kutkin has been researched along with Mushroom-Poisoning* in 2 studies
2 other study(ies) available for kutkin and Mushroom-Poisoning
| Article | Year |
|---|---|
Effects of picroliv, the active principle of Picrorhiza kurroa, on biochemical changes in rat liver poisoned by Amanita phalloides.
The efficacy of Picroliv, a standardized iridoid glycoside fraction of Picrorhiza kurroa, was studied against the Amanita phalloides-induced biochemical changes in rat liver. A phalloides (50 mg.kg-1) caused significant increases in the activities of hepatic 5'-nucleotidase, gamma-glutamyl transpeptidase, acid ribonuclease, and succinate dehydrogenase, but a decrease in glucose-6-phosphatase. The level of cytochrome P-450 in microsomal fraction and content of glycogen in liver showed significant depletions. Picroliv (25 mg.kg-1.d-1 x 10 d) provided significant restorations of all the biochemical changes poisoned by A phalloides except cytochrome P-450 and glycogen. These results demonstrated the protective effect of Picroliv against A phalloides-induced hepatotoxicity in rats. Topics: Amanita; Animals; Chemical and Drug Induced Liver Injury; Cinnamates; gamma-Glutamyltransferase; Glycosides; Liver Glycogen; Male; Mushroom Poisoning; Oxidoreductases; Phosphoric Monoester Hydrolases; Rats; Rats, Inbred Strains; Vanillic Acid | 1992 |
Protection against Amanita phalloides by the iridoid glycoside mixture of Picrorhiza kurroa (kutkin).
Survival of mice after lethal doses of lyophilizate from Amanita phalloides ('death cap') was markedly increased by pretreatment with single doses of kutkin, a mixture of iridoid glycosides picroside I and kutkoside isolated from the roots of Picrorhiza kurroa. The protective effect of kutkin was comparable to that of silibinin. The curative efficacy of kutkin appeared to be slightly superior. Topics: Amanita; Animals; Cinnamates; Female; Glycosides; Hydroxybenzoates; Mice; Mushroom Poisoning; Silymarin; Vanillic Acid | 1990 |