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kynurenic acid and Acute Brain Injuries

kynurenic acid has been researched along with Acute Brain Injuries in 11 studies

Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.

Research Excerpts

ExcerptRelevanceReference
"Clinical studies indicate that phenytoin prevents acute post-traumatic seizures but not subsequent post-traumatic epilepsy."3.78Interictal spikes, seizures and ictal cell death are not necessary for post-traumatic epileptogenesis in vitro. ( Berdichevsky, Y; Dzhala, V; Mail, M; Staley, KJ, 2012)
"Acute subdural hematoma (ASDH) gives rise to a mass effect not only by itself but also through unilateral hemispheric swelling."1.29Attenuation of hemispheric swelling associated with acute subdural hematomas by excitatory amino acid antagonist in rats. ( Hirayama, T; Kano, T; Katayama, Y; Kinoshita, K; Tsubokawa, T, 1994)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (81.82)18.2507
2000's1 (9.09)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Berdichevsky, Y1
Dzhala, V1
Mail, M1
Staley, KJ1
Suma, T1
Koshinaga, M1
Fukushima, M1
Kano, T2
Katayama, Y4
Hicks, RR2
Smith, DH3
McIntosh, TK2
Gennarelli, TA1
McIntosh, T1
Kinoshita, K1
Hirayama, T1
Tsubokawa, T1
Okiyama, K1
Thomas, MJ1
Walker, DW1
Curtis, B1
Lacey, B1
Nitsos, I1
Dhillon, HS1
Prasad, RM1
D'Ambrosio, R1
Maris, DO1
Grady, MS1
Winn, HR1
Janigro, D1
Becker, DP2
Tamura, T1
Ikezaki, K1
Hovda, DA1
Yoshino, A1
Kawamata, T1
Fineman, I1

Other Studies

11 other studies available for kynurenic acid and Acute Brain Injuries

ArticleYear
Interictal spikes, seizures and ictal cell death are not necessary for post-traumatic epileptogenesis in vitro.
    Neurobiology of disease, 2012, Volume: 45, Issue:2

    Topics: Action Potentials; Animals; Anticonvulsants; Brain Injuries; Cell Death; Epilepsy; Excitatory Amino

2012
Effects of in situ administration of excitatory amino acid antagonists on rapid microglial and astroglial reactions in rat hippocampus following traumatic brain injury.
    Neurological research, 2008, Volume: 30, Issue:4

    Topics: Animals; Astrocytes; Brain Injuries; CD11b Antigen; Disease Models, Animal; Excitatory Amino Acid An

2008
Temporal response and effects of excitatory amino acid antagonism on microtubule-associated protein 2 immunoreactivity following experimental brain injury in rats.
    Brain research, 1995, Apr-24, Volume: 678, Issue:1-2

    Topics: Animals; Brain Injuries; Cell Survival; Cerebral Cortex; Cytoskeleton; Excitatory Amino Acid Antagon

1995
Kynurenate is neuroprotective following experimental brain injury in the rat.
    Brain research, 1994, Aug-29, Volume: 655, Issue:1-2

    Topics: Animals; Body Temperature; Brain Injuries; Cell Survival; Hippocampus; Kynurenic Acid; Male; Neurons

1994
Attenuation of hemispheric swelling associated with acute subdural hematomas by excitatory amino acid antagonist in rats.
    Acta neurochirurgica. Supplementum, 1994, Volume: 60

    Topics: Animals; Brain Edema; Brain Injuries; Electron Transport Complex IV; Energy Metabolism; Excitatory A

1994
Effects of the excitatory amino acid receptor antagonists kynurenate and indole-2-carboxylic acid on behavioral and neurochemical outcome following experimental brain injury.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1993, Volume: 13, Issue:12

    Topics: Animals; Brain; Brain Injuries; Carboxylic Acids; Cations; Indoles; Kynurenic Acid; Male; Memory Dis

1993
Kynurenic acid in brain and cerebrospinal fluid of fetal, newborn, and adult sheep and effects of placental embolization.
    Pediatric research, 1999, Volume: 45, Issue:6

    Topics: Animals; Animals, Newborn; Brain; Brain Injuries; Embolism; Female; Fetal Hypoxia; Fetus; Kynurenic

1999
Kynurenate attenuates the accumulation of diacylglycerol and free fatty acids after experimental brain injury in the rat.
    Brain research, 1999, Jun-19, Volume: 832, Issue:1-2

    Topics: Analysis of Variance; Animals; Brain Injuries; Diglycerides; Drug Evaluation, Preclinical; Excitator

1999
Impaired K(+) homeostasis and altered electrophysiological properties of post-traumatic hippocampal glia.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Sep-15, Volume: 19, Issue:18

    Topics: Animals; Astrocytes; Brain Injuries; Electric Stimulation; Glial Fibrillary Acidic Protein; Hippocam

1999
Early cellular swelling in experimental traumatic brain injury: a phenomenon mediated by excitatory amino acids.
    Acta neurochirurgica. Supplementum, 1990, Volume: 51

    Topics: Amino Acids; Animals; Body Water; Brain Injuries; Female; Ions; Kynurenic Acid; Neurons; Potassium;

1990
The increase in local cerebral glucose utilization following fluid percussion brain injury is prevented with kynurenic acid and is associated with an increase in calcium.
    Acta neurochirurgica. Supplementum, 1990, Volume: 51

    Topics: Animals; Brain; Brain Injuries; Calcium; Dialysis; Glucose; Kynurenic Acid; Male; Rats; Rats, Inbred

1990