kynurenic acid has been researched along with Ache in 25 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the relationship between the tryptophan-kynurenine (TRP-KYN) pathway and painful physical symptoms (PPS) in major depressive disorder (MDD)." | 8.12 | Relationship between the tryptophan-kynurenine pathway and painful physical symptoms in patients with major depressive disorder. ( An, H; Bai, L; Fan, H; Ma, B; Ma, T; Qi, S; Wang, Z; Yang, F; Yun, Y; Zhang, Q; Zhao, W, 2022) |
| "Pain is a complex experience composed of sensory and affective components." | 5.39 | Opposing roles of corticotropin-releasing factor and neuropeptide Y within the dorsolateral bed nucleus of the stria terminalis in the negative affective component of pain in rats. ( Hara, T; Ide, S; Kaneda, K; Koseki, K; Maruyama, C; Minami, M; Naka, T; Ohno, A; Tamano, R; Yoshioka, M, 2013) |
| " In recent years, migraine research focused on tryptophan, which is metabolized via two main pathways, the serotonin and kynurenine pathways, both of which produce neuroactive molecules that influence pain processing and stress response by disturbing neural and brain hypersensitivity and by interacting with molecules that control vascular and inflammatory actions." | 5.22 | Exploring the Tryptophan Metabolic Pathways in Migraine-Related Mechanisms. ( Körtési, T; Spekker, E; Vécsei, L, 2022) |
| "To investigate the relationship between the tryptophan-kynurenine (TRP-KYN) pathway and painful physical symptoms (PPS) in major depressive disorder (MDD)." | 4.12 | Relationship between the tryptophan-kynurenine pathway and painful physical symptoms in patients with major depressive disorder. ( An, H; Bai, L; Fan, H; Ma, B; Ma, T; Qi, S; Wang, Z; Yang, F; Yun, Y; Zhang, Q; Zhao, W, 2022) |
| "Kynurenic acid (KYNA) is a neuroactive metabolite that interacts with NMDA, AMPA/kainate and alpha 7 nicotinic receptors." | 1.42 | The inimitable kynurenic acid: the roles of different ionotropic receptors in the action of kynurenic acid at a spinal level. ( Bohar, Z; Horvath, G; Kekesi, G; Pardutz, A; Petrovszki, Z; Safrany-Fark, A; Tar, L; Tuboly, G; Vecsei, L, 2015) |
| "Pain is a complex experience composed of sensory and affective components." | 1.39 | Opposing roles of corticotropin-releasing factor and neuropeptide Y within the dorsolateral bed nucleus of the stria terminalis in the negative affective component of pain in rats. ( Hara, T; Ide, S; Kaneda, K; Koseki, K; Maruyama, C; Minami, M; Naka, T; Ohno, A; Tamano, R; Yoshioka, M, 2013) |
| " However, co-administration of these antagonists with morphine into the vPAG enhanced the acute antinociceptive effects of morphine as measured by a leftward shift in the morphine dose-response curves." | 1.35 | Glutamate modulation of antinociception, but not tolerance, produced by morphine microinjection into the periaqueductal gray of the rat. ( Bobeck, EN; Ingram, SL; Morgan, MM, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 8 (32.00) | 18.2507 |
| 2000's | 9 (36.00) | 29.6817 |
| 2010's | 5 (20.00) | 24.3611 |
| 2020's | 2 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yun, Y | 1 |
| Zhang, Q | 1 |
| Zhao, W | 1 |
| Ma, T | 1 |
| Fan, H | 1 |
| Bai, L | 1 |
| Ma, B | 1 |
| Qi, S | 1 |
| Wang, Z | 1 |
| An, H | 1 |
| Yang, F | 1 |
| Körtési, T | 2 |
| Spekker, E | 2 |
| Vécsei, L | 3 |
| Ide, S | 1 |
| Hara, T | 1 |
| Ohno, A | 1 |
| Tamano, R | 1 |
| Koseki, K | 1 |
| Naka, T | 1 |
| Maruyama, C | 1 |
| Kaneda, K | 1 |
| Yoshioka, M | 1 |
| Minami, M | 1 |
| Tuboly, G | 2 |
| Tar, L | 1 |
| Bohar, Z | 1 |
| Safrany-Fark, A | 1 |
| Petrovszki, Z | 1 |
| Kekesi, G | 3 |
| Pardutz, A | 1 |
| Horvath, G | 4 |
| Morgan, MM | 1 |
| Bobeck, EN | 1 |
| Ingram, SL | 1 |
| Martins, MA | 1 |
| De Castro Bastos, L | 1 |
| Melo, NE | 1 |
| Tonussi, CR | 1 |
| Cosi, C | 1 |
| Mannaioni, G | 1 |
| Cozzi, A | 1 |
| Carlà, V | 1 |
| Sili, M | 1 |
| Cavone, L | 1 |
| Maratea, D | 1 |
| Moroni, F | 1 |
| Mécs, L | 1 |
| Zhang, YQ | 2 |
| Ji, GC | 1 |
| Wu, GC | 1 |
| Zhao, ZQ | 2 |
| Ren, WH | 1 |
| Guo, JD | 1 |
| Cao, H | 1 |
| Wang, H | 1 |
| Wang, PF | 1 |
| Sha, H | 1 |
| Ji, RR | 1 |
| Tan-No, K | 1 |
| Esashi, A | 1 |
| Nakagawasai, O | 1 |
| Niijima, F | 1 |
| Furuta, S | 1 |
| Sato, T | 1 |
| Satoh, S | 1 |
| Yasuhara, H | 1 |
| Tadano, T | 1 |
| Benedek, G | 1 |
| Jinks, SL | 1 |
| Carstens, EE | 1 |
| Antognini, JF | 1 |
| Chapman, V | 2 |
| Dickenson, AH | 3 |
| Heinricher, MM | 2 |
| Roychowdhury, SM | 1 |
| Chiang, CY | 1 |
| Hu, JW | 1 |
| Sessle, BJ | 1 |
| Reeve, AJ | 1 |
| Kerr, NC | 1 |
| Heyliger, SO | 1 |
| Goodman, CB | 1 |
| Ngong, JM | 1 |
| Soliman, KF | 1 |
| McGaraughty, S | 1 |
| Farr, DA | 1 |
| Edwards, SR | 1 |
| Mather, LE | 1 |
| Lin, Y | 1 |
| Power, I | 1 |
| Cousins, MJ | 1 |
| Blessing, WW | 1 |
| Nalivaiko, E | 1 |
| Hajós, M | 1 |
| Engberg, G | 1 |
| Holohean, AM | 1 |
| Vega, JL | 1 |
| Hackman, JC | 1 |
| Davidoff, RA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Exploration of the Role of Tryptophan Metabolites in Pediatric Migraine[NCT05969990] | 200 participants (Anticipated) | Observational | 2022-01-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for kynurenic acid and Ache
| Article | Year |
|---|---|
Exploring the Tryptophan Metabolic Pathways in Migraine-Related Mechanisms.
Topics: Humans; Kynurenic Acid; Kynurenine; Metabolic Networks and Pathways; Migraine Disorders; Pain; Serot | 2022 |
Exploring the Tryptophan Metabolic Pathways in Migraine-Related Mechanisms.
Topics: Humans; Kynurenic Acid; Kynurenine; Metabolic Networks and Pathways; Migraine Disorders; Pain; Serot | 2022 |
Exploring the Tryptophan Metabolic Pathways in Migraine-Related Mechanisms.
Topics: Humans; Kynurenic Acid; Kynurenine; Metabolic Networks and Pathways; Migraine Disorders; Pain; Serot | 2022 |
Exploring the Tryptophan Metabolic Pathways in Migraine-Related Mechanisms.
Topics: Humans; Kynurenic Acid; Kynurenine; Metabolic Networks and Pathways; Migraine Disorders; Pain; Serot | 2022 |
Antinociception by endogenous ligands at peripheral level.
Topics: Analgesics, Opioid; Animals; Annexin A1; beta-Endorphin; Cytokines; Endorphins; Excitatory Amino Aci | 2011 |
23 other studies available for kynurenic acid and Ache
| Article | Year |
|---|---|
Relationship between the tryptophan-kynurenine pathway and painful physical symptoms in patients with major depressive disorder.
Topics: Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Pain; Quinolinic Acid; Serotonin; Ta | 2022 |
Opposing roles of corticotropin-releasing factor and neuropeptide Y within the dorsolateral bed nucleus of the stria terminalis in the negative affective component of pain in rats.
Topics: Action Potentials; Affective Symptoms; Analysis of Variance; Aniline Compounds; Animals; Arginine; C | 2013 |
The inimitable kynurenic acid: the roles of different ionotropic receptors in the action of kynurenic acid at a spinal level.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Disease Models, Animal; Dose-Response | 2015 |
Glutamate modulation of antinociception, but not tolerance, produced by morphine microinjection into the periaqueductal gray of the rat.
Topics: Analgesia; Analgesics, Opioid; Analysis of Variance; Animals; Dizocilpine Maleate; Dose-Response Rel | 2009 |
Dependency of nociception facilitation or inhibition after periaqueductal gray matter stimulation on the context.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; | 2010 |
G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast.
Topics: Analgesics; Animals; Antidepressive Agents, Second-Generation; Dose-Response Relationship, Drug; Dru | 2011 |
[Analgesic effect of kynurenic acid].
Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination | 2002 |
Kynurenic acid enhances electroacupuncture analgesia in normal and carrageenan-injected rats.
Topics: Animals; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Electroacupuncture; | 2003 |
Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect?
Topics: Animals; Anxiety; D-Amino-Acid Oxidase; Excitatory Amino Acid Antagonists; Fear; Glycine; Gyrus Cing | 2006 |
Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site.
Topics: 2-Amino-5-phosphonovalerate; Agmatine; Animals; Cycloserine; Dizocilpine Maleate; Dose-Response Rela | 2007 |
Antinociceptive interactions of triple and quadruple combinations of endogenous ligands at the spinal level.
Topics: Adenosine; Agmatine; Analgesics; Animals; Area Under Curve; Disease Models, Animal; Drug Combination | 2007 |
Glutamate receptor blockade in the rostral ventromedial medulla reduces the force of multisegmental motor responses to supramaximal noxious stimuli.
Topics: Animals; Electric Stimulation; Escape Reaction; Excitatory Amino Acid Antagonists; Kynurenic Acid; M | 2007 |
Time-related roles of excitatory amino acid receptors during persistent noxiously evoked responses of rat dorsal horn neurones.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Evoked Potentials; Excitatory Amino Acid Antagonists; | 1995 |
Reflex-related activation of putative pain facilitating neurons in rostral ventromedial medulla requires excitatory amino acid transmission.
Topics: Animals; Electrophysiology; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid | 1997 |
NMDA receptor involvement in neuroplastic changes induced by neonatal capsaicin treatment in trigeminal nociceptive neurons.
Topics: Animals; Animals, Newborn; Capsaicin; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Functi | 1997 |
Spinal effects of bicuculline: modulation of an allodynia-like state by an A1-receptor agonist, morphine, and an NMDA-receptor antagonist.
Topics: Adenosine; Animals; Bicuculline; Dose-Response Relationship, Drug; GABA Antagonists; Kynurenic Acid; | 1998 |
The analgesic effects of tryptophan and its metabolites in the rat.
Topics: Analgesics; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Antago | 1998 |
The role of excitatory amino acid transmission within the rostral ventromedial medulla in the antinociceptive actions of systemically administered morphine.
Topics: Analgesics, Opioid; Animals; Electrophysiology; Excitatory Amino Acid Antagonists; Excitatory Amino | 1999 |
Glutamate and kynurenate in the rat central nervous system following treatments with tail ischaemia or diclofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System; Chromatography, High Press | 2000 |
Regional blood flow and nociceptive stimuli in rabbits: patterning by medullary raphe, not ventrolateral medulla.
Topics: Animals; Arterioles; Blood Pressure; Cerebrovascular Circulation; Electric Stimulation; Kynurenic Ac | 2000 |
The combination of NMDA antagonism and morphine produces profound antinociception in the rat dorsal horn.
Topics: Afferent Pathways; Animals; Electric Stimulation; Hot Temperature; Injections, Spinal; Kynurenic Aci | 1992 |
Kynurenic acid blocks chemogenic nociception.
Topics: Animals; Behavior, Animal; Capsaicin; Cisterna Magna; Dizocilpine Maleate; Injections; Kynurenic Aci | 1990 |
Excitatory transmitters, ventral root potentials and [K+]o in the isolated frog leg-spinal cord preparation.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; In Vitro Techniques; Kynurenic Acid; Pain; | 1988 |