ku-0060648 and Neoplasms

ku-0060648 has been researched along with Neoplasms* in 1 studies

Reviews

1 review(s) available for ku-0060648 and Neoplasms

Article	Year
Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family. Bioorganic & medicinal chemistry letters, 2012, Sep-01, Volume: 22, Issue:17 Modulation of DNA repair pathways in oncology has been an area of intense interest in the last decade, not least as a consequence of the promising clinical activity of poly(ADP-ribose) polymerase (PARP) inhibitors. In this review article, we highlight inhibitors of the phosphatidylinositol 3-kinase related kinase (PIKK) family as of potential interest in the treatment of cancer, both in combination with DNA-damaging therapies and as stand-alone agents. Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; DNA; DNA Repair; DNA-Activated Protein Kinase; DNA-Binding Proteins; Humans; Models, Molecular; Neoplasms; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Tumor Suppressor Proteins	2012

Article

Year

Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.

Bioorganic & medicinal chemistry letters, 2012, Sep-01, Volume: 22, Issue:17

Modulation of DNA repair pathways in oncology has been an area of intense interest in the last decade, not least as a consequence of the promising clinical activity of poly(ADP-ribose) polymerase (PARP) inhibitors. In this review article, we highlight inhibitors of the phosphatidylinositol 3-kinase related kinase (PIKK) family as of potential interest in the treatment of cancer, both in combination with DNA-damaging therapies and as stand-alone agents.

Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; DNA; DNA Repair; DNA-Activated Protein Kinase; DNA-Binding Proteins; Humans; Models, Molecular; Neoplasms; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Tumor Suppressor Proteins

2012