krn-7000 and Cytomegalovirus-Infections

krn-7000 has been researched along with Cytomegalovirus-Infections* in 1 studies

Other Studies

1 other study(ies) available for krn-7000 and Cytomegalovirus-Infections

ArticleYear
Activated iNKT cells promote memory CD8+ T cell differentiation during viral infection.
    PloS one, 2012, Volume: 7, Issue:5

    α-Galactosylceramide (α-GalCer) is the prototypical lipid ligand for invariant NKT cells. Recent studies have proposed that α-GalCer is an effective adjuvant in vaccination against a range of immune challenges, however its mechanism of action has not been completely elucidated. A variety of delivery methods have been examined including pulsing dendritic cells with α-GalCer to optimize the potential of α-GalCer. These methods are currently being used in a variety of clinical trials in patients with advanced cancer but cannot be used in the context of vaccine development against pathogens due to their complexity. Using a simple delivery method, we evaluated α-GalCer adjuvant properties, using the mouse model for cytomegalovirus (MCMV). We measured several key parameters of the immune response to MCMV, including inflammation, effector, and central memory CD8(+) T cell responses. We found that α-GalCer injection at the time of the infection decreases viral titers, alters the kinetics of the inflammatory response, and promotes both increased frequencies and numbers of virus-specific memory CD8(+) T cells. Overall, our data suggest that iNKT cell activation by α-GalCer promotes the development of long-term protective immunity through increased fitness of central memory CD8(+) T cells, as a consequence of reduced inflammation.

    Topics: Adjuvants, Immunologic; Animals; CD8-Positive T-Lymphocytes; Cell Differentiation; Cytokines; Cytomegalovirus Infections; Flow Cytometry; Galactosylceramides; Immunologic Memory; Inflammation; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Natural Killer T-Cells; Statistics, Nonparametric

2012