koumine and Edema

koumine has been researched along with Edema* in 1 studies

Other Studies

1 other study(ies) available for koumine and Edema

ArticleYear
Effects of Koumine on Adjuvant- and Collagen-Induced Arthritis in Rats.
    Journal of natural products, 2016, 10-28, Volume: 79, Issue:10

    To examine the effect of koumine, a Gelsemium alkaloid, on two experimental models of rheumatoid arthritis (RA), rats with adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA) were administered koumine (0.6, 3, or 15 mg/kg/day) or vehicle through gastric gavage (i.g.). Clinical evaluation was performed via measurements of hind paw volume, arthritis index (AI) score, mechanical withdrawal threshold, organ weight, and by radiographic and histological examinations. Levels of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and antitype II collagen (CII) antibody were also examined. In rats with AIA, koumine reduced the AI score and mechanical allodynia of the injected hind paw in a dose-dependent manner and significantly inhibited increase in thymus and liver weights. In rats with CIA, koumine inhibited increase in hind paw volume, AI score, and mechanical allodynia in a dose-dependent manner and reduced joint space narrowing. Furthermore, koumine also attenuated the increase in the expression of IL-1β and TNF-α, as well as the robust increase of serum anti-CII antibodies in response to immunization. These results suggested that koumine effectively attenuated arthritis progression in two rat models of RA and that this therapeutic effect may be associated with its immunoregulatory action.

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Collagen; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Female; Gelsemium; Indole Alkaloids; Interleukin-1beta; Male; Methotrexate; Molecular Structure; Rats; Rats, Inbred Lew; Rats, Wistar; Tumor Necrosis Factor-alpha

2016