kt-5720 has been researched along with Epilepsy* in 1 studies
1 other study(ies) available for kt-5720 and Epilepsy
| Article | Year |
|---|---|
Loss of constitutive functional γ-aminobutyric acid type A-B receptor crosstalk in layer 5 pyramidal neurons of human epileptic temporal cortex.
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in adult central nervous system, and profound alterations of GABA receptor functions are linked to temporal lobe epilepsy (TLE). Here we describe the functional relationships between GABA receptors type B (GABA. Miniature inhibitory postsynaptic currents (mIPSCs) were recorded by patch-clamp techniques from human L5 pyramidal neurons in slices from temporal cortex tissue obtained from surgery.. We describe a constitutive functional crosstalk between GABA. Our results highlight the association of TLE with functional changes of GABAergic signaling that may be related to seizure propagation, and suggest that the selective activation of a definite subset of nonpresynaptic GABA Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adolescent; Adult; Animals; Baclofen; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Drug Resistant Epilepsy; Enzyme Inhibitors; Epilepsy; Epilepsy, Temporal Lobe; Female; GABA-B Receptor Agonists; Humans; Inhibitory Postsynaptic Potentials; Male; Middle Aged; Muscarinic Agonists; Neocortex; Patch-Clamp Techniques; Pertussis Toxin; Pilocarpine; Protein Kinase C; Pyramidal Cells; Pyrroles; Rats; Receptors, GABA-A; Receptors, GABA-B; Temporal Lobe | 2018 |