krn-7000 and Leukodystrophy--Metachromatic

krn-7000 has been researched along with Leukodystrophy--Metachromatic* in 1 studies

Other Studies

1 other study(ies) available for krn-7000 and Leukodystrophy--Metachromatic

Article	Year
Autoreactivity to Sulfatide by Human Invariant NKT Cells. Journal of immunology (Baltimore, Md. : 1950), 2017, 07-01, Volume: 199, Issue:1 Invariant NKT (iNKT) cells are innate-like lymphocytes that recognize lipid Ags presented by CD1d. The prototypical Ag, α-galactosylceramide, strongly activates human and mouse iNKT cells, leading to the assumption that iNKT cell physiology in human and mouse is similar. In this article, we report the surprising finding that human, but not mouse, iNKT cells directly recognize myelin-derived sulfatide presented by CD1d. We propose that sulfatide is recognized only by human iNKT cells because of the unique positioning of the 3- Topics: Animals; Antigen Presentation; Antigens, CD1d; Apolipoproteins E; Cell Line; Cerebroside-Sulfatase; Galactosylceramides; Humans; Leukodystrophy, Metachromatic; Lymphocyte Activation; Mice; Natural Killer T-Cells; Receptors, Antigen, T-Cell; Sulfoglycosphingolipids; Surface Plasmon Resonance; T-Lymphocyte Subsets	2017

Article

Year

Autoreactivity to Sulfatide by Human Invariant NKT Cells.

Journal of immunology (Baltimore, Md. : 1950), 2017, 07-01, Volume: 199, Issue:1

Invariant NKT (iNKT) cells are innate-like lymphocytes that recognize lipid Ags presented by CD1d. The prototypical Ag, α-galactosylceramide, strongly activates human and mouse iNKT cells, leading to the assumption that iNKT cell physiology in human and mouse is similar. In this article, we report the surprising finding that human, but not mouse, iNKT cells directly recognize myelin-derived sulfatide presented by CD1d. We propose that sulfatide is recognized only by human iNKT cells because of the unique positioning of the 3-

Topics: Animals; Antigen Presentation; Antigens, CD1d; Apolipoproteins E; Cell Line; Cerebroside-Sulfatase; Galactosylceramides; Humans; Leukodystrophy, Metachromatic; Lymphocyte Activation; Mice; Natural Killer T-Cells; Receptors, Antigen, T-Cell; Sulfoglycosphingolipids; Surface Plasmon Resonance; T-Lymphocyte Subsets

2017