kynurenic acid has been researched along with AIDS Dementia Complex in 4 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
AIDS Dementia Complex: A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
| Excerpt | Relevance | Reference |
|---|---|---|
| "There is good evidence that the kynurenine pathway (KP) and one of its products, quinolinic acid (QUIN), play a role in the pathogenesis of neurological diseases, in particular AIDS dementia complex." | 3.71 | Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection. ( Armati, PJ; Brew, BJ; Croitoru, J; Guillemin, GJ; Kapoor, V; Kerr, SJ; Smith, DG; Smythe, GA, 2001) |
| " In addition, Tat, at similar concentrations, was toxic to human fetal neurons in culture." | 1.29 | Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity. ( Brownstone, RM; Geiger, JD; Knudsen, BE; Magnuson, DS; Nath, A, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Magnuson, DS | 1 |
| Knudsen, BE | 1 |
| Geiger, JD | 1 |
| Brownstone, RM | 1 |
| Nath, A | 1 |
| Baran, H | 1 |
| Hainfellner, JA | 1 |
| Kepplinger, B | 1 |
| Mazal, PR | 1 |
| Schmid, H | 1 |
| Budka, H | 1 |
| Guillemin, GJ | 1 |
| Kerr, SJ | 1 |
| Smythe, GA | 1 |
| Smith, DG | 1 |
| Kapoor, V | 1 |
| Armati, PJ | 1 |
| Croitoru, J | 1 |
| Brew, BJ | 1 |
| Schwarcz, R | 1 |
| Du, F | 1 |
1 review available for kynurenic acid and AIDS Dementia Complex
| Article | Year |
|---|---|
Quinolinic acid and kynurenic acid in the mammalian brain.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; AIDS Dementia Complex; Animals; Aspartic Acid; Biological Tra | 1991 |
3 other studies available for kynurenic acid and AIDS Dementia Complex
| Article | Year |
|---|---|
Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity.
Topics: 2-Amino-5-phosphonovalerate; AIDS Dementia Complex; Animals; Cells, Cultured; Cerebral Cortex; Dose- | 1995 |
Kynurenic acid metabolism in the brain of HIV-1 infected patients.
Topics: Adult; AIDS Dementia Complex; Brain; Cerebellum; Female; Frontal Lobe; HIV-1; Humans; Kynurenic Acid | 2000 |
Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection.
Topics: AIDS Dementia Complex; Astrocytes; Brain; Cells, Cultured; Cytokines; Enzymes; Fetus; Humans; Kynure | 2001 |