| Turski, WA | 4 |
| Gasior, M | 1 |
| Junemann, A | 1 |
| Grieb, P | 1 |
| Schuettauf, F | 2 |
| Zrenner, E | 2 |
| Tan, L | 2 |
| Yu, JT | 1 |
| DiGregorio, DA | 1 |
| Nusser, Z | 1 |
| Silver, RA | 1 |
| Kohler, K | 1 |
| Kocki, T | 1 |
| Shenk, Y | 1 |
| Okuno, E | 1 |
| Lehaci, C | 1 |
| Zagorski, Z | 1 |
| Yang, S | 1 |
| Qiao, H | 1 |
| Wen, L | 1 |
| Zhou, W | 1 |
| Zhang, Y | 1 |
| Kepplinger, B | 1 |
| Baran, H | 2 |
| Kainz, A | 1 |
| Ferraz-Leite, H | 1 |
| Newcombe, J | 1 |
| Kalina, P | 1 |
| Stone, TW | 1 |
| Zhong, J | 1 |
| Gribkoff, VK | 1 |
| Molinoff, PB | 1 |
| Ceresoli, G | 1 |
| Fuller, MS | 1 |
| Richter, A | 1 |
| Loscher, W | 1 |
| Gramer, M | 1 |
| Poeggeler, B | 2 |
| Rassoulpour, A | 2 |
| Guidetti, P | 2 |
| Wu, HQ | 2 |
| Ho, SM | 1 |
| Waite, PM | 1 |
| Ceresoli-Borroni, G | 1 |
| Hodgkins, PS | 1 |
| Fitzjohn, SM | 1 |
| Morton, RA | 1 |
| Kuenzi, F | 1 |
| Rosahl, TW | 1 |
| Shearman, M | 1 |
| Lewis, H | 1 |
| Smith, D | 1 |
| Reynolds, DS | 1 |
| Davies, CH | 1 |
| Collingridge, GL | 1 |
| Seabrook, GR | 1 |
| Cannazza, G | 1 |
| Chiarugi, A | 1 |
| Parenti, C | 1 |
| Zanoli, P | 1 |
| Baraldi, M | 1 |
| Rozas, C | 1 |
| Frank, H | 1 |
| Heynen, AJ | 1 |
| Morales, B | 1 |
| Bear, MF | 1 |
| Kirkwood, A | 1 |
| Clayton, DA | 1 |
| Mesches, MH | 1 |
| Alvarez, E | 1 |
| Bickford, PC | 1 |
| Browning, MD | 1 |
| Gramsbergen, JB | 1 |
| Schmidt, W | 1 |
| Aamodt, SM | 1 |
| Kozlowski, MR | 1 |
| Nordeen, EJ | 1 |
| Nordeen, KW | 1 |
| Elderfield, A | 1 |
| Truscott, R | 1 |
| Moroni, F | 1 |
| Russi, P | 1 |
| Carlá, V | 1 |
| Lombardi, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised Controlled Trial Evaluating the Efficacy and Mechanisms of a Ketogenic Diet as an Adjunctive Treatment for People With Treatment-resistant Depression[NCT06091163] | 100 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for kynurenic acid and Aging
| Article | Year |
|---|---|
Kynurenic acid and kynurenine aminotransferases in retinal aging and neurodegeneration.
Topics: Aging; Animals; Humans; Kynurenic Acid; Kynurenine; Retina; Retinal Degeneration; Retinal Ganglion C | 2011 |
The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.
Topics: Aging; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Enzyme Inhibitors; Humans; Hunting | 2012 |
25 other studies available for kynurenic acid and Aging
| Article | Year |
|---|---|
Plasma tryptophan and kynurenine pathway metabolites in abstinent patients with alcohol use disorder and high prevalence of psychiatric comorbidity.
Topics: Adolescent; Adult; Aged; Aging; Alcohol Abstinence; Alcoholism; Body Mass Index; Cross-Sectional Stu | 2020 |
Kynurenic acid accumulation underlies learning and memory impairment associated with aging.
Topics: Aging; Animals; Caenorhabditis elegans; Insulin; Kynurenic Acid; Learning; Memory; Signal Transducti | 2018 |
A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aging; Biomarkers; Body Mass Index; Creatinine; Female; Humans; Inf | 2013 |
Central kynurenine pathway shift with age in women.
Topics: Adult; Aged; Aged, 80 and over; Aging; Brain; Female; Humans; Inflammation; Kynurenic Acid; Kynureni | 2016 |
Age dependency of inhibition of alpha7 nicotinic receptors and tonically active N-methyl-D-aspartate receptors by endogenously produced kynurenic acid in the brain.
Topics: Adult; Aging; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bicuculline; Choline; Female; GABA-A | 2011 |
Ketogenic diet increases concentrations of kynurenic acid in discrete brain structures of young and adult rats.
Topics: 3-Hydroxybutyric Acid; Aging; Animals; Blood Glucose; Brain Chemistry; Cerebral Cortex; Corpus Stria | 2012 |
Spillover of glutamate onto synaptic AMPA receptors enhances fast transmission at a cerebellar synapse.
Topics: Aging; Animals; Cell Differentiation; Cerebellar Cortex; Dendrites; Electric Stimulation; Excitatory | 2002 |
Age-dependent decrease of retinal kynurenate and kynurenine aminotransferases in DBA/2J mice, a model of ocular hypertension.
Topics: Aging; Animals; Chromatography, High Pressure Liquid; Female; Immunohistochemistry; Kynurenic Acid; | 2004 |
D-serine enhances impaired long-term potentiation in CA1 subfield of hippocampal slices from aged senescence-accelerated mouse prone/8.
Topics: Age Factors; Aging; Analysis of Variance; Animals; D-Amino-Acid Oxidase; Drug Interactions; Electric | 2005 |
Age-related increase of kynurenic acid in human cerebrospinal fluid - IgG and beta2-microglobulin changes.
Topics: Adult; Aged; Aging; Analysis of Variance; beta 2-Microglobulin; Brain Chemistry; Chromatography, Hig | 2005 |
Kynurenic acid blocks nicotinic synaptic transmission to hippocampal interneurons in young rats.
Topics: Acetylcholine; Action Potentials; Aging; Animals; Cell Differentiation; Dose-Response Relationship, | 2007 |
Use of subunit-specific antisense oligodeoxynucleotides to define developmental changes in the properties of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Base Sequence; Cerebral Cortex; Excit | 1996 |
Excitotoxic lesions of the rat striatum: different responses of kynurenine pathway enzymes during ontogeny.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Aging; Animals; Animals, Newborn; Corpus Striatum; Dioxygenas | 1996 |
Increased levels of kynurenic acid in brains of genetically dystonic hamsters.
Topics: Aging; Animals; Animals, Newborn; Brain; Cricetinae; Dystonia; Excitatory Amino Acid Antagonists; Ky | 1996 |
Dopaminergic control of kynurenate levels and N-methyl-D-aspartate toxicity in the developing rat striatum.
Topics: Aging; Animals; Animals, Newborn; Corpus Striatum; Dextroamphetamine; Dopamine; Dopamine Agents; Dop | 1998 |
Spontaneous activity in the perinatal trigeminal nucleus of the rat.
Topics: Aging; Animals; Animals, Newborn; Bicuculline; Electrophysiology; Excitatory Amino Acid Antagonists; | 1999 |
Modulation and function of kynurenic acid in the immature rat brain.
Topics: 2-Amino-5-phosphonovalerate; Aging; Alanine; Animals; Brain; Dextroamphetamine; Enzyme Inhibitors; E | 1999 |
Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Electric | 2001 |
Changes in kynurenic, anthranilic, and quinolinic acid concentrations in rat brain tissue during development.
Topics: Aging; Animals; Animals, Newborn; Brain; Embryo, Mammalian; Female; Kynurenic Acid; Male; ortho-Amin | 2001 |
Developmental inhibitory gate controls the relay of activity to the superficial layers of the visual cortex.
Topics: Aging; Animals; Axons; Critical Period, Psychological; Darkness; Electric Stimulation; Excitatory Po | 2001 |
A hippocampal NR2B deficit can mimic age-related changes in long-term potentiation and spatial learning in the Fischer 344 rat.
Topics: Action Potentials; Aging; Animals; Behavior, Animal; Blotting, Western; Calcium Channel Blockers; Ca | 2002 |
Age-related changes in kynurenic acid production in rat brain.
Topics: Aging; Animals; Brain; In Vitro Techniques; Kynurenic Acid; Lyases; Male; Nerve Tissue Proteins; Rat | 1992 |
Distribution and developmental change in [3H]MK-801 binding within zebra finch song nuclei.
Topics: Aging; Animals; Auditory Pathways; Autoradiography; Binding, Competitive; Birds; Dizocilpine Maleate | 1992 |
Tryptophan metabolism in senile cataract patients assessed by high-performance liquid chromatography.
Topics: Aging; Cataract; Chromatography, High Pressure Liquid; Humans; Kynurenic Acid; Kynurenine; Tryptopha | 1991 |
Kynurenic acid is present in the rat brain and its content increases during development and aging processes.
Topics: Aging; Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Hydroxyindoleacetic Ac | 1988 |